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Query: VCL

RNAi screen result RNAPII IP (PI) CSB IP CSB IP (PI) Chrom. Chrom. (PI) Phosphorylation Ubiquitylation
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[Click on the plots to view the data selection in the respective scatterplot]

Protein Results:

 Results for post-translational modifications: see below | Red/green: hit at lower/upper end of the respective screen
Gene name Point score Z-score sums RNAi high RNAi low RNAPII-IP (PI) CSB-IP CSB-IP (PI) Chrom. Chrom. (PI)
VCL 1 4.851 0.570 -0.620 2.233 0.870

PTM Sites:

 Back to Protein Results | Red/green: hit at lower/upper end of the respective screen
Gene name PTM type PTM site UV UV (PI) Sequence
VCL Ubiquitylation K639 0.665 0.718 _AANFENHSGK(gl)LGATAEK_
VCL Ubiquitylation K1070 0.504 0.692 _ILSTVK(gl)ATMLGR_
VCL Ubiquitylation K1020 0.159 0.667 _ALIQCAK(gl)DIAK_
VCL Phosphorylation S288 0.364 _DPS(ph)ASPGDAGEQAIR_
VCL Ubiquitylation K476 0.572 0.356 _QVATALQNLQTK(gl)TNR_
VCL Ubiquitylation K228 0.195 _NQGIEEALK(gl)NR_
VCL Ubiquitylation K219 -0.376 0.161 _NSK(gl)NQGIEEALK_
VCL Phosphorylation S290 -0.415 _DPSAS(ph)PGDAGEQAIR_
VCL Ubiquitylation K792 -0.889 -1.201 _AASDELSK(gl)TISPMVMDAK_
VCL Ubiquitylation K666 0.502 _STVEGIQASVK(gl)TAR_
VCL Ubiquitylation K768 0.256 _ILLVAK(gl)R_
VCL Ubiquitylation K784 -0.707 _EAVK(gl)AASDELSK_
VCL Ubiquitylation K815 -0.780 _AVAGNISDPGLQK(gl)SFLDSGYR_

Background Information for VCL:


Pubmed-VCL »
Uniprot-VCL »
Biogrid-VCL »
ProteomicsDB-VCL »

Tumorportal-VCL »
COSMIC-VCL »
GenomeRNAi-VCL »
Genecards-VCL


Protein-protein Interactions for VCL
Show screen data for Category Name and Description Link to cat description Data Source
Category members IP bait CDCA5 Cat. description Hein, Mann, Cell 2015
Category members IP bait MKNK2 Cat. description Hein, Mann, Cell 2015
Category members IP bait PTPN13 Cat. description Hein, Mann, Cell 2015
Category members IP bait SEC16A Cat. description Hein, Mann, Cell 2015
Category members IP bait VCL Cat. description Hein, Mann, Cell 2015


Protein Domains in VCL
Domain name Domain Description TC-NER relevance -log10(p-value)
Category members Vinculin/catenin IPR006077 0.27
Category members Vinculin IPR017997 0


Protein complexes (CORUM database) featuring VCL
Category Type Category ID Category Name Data Source TC-NER relevance -log10(p-value)
Category members Corum 5177 Polycystin-1 multiprotein complex (ACTN1, CDH1, SRC, JUP, VCL, CTNNB1, PXN, BCAR1, PKD1, PTK2, TLN1) Database 0.31


Categories featuring VCL
Category Type Category ID Category Name Data Source TC-NER relevance -log10(p-value)
Category members GO Category GO:0005515 protein binding Database INF
Category members GO Category GO:0005829 cytosol Database INF
Category members GO Category GO:0005576 extracellular region Database 10.9
Category members GO Category GO:0003779 actin binding Database 5.41
Category members GO Category GO:0043234 protein complex Database 2.73
Category members GO Category GO:0015629 actin cytoskeleton Database 2.22
Category members Pathway Pathway_541 PID_FAK_PATHWAY 0 1.88
Category members GO Category GO:0043034 costamere Database 1.42
Category members Pathway Pathway_466 PID_ECADHERIN_STABILIZATION_PATHWAY 0 1.4
Category members GO Category GO:0005911 cell-cell junction Database 1.4
Category members GO Category GO:0005886 plasma membrane Database 1.21
Category members Pathway Pathway_595 KEGG_FOCAL_ADHESION 0 1.08
Category members GO Category GO:0005913 cell-cell adherens junction Database 1.05
Category members GO Category GO:0005198 structural molecule activity Database 0.94
Category members GO Category GO:0030336 negative regulation of cell migration Database 0.85
Category members GO Category GO:0017048 Rho GTPase binding Database 0.69
Category members GO Category GO:0005925 focal adhesion Database 0.68
Category members Pathway Pathway_1061 BIOCARTA_INTEGRIN_PATHWAY 0 0.66
Category members GO Category GO:0030032 lamellipodium assembly Database 0.66
Category members GO Category GO:0005856 cytoskeleton Database 0.63
Category members GO Category GO:0030334 regulation of cell migration Database 0.61
Category members GO Category GO:0005916 fascia adherens Database 0.47
Category members Pathway Pathway_747 KEGG_ADHERENS_JUNCTION 0 0.43
Category members Pathway Pathway_53 REACTOME_HEMOSTASIS 0 0.4
Category members GO Category GO:0007596 blood coagulation Database 0.4
Category members GO Category GO:0042383 sarcolemma Database 0.36
Category members GO Category GO:0008013 beta-catenin binding Database 0.35
Category members GO Category GO:0030018 Z disc Database 0.32
Category members Pathway Pathway_667 BIOCARTA_RHO_PATHWAY 0 0.3
Category members GO Category GO:0030055 cell-substrate junction Database 0.29
Category members GO Category GO:0043297 apical junction assembly Database 0.28
Category members GO Category GO:0045296 cadherin binding Database 0.26
Category members GO Category GO:0005912 adherens junction Database 0.25
Category members GO Category GO:0006928 cellular component movement Database 0.24
Category members Pathway Pathway_605 KEGG_LEUKOCYTE_TRANSENDOTHELIAL_MIGRATION 0 0.2
Category members GO Category GO:0030168 platelet activation Database 0.13
Category members Pathway Pathway_437 PID_VEGFR1_2_PATHWAY 0 0.13
Category members Pathway Pathway_56 REACTOME_PLATELET_ACTIVATION_SIGNALING_AND_AGGREGATION 0 0.11
Category members Disease phenotype Familial_isolated_dilated_cardiomyopathy Familial isolated dilated cardiomyopathy Database 0.08
Category members Pathway Pathway_580 KEGG_REGULATION_OF_ACTIN_CYTOSKELETON 0 0.08
Category members Pathway Pathway_1178 BIOCARTA_CELL2CELL_PATHWAY 0 0.08
Category members Pathway Pathway_521 PID_AVB3_INTEGRIN_PATHWAY 0 0.03
Category members GO Category GO:0045294 alpha-catenin binding Database 0.03
Category members Pathway Pathway_55 REACTOME_RESPONSE_TO_ELEVATED_PLATELET_CYTOSOLIC_CA2_ 0 0
Category members Pathway Pathway_668 PID_RHOA_PATHWAY 0 0
Category members Pathway Pathway_949 REACTOME_SMOOTH_MUSCLE_CONTRACTION 0 0
Category members Pathway Pathway_950 REACTOME_MUSCLE_CONTRACTION 0 0
Category members GO Category GO:0002009 morphogenesis of an epithelium Database 0
Category members GO Category GO:0002162 dystroglycan binding Database 0
Category members GO Category GO:0002576 platelet degranulation Database 0
Category members GO Category GO:0006936 muscle contraction Database 0
Category members GO Category GO:0007155 cell adhesion Database 0
Category members GO Category GO:0007160 cell-matrix adhesion Database 0
Category members GO Category GO:0034333 adherens junction assembly Database 0
Category members GO Category GO:0034394 protein localization to cell surface Database 0


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