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Query: DSG2

RNAi screen result RNAPII IP (PI) CSB IP CSB IP (PI) Chrom. Chrom. (PI) Phosphorylation Ubiquitylation
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[Click on the plots to view the data selection in the respective scatterplot]

Protein Results:

 Results for post-translational modifications: see below | Red/green: hit at lower/upper end of the respective screen
Gene name Point score Z-score sums RNAi high RNAi low RNAPII-IP (PI) CSB-IP CSB-IP (PI) Chrom. Chrom. (PI)
DSG2 0 3.014 0.200 0.000 0.827 -0.456 -0.256

PTM Sites:

 Back to Protein Results | Red/green: hit at lower/upper end of the respective screen
Gene name PTM type PTM site UV UV (PI) Sequence
DSG2 Ubiquitylation K746 1.168 1.231 _ATQFTGATGAIM(ox)TTETTK(gl)TAR_
DSG2 Ubiquitylation K697 0.688 0.914 _EATMK(gl)GSSSASIVK_
DSG2 Ubiquitylation K692 0.377 _NGVGGMAK(gl)EATMK_
DSG2 Phosphorylation S680 -0.220 -0.071 _VVPSFLPVDQGGS(ph)LVGR_
DSG2 Ubiquitylation K706 0.722 _GSSSASIVK(gl)GQHEMSEMDGR_
DSG2 Phosphorylation S782 0.571 _AAS(ph)YTEEDENHTAK_

Background Information for DSG2:


Pubmed-DSG2 »
Uniprot-DSG2 »
Biogrid-DSG2 »
ProteomicsDB-DSG2 »

Tumorportal-DSG2 »
COSMIC-DSG2 »
GenomeRNAi-DSG2 »
Genecards-DSG2


Protein-protein Interactions for DSG2
Show screen data for Category Name and Description Link to cat description Data Source
Category members IP bait ACTB Cat. description Hein, Mann, Cell 2015
Category members IP bait ACTR2 Cat. description Hein, Mann, Cell 2015
Category members IP bait BMPR1A Cat. description Hein, Mann, Cell 2015
Category members IP bait CHMP4B Cat. description Hein, Mann, Cell 2015
Category members IP bait CORO1C Cat. description Hein, Mann, Cell 2015
Category members IP bait DBN1 Cat. description Hein, Mann, Cell 2015
Category members IP bait FLNA Cat. description Hein, Mann, Cell 2015
Category members IP bait FLNB Cat. description Hein, Mann, Cell 2015
Category members IP bait FLOT1 Cat. description Hein, Mann, Cell 2015
Category members IP bait FLOT2 Cat. description Hein, Mann, Cell 2015
Category members IP bait GOLT1B Cat. description Hein, Mann, Cell 2015
Category members IP bait IQGAP1 Cat. description Hein, Mann, Cell 2015
Category members IP bait JUP Cat. description Hein, Mann, Cell 2015
Category members IP bait LIMA1 Cat. description Hein, Mann, Cell 2015
Category members IP bait MYH10 Cat. description Hein, Mann, Cell 2015
Category members IP bait MYH9 Cat. description Hein, Mann, Cell 2015
Category members IP bait MYO18A Cat. description Hein, Mann, Cell 2015
Category members IP bait MYO19 Cat. description Hein, Mann, Cell 2015
Category members IP bait MYO5C Cat. description Hein, Mann, Cell 2015
Category members IP bait PDGFRA Cat. description Hein, Mann, Cell 2015
Category members IP bait PPP1CB Cat. description Hein, Mann, Cell 2015
Category members IP bait SYNPO Cat. description Hein, Mann, Cell 2015
Category members IP bait TMOD3 Cat. description Hein, Mann, Cell 2015
Category members IP bait TPM1 Cat. description Hein, Mann, Cell 2015


Protein Domains in DSG2
Domain name Domain Description TC-NER relevance -log10(p-value)
Category members Cadherin IPR002126 0.32
Category members Cadherin_cytoplasmic-dom IPR000233 0.29
Category members Desmosomal_cadherin IPR009122 0.28
Category members Cadherin-like IPR015919 0.21
Category members Desmoglein IPR009123 0


Protein complexes (CORUM database) featuring DSG2
Category Type Category ID Category Name Data Source TC-NER relevance -log10(p-value)


Categories featuring DSG2
Category Type Category ID Category Name Data Source TC-NER relevance -log10(p-value)
Category members GO Category GO:0016021 integral to membrane Database 7.67
Category members DDR Literature pubmedid:19647519 Paulsen et al., 2009 siRNA screen for g-H2A.x phosphorylation 3.6
Category members GO Category GO:0006921 cellular component disassembly involved in execution phase of apoptosis Database 2.98
Category members Pathway Pathway_876 REACTOME_APOPTOTIC_EXECUTION_PHASE 0 2.5
Category members Pathway Pathway_837 REACTOME_APOPTOSIS 0 2.39
Category members GO Category GO:0006915 apoptotic process Database 2.12
Category members GO Category GO:0005911 cell-cell junction Database 1.4
Category members Pathway Pathway_877 REACTOME_APOPTOTIC_CLEAVAGE_OF_CELLULAR_PROTEINS 0 1.25
Category members GO Category GO:0005886 plasma membrane Database 1.21
Category members GO Category GO:0016020 membrane Database 0.52
Category members GO Category GO:0016328 lateral plasma membrane Database 0.41
Category members GO Category GO:0007156 homophilic cell adhesion Database 0.28
Category members GO Category GO:0030057 desmosome Database 0.26
Category members Pathway Pathway_1019 REACTOME_APOPTOTIC_CLEAVAGE_OF_CELL_ADHESION_PROTEINS 0 0.17
Category members GO Category GO:0005509 calcium ion binding Database 0.11
Category members GO Category GO:0032570 response to progesterone Database 0.1
Category members Disease phenotype Familial_isolated_dilated_cardiomyopathy Familial isolated dilated cardiomyopathy Database 0.08
Category members Disease phenotype Familial_isolated_arrhythmogenic_ventricular_dysplasia_biventricular_form Familial isolated arrhythmogenic ventricular dysplasia biventricular form Database 0.05
Category members Disease phenotype Familial_isolated_arrhythmogenic_ventricular_dysplasia_left_dominant_form Familial isolated arrhythmogenic ventricular dysplasia left dominant form Database 0.05
Category members Disease phenotype Familial_isolated_arrhythmogenic_ventricular_dysplasia_right_dominant_form Familial isolated arrhythmogenic ventricular dysplasia right dominant form Database 0.05
Category members Pathway Pathway_1007 KEGG_ARRHYTHMOGENIC_RIGHT_VENTRICULAR_CARDIOMYOPATHY_ARVC 0 0.03
Category members GO Category GO:0007155 cell adhesion Database 0
Category members GO Category GO:0016324 apical plasma membrane Database 0
Category members GO Category GO:0060135 maternal process involved in female pregnancy Database 0


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