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Query: TPM1

RNAi screen result RNAPII IP (PI) CSB IP CSB IP (PI) Chrom. Chrom. (PI) Phosphorylation Ubiquitylation
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[Click on the plots to view the data selection in the respective scatterplot]

Protein Results:

 Results for post-translational modifications: see below | Red/green: hit at lower/upper end of the respective screen
Gene name Point score Z-score sums RNAi high RNAi low RNAPII-IP (PI) CSB-IP CSB-IP (PI) Chrom. Chrom. (PI)
TPM1 0 -1.537 0.280 -0.190

PTM Sites:

 Back to Protein Results | Red/green: hit at lower/upper end of the respective screen
Gene name PTM type PTM site UV UV (PI) Sequence
TPM1 Ubiquitylation K30 -1.537 _AEQAEADKK(gl)AAEDR_

Background Information for TPM1:


Pubmed-TPM1 »
Uniprot-TPM1 »
Biogrid-TPM1 »
ProteomicsDB-TPM1 »

Tumorportal-TPM1 »
COSMIC-TPM1 »
GenomeRNAi-TPM1 »
Genecards-TPM1


Protein-protein Interactions for TPM1
Show screen data for Category Name and Description Link to cat description Data Source
Category members IP bait ACTB Cat. description Hein, Mann, Cell 2015
Category members IP bait ANLN Cat. description Hein, Mann, Cell 2015
Category members IP bait CALML3 Cat. description Hein, Mann, Cell 2015
Category members IP bait CAPZA2 Cat. description Hein, Mann, Cell 2015
Category members IP bait CDK2 Cat. description Hein, Mann, Cell 2015
Category members IP bait CORO1C Cat. description Hein, Mann, Cell 2015
Category members IP bait DBN1 Cat. description Hein, Mann, Cell 2015
Category members IP bait FLNA Cat. description Hein, Mann, Cell 2015
Category members IP bait IQGAP1 Cat. description Hein, Mann, Cell 2015
Category members IP bait ITGA5 Cat. description Hein, Mann, Cell 2015
Category members IP bait KIAA1279 Cat. description Hein, Mann, Cell 2015
Category members IP bait KIAA1430 Cat. description Hein, Mann, Cell 2015
Category members IP bait LIMA1 Cat. description Hein, Mann, Cell 2015
Category members IP bait MAPRE1 Cat. description Hein, Mann, Cell 2015
Category members IP bait MYH10 Cat. description Hein, Mann, Cell 2015
Category members IP bait MYH9 Cat. description Hein, Mann, Cell 2015
Category members IP bait MYO18A Cat. description Hein, Mann, Cell 2015
Category members IP bait MYO19 Cat. description Hein, Mann, Cell 2015
Category members IP bait MYO1C Cat. description Hein, Mann, Cell 2015
Category members IP bait PDLIM7 Cat. description Hein, Mann, Cell 2015
Category members IP bait PEO1 Cat. description Hein, Mann, Cell 2015
Category members IP bait PPP1CB Cat. description Hein, Mann, Cell 2015
Category members IP bait SAMM50 Cat. description Hein, Mann, Cell 2015
Category members IP bait SESN2 Cat. description Hein, Mann, Cell 2015
Category members IP bait SHCBP1 Cat. description Hein, Mann, Cell 2015
Category members IP bait SYNPO Cat. description Hein, Mann, Cell 2015
Category members IP bait TMED10 Cat. description Hein, Mann, Cell 2015
Category members IP bait TMOD3 Cat. description Hein, Mann, Cell 2015
Category members IP bait TPM1 Cat. description Hein, Mann, Cell 2015
Category members IP bait TPM4 Cat. description Hein, Mann, Cell 2015
Category members IP bait TTLL12 Cat. description Hein, Mann, Cell 2015
Category members IP bait USO1 Cat. description Hein, Mann, Cell 2015
Category members IP bait TPM1 Cat. description BioPlex, Huttlin, Gygi, Cell 2015
Category members IP bait TSSC4 Cat. description BioPlex, Huttlin, Gygi, Cell 2015


Protein Domains in TPM1
Domain name Domain Description TC-NER relevance -log10(p-value)
Category members Tropomyosin IPR000533 0.08


Protein complexes (CORUM database) featuring TPM1
Category Type Category ID Category Name Data Source TC-NER relevance -log10(p-value)


Categories featuring TPM1
Category Type Category ID Category Name Data Source TC-NER relevance -log10(p-value)
Category members GO Category GO:0005829 cytosol Database INF
Category members DDR Literature pubmedid:24055347 Jungmichel et al., 2013 UV-stimulated poly(ADP-Ribosyl)ation targets Jungmichel et al., 2013 INF
Category members GO Category GO:0005737 cytoplasm Database 12.81
Category members GO Category GO:0003779 actin binding Database 5.41
Category members DDR Literature pubmedid:19647519 Paulsen et al., 2009 siRNA screen for g-H2A.x phosphorylation 3.6
Category members GO Category GO:0015629 actin cytoskeleton Database 2.22
Category members GO Category GO:0030336 negative regulation of cell migration Database 0.85
Category members GO Category GO:0032587 ruffle membrane Database 0.65
Category members GO Category GO:0005856 cytoskeleton Database 0.63
Category members GO Category GO:0008092 cytoskeletal protein binding Database 0.5
Category members GO Category GO:0006928 cellular component movement Database 0.24
Category members GO Category GO:0001701 in utero embryonic development Database 0.2
Category members Disease phenotype Familial_isolated_dilated_cardiomyopathy Familial isolated dilated cardiomyopathy Database 0.08
Category members GO Category GO:0032059 bleb Database 0.08
Category members GO Category GO:0030017 sarcomere Database 0.06
Category members GO Category GO:0008016 regulation of heart contraction Database 0.04
Category members GO Category GO:0045785 positive regulation of cell adhesion Database 0.04
Category members GO Category GO:0001725 stress fiber Database 0.04
Category members GO Category GO:0031941 filamentous actin Database 0.01
Category members Pathway Pathway_1008 KEGG_HYPERTROPHIC_CARDIOMYOPATHY_HCM 0 0
Category members Pathway Pathway_1208 REACTOME_STRIATED_MUSCLE_CONTRACTION 0 0
Category members Pathway Pathway_198 KEGG_CARDIAC_MUSCLE_CONTRACTION 0 0
Category members Pathway Pathway_262 KEGG_DILATED_CARDIOMYOPATHY 0 0
Category members Pathway Pathway_949 REACTOME_SMOOTH_MUSCLE_CONTRACTION 0 0
Category members Pathway Pathway_950 REACTOME_MUSCLE_CONTRACTION 0 0
Category members Disease phenotype Left_ventricular_noncompaction Left ventricular noncompaction Database 0
Category members GO Category GO:0005200 structural constituent of cytoskeleton Database 0
Category members GO Category GO:0005862 muscle thin filament tropomyosin Database 0
Category members GO Category GO:0006936 muscle contraction Database 0
Category members GO Category GO:0006937 regulation of muscle contraction Database 0
Category members GO Category GO:0007010 cytoskeleton organization Database 0
Category members GO Category GO:0008307 structural constituent of muscle Database 0
Category members GO Category GO:0009790 embryo development Database 0
Category members GO Category GO:0030016 myofibril Database 0
Category members GO Category GO:0030049 muscle filament sliding Database 0
Category members GO Category GO:0031529 ruffle organization Database 0
Category members GO Category GO:0032781 positive regulation of ATPase activity Database 0
Category members GO Category GO:0034614 cellular response to reactive oxygen species Database 0
Category members GO Category GO:0042060 wound healing Database 0
Category members GO Category GO:0045214 sarcomere organization Database 0
Category members GO Category GO:0051496 positive regulation of stress fiber assembly Database 0
Category members GO Category GO:0055010 ventricular cardiac muscle tissue morphogenesis Database 0
Category members GO Category GO:0060048 cardiac muscle contraction Database 0


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