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Query: TXNRD2

RNAi screen result RNAPII IP (PI) CSB IP CSB IP (PI) Chrom. Chrom. (PI) Phosphorylation Ubiquitylation
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[Click on the plots to view the data selection in the respective scatterplot]

Protein Results:

 Results for post-translational modifications: see below | Red/green: hit at lower/upper end of the respective screen
Gene name Point score Z-score sums RNAi high RNAi low RNAPII-IP (PI) CSB-IP CSB-IP (PI) Chrom. Chrom. (PI)
TXNRD2 1 0.253 2.400 -0.860

PTM Sites:

 Back to Protein Results | Red/green: hit at lower/upper end of the respective screen
Gene name PTM type PTM site UV UV (PI) Sequence
TXNRD2 Ubiquitylation K151 0.253 _VQLQDRK(gl)_

Background Information for TXNRD2:


Pubmed-TXNRD2 »
Uniprot-TXNRD2 »
Biogrid-TXNRD2 »
ProteomicsDB-TXNRD2 »

Tumorportal-TXNRD2 »
COSMIC-TXNRD2 »
GenomeRNAi-TXNRD2 »
Genecards-TXNRD2


Protein-protein Interactions for TXNRD2
Show screen data for Category Name and Description Link to cat description Data Source
Category members IP bait CYP2S1 Cat. description BioPlex, Huttlin, Gygi, Cell 2015
Category members IP bait FOXR2 Cat. description BioPlex, Huttlin, Gygi, Cell 2015
Category members IP bait PNPLA2 Cat. description BioPlex, Huttlin, Gygi, Cell 2015
Category members IP bait PPP1R3C Cat. description BioPlex, Huttlin, Gygi, Cell 2015
Category members IP bait TXNRD2 Cat. description BioPlex, Huttlin, Gygi, Cell 2015


Protein Domains in TXNRD2
Domain name Domain Description TC-NER relevance -log10(p-value)
Category members Pyr_OxRdtase_NAD-bd_dom IPR001327 0.03
Category members Pyridine_nuc-diS_OxRdtase_2 IPR000103 0
Category members Hg_reductase IPR000815 0
Category members GIDA-rel IPR002218 0
Category members FAD_bind_dom IPR003953 0
Category members Pyr_nucl-diS_OxRdtase_dimer IPR004099 0
Category members Thioredoxin/glutathione_Rdtase IPR006338 0
Category members FAD_pyr_nucl-diS_OxRdtase IPR013027 0
Category members FAD/NAD-linked_Rdtase_dimer IPR016156 0
Category members Pyr_nucl-diS_OxRdtase_FAD/NAD IPR023753 0


Protein complexes (CORUM database) featuring TXNRD2
Category Type Category ID Category Name Data Source TC-NER relevance -log10(p-value)


Categories featuring TXNRD2
Category Type Category ID Category Name Data Source TC-NER relevance -log10(p-value)
Category members GO Category GO:0005515 protein binding Database INF
Category members GO Category GO:0005739 mitochondrion Database 1.67
Category members GO Category GO:0008033 tRNA processing Database 0.39
Category members Pathway Pathway_277 KEGG_PYRIMIDINE_METABOLISM 0 0.18
Category members GO Category GO:0050660 flavin adenine dinucleotide binding Database 0.12
Category members Disease phenotype Familial_isolated_dilated_cardiomyopathy Familial isolated dilated cardiomyopathy Database 0.08
Category members GO Category GO:0045454 cell redox homeostasis Database 0.05
Category members GO Category GO:0004791 thioredoxin-disulfide reductase activity Database 0
Category members GO Category GO:0007507 heart development Database 0
Category members GO Category GO:0016491 oxidoreductase activity Database 0
Category members GO Category GO:0016668 oxidoreductase activity, acting on a sulfur group of donors, NAD(P) as acceptor Database 0
Category members GO Category GO:0030097 hemopoiesis Database 0
Category members GO Category GO:0050661 NADP binding Database 0
Category members GO Category GO:0055114 oxidation-reduction process Database 0


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