bioLOGIC Data » bioLOGIC CategoryView » bioLOGIC VennView » Experimental Details »

bioLOGIC Data

bioLOGIC Data


Exact search


Query: HSP90B1

RNAi screen result RNAPII IP (PI) CSB IP CSB IP (PI) Chrom. Chrom. (PI) Phosphorylation Ubiquitylation
W
[Click on the plots to view the data selection in the respective scatterplot]

Protein Results:

 Results for post-translational modifications: see below | Red/green: hit at lower/upper end of the respective screen
Gene name Point score Z-score sums RNAi high RNAi low RNAPII-IP (PI) CSB-IP CSB-IP (PI) Chrom. Chrom. (PI)
HSP90B1 2 4.443 0.100 0.120 0.724 1.982 -1.206 0.484 0.477

PTM Sites:

 Back to Protein Results | Red/green: hit at lower/upper end of the respective screen
Gene name PTM type PTM site UV UV (PI) Sequence
HSP90B1 Ubiquitylation K97 -0.155 1.541 _NK(gl)EIFLR_
HSP90B1 Ubiquitylation K404 -0.189 1.394 _GLFDEYGSK(gl)K_
HSP90B1 Ubiquitylation K405 -0.189 1.394 _GLFDEYGSK(gl)K_
HSP90B1 Ubiquitylation K95 0.097 1.380 _LIINSLYK(gl)NK_
HSP90B1 Ubiquitylation K168 1.363 _NLGTIAK(gl)SGTSEFLNK_
HSP90B1 Ubiquitylation K682 0.380 1.163 _DISTNYYASQK(gl)K_
HSP90B1 Ubiquitylation K683 0.380 1.163 _DISTNYYASQK(gl)K_
HSP90B1 Ubiquitylation K671 -0.264 0.676 _AQAYQTGK(gl)DISTNYYASQK_
HSP90B1 Ubiquitylation K161 0.157 0.544 _EELVK(gl)NLGTIAK_
HSP90B1 Ubiquitylation K455 0.816 0.384 _ETLQQHK(gl)LLK_
HSP90B1 Ubiquitylation K593 -0.763 0.376 _FQNVAK(gl)EGVK_
HSP90B1 Phosphorylation S306 -0.709 0.213 _TETVEEPMEEEEAAKEEKEES(ph)DDEAAVEEEEEEK_
HSP90B1 Ubiquitylation K663 -0.272 _IMK(gl)AQAYQTGK_

Background Information for HSP90B1:


Pubmed-HSP90B1 »
Uniprot-HSP90B1 »
Biogrid-HSP90B1 »
ProteomicsDB-HSP90B1 »

Tumorportal-HSP90B1 »
COSMIC-HSP90B1 »
GenomeRNAi-HSP90B1 »
Genecards-HSP90B1


Protein-protein Interactions for HSP90B1
Show screen data for Category Name and Description Link to cat description Data Source
Category members IP bait BMPR1A Cat. description Hein, Mann, Cell 2015
Category members IP bait CALML3 Cat. description Hein, Mann, Cell 2015
Category members IP bait GBA Cat. description Hein, Mann, Cell 2015
Category members IP bait HSP90B1 Cat. description Hein, Mann, Cell 2015
Category members IP bait HSPA5 Cat. description Hein, Mann, Cell 2015
Category members IP bait ITGB1 Cat. description Hein, Mann, Cell 2015
Category members IP bait KIF20B Cat. description Hein, Mann, Cell 2015
Category members IP bait LIMA1 Cat. description Hein, Mann, Cell 2015
Category members IP bait MGP Cat. description Hein, Mann, Cell 2015
Category members IP bait RFWD3 Cat. description Hein, Mann, Cell 2015
Category members IP bait SEL1L Cat. description Hein, Mann, Cell 2015
Category members IP bait SLC33A1 Cat. description Hein, Mann, Cell 2015
Category members IP bait TUBA3C;TUBA3E Cat. description Hein, Mann, Cell 2015
Category members IP bait UGGT1 Cat. description Hein, Mann, Cell 2015
Category members IP bait XRCC3 Cat. description Hein, Mann, Cell 2015
Category members IP bait LYZL2 Cat. description BioPlex, Huttlin, Gygi, Cell 2015


Protein Domains in HSP90B1
Domain name Domain Description TC-NER relevance -log10(p-value)
Category members Hsp90_fam IPR001404 1.09
Category members Hsp90_N IPR020575 1.09
Category members HATPase_C IPR003594 1.07
Category members Ribosomal_S5_D2-typ_fold IPR020568 1.06


Protein complexes (CORUM database) featuring HSP90B1
Category Type Category ID Category Name Data Source TC-NER relevance -log10(p-value)


Categories featuring HSP90B1
Category Type Category ID Category Name Data Source TC-NER relevance -log10(p-value)
Category members GO Category GO:0003723 RNA binding Database INF
Category members GO Category GO:0005515 protein binding Database INF
Category members GO Category GO:0005829 cytosol Database INF
Category members GO Category GO:0005576 extracellular region Database 10.9
Category members GO Category GO:0044267 cellular protein metabolic process Database 10.42
Category members GO Category GO:0042470 melanosome Database 5.59
Category members GO Category GO:0005524 ATP binding Database 5.54
Category members GO Category GO:0006457 protein folding Database 4.93
Category members GO Category GO:0051082 unfolded protein binding Database 3.74
Category members GO Category GO:0015031 protein transport Database 3.48
Category members Pathway Pathway_458 REACTOME_IMMUNE_SYSTEM 0 3
Category members GO Category GO:0005789 endoplasmic reticulum membrane Database 1.57
Category members GO Category GO:0030968 endoplasmic reticulum unfolded protein response Database 1.35
Category members GO Category GO:0006987 activation of signaling protein activity involved in unfolded protein response Database 1.26
Category members GO Category GO:0005886 plasma membrane Database 1.21
Category members Pathway Pathway_147 REACTOME_UNFOLDED_PROTEIN_RESPONSE 0 1.08
Category members GO Category GO:0005783 endoplasmic reticulum Database 0.62
Category members GO Category GO:0043066 negative regulation of apoptotic process Database 0.6
Category members GO Category GO:0030496 midbody Database 0.39
Category members Pathway Pathway_146 REACTOME_DIABETES_PATHWAYS 0 0.39
Category members GO Category GO:0048471 perinuclear region of cytoplasm Database 0.39
Category members GO Category GO:0019903 protein phosphatase binding Database 0.33
Category members Pathway Pathway_916 REACTOME_ACTIVATION_OF_CHAPERONE_GENES_BY_ATF6_ALPHA 0 0.33
Category members GO Category GO:0030433 ER-associated ubiquitin-dependent protein catabolic process Database 0.33
Category members Pathway Pathway_915 REACTOME_ACTIVATION_OF_CHAPERONES_BY_ATF6_ALPHA 0 0.31
Category members Pathway Pathway_460 REACTOME_INNATE_IMMUNE_SYSTEM 0 0.29
Category members Pathway Pathway_1053 KEGG_NOD_LIKE_RECEPTOR_SIGNALING_PATHWAY 0 0.25
Category members Pathway Pathway_527 REACTOME_TOLL_RECEPTOR_CASCADES 0 0.17
Category members Pathway Pathway_177 KEGG_PROSTATE_CANCER 0 0.13
Category members GO Category GO:0002224 toll-like receptor signaling pathway Database 0.12
Category members GO Category GO:0005509 calcium ion binding Database 0.11
Category members GO Category GO:0045087 innate immune response Database 0.05
Category members GO Category GO:0050750 low-density lipoprotein particle receptor binding Database 0.04
Category members Pathway Pathway_1269 REACTOME_TRAFFICKING_AND_PROCESSING_OF_ENDOSOMAL_TLR 0 0
Category members Pathway Pathway_24 KEGG_PATHWAYS_IN_CANCER 0 0
Category members Pathway Pathway_652 PID_IL6_7_PATHWAY 0 0
Category members GO Category GO:0001666 response to hypoxia Database 0
Category members GO Category GO:0005788 endoplasmic reticulum lumen Database 0
Category members GO Category GO:0006950 response to stress Database 0
Category members GO Category GO:0031247 actin rod assembly Database 0
Category members GO Category GO:0043666 regulation of phosphoprotein phosphatase activity Database 0
Category members GO Category GO:0046790 virion binding Database 0
Category members GO Category GO:0051208 sequestering of calcium ion Database 0
Category members GO Category GO:0071318 cellular response to ATP Database 0


.

© Copyright Svejstrup Laboratory 2015