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Familial isolated dilated cardiomyopathy
(Familial_isolated_dilated_cardiomyopathy)

RNAi screen result RNAPII IP (MG132) CSB IP CSB IP (MG132) Chrom. Chrom. (MG132) Ubi /Phospo Ubi /Phospho (MG132)
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Protein Results:

 Results for post-translational modifications (below)
Gene name MGoogle Score RNAi high RNAi low RNAPII-IP (MG132) CSB-IP CSB-IP (MG132) Chrom. Chrom. (MG132)
ACTN2 3 -1.480 2.640 0.936 1.929 -1.407 0.572 0.293
ACTN2 3 -1.480 2.640 0.790 0.055 0.246
TMPO 3 -1.220 1.690 -0.946 1.359 0.557 -0.392 -0.253
TMPO 3 -1.220 1.690 -0.315 -0.601 -0.208 0.507 0.452
VCL 1 0.570 -0.620 2.233 0.870
RAF1 1 2.020 -1.230
PSEN2 1 -1.820 3.280
BAG3 1 0.180 -0.820
TTN 1 2.130 -1.190 0.133 0.277 0.244 0.213
TXNRD2 1 2.400 -0.860
DMD 1 0.960 -0.560 0.854 0.214
DSG2 0 0.200 0.000 0.827 -0.456 -0.256
SDHA 0 1.350 -1.030 0.223 0.787 0.745
SDHA 0 1.350 -1.030 0.602 0.333 -0.951 0.718 0.496
PSEN1 0 0.930 -1.110
MYH7 0
TPM1 0 0.280 -0.190
PRDM16 0 -1.320 2.300 -0.189 0.565 -1.171
ACTC1 0 0.220 -0.730 -0.189 0.025 -0.002 -0.165
ACTC1 0 0.220 -0.730 0.157
NEXN 0 0.410 -0.530
MYH6 0 -0.350 1.110
MYH6 0 -0.240 -0.750
RBM20 0 -0.060 -0.060 1.235

PTM Sites:

 Back to Protein Results
Gene name PTM type PTM site UV UV (MG132) Sequence
ACTN2 Ubiquitylation K125 1.906 _ALDFIASKGVK(gl)_
ACTN2 Ubiquitylation K350 0.585 _VQEK(gl)CQLEINFNTLQTK_
ACTN2 Ubiquitylation K417 0.789 _LDHLAEK(gl)FR_
ACTN2 Ubiquitylation K592 -0.644 0.678 _EAILAIHK(gl)EAQR_
ACTN2 Ubiquitylation K760 0.273 1.507 _DAK(gl)GISQEQMQEFR_
BAG3 Phosphorylation S173 -0.549 -0.580 _SQS(ph)PAASDCSSSSSSASLPSSGR_
BAG3 Phosphorylation S194 -0.402 -0.523 _S(ph)SLGSHQLPR_
BAG3 Phosphorylation S195 0.244 -0.933 _SS(ph)LGSHQLPR_
BAG3 Phosphorylation S289 4.691 -1.292 _SSTPLHS(ph)PSPIR_
BAG3 Phosphorylation S291 0.973 -1.061 _SSTPLHSPS(ph)PIR_
BAG3 Phosphorylation S377 -2.611 -2.836 _VPPAPVPCPPPS(ph)PGPSAVPSSPK_
BAG3 Phosphorylation S381 -1.826 _VPPAPVPCPPPSPGPS(ph)AVPS(ph)SPK_
BAG3 Phosphorylation S385 -3.389 -1.522 _VPPAPVPCPPPS(ph)PGPSAVPS(ph)SPK_
BAG3 Phosphorylation S386 -3.389 -3.269 _VPPAPVPCPPPS(ph)PGPSAVPSS(ph)PK_
DMD Ubiquitylation K3317 -0.200 -0.978 _CNICK(gl)ECPIIGFR_
DMD Phosphorylation S3623 2.940 0.225 _SDS(ph)SQPMLLR_
DSG2 Phosphorylation S680 -0.220 -0.071 _VVPSFLPVDQGGS(ph)LVGR_
DSG2 Ubiquitylation K692 0.377 _NGVGGMAK(gl)EATMK_
DSG2 Ubiquitylation K697 0.688 0.914 _EATMK(gl)GSSSASIVK_
DSG2 Ubiquitylation K706 0.722 _GSSSASIVK(gl)GQHEMSEMDGR_
DSG2 Ubiquitylation K746 1.168 1.231 _ATQFTGATGAIM(ox)TTETTK(gl)TAR_
DSG2 Phosphorylation S782 0.571 _AAS(ph)YTEEDENHTAK_
MYH6 Ubiquitylation K1446 -1.408 -0.411 _SNAAAAALDK(gl)K_
MYH6 Ubiquitylation K1447 -1.408 -0.411 _SNAAAAALDK(gl)K_
MYH7 Ubiquitylation K1446 -1.408 -0.411 _SNAAAAALDK(gl)K_
MYH7 Ubiquitylation K1447 -1.408 -0.411 _SNAAAAALDK(gl)K_
NEXN Phosphorylation S80 0.595 0.611 _EM(ox)LAS(ph)DDEEDVSSK_
NEXN Phosphorylation S365 0.094 0.720 _TIS(ph)QEFLTPGK_
PRDM16 Phosphorylation S62 -1.041 -0.744 _EGS(ph)PYKAPIYIPDDIPIPAEFELR_
PRDM16 Phosphorylation S1039 -0.074 0.136 _NFIGNSNHGSQS(ph)PR_
PSEN1 Phosphorylation S313 0.844 _VSKNS(ph)KYNAESTER_
PSEN1 Ubiquitylation K314 0.016 0.414 _NSK(gl)YNAESTER_
PSEN1 Phosphorylation S366 -0.340 0.055 _AAVQELSS(ph)SILAGEDPEER_
PSEN1 Phosphorylation S367 0.005 0.066 _AAVQELSSS(ph)ILAGEDPEER_
PSEN2 Phosphorylation S58 -0.112 -0.130 _TSLM(ox)SAES(ph)PTPR_
RAF1 Phosphorylation S29 0.028 -0.571 _DAVFDGSSCIS(ph)PTIVQQFGYQR_
RAF1 Phosphorylation T31 0.028 -0.669 _DAVFDGSSCIS(ph)PTIVQQFGYQR_
RAF1 Phosphorylation S244 0.053 _YSTPHAFTFNTSS(ph)PSSEGSLSQR_
RAF1 Phosphorylation S259 -0.069 0.054 _STS(ph)TPNVHM(ox)VSTTLPVDSR_
RAF1 Phosphorylation S301 -0.651 _SHSESASPSALSSSPNNLS(ph)PTGWSQPK_
RAF1 Phosphorylation T303 -0.664 _SHSESASPSALSSSPNNLSPT(ph)GWSQPK_
RAF1 Phosphorylation S497 -0.449 _SRWS(ph)GSQQVEQPTGSVLWMAPEVIR_
RAF1 Phosphorylation S621 0.212 0.271 _SAS(ph)EPSLHR_
RAF1 Phosphorylation S642 -0.197 0.463 _AAHTEDINACTLTTS(ph)PR_
RBM20 Phosphorylation S660 -0.005 _SHTPSFTSCSSSHS(ph)PPGPSR_
RBM20 Phosphorylation S740 -0.479 0.069 _S(ph)GSPNLPHSVSSYK_
RBM20 Phosphorylation S742 -0.012 -0.169 _SGS(ph)PNLPHSVSSYK_
RBM20 Phosphorylation S876 0.321 0.370 _EAEFS(ph)DPENTR_
RBM20 Phosphorylation S1047 -0.393 -0.337 _GVESSDVHPAPTVQQMS(ph)SPKPAEER_
RBM20 Phosphorylation S1048 -0.208 -0.438 _GVESSDVHPAPTVQQMSS(ph)PKPAEER_
RBM20 Phosphorylation S1060 0.101 0.255 _ARQPS(ph)PFVDDCK_
RBM20 Phosphorylation S1120 0.952 1.033 _SLEVRS(ph)PEYTEVELK_
SDHA Ubiquitylation K341 -1.790 _YAPVAK(gl)DLASR_
TMPO Phosphorylation S66 -0.409 -0.162 _GPPDFS(ph)SDEEREPTPVLGSGAAAAGR_
TMPO Phosphorylation S67 -0.758 -0.434 _GPPDFSS(ph)DEEREPTPVLGSGAAAAGR_
TMPO Phosphorylation T74 -0.746 -1.414 _GPPDFSSDEEREPT(ph)PVLGSGAAAAGR_
TMPO Phosphorylation S158 0.035 -0.983 _S(ph)STPLPTISSSAENTR_
TMPO Phosphorylation T160 0.243 -0.889 _SST(ph)PLPTISSSAENTR_
TMPO Phosphorylation T164 -1.020 _S(ph)STPLPT(ph)ISSSAENTR_
TMPO Phosphorylation S166 -0.979 _SST(ph)PLPTIS(ph)SSAENTR_
TMPO Phosphorylation S167 0.070 -1.235 _S(ph)STPLPTISS(ph)SAENTR_
TMPO Phosphorylation S184 0.671 _QNGSNDSDRYS(ph)DNEEDSKIELK_
TMPO Phosphorylation T208 0.142 -0.074 _AKT(ph)PVTLK_
TMPO Ubiquitylation K213 -0.188 0.196 _TPVTLK(gl)QR_
TMPO Phosphorylation S224 1.514 _RVEHNQSYS(ph)QAGITETEWTSGSSK_
TMPO Phosphorylation T247 1.340 _GGPLQALT(ph)RESTR_
TMPO Phosphorylation S250 -0.342 -0.058 _GGPLQALTRES(ph)TR_
TMPO Phosphorylation S276 -0.938 _IDGPVIS(ph)ESTPIAETIMASSNESLVVNR_
TMPO Phosphorylation S291 1.067 _S(ph)SSSSSQPEHSAMLVSTAASPSLIK_
TMPO Phosphorylation S293 0.066 1.213 _SSS(ph)SSSQPEHSAMLVSTAASPSLIK_
TMPO Phosphorylation S296 0.295 _SSSSSS(ph)QPEHSAMLVSTAASPSLIK_
TMPO Phosphorylation S301 0.735 1.087 _SSSSSSQPEHS(ph)AM(ox)LVSTAASPSLIK_
TMPO Phosphorylation S306 -1.540 -0.863 _HAS(ph)PILPITEFSDIPR_
TMPO Phosphorylation S310 1.456 -0.147 _SSSSSSQPEHSAMLVSTAAS(ph)PSLIK_
TMPO Ubiquitylation K323 0.295 _ETTTGYYK(gl)DIVENICGR_
TMPO Ubiquitylation K334 -1.660 _EK(gl)SGIQPLCPER_
TMPO Ubiquitylation K334 0.248 _AEVGEK(gl)TEER_
TMPO Phosphorylation S351 0.260 -0.013 _SHISDQS(ph)PLSSK_
TMPO Phosphorylation S354 -0.183 0.458 _SHISDQSPLS(ph)SK_
TMPO Phosphorylation S355 -0.223 0.440 _SHISDQSPLSS(ph)K_
TMPO Phosphorylation T355 -0.542 -1.007 _EMFPYEAST(ph)PTGISASCR_
TMPO Ubiquitylation K356 -0.010 -1.409 _SHISDQSPLSSK(gl)R_
TMPO Ubiquitylation K389 -0.432 0.012 _MEESFSSK(gl)YVPK_
TMPO Ubiquitylation K393 -1.116 -0.783 _YVPK(gl)YVPLADVK_
TMPO Ubiquitylation K401 -0.880 -0.191 _YVPLADVK(gl)SEK_
TMPO Ubiquitylation K404 -0.454 _YVPLADVKSEK(gl)_
TMPO Phosphorylation S424 -0.254 -0.005 _FQETEFLS(ph)PPR_
TMPO Ubiquitylation K435 4.273 10.564 _LSEK(gl)SVEER_
TMPO Phosphorylation S436 0.403 _LSEKS(ph)VEER_
TMPO Phosphorylation S442 1.247 _DS(ph)GSFVAFQNIPGSELMSSFAK_
TMPO Phosphorylation S444 1.247 _DS(ph)GSFVAFQNIPGSELMSSFAK_
TMPO Ubiquitylation K667 -1.096 _NK(gl)LASTPFK_
TPM1 Ubiquitylation K30 -1.537 _AEQAEADKK(gl)AAEDR_
TTN Ubiquitylation K27327 -0.283 0.183 _AGEVLK(gl)INADIAGR_
TXNRD2 Ubiquitylation K151 0.253 _VQLQDRK(gl)_
VCL Ubiquitylation K219 -0.376 0.161 _NSK(gl)NQGIEEALK_
VCL Ubiquitylation K228 0.195 _NQGIEEALK(gl)NR_
VCL Phosphorylation S288 0.364 _DPS(ph)ASPGDAGEQAIR_
VCL Phosphorylation S290 -0.415 _DPSAS(ph)PGDAGEQAIR_
VCL Ubiquitylation K476 0.572 0.356 _QVATALQNLQTK(gl)TNR_
VCL Ubiquitylation K639 0.665 0.718 _AANFENHSGK(gl)LGATAEK_
VCL Ubiquitylation K666 0.502 _STVEGIQASVK(gl)TAR_
VCL Ubiquitylation K768 0.256 _ILLVAK(gl)R_
VCL Ubiquitylation K784 -0.707 _EAVK(gl)AASDELSK_
VCL Ubiquitylation K792 -0.889 -1.201 _AASDELSK(gl)TISPMVMDAK_
VCL Ubiquitylation K815 -0.780 _AVAGNISDPGLQK(gl)SFLDSGYR_
VCL Ubiquitylation K1020 0.159 0.667 _ALIQCAK(gl)DIAK_
VCL Ubiquitylation K1070 0.504 0.692 _ILSTVK(gl)ATMLGR_


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