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Query: PSEN2

RNAi screen result RNAPII IP (PI) CSB IP CSB IP (PI) Chrom. Chrom. (PI) Phosphorylation Ubiquitylation
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[Click on the plots to view the data selection in the respective scatterplot]

Protein Results:

 Results for post-translational modifications: see below | Red/green: hit at lower/upper end of the respective screen
Gene name Point score Z-score sums RNAi high RNAi low RNAPII-IP (PI) CSB-IP CSB-IP (PI) Chrom. Chrom. (PI)
PSEN2 1 3.038 -1.820 3.280

PTM Sites:

 Back to Protein Results | Red/green: hit at lower/upper end of the respective screen
Gene name PTM type PTM site UV UV (PI) Sequence
PSEN2 Phosphorylation S58 -0.112 -0.130 _TSLM(ox)SAES(ph)PTPR_

Background Information for PSEN2:


Pubmed-PSEN2 »
Uniprot-PSEN2 »
Biogrid-PSEN2 »
ProteomicsDB-PSEN2 »

Tumorportal-PSEN2 »
COSMIC-PSEN2 »
GenomeRNAi-PSEN2 »
Genecards-PSEN2


Protein-protein Interactions for PSEN2
Show screen data for Category Name and Description Link to cat description Data Source
Category members IP bait KIF22 Cat. description Hein, Mann, Cell 2015
Category members IP bait PPP5C Cat. description Hein, Mann, Cell 2015
Category members IP bait PSEN2 Cat. description Hein, Mann, Cell 2015


Protein Domains in PSEN2
Domain name Domain Description TC-NER relevance -log10(p-value)
Category members Peptidase_A22A IPR001108 0.08
Category members Preselin/SPP IPR006639 0


Protein complexes (CORUM database) featuring PSEN2
Category Type Category ID Category Name Data Source TC-NER relevance -log10(p-value)
Category members Corum 467 Gamma-secretase complex (APH1B, PSEN2, PSENEN, NCSTN) Database 0.18
Category members Corum 2735 APH1A-PSEN2-NCSTN complex Database 0.09
Category members Corum 468 Gamma-secretase complex (APH1A, PSEN2, PSENEN, NCSTN) Database 0.07


Categories featuring PSEN2
Category Type Category ID Category Name Data Source TC-NER relevance -log10(p-value)
Category members GO Category GO:0005515 protein binding Database INF
Category members GO Category GO:0005829 cytosol Database INF
Category members GO Category GO:0044267 cellular protein metabolic process Database 10.42
Category members GO Category GO:0016021 integral to membrane Database 7.67
Category members GO Category GO:0015031 protein transport Database 3.48
Category members GO Category GO:0043234 protein complex Database 2.73
Category members GO Category GO:0005938 cell cortex Database 2.26
Category members GO Category GO:0000776 kinetochore Database 2.24
Category members Pathway Pathway_221 REACTOME_SIGNALLING_BY_NGF 0 2.14
Category members GO Category GO:0006915 apoptotic process Database 2.12
Category members GO Category GO:0005637 nuclear inner membrane Database 1.98
Category members GO Category GO:0005887 integral to plasma membrane Database 1.69
Category members GO Category GO:0030426 growth cone Database 1.61
Category members GO Category GO:0005789 endoplasmic reticulum membrane Database 1.57
Category members GO Category GO:0032469 endoplasmic reticulum calcium ion homeostasis Database 1.26
Category members GO Category GO:0005886 plasma membrane Database 1.21
Category members GO Category GO:0043198 dendritic shaft Database 0.93
Category members GO Category GO:0005765 lysosomal membrane Database 0.82
Category members GO Category GO:0043085 positive regulation of catalytic activity Database 0.78
Category members GO Category GO:0005813 centrosome Database 0.75
Category members GO Category GO:0048011 neurotrophin TRK receptor signaling pathway Database 0.63
Category members GO Category GO:0005783 endoplasmic reticulum Database 0.62
Category members Pathway Pathway_1142 PID_LKB1_PATHWAY 0 0.6
Category members GO Category GO:0043066 negative regulation of apoptotic process Database 0.6
Category members GO Category GO:0016485 protein processing Database 0.57
Category members GO Category GO:0016020 membrane Database 0.52
Category members GO Category GO:0048471 perinuclear region of cytoplasm Database 0.39
Category members Pathway Pathway_117 REACTOME_SIGNALING_BY_NOTCH 0 0.33
Category members GO Category GO:0030018 Z disc Database 0.32
Category members GO Category GO:0005794 Golgi apparatus Database 0.27
Category members GO Category GO:0043065 positive regulation of apoptotic process Database 0.26
Category members Pathway Pathway_739 REACTOME_P75_NTR_RECEPTOR_MEDIATED_SIGNALLING 0 0.23
Category members GO Category GO:0030424 axon Database 0.23
Category members Pathway Pathway_789 REACTOME_SIGNALING_BY_NOTCH1 0 0.22
Category members Pathway Pathway_779 REACTOME_CELL_DEATH_SIGNALLING_VIA_NRAGE_NRIF_AND_NADE 0 0.2
Category members GO Category GO:0009986 cell surface Database 0.17
Category members Pathway Pathway_960 BIOCARTA_HIVNEF_PATHWAY 0 0.17
Category members GO Category GO:0005743 mitochondrial inner membrane Database 0.15
Category members GO Category GO:0048167 regulation of synaptic plasticity Database 0.14
Category members GO Category GO:0006509 membrane protein ectodomain proteolysis Database 0.14
Category members GO Category GO:0002573 myeloid leukocyte differentiation Database 0.11
Category members GO Category GO:0045121 membrane raft Database 0.11
Category members GO Category GO:0042987 amyloid precursor protein catabolic process Database 0.09
Category members Disease phenotype Familial_isolated_dilated_cardiomyopathy Familial isolated dilated cardiomyopathy Database 0.08
Category members GO Category GO:0032091 negative regulation of protein binding Database 0.08
Category members GO Category GO:0050820 positive regulation of coagulation Database 0.08
Category members GO Category GO:0051604 protein maturation Database 0.06
Category members GO Category GO:0050852 T cell receptor signaling pathway Database 0.06
Category members Pathway Pathway_545 REACTOME_SIGNALING_BY_ERBB4 0 0.05
Category members GO Category GO:0007219 Notch signaling pathway Database 0.05
Category members GO Category GO:0043393 regulation of protein binding Database 0.04
Category members Pathway Pathway_1159 REACTOME_REGULATED_PROTEOLYSIS_OF_P75NTR 0 0.04
Category members GO Category GO:0001933 negative regulation of protein phosphorylation Database 0.04
Category members Disease phenotype Early-onset_autosomal_dominant_Alzheimer_disease Early-onset autosomal dominant Alzheimer disease Database 0.04
Category members GO Category GO:0002286 T cell activation involved in immune response Database 0.04
Category members GO Category GO:0035253 ciliary rootlet Database 0.03
Category members Pathway Pathway_1278 REACTOME_SIGNALING_BY_NOTCH2 0 0
Category members Pathway Pathway_1279 REACTOME_SIGNALING_BY_NOTCH3 0 0
Category members Pathway Pathway_1280 REACTOME_SIGNALING_BY_NOTCH4 0 0
Category members Pathway Pathway_29 KEGG_ALZHEIMERS_DISEASE 0 0
Category members Pathway Pathway_799 REACTOME_NRIF_SIGNALS_CELL_DEATH_FROM_THE_NUCLEUS 0 0
Category members Pathway Pathway_831 REACTOME_ACTIVATED_NOTCH1_TRANSMITS_SIGNAL_TO_THE_NUCLEUS 0 0
Category members Pathway Pathway_892 KEGG_NOTCH_SIGNALING_PATHWAY 0 0
Category members Pathway Pathway_977 REACTOME_NUCLEAR_SIGNALING_BY_ERBB4 0 0
Category members GO Category GO:0000139 Golgi membrane Database 0
Category members GO Category GO:0001666 response to hypoxia Database 0
Category members GO Category GO:0001708 cell fate specification Database 0
Category members GO Category GO:0001756 somitogenesis Database 0
Category members GO Category GO:0001942 hair follicle development Database 0
Category members GO Category GO:0002244 hematopoietic progenitor cell differentiation Database 0
Category members GO Category GO:0004175 endopeptidase activity Database 0
Category members GO Category GO:0004190 aspartic-type endopeptidase activity Database 0
Category members GO Category GO:0006816 calcium ion transport Database 0
Category members GO Category GO:0007176 regulation of epidermal growth factor-activated receptor activity Database 0
Category members GO Category GO:0007220 Notch receptor processing Database 0
Category members GO Category GO:0007611 learning or memory Database 0
Category members GO Category GO:0007613 memory Database 0
Category members GO Category GO:0009790 embryo development Database 0
Category members GO Category GO:0016324 apical plasma membrane Database 0
Category members GO Category GO:0021904 dorsal/ventral neural tube patterning Database 0
Category members GO Category GO:0030326 embryonic limb morphogenesis Database 0
Category members GO Category GO:0030900 forebrain development Database 0
Category members GO Category GO:0031293 membrane protein intracellular domain proteolysis Database 0
Category members GO Category GO:0031333 negative regulation of protein complex assembly Database 0
Category members GO Category GO:0031594 neuromuscular junction Database 0
Category members GO Category GO:0035556 intracellular signal transduction Database 0
Category members GO Category GO:0040011 locomotion Database 0
Category members GO Category GO:0042640 anagen Database 0
Category members GO Category GO:0043025 neuronal cell body Database 0
Category members GO Category GO:0048286 lung alveolus development Database 0
Category members GO Category GO:0048538 thymus development Database 0
Category members GO Category GO:0048854 brain morphogenesis Database 0
Category members GO Category GO:0050435 beta-amyloid metabolic process Database 0
Category members GO Category GO:0060048 cardiac muscle contraction Database 0


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