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Query: ACTN2

RNAi screen result RNAPII IP (PI) CSB IP CSB IP (PI) Chrom. Chrom. (PI) Phosphorylation Ubiquitylation
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[Click on the plots to view the data selection in the respective scatterplot]

Protein Results:

 Results for post-translational modifications: see below | Red/green: hit at lower/upper end of the respective screen
Gene name Point score Z-score sums RNAi high RNAi low RNAPII-IP (PI) CSB-IP CSB-IP (PI) Chrom. Chrom. (PI)
ACTN2 3 7.455 -1.480 2.640 0.790 0.055 0.246
ACTN2 3 7.455 -1.480 2.640 0.936 1.929 -1.407 0.572 0.293

PTM Sites:

 Back to Protein Results | Red/green: hit at lower/upper end of the respective screen
Gene name PTM type PTM site UV UV (PI) Sequence
ACTN2 Ubiquitylation K125 1.906 _ALDFIASKGVK(gl)_
ACTN2 Ubiquitylation K760 0.273 1.507 _DAK(gl)GISQEQMQEFR_
ACTN2 Ubiquitylation K417 0.789 _LDHLAEK(gl)FR_
ACTN2 Ubiquitylation K592 -0.644 0.678 _EAILAIHK(gl)EAQR_
ACTN2 Ubiquitylation K350 0.585 _VQEK(gl)CQLEINFNTLQTK_

Background Information for ACTN2:


Pubmed-ACTN2 »
Uniprot-ACTN2 »
Biogrid-ACTN2 »
ProteomicsDB-ACTN2 »

Tumorportal-ACTN2 »
COSMIC-ACTN2 »
GenomeRNAi-ACTN2 »
Genecards-ACTN2


Protein-protein Interactions for ACTN2
Show screen data for Category Name and Description Link to cat description Data Source
Category members IP bait PDLIM1 Cat. description BioPlex, Huttlin, Gygi, Cell 2015


Protein Domains in ACTN2
Domain name Domain Description TC-NER relevance -log10(p-value)
Category members Spectrin_repeat IPR002017 2.4
Category members Spectrin/alpha-actinin IPR018159 1.6
Category members CH-domain IPR001715 0.63
Category members CAMSAP_CH IPR022613 0.13
Category members EF_hand_dom IPR002048 0
Category members EF-hand_Ca_insen IPR014837 0


Protein complexes (CORUM database) featuring ACTN2
Category Type Category ID Category Name Data Source TC-NER relevance -log10(p-value)


Categories featuring ACTN2
Category Type Category ID Category Name Data Source TC-NER relevance -log10(p-value)
Category members GO Category GO:0005515 protein binding Database INF
Category members GO Category GO:0005829 cytosol Database INF
Category members GO Category GO:0005576 extracellular region Database 10.9
Category members GO Category GO:0003779 actin binding Database 5.41
Category members Pathway Pathway_413 KEGG_TIGHT_JUNCTION 0 2.08
Category members Pathway Pathway_1156 BIOCARTA_UCALPAIN_PATHWAY 0 1.12
Category members Pathway Pathway_595 KEGG_FOCAL_ADHESION 0 1.08
Category members GO Category GO:0051015 actin filament binding Database 0.99
Category members Pathway Pathway_889 KEGG_SYSTEMIC_LUPUS_ERYTHEMATOSUS 0 0.9
Category members GO Category GO:0043197 dendritic spine Database 0.86
Category members GO Category GO:0042981 regulation of apoptotic process Database 0.79
Category members GO Category GO:0005925 focal adhesion Database 0.68
Category members Pathway Pathway_1061 BIOCARTA_INTEGRIN_PATHWAY 0 0.66
Category members GO Category GO:0005856 cytoskeleton Database 0.63
Category members GO Category GO:0008092 cytoskeletal protein binding Database 0.5
Category members Pathway Pathway_563 REACTOME_NEPHRIN_INTERACTIONS 0 0.49
Category members GO Category GO:0031143 pseudopodium Database 0.46
Category members GO Category GO:0051289 protein homotetramerization Database 0.44
Category members GO Category GO:0043268 positive regulation of potassium ion transport Database 0.44
Category members Pathway Pathway_747 KEGG_ADHERENS_JUNCTION 0 0.43
Category members Pathway Pathway_53 REACTOME_HEMOSTASIS 0 0.4
Category members GO Category GO:0007596 blood coagulation Database 0.4
Category members GO Category GO:0030018 Z disc Database 0.32
Category members GO Category GO:0042802 identical protein binding Database 0.26
Category members Pathway Pathway_560 REACTOME_CELL_CELL_COMMUNICATION 0 0.25
Category members GO Category GO:0007268 synaptic transmission Database 0.23
Category members Pathway Pathway_605 KEGG_LEUKOCYTE_TRANSENDOTHELIAL_MIGRATION 0 0.2
Category members GO Category GO:0030168 platelet activation Database 0.13
Category members GO Category GO:0030374 ligand-dependent nuclear receptor transcription coactivator activity Database 0.12
Category members Pathway Pathway_56 REACTOME_PLATELET_ACTIVATION_SIGNALING_AND_AGGREGATION 0 0.11
Category members GO Category GO:0005509 calcium ion binding Database 0.11
Category members GO Category GO:0048041 focal adhesion assembly Database 0.1
Category members GO Category GO:0005178 integrin binding Database 0.09
Category members Disease phenotype Familial_isolated_dilated_cardiomyopathy Familial isolated dilated cardiomyopathy Database 0.08
Category members Pathway Pathway_580 KEGG_REGULATION_OF_ACTIN_CYTOSKELETON 0 0.08
Category members Pathway Pathway_1178 BIOCARTA_CELL2CELL_PATHWAY 0 0.08
Category members GO Category GO:0005884 actin filament Database 0.08
Category members GO Category GO:0030017 sarcomere Database 0.06
Category members GO Category GO:0030375 thyroid hormone receptor coactivator activity Database 0.06
Category members GO Category GO:0030175 filopodium Database 0.05
Category members GO Category GO:0044325 ion channel binding Database 0.03
Category members Pathway Pathway_1007 KEGG_ARRHYTHMOGENIC_RIGHT_VENTRICULAR_CARDIOMYOPATHY_ARVC 0 0.03
Category members GO Category GO:0042391 regulation of membrane potential Database 0
Category members Pathway Pathway_1168 REACTOME_UNBLOCKING_OF_NMDA_RECEPTOR_GLUTAMATE_BINDING_AND_ACTIVATION 0 0
Category members Pathway Pathway_1119 REACTOME_RAS_ACTIVATION_UOPN_CA2_INFUX_THROUGH_NMDA_RECEPTOR 0 0
Category members Pathway Pathway_1169 REACTOME_CREB_PHOSPHORYLATION_THROUGH_THE_ACTIVATION_OF_CAMKII 0 0
Category members Pathway Pathway_1208 REACTOME_STRIATED_MUSCLE_CONTRACTION 0 0
Category members Pathway Pathway_139 REACTOME_NEURONAL_SYSTEM 0 0
Category members Pathway Pathway_140 REACTOME_TRANSMISSION_ACROSS_CHEMICAL_SYNAPSES 0 0
Category members Pathway Pathway_224 REACTOME_POST_NMDA_RECEPTOR_ACTIVATION_EVENTS 0 0
Category members Pathway Pathway_230 REACTOME_NEUROTRANSMITTER_RECEPTOR_BINDING_AND_DOWNSTREAM_TRANSMISSION_IN_THE_POSTSYNAPTIC_CELL 0 0
Category members Pathway Pathway_238 REACTOME_ACTIVATION_OF_NMDA_RECEPTOR_UPON_GLUTAMATE_BINDING_AND_POSTSYNAPTIC_EVENTS 0 0
Category members Pathway Pathway_55 REACTOME_RESPONSE_TO_ELEVATED_PLATELET_CYTOSOLIC_CA2_ 0 0
Category members Pathway Pathway_935 REACTOME_CREB_PHOSPHORYLATION_THROUGH_THE_ACTIVATION_OF_RAS 0 0
Category members Pathway Pathway_950 REACTOME_MUSCLE_CONTRACTION 0 0
Category members GO Category GO:0002576 platelet degranulation Database 0
Category members GO Category GO:0006936 muscle contraction Database 0
Category members GO Category GO:0007155 cell adhesion Database 0
Category members GO Category GO:0008307 structural constituent of muscle Database 0
Category members GO Category GO:0030035 microspike assembly Database 0
Category members GO Category GO:0030049 muscle filament sliding Database 0
Category members GO Category GO:0030274 LIM domain binding Database 0
Category members GO Category GO:0031093 platelet alpha granule lumen Database 0
Category members GO Category GO:0031432 titin binding Database 0
Category members GO Category GO:0043267 negative regulation of potassium ion transport Database 0
Category members GO Category GO:0046983 protein dimerization activity Database 0
Category members GO Category GO:0051373 FATZ binding Database 0
Category members GO Category GO:0070080 titin Z domain binding Database 0


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