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Query: PSEN1

RNAi screen result RNAPII IP (PI) CSB IP CSB IP (PI) Chrom. Chrom. (PI) Phosphorylation Ubiquitylation
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[Click on the plots to view the data selection in the respective scatterplot]

Protein Results:

 Results for post-translational modifications: see below | Red/green: hit at lower/upper end of the respective screen
Gene name Point score Z-score sums RNAi high RNAi low RNAPII-IP (PI) CSB-IP CSB-IP (PI) Chrom. Chrom. (PI)
PSEN1 0 1.279 0.930 -1.110

PTM Sites:

 Back to Protein Results | Red/green: hit at lower/upper end of the respective screen
Gene name PTM type PTM site UV UV (PI) Sequence
PSEN1 Phosphorylation S313 0.844 _VSKNS(ph)KYNAESTER_
PSEN1 Ubiquitylation K314 0.016 0.414 _NSK(gl)YNAESTER_
PSEN1 Phosphorylation S367 0.005 0.066 _AAVQELSSS(ph)ILAGEDPEER_
PSEN1 Phosphorylation S366 -0.340 0.055 _AAVQELSS(ph)SILAGEDPEER_

Background Information for PSEN1:


Pubmed-PSEN1 »
Uniprot-PSEN1 »
Biogrid-PSEN1 »
ProteomicsDB-PSEN1 »

Tumorportal-PSEN1 »
COSMIC-PSEN1 »
GenomeRNAi-PSEN1 »
Genecards-PSEN1


Protein-protein Interactions for PSEN1
Show screen data for Category Name and Description Link to cat description Data Source
Category members IP bait NCSTN Cat. description Hein, Mann, Cell 2015
Category members IP bait CDH8 Cat. description BioPlex, Huttlin, Gygi, Cell 2015
Category members IP bait SPPL2B Cat. description BioPlex, Huttlin, Gygi, Cell 2015


Protein Domains in PSEN1
Domain name Domain Description TC-NER relevance -log10(p-value)
Category members Peptidase_A22A IPR001108 0.08
Category members Preselin/SPP IPR006639 0


Protein complexes (CORUM database) featuring PSEN1
Category Type Category ID Category Name Data Source TC-NER relevance -log10(p-value)
Category members Corum 142 CD147-gamma-secretase complex (APH-1a, PS-1, PEN-2, NCT variant) Database 0.18
Category members Corum 3128 Gamma-secretase complex (APH1B, PSEN1, PSENEN, NCSTN) Database 0.18
Category members Corum 2734 APH1A-PSEN1-NCSTN complex Database 0.08
Category members Corum 2891 Gamma-secretase complex (APH1A, PSEN1, PSENEN, NCSTN) Database 0.07
Category members Corum 43 Gamma-secretase complex (APH1A, PSEN1, PSENEN, NCSTN variant) Database 0.07
Category members Corum 45 Gamma-secretase complex (APH1A, PSEN1, PSENEN, NCSTN variant) Database 0.07
Category members Corum 466 Gamma-secretase complex (APH1A, PSEN1, PSENEN, NCSTN) Database 0.07
Category members Corum 3271 Gamma-secretase-Delta1 complex Database 0


Categories featuring PSEN1
Category Type Category ID Category Name Data Source TC-NER relevance -log10(p-value)
Category members GO Category GO:0005515 protein binding Database INF
Category members GO Category GO:0005634 nucleus Database INF
Category members GO Category GO:0044267 cellular protein metabolic process Database 10.42
Category members GO Category GO:0016021 integral to membrane Database 7.67
Category members GO Category GO:0006974 cellular response to DNA damage stimulus Database 3.57
Category members GO Category GO:0015031 protein transport Database 3.48
Category members GO Category GO:0043234 protein complex Database 2.73
Category members GO Category GO:0031965 nuclear membrane Database 2.59
Category members GO Category GO:0005938 cell cortex Database 2.26
Category members GO Category GO:0000776 kinetochore Database 2.24
Category members Pathway Pathway_221 REACTOME_SIGNALLING_BY_NGF 0 2.14
Category members GO Category GO:0005887 integral to plasma membrane Database 1.69
Category members GO Category GO:0005739 mitochondrion Database 1.67
Category members GO Category GO:0030426 growth cone Database 1.61
Category members GO Category GO:0005789 endoplasmic reticulum membrane Database 1.57
Category members GO Category GO:0032469 endoplasmic reticulum calcium ion homeostasis Database 1.26
Category members GO Category GO:0005886 plasma membrane Database 1.21
Category members GO Category GO:0043198 dendritic shaft Database 0.93
Category members GO Category GO:0005765 lysosomal membrane Database 0.82
Category members GO Category GO:0043085 positive regulation of catalytic activity Database 0.78
Category members GO Category GO:0005813 centrosome Database 0.75
Category members Pathway Pathway_529 KEGG_NEUROTROPHIN_SIGNALING_PATHWAY 0 0.75
Category members GO Category GO:0043524 negative regulation of neuron apoptotic process Database 0.66
Category members Pathway Pathway_1074 PID_SYNDECAN_3_PATHWAY 0 0.65
Category members GO Category GO:0005783 endoplasmic reticulum Database 0.62
Category members Pathway Pathway_840 ST_WNT_BETA_CATENIN_PATHWAY 0 0.6
Category members GO Category GO:0043066 negative regulation of apoptotic process Database 0.6
Category members GO Category GO:0016485 protein processing Database 0.57
Category members GO Category GO:0016020 membrane Database 0.52
Category members GO Category GO:0048471 perinuclear region of cytoplasm Database 0.39
Category members GO Category GO:0021987 cerebral cortex development Database 0.37
Category members GO Category GO:0008013 beta-catenin binding Database 0.35
Category members Pathway Pathway_117 REACTOME_SIGNALING_BY_NOTCH 0 0.33
Category members GO Category GO:0005622 intracellular Database 0.32
Category members GO Category GO:0030018 Z disc Database 0.32
Category members GO Category GO:0030165 PDZ domain binding Database 0.29
Category members Pathway Pathway_849 PID_NOTCH_PATHWAY 0 0.29
Category members Pathway Pathway_1173 BIOCARTA_PS1_PATHWAY 0 0.28
Category members GO Category GO:0005794 Golgi apparatus Database 0.27
Category members GO Category GO:0030425 dendrite Database 0.26
Category members GO Category GO:0045296 cadherin binding Database 0.26
Category members GO Category GO:0043065 positive regulation of apoptotic process Database 0.26
Category members GO Category GO:0043227 membrane-bounded organelle Database 0.25
Category members GO Category GO:0051402 neuron apoptotic process Database 0.25
Category members GO Category GO:0070588 calcium ion transmembrane transport Database 0.25
Category members GO Category GO:0032436 positive regulation of proteasomal ubiquitin-dependent protein catabolic process Database 0.24
Category members Pathway Pathway_739 REACTOME_P75_NTR_RECEPTOR_MEDIATED_SIGNALLING 0 0.23
Category members GO Category GO:0030424 axon Database 0.23
Category members GO Category GO:0001934 positive regulation of protein phosphorylation Database 0.22
Category members Pathway Pathway_789 REACTOME_SIGNALING_BY_NOTCH1 0 0.22
Category members GO Category GO:0006486 protein glycosylation Database 0.21
Category members GO Category GO:0050673 epithelial cell proliferation Database 0.21
Category members Pathway Pathway_779 REACTOME_CELL_DEATH_SIGNALLING_VIA_NRAGE_NRIF_AND_NADE 0 0.2
Category members GO Category GO:0005640 nuclear outer membrane Database 0.18
Category members GO Category GO:0009986 cell surface Database 0.17
Category members Pathway Pathway_960 BIOCARTA_HIVNEF_PATHWAY 0 0.17
Category members GO Category GO:0000186 activation of MAPKK activity Database 0.16
Category members GO Category GO:0022008 neurogenesis Database 0.16
Category members GO Category GO:0005743 mitochondrial inner membrane Database 0.15
Category members GO Category GO:0048167 regulation of synaptic plasticity Database 0.14
Category members GO Category GO:0006509 membrane protein ectodomain proteolysis Database 0.14
Category members GO Category GO:0002573 myeloid leukocyte differentiation Database 0.11
Category members GO Category GO:0045121 membrane raft Database 0.11
Category members Pathway Pathway_679 KEGG_WNT_SIGNALING_PATHWAY 0 0.09
Category members GO Category GO:0042987 amyloid precursor protein catabolic process Database 0.09
Category members Disease phenotype Familial_isolated_dilated_cardiomyopathy Familial isolated dilated cardiomyopathy Database 0.08
Category members GO Category GO:0001947 heart looping Database 0.08
Category members GO Category GO:0043005 neuron projection Database 0.08
Category members GO Category GO:0005262 calcium channel activity Database 0.08
Category members GO Category GO:0005790 smooth endoplasmic reticulum Database 0.08
Category members GO Category GO:0016080 synaptic vesicle targeting Database 0.08
Category members GO Category GO:0050820 positive regulation of coagulation Database 0.08
Category members GO Category GO:0051604 protein maturation Database 0.06
Category members GO Category GO:0050852 T cell receptor signaling pathway Database 0.06
Category members GO Category GO:0045860 positive regulation of protein kinase activity Database 0.06
Category members Pathway Pathway_545 REACTOME_SIGNALING_BY_ERBB4 0 0.05
Category members GO Category GO:0007219 Notch signaling pathway Database 0.05
Category members GO Category GO:0043393 regulation of protein binding Database 0.04
Category members Pathway Pathway_1159 REACTOME_REGULATED_PROTEOLYSIS_OF_P75NTR 0 0.04
Category members Pathway Pathway_557 PID_P75_NTR_PATHWAY 0 0.04
Category members Disease phenotype Behavioral_variant_of_frontotemporal_dementia Behavioral variant of frontotemporal dementia Database 0.04
Category members Disease phenotype Progressive_non-fluent_aphasia Progressive non-fluent aphasia Database 0.04
Category members Disease phenotype Semantic_dementia Semantic dementia Database 0.04
Category members GO Category GO:0001933 negative regulation of protein phosphorylation Database 0.04
Category members Disease phenotype Early-onset_autosomal_dominant_Alzheimer_disease Early-onset autosomal dominant Alzheimer disease Database 0.04
Category members GO Category GO:0002286 T cell activation involved in immune response Database 0.04
Category members GO Category GO:0034205 beta-amyloid formation Database 0.04
Category members GO Category GO:0035253 ciliary rootlet Database 0.03
Category members Pathway Pathway_942 PID_PS1_PATHWAY 0 0.03
Category members GO Category GO:0001921 positive regulation of receptor recycling Database 0.02
Category members GO Category GO:0000122 negative regulation of transcription from RNA polymerase II promoter Database 0.02
Category members GO Category GO:0008233 peptidase activity Database 0.02
Category members Pathway Pathway_1278 REACTOME_SIGNALING_BY_NOTCH2 0 0
Category members Pathway Pathway_1279 REACTOME_SIGNALING_BY_NOTCH3 0 0
Category members Pathway Pathway_1280 REACTOME_SIGNALING_BY_NOTCH4 0 0
Category members Pathway Pathway_29 KEGG_ALZHEIMERS_DISEASE 0 0
Category members Pathway Pathway_799 REACTOME_NRIF_SIGNALS_CELL_DEATH_FROM_THE_NUCLEUS 0 0
Category members Pathway Pathway_831 REACTOME_ACTIVATED_NOTCH1_TRANSMITS_SIGNAL_TO_THE_NUCLEUS 0 0
Category members Pathway Pathway_892 KEGG_NOTCH_SIGNALING_PATHWAY 0 0
Category members Pathway Pathway_977 REACTOME_NUCLEAR_SIGNALING_BY_ERBB4 0 0
Category members Disease phenotype FRONTOTEMPORAL_DEMENTIA FRONTOTEMPORAL DEMENTIA Database 0
Category members GO Category GO:0000045 autophagic vacuole assembly Database 0
Category members GO Category GO:0000139 Golgi membrane Database 0
Category members GO Category GO:0001568 blood vessel development Database 0
Category members GO Category GO:0001708 cell fate specification Database 0
Category members GO Category GO:0001756 somitogenesis Database 0
Category members GO Category GO:0001764 neuron migration Database 0
Category members GO Category GO:0002244 hematopoietic progenitor cell differentiation Database 0
Category members GO Category GO:0004175 endopeptidase activity Database 0
Category members GO Category GO:0004190 aspartic-type endopeptidase activity Database 0
Category members GO Category GO:0005791 rough endoplasmic reticulum Database 0
Category members GO Category GO:0006469 negative regulation of protein kinase activity Database 0
Category members GO Category GO:0006816 calcium ion transport Database 0
Category members GO Category GO:0006839 mitochondrial transport Database 0
Category members GO Category GO:0006874 cellular calcium ion homeostasis Database 0
Category members GO Category GO:0006914 autophagy Database 0
Category members GO Category GO:0006979 response to oxidative stress Database 0
Category members GO Category GO:0007175 negative regulation of epidermal growth factor-activated receptor activity Database 0
Category members GO Category GO:0007176 regulation of epidermal growth factor-activated receptor activity Database 0
Category members GO Category GO:0007220 Notch receptor processing Database 0
Category members GO Category GO:0007420 brain development Database 0
Category members GO Category GO:0007507 heart development Database 0
Category members GO Category GO:0007611 learning or memory Database 0
Category members GO Category GO:0007613 memory Database 0
Category members GO Category GO:0009790 embryo development Database 0
Category members GO Category GO:0009791 post-embryonic development Database 0
Category members GO Category GO:0015813 L-glutamate transport Database 0
Category members GO Category GO:0015871 choline transport Database 0
Category members GO Category GO:0016324 apical plasma membrane Database 0
Category members GO Category GO:0016337 cell-cell adhesion Database 0
Category members GO Category GO:0021795 cerebral cortex cell migration Database 0
Category members GO Category GO:0021904 dorsal/ventral neural tube patterning Database 0
Category members GO Category GO:0030182 neuron differentiation Database 0
Category members GO Category GO:0030326 embryonic limb morphogenesis Database 0
Category members GO Category GO:0030900 forebrain development Database 0
Category members GO Category GO:0031410 cytoplasmic vesicle Database 0
Category members GO Category GO:0031594 neuromuscular junction Database 0
Category members GO Category GO:0035282 segmentation Database 0
Category members GO Category GO:0035556 intracellular signal transduction Database 0
Category members GO Category GO:0040011 locomotion Database 0
Category members GO Category GO:0042325 regulation of phosphorylation Database 0
Category members GO Category GO:0042640 anagen Database 0
Category members GO Category GO:0043025 neuronal cell body Database 0
Category members GO Category GO:0043406 positive regulation of MAP kinase activity Database 0
Category members GO Category GO:0043589 skin morphogenesis Database 0
Category members GO Category GO:0048538 thymus development Database 0
Category members GO Category GO:0048666 neuron development Database 0
Category members GO Category GO:0048705 skeletal system morphogenesis Database 0
Category members GO Category GO:0048854 brain morphogenesis Database 0
Category members GO Category GO:0050435 beta-amyloid metabolic process Database 0
Category members GO Category GO:0050771 negative regulation of axonogenesis Database 0
Category members GO Category GO:0051444 negative regulation of ubiquitin-protein ligase activity Database 0
Category members GO Category GO:0051563 smooth endoplasmic reticulum calcium ion homeostasis Database 0
Category members GO Category GO:0051966 regulation of synaptic transmission, glutamatergic Database 0
Category members GO Category GO:0060075 regulation of resting membrane potential Database 0
Category members GO Category GO:0070765 gamma-secretase complex Database 0


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