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Query: PIAS1

RNAi screen result RNAPII IP (PI) CSB IP CSB IP (PI) Chrom. Chrom. (PI) Phosphorylation Ubiquitylation
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[Click on the plots to view the data selection in the respective scatterplot]

Protein Results:

 Results for post-translational modifications: see below | Red/green: hit at lower/upper end of the respective screen
Gene name Point score Z-score sums RNAi high RNAi low RNAPII-IP (PI) CSB-IP CSB-IP (PI) Chrom. Chrom. (PI)
PIAS1 0 0.204 -1.020 1.720 -1.034 -0.678 0.471 -0.051 1.019

PTM Sites:

 Back to Protein Results | Red/green: hit at lower/upper end of the respective screen
Gene name PTM type PTM site UV UV (PI) Sequence
PIAS1 Phosphorylation S505 0.198 -0.250 _GILSLPHQAS(ph)PVSR_
PIAS1 Phosphorylation S490 -0.898 -0.944 _RTCPSLSPTS(ph)PLNNK_
PIAS1 Ubiquitylation K60 -1.191 _AGCSPAVQMKIK(gl)_
PIAS1 Ubiquitylation K341 -1.248 _VSLLCPLGK(gl)MR_

Background Information for PIAS1:


Pubmed-PIAS1 »
Uniprot-PIAS1 »
Biogrid-PIAS1 »
ProteomicsDB-PIAS1 »

Tumorportal-PIAS1 »
COSMIC-PIAS1 »
GenomeRNAi-PIAS1 »
Genecards-PIAS1


Protein-protein Interactions for PIAS1
Show screen data for Category Name and Description Link to cat description Data Source
Category members IP bait ERP44 Cat. description Hein, Mann, Cell 2015
Category members IP bait FRAT1 Cat. description Hein, Mann, Cell 2015
Category members IP bait HIF1A Cat. description Hein, Mann, Cell 2015
Category members IP bait ID1 Cat. description Hein, Mann, Cell 2015
Category members IP bait KLC1 Cat. description Hein, Mann, Cell 2015
Category members IP bait POLK Cat. description Hein, Mann, Cell 2015
Category members IP bait VPS16 Cat. description Hein, Mann, Cell 2015
Category members IP bait TRIM35 Cat. description BioPlex, Huttlin, Gygi, Cell 2015


Protein Domains in PIAS1
Domain name Domain Description TC-NER relevance -log10(p-value)
Category members SAP_dom IPR003034 1.96
Category members Znf_MIZ IPR004181 0.13


Protein complexes (CORUM database) featuring PIAS1
Category Type Category ID Category Name Data Source TC-NER relevance -log10(p-value)


Categories featuring PIAS1
Category Type Category ID Category Name Data Source TC-NER relevance -log10(p-value)
Category members GO Category GO:0005515 protein binding Database INF
Category members GO Category GO:0005634 nucleus Database INF
Category members GO Category GO:0005654 nucleoplasm Database INF
Category members GO Category GO:0016607 nuclear speck Database 4.84
Category members GO Category GO:0003713 transcription coactivator activity Database 3.68
Category members Pathway Pathway_458 REACTOME_IMMUNE_SYSTEM 0 3
Category members GO Category GO:0031625 ubiquitin protein ligase binding Database 2.54
Category members Pathway Pathway_888 KEGG_UBIQUITIN_MEDIATED_PROTEOLYSIS 0 2.22
Category members GO Category GO:0019904 protein domain specific binding Database 1.85
Category members GO Category GO:0019899 enzyme binding Database 1.57
Category members GO Category GO:0003677 DNA binding Database 1.53
Category members GO Category GO:0016605 PML body Database 1.41
Category members Pathway Pathway_1254 PID_RANBP2_PATHWAY 0 1.33
Category members GO Category GO:0030521 androgen receptor signaling pathway Database 1.25
Category members GO Category GO:0006351 transcription, DNA-templated Database 1.07
Category members Pathway Pathway_699 REACTOME_INTERFERON_SIGNALING 0 0.86
Category members GO Category GO:0003676 nucleic acid binding Database 0.83
Category members GO Category GO:0033235 positive regulation of protein sumoylation Database 0.61
Category members Pathway Pathway_880 PID_AR_PATHWAY 0 0.58
Category members GO Category GO:0019221 cytokine-mediated signaling pathway Database 0.44
Category members Pathway Pathway_505 REACTOME_CYTOKINE_SIGNALING_IN_IMMUNE_SYSTEM 0 0.33
Category members GO Category GO:0016925 protein sumoylation Database 0.33
Category members GO Category GO:0008270 zinc ion binding Database 0.29
Category members GO Category GO:0045893 positive regulation of transcription, DNA-dependent Database 0.28
Category members GO Category GO:0032436 positive regulation of proteasomal ubiquitin-dependent protein catabolic process Database 0.24
Category members Pathway Pathway_447 KEGG_JAK_STAT_SIGNALING_PATHWAY 0 0.13
Category members GO Category GO:0050681 androgen receptor binding Database 0.12
Category members Pathway Pathway_537 PID_IFNG_PATHWAY 0 0.11
Category members Pathway Pathway_984 PID_HEDGEHOG_GLI_PATHWAY 0 0.1
Category members GO Category GO:0060334 regulation of interferon-gamma-mediated signaling pathway Database 0.07
Category members GO Category GO:0042127 regulation of cell proliferation Database 0.06
Category members GO Category GO:0019789 SUMO ligase activity Database 0.05
Category members GO Category GO:0065004 protein-DNA complex assembly Database 0.03
Category members GO Category GO:0000122 negative regulation of transcription from RNA polymerase II promoter Database 0.02
Category members Pathway Pathway_906 REACTOME_REGULATION_OF_IFNG_SIGNALING 0 0.01
Category members Pathway Pathway_166 ST_JAK_STAT_PATHWAY 0 0
Category members Pathway Pathway_24 KEGG_PATHWAYS_IN_CANCER 0 0
Category members Pathway Pathway_283 KEGG_SMALL_CELL_LUNG_CANCER 0 0
Category members Pathway Pathway_593 PID_TCPTP_PATHWAY 0 0
Category members Pathway Pathway_652 PID_IL6_7_PATHWAY 0 0
Category members Pathway Pathway_898 REACTOME_INTERFERON_GAMMA_SIGNALING 0 0
Category members GO Category GO:0003714 transcription corepressor activity Database 0
Category members GO Category GO:0007259 JAK-STAT cascade Database 0
Category members GO Category GO:0007283 spermatogenesis Database 0
Category members GO Category GO:0051152 positive regulation of smooth muscle cell differentiation Database 0
Category members GO Category GO:0060333 interferon-gamma-mediated signaling pathway Database 0


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