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Query: SRC

RNAi screen result RNAPII IP (PI) CSB IP CSB IP (PI) Chrom. Chrom. (PI) Phosphorylation Ubiquitylation
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[Click on the plots to view the data selection in the respective scatterplot]

Protein Results:

 Results for post-translational modifications: see below | Red/green: hit at lower/upper end of the respective screen
Gene name Point score Z-score sums RNAi high RNAi low RNAPII-IP (PI) CSB-IP CSB-IP (PI) Chrom. Chrom. (PI)
SRC 0 0.830 0.050 0.470 -0.031

PTM Sites:

 Back to Protein Results | Red/green: hit at lower/upper end of the respective screen
Gene name PTM type PTM site UV UV (PI) Sequence
SRC Phosphorylation S75 0.060 0.331 _LFGGFNSSDTVTS(ph)PQR_
SRC Phosphorylation S17 -0.604 -0.689 _S(ph)LEPAENVHGAGGGAFPASQTPSKPASADGHR_

Background Information for SRC:


Pubmed-SRC »
Uniprot-SRC »
Biogrid-SRC »
ProteomicsDB-SRC »

Tumorportal-SRC »
COSMIC-SRC »
GenomeRNAi-SRC »
Genecards-SRC


Protein-protein Interactions for SRC
Show screen data for Category Name and Description Link to cat description Data Source
Category members IP bait ACBD7 Cat. description BioPlex, Huttlin, Gygi, Cell 2015
Category members IP bait ALOXE3 Cat. description BioPlex, Huttlin, Gygi, Cell 2015
Category members IP bait C1QL4 Cat. description BioPlex, Huttlin, Gygi, Cell 2015
Category members IP bait CCNL2 Cat. description BioPlex, Huttlin, Gygi, Cell 2015
Category members IP bait CEACAM21 Cat. description BioPlex, Huttlin, Gygi, Cell 2015
Category members IP bait COX6B1 Cat. description BioPlex, Huttlin, Gygi, Cell 2015
Category members IP bait CYP2S1 Cat. description BioPlex, Huttlin, Gygi, Cell 2015
Category members IP bait DHX57 Cat. description BioPlex, Huttlin, Gygi, Cell 2015
Category members IP bait FMO5 Cat. description BioPlex, Huttlin, Gygi, Cell 2015
Category members IP bait FSD1 Cat. description BioPlex, Huttlin, Gygi, Cell 2015
Category members IP bait FYN Cat. description BioPlex, Huttlin, Gygi, Cell 2015
Category members IP bait FYTTD1 Cat. description BioPlex, Huttlin, Gygi, Cell 2015
Category members IP bait GLRX3 Cat. description BioPlex, Huttlin, Gygi, Cell 2015
Category members IP bait HOXB5 Cat. description BioPlex, Huttlin, Gygi, Cell 2015
Category members IP bait IFNGR1 Cat. description BioPlex, Huttlin, Gygi, Cell 2015
Category members IP bait IL1F5 Cat. description BioPlex, Huttlin, Gygi, Cell 2015
Category members IP bait ISG20 Cat. description BioPlex, Huttlin, Gygi, Cell 2015
Category members IP bait KIFAP3 Cat. description BioPlex, Huttlin, Gygi, Cell 2015
Category members IP bait MED21 Cat. description BioPlex, Huttlin, Gygi, Cell 2015
Category members IP bait NCSTN Cat. description BioPlex, Huttlin, Gygi, Cell 2015
Category members IP bait NFKBIA Cat. description BioPlex, Huttlin, Gygi, Cell 2015
Category members IP bait PCDHGC3 Cat. description BioPlex, Huttlin, Gygi, Cell 2015
Category members IP bait PDIK1L Cat. description BioPlex, Huttlin, Gygi, Cell 2015
Category members IP bait PRDM1 Cat. description BioPlex, Huttlin, Gygi, Cell 2015
Category members IP bait PRUNE2 Cat. description BioPlex, Huttlin, Gygi, Cell 2015
Category members IP bait RPS27 Cat. description BioPlex, Huttlin, Gygi, Cell 2015
Category members IP bait S1PR1 Cat. description BioPlex, Huttlin, Gygi, Cell 2015
Category members IP bait S1PR2 Cat. description BioPlex, Huttlin, Gygi, Cell 2015
Category members IP bait SLC25A41 Cat. description BioPlex, Huttlin, Gygi, Cell 2015
Category members IP bait SLC29A1 Cat. description BioPlex, Huttlin, Gygi, Cell 2015
Category members IP bait TMEM185A Cat. description BioPlex, Huttlin, Gygi, Cell 2015
Category members IP bait TMEM220 Cat. description BioPlex, Huttlin, Gygi, Cell 2015
Category members IP bait TNFAIP3 Cat. description BioPlex, Huttlin, Gygi, Cell 2015
Category members IP bait VDAC3 Cat. description BioPlex, Huttlin, Gygi, Cell 2015


Protein Domains in SRC
Domain name Domain Description TC-NER relevance -log10(p-value)
Category members SH3_2 IPR011511 0.08
Category members SH2 IPR000980 0.05
Category members Kinase-like_dom IPR011009 0.03
Category members Prot_kinase_dom IPR000719 0
Category members Ser-Thr/Tyr_kinase_cat_dom IPR001245 0
Category members SH3_domain IPR001452 0
Category members Ser/Thr_dual-sp_kinase IPR002290 0
Category members Tyr_kinase_cat_dom IPR020635 0


Protein complexes (CORUM database) featuring SRC
Category Type Category ID Category Name Data Source TC-NER relevance -log10(p-value)
Category members Corum 3137 MASH1 promoter-coactivator complex Database 5.32
Category members Corum 5177 Polycystin-1 multiprotein complex (ACTN1, CDH1, SRC, JUP, VCL, CTNNB1, PXN, BCAR1, PKD1, PTK2, TLN1) Database 0.31
Category members Corum 3142 CAMK2-delta-MASH1 promoter-coactivator complex Database 0.07
Category members Corum 2073 TNFRSF11A-TRAF6-SRC complex Database 0
Category members Corum 2377 ITGA2b-ITGB3-CD47-SRC complex Database 0
Category members Corum 2470 p130Cas-ER-alpha-cSrc-kinase- PI3-kinase p85-subunit complex Database 0
Category members Corum 2471 SRC-PRKCD-CDCP1 complex Database 0
Category members Corum 5282 CAS-SRC-FAK complex Database 0
Category members Corum 5713 SH3P2/OSTF1-CBL-SRC complex Database 0
Category members Corum 5928 CNK1-SRC-RAF1 complex Database 0


Categories featuring SRC
Category Type Category ID Category Name Data Source TC-NER relevance -log10(p-value)
Category members GO Category GO:0005515 protein binding Database INF
Category members GO Category GO:0005634 nucleus Database INF
Category members GO Category GO:0005829 cytosol Database INF
Category members GO Category GO:0005737 cytoplasm Database 12.81
Category members GO Category GO:0019048 modulation by virus of host morphology or physiology Database 7.81
Category members GO Category GO:0005524 ATP binding Database 5.54
Category members Pathway Pathway_621 REACTOME_ADAPTIVE_IMMUNE_SYSTEM 0 4.72
Category members Pathway Pathway_458 REACTOME_IMMUNE_SYSTEM 0 3
Category members Pathway Pathway_292 PID_ECADHERIN_NASCENT_AJ_PATHWAY 0 2.74
Category members Pathway Pathway_934 PID_PI3KCI_AKT_PATHWAY 0 2.5
Category members Pathway Pathway_259 REACTOME_NGF_SIGNALLING_VIA_TRKA_FROM_THE_PLASMA_MEMBRANE 0 2.34
Category members Pathway Pathway_221 REACTOME_SIGNALLING_BY_NGF 0 2.14
Category members Pathway Pathway_413 KEGG_TIGHT_JUNCTION 0 2.08
Category members Pathway Pathway_579 PID_ERBB1_DOWNSTREAM_PATHWAY 0 1.97
Category members Pathway Pathway_541 PID_FAK_PATHWAY 0 1.88
Category members GO Category GO:0019904 protein domain specific binding Database 1.85
Category members Pathway Pathway_636 PID_PI3K_PLC_TRK_PATHWAY 0 1.85
Category members Pathway Pathway_258 REACTOME_SIGNALING_BY_EGFR_IN_CANCER 0 1.81
Category members GO Category GO:0005739 mitochondrion Database 1.67
Category members Pathway Pathway_265 REACTOME_SIGNALING_BY_FGFR_IN_DISEASE 0 1.42
Category members Pathway Pathway_645 PID_CXCR4_PATHWAY 0 1.42
Category members Pathway Pathway_309 ST_INTEGRIN_SIGNALING_PATHWAY 0 1.35
Category members Pathway Pathway_611 PID_ECADHERIN_KERATINOCYTE_PATHWAY 0 1.34
Category members Pathway Pathway_1075 REACTOME_L1CAM_INTERACTIONS 0 1.32
Category members Pathway Pathway_549 REACTOME_GAB1_SIGNALOSOME 0 1.25
Category members Pathway Pathway_666 KEGG_ENDOCYTOSIS 0 1.25
Category members GO Category GO:0005886 plasma membrane Database 1.21
Category members Pathway Pathway_561 PID_PDGFRB_PATHWAY 0 1.18
Category members Pathway Pathway_474 REACTOME_MEMBRANE_TRAFFICKING 0 1.14
Category members Pathway Pathway_1156 BIOCARTA_UCALPAIN_PATHWAY 0 1.12
Category members Pathway Pathway_237 PID_LYSOPHOSPHOLIPID_PATHWAY 0 1.09
Category members Pathway Pathway_595 KEGG_FOCAL_ADHESION 0 1.08
Category members Pathway Pathway_673 REACTOME_AXON_GUIDANCE 0 1.06
Category members Pathway Pathway_308 PID_AR_TF_PATHWAY 0 0.86
Category members Pathway Pathway_507 PID_MET_PATHWAY 0 0.82
Category members Pathway Pathway_936 REACTOME_CTLA4_INHIBITORY_SIGNALING 0 0.77
Category members GO Category GO:0007049 cell cycle Database 0.69
Category members Pathway Pathway_229 REACTOME_SIGNALING_BY_ERBB2 0 0.68
Category members Pathway Pathway_568 PID_CDC42_PATHWAY 0 0.68
Category members Pathway Pathway_1061 BIOCARTA_INTEGRIN_PATHWAY 0 0.66
Category members Pathway Pathway_1074 PID_SYNDECAN_3_PATHWAY 0 0.65
Category members GO Category GO:0070374 positive regulation of ERK1 and ERK2 cascade Database 0.65
Category members GO Category GO:0048011 neurotrophin TRK receptor signaling pathway Database 0.63
Category members GO Category GO:0005856 cytoskeleton Database 0.63
Category members Pathway Pathway_254 REACTOME_SIGNALING_BY_FGFR 0 0.61
Category members GO Category GO:0043066 negative regulation of apoptotic process Database 0.6
Category members Pathway Pathway_599 REACTOME_SIGNALING_BY_SCF_KIT 0 0.48
Category members Pathway Pathway_992 PID_ARF6_PATHWAY 0 0.46
Category members Pathway Pathway_747 KEGG_ADHERENS_JUNCTION 0 0.43
Category members Pathway Pathway_255 REACTOME_DOWNSTREAM_SIGNAL_TRANSDUCTION 0 0.42
Category members Pathway Pathway_247 REACTOME_SIGNALING_BY_PDGF 0 0.4
Category members Pathway Pathway_53 REACTOME_HEMOSTASIS 0 0.4
Category members GO Category GO:0007596 blood coagulation Database 0.4
Category members GO Category GO:0038096 Fc-gamma receptor signaling pathway involved in phagocytosis Database 0.33
Category members GO Category GO:0051219 phosphoprotein binding Database 0.33
Category members Pathway Pathway_42 REACTOME_DEVELOPMENTAL_BIOLOGY 0 0.32
Category members GO Category GO:0046875 ephrin receptor binding Database 0.3
Category members Pathway Pathway_667 BIOCARTA_RHO_PATHWAY 0 0.3
Category members GO Category GO:0008543 fibroblast growth factor receptor signaling pathway Database 0.29
Category members Pathway Pathway_987 PID_S1P_S1P3_PATHWAY 0 0.28
Category members Pathway Pathway_1135 PID_PRL_SIGNALING_EVENTS_PATHWAY 0 0.27
Category members GO Category GO:0007173 epidermal growth factor receptor signaling pathway Database 0.26
Category members GO Category GO:0042802 identical protein binding Database 0.26
Category members Pathway Pathway_560 REACTOME_CELL_CELL_COMMUNICATION 0 0.25
Category members Pathway Pathway_536 BIOCARTA_ECM_PATHWAY 0 0.25
Category members Pathway Pathway_188 KEGG_EPITHELIAL_CELL_SIGNALING_IN_HELICOBACTER_PYLORI_INFECTION 0 0.24
Category members GO Category GO:0046777 protein autophosphorylation Database 0.23
Category members Pathway Pathway_433 PID_ER_NONGENOMIC_PATHWAY 0 0.23
Category members GO Category GO:0016301 kinase activity Database 0.23
Category members Pathway Pathway_581 PID_NECTIN_PATHWAY 0 0.21
Category members Pathway Pathway_710 PID_UPA_UPAR_PATHWAY 0 0.2
Category members Pathway Pathway_957 PID_AMB2_NEUTROPHILS_PATHWAY 0 0.2
Category members GO Category GO:0004672 protein kinase activity Database 0.19
Category members Pathway Pathway_294 PID_AJDISS_2PATHWAY 0 0.18
Category members GO Category GO:0005743 mitochondrial inner membrane Database 0.15
Category members Pathway Pathway_1033 REACTOME_DCC_MEDIATED_ATTRACTIVE_SIGNALING 0 0.14
Category members Pathway Pathway_629 PID_EPHB_FWD_PATHWAY 0 0.14
Category members Pathway Pathway_1067 BIOCARTA_CBL_PATHWAY 0 0.14
Category members Pathway Pathway_694 REACTOME_SIGNALLING_TO_ERKS 0 0.13
Category members GO Category GO:0030168 platelet activation Database 0.13
Category members Pathway Pathway_437 PID_VEGFR1_2_PATHWAY 0 0.13
Category members GO Category GO:0007411 axon guidance Database 0.13
Category members Pathway Pathway_1041 BIOCARTA_AGR_PATHWAY 0 0.13
Category members Pathway Pathway_532 PID_ERBB2_ERBB3_PATHWAY 0 0.13
Category members Pathway Pathway_546 PID_ERBB1_RECEPTOR_PROXIMAL_PATHWAY 0 0.13
Category members Pathway Pathway_622 REACTOME_CD28_CO_STIMULATION 0 0.13
Category members Pathway Pathway_733 ST_G_ALPHA_S_PATHWAY 0 0.13
Category members GO Category GO:0032463 negative regulation of protein homooligomerization Database 0.11
Category members GO Category GO:0048477 oogenesis Database 0.11
Category members Pathway Pathway_56 REACTOME_PLATELET_ACTIVATION_SIGNALING_AND_AGGREGATION 0 0.11
Category members Pathway Pathway_213 KEGG_GAP_JUNCTION 0 0.11
Category members GO Category GO:0005178 integrin binding Database 0.09
Category members Pathway Pathway_810 REACTOME_SPRY_REGULATION_OF_FGF_SIGNALING 0 0.09
Category members GO Category GO:0005770 late endosome Database 0.09
Category members Pathway Pathway_1022 PID_SYNDECAN_2_PATHWAY 0 0.08
Category members Pathway Pathway_1178 BIOCARTA_CELL2CELL_PATHWAY 0 0.08
Category members Pathway Pathway_513 ST_ADRENERGIC 0 0.08
Category members Pathway Pathway_1029 BIOCARTA_SRCRPTP_PATHWAY 0 0.08
Category members Pathway Pathway_405 PID_ALPHA_SYNUCLEIN_PATHWAY 0 0.08
Category members Pathway Pathway_721 REACTOME_SIGNAL_AMPLIFICATION 0 0.06
Category members Pathway Pathway_236 BIOCARTA_MPR_PATHWAY 0 0.06
Category members Pathway Pathway_620 REACTOME_COSTIMULATION_BY_THE_CD28_FAMILY 0 0.06
Category members Pathway Pathway_600 REACTOME_CELL_SURFACE_INTERACTIONS_AT_THE_VASCULAR_WALL 0 0.05
Category members Pathway Pathway_680 BIOCARTA_SPPA_PATHWAY 0 0.05
Category members GO Category GO:0045087 innate immune response Database 0.05
Category members Pathway Pathway_511 PID_EPHA2_FWD_PATHWAY 0 0.05
Category members Pathway Pathway_518 ST_G_ALPHA_I_PATHWAY 0 0.05
Category members GO Category GO:0043393 regulation of protein binding Database 0.04
Category members Pathway Pathway_1136 REACTOME_RECYCLING_PATHWAY_OF_L1 0 0.04
Category members GO Category GO:0006468 protein phosphorylation Database 0.04
Category members Pathway Pathway_653 BIOCARTA_MET_PATHWAY 0 0.04
Category members GO Category GO:0050900 leukocyte migration Database 0.04
Category members GO Category GO:0070851 growth factor receptor binding Database 0.04
Category members Pathway Pathway_695 REACTOME_PECAM1_INTERACTIONS 0 0.04
Category members GO Category GO:0020037 heme binding Database 0.04
Category members GO Category GO:0044325 ion channel binding Database 0.03
Category members Pathway Pathway_521 PID_AVB3_INTEGRIN_PATHWAY 0 0.03
Category members GO Category GO:0070555 response to interleukin-1 Database 0.02
Category members Pathway Pathway_932 REACTOME_PLATELET_AGGREGATION_PLUG_FORMATION 0 0.01
Category members Pathway Pathway_1180 BIOCARTA_GABA_PATHWAY 0 0.01
Category members GO Category GO:0004713 protein tyrosine kinase activity Database 0.01
Category members Pathway Pathway_665 PID_EPHA_FWDPATHWAY 0 0.01
Category members Pathway Pathway_1010 REACTOME_NCAM_SIGNALING_FOR_NEURITE_OUT_GROWTH 0 0
Category members Pathway Pathway_1024 PID_INTEGRIN_A4B1_PATHWAY 0 0
Category members Pathway Pathway_1039 PID_P38_ALPHA_BETA_PATHWAY 0 0
Category members Pathway Pathway_1060 REACTOME_P130CAS_LINKAGE_TO_MAPK_SIGNALING_FOR_INTEGRINS 0 0
Category members Pathway Pathway_1071 BIOCARTA_SPRY_PATHWAY 0 0
Category members Pathway Pathway_1072 BIOCARTA_ERK_PATHWAY 0 0
Category members Pathway Pathway_1109 REACTOME_GRB2_SOS_PROVIDES_LINKAGE_TO_MAPK_SIGNALING_FOR_INTERGRINS_ 0 0
Category members Pathway Pathway_1110 REACTOME_SIGNAL_REGULATORY_PROTEIN_SIRP_FAMILY_INTERACTIONS 0 0
Category members Pathway Pathway_1113 REACTOME_REGULATION_OF_KIT_SIGNALING 0 0
Category members Pathway Pathway_1114 REACTOME_SIGNALLING_TO_RAS 0 0
Category members Pathway Pathway_1117 REACTOME_P38MAPK_EVENTS 0 0
Category members Pathway Pathway_1179 ST_STAT3_PATHWAY 0 0
Category members Pathway Pathway_216 BIOCARTA_EDG1_PATHWAY 0 0
Category members Pathway Pathway_231 BIOCARTA_BARRESTIN_SRC_PATHWAY 0 0
Category members Pathway Pathway_234 PID_ENDOTHELIN_PATHWAY 0 0
Category members Pathway Pathway_257 KEGG_GNRH_SIGNALING_PATHWAY 0 0
Category members Pathway Pathway_410 ST_INTERLEUKIN_4_PATHWAY 0 0
Category members Pathway Pathway_426 PID_INTEGRIN_A9B1_PATHWAY 0 0
Category members Pathway Pathway_430 PID_TXA2PATHWAY 0 0
Category members Pathway Pathway_436 KEGG_VEGF_SIGNALING_PATHWAY 0 0
Category members Pathway Pathway_445 ST_DIFFERENTIATION_PATHWAY_IN_PC12_CELLS 0 0
Category members Pathway Pathway_502 PID_PI3KCI_PATHWAY 0 0
Category members Pathway Pathway_538 PID_ERBB1_INTERNALIZATION_PATHWAY 0 0
Category members Pathway Pathway_547 PID_EPHRINB_REV_PATHWAY 0 0
Category members Pathway Pathway_575 KEGG_ERBB_SIGNALING_PATHWAY 0 0
Category members Pathway Pathway_593 PID_TCPTP_PATHWAY 0 0
Category members Pathway Pathway_602 PID_PTP1B_PATHWAY 0 0
Category members Pathway Pathway_610 PID_NFKAPPAB_ATYPICAL_PATHWAY 0 0
Category members Pathway Pathway_613 BIOCARTA_ACH_PATHWAY 0 0
Category members Pathway Pathway_624 PID_AR_NONGENOMIC_PATHWAY 0 0
Category members Pathway Pathway_640 PID_NETRIN_PATHWAY 0 0
Category members Pathway Pathway_643 PID_RET_PATHWAY 0 0
Category members Pathway Pathway_650 PID_FAS_PATHWAY 0 0
Category members Pathway Pathway_655 PID_CXCR3_PATHWAY 0 0
Category members Pathway Pathway_657 PID_FGF_PATHWAY 0 0
Category members Pathway Pathway_692 REACTOME_NETRIN1_SIGNALING 0 0
Category members Pathway Pathway_693 BIOCARTA_PYK2_PATHWAY 0 0
Category members Pathway Pathway_718 PID_GLYPICAN_1PATHWAY 0 0
Category members Pathway Pathway_722 REACTOME_ADP_SIGNALLING_THROUGH_P2RY1 0 0
Category members Pathway Pathway_725 ST_GA12_PATHWAY 0 0
Category members Pathway Pathway_783 REACTOME_NEGATIVE_REGULATION_OF_FGFR_SIGNALING 0 0
Category members Pathway Pathway_930 REACTOME_INTEGRIN_CELL_SURFACE_INTERACTIONS 0 0
Category members Pathway Pathway_931 REACTOME_INTEGRIN_ALPHAIIB_BETA3_SIGNALING 0 0
Category members Pathway Pathway_994 REACTOME_THROMBIN_SIGNALLING_THROUGH_PROTEINASE_ACTIVATED_RECEPTORS_PARS 0 0
Category members Pathway Pathway_998 BIOCARTA_AT1R_PATHWAY 0 0
Category members GO Category GO:0004715 non-membrane spanning protein tyrosine kinase activity Database 0
Category members GO Category GO:0005070 SH3/SH2 adaptor activity Database 0
Category members GO Category GO:0005102 receptor binding Database 0
Category members GO Category GO:0005764 lysosome Database 0
Category members GO Category GO:0005901 caveola Database 0
Category members GO Category GO:0007155 cell adhesion Database 0
Category members GO Category GO:0007165 signal transduction Database 0
Category members GO Category GO:0007172 signal complex assembly Database 0
Category members GO Category GO:0007265 Ras protein signal transduction Database 0
Category members GO Category GO:0016477 cell migration Database 0
Category members GO Category GO:0016772 transferase activity, transferring phosphorus-containing groups Database 0
Category members GO Category GO:0018108 peptidyl-tyrosine phosphorylation Database 0
Category members GO Category GO:0030900 forebrain development Database 0
Category members GO Category GO:0031295 T cell costimulation Database 0
Category members GO Category GO:0033146 regulation of intracellular estrogen receptor signaling pathway Database 0
Category members GO Category GO:0033625 positive regulation of integrin activation Database 0
Category members GO Category GO:0035556 intracellular signal transduction Database 0
Category members GO Category GO:0042169 SH2 domain binding Database 0
Category members GO Category GO:0043114 regulation of vascular permeability Database 0
Category members GO Category GO:0043154 negative regulation of cysteine-type endopeptidase activity involved in apoptotic process Database 0
Category members GO Category GO:0045124 regulation of bone resorption Database 0
Category members GO Category GO:0045453 bone resorption Database 0
Category members GO Category GO:0050847 progesterone receptor signaling pathway Database 0
Category members GO Category GO:0051895 negative regulation of focal adhesion assembly Database 0
Category members GO Category GO:0051897 positive regulation of protein kinase B signaling Database 0
Category members GO Category GO:0051902 negative regulation of mitochondrial depolarization Database 0
Category members GO Category GO:0060065 uterus development Database 0
Category members GO Category GO:0060444 branching involved in mammary gland duct morphogenesis Database 0


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