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Query: MYH6

RNAi screen result RNAPII IP (PI) CSB IP CSB IP (PI) Chrom. Chrom. (PI) Phosphorylation Ubiquitylation
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[Click on the plots to view the data selection in the respective scatterplot]

Protein Results:

 Results for post-translational modifications: see below | Red/green: hit at lower/upper end of the respective screen
Gene name Point score Z-score sums RNAi high RNAi low RNAPII-IP (PI) CSB-IP CSB-IP (PI) Chrom. Chrom. (PI)
MYH6 0 -0.709 -0.350 1.110
MYH6 0 -0.709 -0.240 -0.750

PTM Sites:

 Back to Protein Results | Red/green: hit at lower/upper end of the respective screen
Gene name PTM type PTM site UV UV (PI) Sequence
MYH6 Ubiquitylation K1446 -1.408 -0.411 _SNAAAAALDK(gl)K_
MYH6 Ubiquitylation K1447 -1.408 -0.411 _SNAAAAALDK(gl)K_

Background Information for MYH6:


Pubmed-MYH6 »
Uniprot-MYH6 »
Biogrid-MYH6 »
ProteomicsDB-MYH6 »

Tumorportal-MYH6 »
COSMIC-MYH6 »
GenomeRNAi-MYH6 »
Genecards-MYH6


Protein-protein Interactions for MYH6
Show screen data for Category Name and Description Link to cat description Data Source
Category members IP bait BRCA1 Cat. description Hein, Mann, Cell 2015
Category members IP bait MYH6 Cat. description Hein, Mann, Cell 2015
Category members IP bait SORT1 Cat. description Hein, Mann, Cell 2015
Category members IP bait TMEM132A Cat. description Hein, Mann, Cell 2015
Category members IP bait HIF1A Cat. description BioPlex, Huttlin, Gygi, Cell 2015


Protein Domains in MYH6
Domain name Domain Description TC-NER relevance -log10(p-value)
Category members P-loop_NTPase IPR027417 2.83
Category members Myosin_head_motor_dom IPR001609 0.17
Category members IQ_motif_EF-hand-BS IPR000048 0
Category members Myosin_tail IPR002928 0
Category members Myosin_N IPR004009 0
Category members Prefoldin IPR009053 0


Protein complexes (CORUM database) featuring MYH6
Category Type Category ID Category Name Data Source TC-NER relevance -log10(p-value)


Categories featuring MYH6
Category Type Category ID Category Name Data Source TC-NER relevance -log10(p-value)
Category members GO Category GO:0005515 protein binding Database INF
Category members GO Category GO:0005634 nucleus Database INF
Category members GO Category GO:0005829 cytosol Database INF
Category members GO Category GO:0005730 nucleolus Database 13.38
Category members GO Category GO:0005737 cytoplasm Database 12.81
Category members GO Category GO:0005524 ATP binding Database 5.54
Category members GO Category GO:0003779 actin binding Database 5.41
Category members GO Category GO:0016887 ATPase activity Database 2.28
Category members GO Category GO:0006200 ATP catabolic process Database 2.13
Category members Pathway Pathway_413 KEGG_TIGHT_JUNCTION 0 2.08
Category members GO Category GO:0005516 calmodulin binding Database 0.74
Category members GO Category GO:0005925 focal adhesion Database 0.68
Category members GO Category GO:0016459 myosin complex Database 0.38
Category members GO Category GO:0019901 protein kinase binding Database 0.37
Category members GO Category GO:0030018 Z disc Database 0.32
Category members GO Category GO:0030898 actin-dependent ATPase activity Database 0.31
Category members GO Category GO:0030048 actin filament-based movement Database 0.28
Category members GO Category GO:0000146 microfilament motor activity Database 0.27
Category members GO Category GO:0030509 BMP signaling pathway Database 0.2
Category members GO Category GO:0001701 in utero embryonic development Database 0.2
Category members GO Category GO:0003774 motor activity Database 0.2
Category members GO Category GO:0006941 striated muscle contraction Database 0.14
Category members GO Category GO:0008217 regulation of blood pressure Database 0.09
Category members Disease phenotype Familial_isolated_dilated_cardiomyopathy Familial isolated dilated cardiomyopathy Database 0.08
Category members GO Category GO:0030017 sarcomere Database 0.06
Category members GO Category GO:0008016 regulation of heart contraction Database 0.04
Category members GO Category GO:0001725 stress fiber Database 0.04
Category members GO Category GO:0060420 regulation of heart growth Database 0.04
Category members Pathway Pathway_1008 KEGG_HYPERTROPHIC_CARDIOMYOPATHY_HCM 0 0
Category members Pathway Pathway_1014 KEGG_VIRAL_MYOCARDITIS 0 0
Category members Pathway Pathway_1208 REACTOME_STRIATED_MUSCLE_CONTRACTION 0 0
Category members Pathway Pathway_198 KEGG_CARDIAC_MUSCLE_CONTRACTION 0 0
Category members Pathway Pathway_262 KEGG_DILATED_CARDIOMYOPATHY 0 0
Category members Pathway Pathway_950 REACTOME_MUSCLE_CONTRACTION 0 0
Category members Disease phenotype Atrial_septal_defect_ostium_secundum_type Atrial septal defect ostium secundum type Database 0
Category members Disease phenotype Familial_sick_sinus_syndrome Familial sick sinus syndrome Database 0
Category members GO Category GO:0002026 regulation of the force of heart contraction Database 0
Category members GO Category GO:0002027 regulation of heart rate Database 0
Category members GO Category GO:0005859 muscle myosin complex Database 0
Category members GO Category GO:0006936 muscle contraction Database 0
Category members GO Category GO:0007512 adult heart development Database 0
Category members GO Category GO:0008307 structural constituent of muscle Database 0
Category members GO Category GO:0030016 myofibril Database 0
Category members GO Category GO:0030049 muscle filament sliding Database 0
Category members GO Category GO:0030239 myofibril assembly Database 0
Category members GO Category GO:0032982 myosin filament Database 0
Category members GO Category GO:0043462 regulation of ATPase activity Database 0
Category members GO Category GO:0045214 sarcomere organization Database 0
Category members GO Category GO:0048739 cardiac muscle fiber development Database 0
Category members GO Category GO:0055009 atrial cardiac muscle tissue morphogenesis Database 0
Category members GO Category GO:0055010 ventricular cardiac muscle tissue morphogenesis Database 0
Category members GO Category GO:0060070 canonical Wnt signaling pathway Database 0


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