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Query: DMD

RNAi screen result RNAPII IP (PI) CSB IP CSB IP (PI) Chrom. Chrom. (PI) Phosphorylation Ubiquitylation
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[Click on the plots to view the data selection in the respective scatterplot]

Protein Results:

 Results for post-translational modifications: see below | Red/green: hit at lower/upper end of the respective screen
Gene name Point score Z-score sums RNAi high RNAi low RNAPII-IP (PI) CSB-IP CSB-IP (PI) Chrom. Chrom. (PI)
DMD 1 3.055 0.960 -0.560 0.854 0.214

PTM Sites:

 Back to Protein Results | Red/green: hit at lower/upper end of the respective screen
Gene name PTM type PTM site UV UV (PI) Sequence
DMD Phosphorylation S3623 2.940 0.225 _SDS(ph)SQPMLLR_
DMD Ubiquitylation K3317 -0.200 -0.978 _CNICK(gl)ECPIIGFR_

Background Information for DMD:


Pubmed-DMD »
Uniprot-DMD »
Biogrid-DMD »
ProteomicsDB-DMD »

Tumorportal-DMD »
COSMIC-DMD »
GenomeRNAi-DMD »
Genecards-DMD


Protein-protein Interactions for DMD
Show screen data for Category Name and Description Link to cat description Data Source
Category members IP bait DLGAP4 Cat. description Hein, Mann, Cell 2015
Category members IP bait KIF15 Cat. description Hein, Mann, Cell 2015
Category members IP bait NUPL1 Cat. description Hein, Mann, Cell 2015
Category members IP bait OSGEP Cat. description Hein, Mann, Cell 2015
Category members IP bait PSMB5 Cat. description Hein, Mann, Cell 2015
Category members IP bait DMD Cat. description BioPlex, Huttlin, Gygi, Cell 2015
Category members IP bait IFIT5 Cat. description BioPlex, Huttlin, Gygi, Cell 2015
Category members IP bait LPAR6 Cat. description BioPlex, Huttlin, Gygi, Cell 2015
Category members IP bait LRRC8E Cat. description BioPlex, Huttlin, Gygi, Cell 2015
Category members IP bait SNTG2 Cat. description BioPlex, Huttlin, Gygi, Cell 2015


Protein Domains in DMD
Domain name Domain Description TC-NER relevance -log10(p-value)
Category members Spectrin_repeat IPR002017 2.4
Category members Spectrin/alpha-actinin IPR018159 1.6
Category members WW_dom IPR001202 1.15
Category members CH-domain IPR001715 0.63
Category members EF-hand_dom_typ1 IPR015153 0.22
Category members EF-hand_dom_typ2 IPR015154 0.22
Category members Dystrophin/utrophin IPR016344 0.21
Category members CAMSAP_CH IPR022613 0.13
Category members Znf_ZZ IPR000433 0.01
Category members AB_hydrolase IPR029058 0


Protein complexes (CORUM database) featuring DMD
Category Type Category ID Category Name Data Source TC-NER relevance -log10(p-value)


Categories featuring DMD
Category Type Category ID Category Name Data Source TC-NER relevance -log10(p-value)
Category members GO Category GO:0005515 protein binding Database INF
Category members GO Category GO:0005634 nucleus Database INF
Category members GO Category GO:0005829 cytosol Database INF
Category members GO Category GO:0003779 actin binding Database 5.41
Category members DDR Literature pubmedid:19647519 Paulsen et al., 2009 siRNA screen for g-H2A.x phosphorylation 3.6
Category members GO Category GO:0043234 protein complex Database 2.73
Category members GO Category GO:0015629 actin cytoskeleton Database 2.22
Category members GO Category GO:0043034 costamere Database 1.42
Category members GO Category GO:0005886 plasma membrane Database 1.21
Category members GO Category GO:0017166 vinculin binding Database 1.01
Category members GO Category GO:0005856 cytoskeleton Database 0.63
Category members GO Category GO:0043623 cellular protein complex assembly Database 0.45
Category members GO Category GO:0016328 lateral plasma membrane Database 0.41
Category members GO Category GO:0042383 sarcolemma Database 0.36
Category members GO Category GO:0030018 Z disc Database 0.32
Category members GO Category GO:0030055 cell-substrate junction Database 0.29
Category members GO Category GO:0008270 zinc ion binding Database 0.29
Category members GO Category GO:0030198 extracellular matrix organization Database 0.26
Category members GO Category GO:0033137 negative regulation of peptidyl-serine phosphorylation Database 0.21
Category members GO Category GO:0009986 cell surface Database 0.17
Category members Pathway Pathway_1041 BIOCARTA_AGR_PATHWAY 0 0.13
Category members GO Category GO:0010880 regulation of release of sequestered calcium ion into cytosol by sarcoplasmic reticulum Database 0.12
Category members GO Category GO:0045121 membrane raft Database 0.11
Category members GO Category GO:0005509 calcium ion binding Database 0.11
Category members Disease phenotype DUCHENNE_MUSCULAR_DYSTROPHY DUCHENNE MUSCULAR DYSTROPHY Database 0.09
Category members Disease phenotype Familial_isolated_dilated_cardiomyopathy Familial isolated dilated cardiomyopathy Database 0.08
Category members GO Category GO:0045211 postsynaptic membrane Database 0.06
Category members GO Category GO:0045202 synapse Database 0.06
Category members GO Category GO:0030175 filopodium Database 0.05
Category members GO Category GO:0010976 positive regulation of neuron projection development Database 0.05
Category members GO Category GO:0034613 cellular protein localization Database 0.04
Category members GO Category GO:0016010 dystrophin-associated glycoprotein complex Database 0.04
Category members GO Category GO:0014819 regulation of skeletal muscle contraction Database 0.04
Category members Pathway Pathway_1007 KEGG_ARRHYTHMOGENIC_RIGHT_VENTRICULAR_CARDIOMYOPATHY_ARVC 0 0.03
Category members Disease phenotype X-linked_non-syndromic_intellectual_disability X-linked non-syndromic intellectual disability Database 0.01
Category members Pathway Pathway_1008 KEGG_HYPERTROPHIC_CARDIOMYOPATHY_HCM 0 0
Category members Pathway Pathway_1014 KEGG_VIRAL_MYOCARDITIS 0 0
Category members Pathway Pathway_1208 REACTOME_STRIATED_MUSCLE_CONTRACTION 0 0
Category members Pathway Pathway_262 KEGG_DILATED_CARDIOMYOPATHY 0 0
Category members Pathway Pathway_950 REACTOME_MUSCLE_CONTRACTION 0 0
Category members GO Category GO:0001954 positive regulation of cell-matrix adhesion Database 0
Category members GO Category GO:0002027 regulation of heart rate Database 0
Category members GO Category GO:0002162 dystroglycan binding Database 0
Category members GO Category GO:0005200 structural constituent of cytoskeleton Database 0
Category members GO Category GO:0006355 regulation of transcription, DNA-dependent Database 0
Category members GO Category GO:0007517 muscle organ development Database 0
Category members GO Category GO:0007519 skeletal muscle tissue development Database 0
Category members GO Category GO:0008065 establishment of blood-nerve barrier Database 0
Category members GO Category GO:0008307 structural constituent of muscle Database 0
Category members GO Category GO:0010468 regulation of gene expression Database 0
Category members GO Category GO:0010881 regulation of cardiac muscle contraction by regulation of the release of sequestered calcium ion Database 0
Category members GO Category GO:0014809 regulation of skeletal muscle contraction by regulation of release of sequestered calcium ion Database 0
Category members GO Category GO:0014904 myotube cell development Database 0
Category members GO Category GO:0016013 syntrophin complex Database 0
Category members GO Category GO:0017022 myosin binding Database 0
Category members GO Category GO:0030049 muscle filament sliding Database 0
Category members GO Category GO:0043043 peptide biosynthetic process Database 0
Category members GO Category GO:0044306 neuron projection terminus Database 0
Category members GO Category GO:0044458 motile cilium assembly Database 0
Category members GO Category GO:0045213 neurotransmitter receptor metabolic process Database 0
Category members GO Category GO:0045666 positive regulation of neuron differentiation Database 0
Category members GO Category GO:0046716 muscle cell cellular homeostasis Database 0
Category members GO Category GO:0048747 muscle fiber development Database 0
Category members GO Category GO:0050998 nitric-oxide synthase binding Database 0
Category members GO Category GO:0051647 nucleus localization Database 0
Category members GO Category GO:0060048 cardiac muscle contraction Database 0
Category members GO Category GO:0060314 regulation of ryanodine-sensitive calcium-release channel activity Database 0


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