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Query: PRDM16

This is a cancer-associated gene according to the Sanger cancer gene census.

RNAi screen result RNAPII IP (PI) CSB IP CSB IP (PI) Chrom. Chrom. (PI) Phosphorylation Ubiquitylation
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[Click on the plots to view the data selection in the respective scatterplot]

Protein Results:

 Results for post-translational modifications: see below | Red/green: hit at lower/upper end of the respective screen
Gene name Point score Z-score sums RNAi high RNAi low RNAPII-IP (PI) CSB-IP CSB-IP (PI) Chrom. Chrom. (PI)
PRDM16 0 1.567 -1.320 2.300 -0.189 0.565 -1.171

PTM Sites:

 Back to Protein Results | Red/green: hit at lower/upper end of the respective screen
Gene name PTM type PTM site UV UV (PI) Sequence
PRDM16 Phosphorylation S1039 -0.074 0.136 _NFIGNSNHGSQS(ph)PR_
PRDM16 Phosphorylation S62 -1.041 -0.744 _EGS(ph)PYKAPIYIPDDIPIPAEFELR_

Background Information for PRDM16:


Pubmed-PRDM16 »
Uniprot-PRDM16 »
Biogrid-PRDM16 »
ProteomicsDB-PRDM16 »

Tumorportal-PRDM16 »
COSMIC-PRDM16 »
GenomeRNAi-PRDM16 »
Genecards-PRDM16


Protein-protein Interactions for PRDM16
Show screen data for Category Name and Description Link to cat description Data Source
Category members IP bait SPDEF Cat. description BioPlex, Huttlin, Gygi, Cell 2015


Protein Domains in PRDM16
Domain name Domain Description TC-NER relevance -log10(p-value)
Category members Znf_C2H2-like IPR015880 1.29
Category members Znf_C2H2 IPR007087 0.92
Category members SET_dom IPR001214 0.29
Category members Znf_BED IPR003656 0


Protein complexes (CORUM database) featuring PRDM16
Category Type Category ID Category Name Data Source TC-NER relevance -log10(p-value)


Categories featuring PRDM16
Category Type Category ID Category Name Data Source TC-NER relevance -log10(p-value)
Category members GO Category GO:0005515 protein binding Database INF
Category members GO Category GO:0005634 nucleus Database INF
Category members Human mutations Sanger_cancer_genes Sanger cancer genes Database 4.88
Category members GO Category GO:0003713 transcription coactivator activity Database 3.68
Category members GO Category GO:0003677 DNA binding Database 1.53
Category members GO Category GO:0045892 negative regulation of transcription, DNA-dependent Database 1.15
Category members GO Category GO:0006351 transcription, DNA-templated Database 1.07
Category members GO Category GO:0003676 nucleic acid binding Database 0.83
Category members GO Category GO:0017053 transcriptional repressor complex Database 0.28
Category members GO Category GO:0045893 positive regulation of transcription, DNA-dependent Database 0.28
Category members GO Category GO:0060021 palate development Database 0.23
Category members GO Category GO:0043565 sequence-specific DNA binding Database 0.18
Category members GO Category GO:0022008 neurogenesis Database 0.16
Category members Disease phenotype Familial_isolated_dilated_cardiomyopathy Familial isolated dilated cardiomyopathy Database 0.08
Category members GO Category GO:0043457 regulation of cellular respiration Database 0.08
Category members GO Category GO:0000122 negative regulation of transcription from RNA polymerase II promoter Database 0.02
Category members GO Category GO:0030512 negative regulation of transforming growth factor beta receptor signaling pathway Database 0.02
Category members Disease phenotype 1p36_deletion_syndrome 1p36 deletion syndrome Database 0
Category members Disease phenotype Left_ventricular_noncompaction Left ventricular noncompaction Database 0
Category members GO Category GO:0030853 negative regulation of granulocyte differentiation Database 0
Category members GO Category GO:0035019 somatic stem cell maintenance Database 0
Category members GO Category GO:0043586 tongue development Database 0
Category members GO Category GO:0046332 SMAD binding Database 0
Category members GO Category GO:0046872 metal ion binding Database 0
Category members GO Category GO:0050872 white fat cell differentiation Database 0
Category members GO Category GO:0050873 brown fat cell differentiation Database 0


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