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Query: TMPO

RNAi screen result RNAPII IP (PI) CSB IP CSB IP (PI) Chrom. Chrom. (PI) Phosphorylation Ubiquitylation
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[Click on the plots to view the data selection in the respective scatterplot]

Protein Results:

 Results for post-translational modifications: see below | Red/green: hit at lower/upper end of the respective screen
Gene name Point score Z-score sums RNAi high RNAi low RNAPII-IP (PI) CSB-IP CSB-IP (PI) Chrom. Chrom. (PI)
TMPO 3 22.057 -1.220 1.690 -0.946 1.359 0.557 -0.392 -0.253
TMPO 3 22.057 -1.220 1.690 -0.315 -0.601 -0.208 0.507 0.452

PTM Sites:

 Back to Protein Results | Red/green: hit at lower/upper end of the respective screen
Gene name PTM type PTM site UV UV (PI) Sequence
TMPO Ubiquitylation K435 4.273 10.564 _LSEK(gl)SVEER_
TMPO Phosphorylation S224 1.514 _RVEHNQSYS(ph)QAGITETEWTSGSSK_
TMPO Phosphorylation T247 1.340 _GGPLQALT(ph)RESTR_
TMPO Phosphorylation S442 1.247 _DS(ph)GSFVAFQNIPGSELMSSFAK_
TMPO Phosphorylation S444 1.247 _DS(ph)GSFVAFQNIPGSELMSSFAK_
TMPO Phosphorylation S293 0.066 1.213 _SSS(ph)SSSQPEHSAMLVSTAASPSLIK_
TMPO Phosphorylation S301 0.735 1.087 _SSSSSSQPEHS(ph)AM(ox)LVSTAASPSLIK_
TMPO Phosphorylation S291 1.067 _S(ph)SSSSSQPEHSAMLVSTAASPSLIK_
TMPO Phosphorylation S184 0.671 _QNGSNDSDRYS(ph)DNEEDSKIELK_
TMPO Phosphorylation S354 -0.183 0.458 _SHISDQSPLS(ph)SK_
TMPO Phosphorylation S355 -0.223 0.440 _SHISDQSPLSS(ph)K_
TMPO Phosphorylation S436 0.403 _LSEKS(ph)VEER_
TMPO Ubiquitylation K213 -0.188 0.196 _TPVTLK(gl)QR_
TMPO Ubiquitylation K389 -0.432 0.012 _MEESFSSK(gl)YVPK_
TMPO Phosphorylation S424 -0.254 -0.005 _FQETEFLS(ph)PPR_
TMPO Phosphorylation S351 0.260 -0.013 _SHISDQS(ph)PLSSK_
TMPO Phosphorylation S250 -0.342 -0.058 _GGPLQALTRES(ph)TR_
TMPO Phosphorylation T208 0.142 -0.074 _AKT(ph)PVTLK_
TMPO Phosphorylation S310 1.456 -0.147 _SSSSSSQPEHSAMLVSTAAS(ph)PSLIK_
TMPO Phosphorylation S66 -0.409 -0.162 _GPPDFS(ph)SDEEREPTPVLGSGAAAAGR_
TMPO Ubiquitylation K401 -0.880 -0.191 _YVPLADVK(gl)SEK_
TMPO Phosphorylation S67 -0.758 -0.434 _GPPDFSS(ph)DEEREPTPVLGSGAAAAGR_
TMPO Ubiquitylation K404 -0.454 _YVPLADVKSEK(gl)_
TMPO Ubiquitylation K393 -1.116 -0.783 _YVPK(gl)YVPLADVK_
TMPO Phosphorylation S306 -1.540 -0.863 _HAS(ph)PILPITEFSDIPR_
TMPO Phosphorylation T160 0.243 -0.889 _SST(ph)PLPTISSSAENTR_
TMPO Phosphorylation S276 -0.938 _IDGPVIS(ph)ESTPIAETIMASSNESLVVNR_
TMPO Phosphorylation S166 -0.979 _SST(ph)PLPTIS(ph)SSAENTR_
TMPO Phosphorylation S158 0.035 -0.983 _S(ph)STPLPTISSSAENTR_
TMPO Phosphorylation T355 -0.542 -1.007 _EMFPYEAST(ph)PTGISASCR_
TMPO Phosphorylation T164 -1.020 _S(ph)STPLPT(ph)ISSSAENTR_
TMPO Ubiquitylation K667 -1.096 _NK(gl)LASTPFK_
TMPO Phosphorylation S167 0.070 -1.235 _S(ph)STPLPTISS(ph)SAENTR_
TMPO Ubiquitylation K356 -0.010 -1.409 _SHISDQSPLSSK(gl)R_
TMPO Phosphorylation T74 -0.746 -1.414 _GPPDFSSDEEREPT(ph)PVLGSGAAAAGR_
TMPO Phosphorylation S296 0.295 _SSSSSS(ph)QPEHSAMLVSTAASPSLIK_
TMPO Ubiquitylation K323 0.295 _ETTTGYYK(gl)DIVENICGR_
TMPO Ubiquitylation K334 -1.660 _EK(gl)SGIQPLCPER_
TMPO Ubiquitylation K334 0.248 _AEVGEK(gl)TEER_

Background Information for TMPO:


Pubmed-TMPO »
Uniprot-TMPO »
Biogrid-TMPO »
ProteomicsDB-TMPO »

Tumorportal-TMPO »
COSMIC-TMPO »
GenomeRNAi-TMPO »
Genecards-TMPO


Protein-protein Interactions for TMPO
Show screen data for Category Name and Description Link to cat description Data Source
Category members IP bait AP4S1 Cat. description Hein, Mann, Cell 2015
Category members IP bait CBX1 Cat. description Hein, Mann, Cell 2015
Category members IP bait CDC26 Cat. description Hein, Mann, Cell 2015
Category members IP bait MAD2L2 Cat. description Hein, Mann, Cell 2015
Category members IP bait TMEM63B Cat. description Hein, Mann, Cell 2015
Category members IP bait TMPO Cat. description Hein, Mann, Cell 2015
Category members IP bait USP7 Cat. description Hein, Mann, Cell 2015
Category members IP bait XRCC3 Cat. description Hein, Mann, Cell 2015
Category members IP bait ZWINT Cat. description Hein, Mann, Cell 2015


Protein Domains in TMPO
Domain name Domain Description TC-NER relevance -log10(p-value)
Category members LEM_dom IPR003887 0.28
Category members LEM/LEM-like_dom IPR011015 0.28
Category members LAP2alpha IPR021623 0


Protein complexes (CORUM database) featuring TMPO
Category Type Category ID Category Name Data Source TC-NER relevance -log10(p-value)


Categories featuring TMPO
Category Type Category ID Category Name Data Source TC-NER relevance -log10(p-value)
Category members DDR Literature pubmedid:24332808 Marechal et al., 2014 RPA-mediated recruitment INF
Category members GO Category GO:0005515 protein binding Database INF
Category members GO Category GO:0005634 nucleus Database INF
Category members GO Category GO:0016021 integral to membrane Database 7.67
Category members GO Category GO:0005635 nuclear envelope Database 7.22
Category members GO Category GO:0000785 chromatin Database 2.59
Category members GO Category GO:0005637 nuclear inner membrane Database 1.98
Category members GO Category GO:0003677 DNA binding Database 1.53
Category members GO Category GO:0005521 lamin binding Database 0.75
Category members Disease phenotype Familial_isolated_dilated_cardiomyopathy Familial isolated dilated cardiomyopathy Database 0.08
Category members GO Category GO:0006355 regulation of transcription, DNA-dependent Database 0


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