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Query: TTN

RNAi screen result RNAPII IP (PI) CSB IP CSB IP (PI) Chrom. Chrom. (PI) Phosphorylation Ubiquitylation
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[Click on the plots to view the data selection in the respective scatterplot]

Protein Results:

 Results for post-translational modifications: see below | Red/green: hit at lower/upper end of the respective screen
Gene name Point score Z-score sums RNAi high RNAi low RNAPII-IP (PI) CSB-IP CSB-IP (PI) Chrom. Chrom. (PI)
TTN 1 0.767 2.130 -1.190 0.133 0.277 0.244 0.213

PTM Sites:

 Back to Protein Results | Red/green: hit at lower/upper end of the respective screen
Gene name PTM type PTM site UV UV (PI) Sequence
TTN Ubiquitylation K27327 -0.283 0.183 _AGEVLK(gl)INADIAGR_

Background Information for TTN:


Pubmed-TTN »
Uniprot-TTN »
Biogrid-TTN »
ProteomicsDB-TTN »

Tumorportal-TTN »
COSMIC-TTN »
GenomeRNAi-TTN »
Genecards-TTN


Protein-protein Interactions for TTN
Show screen data for Category Name and Description Link to cat description Data Source
Category members IP bait ADAM2 Cat. description BioPlex, Huttlin, Gygi, Cell 2015
Category members IP bait TLE3 Cat. description BioPlex, Huttlin, Gygi, Cell 2015


Protein Domains in TTN
Domain name Domain Description TC-NER relevance -log10(p-value)
Category members ARM-type_fold IPR016024 9.26
Category members P-loop_NTPase IPR027417 2.83
Category members Ig-like_dom IPR007110 0.6
Category members Ig_sub IPR003599 0.43
Category members Immunoglobulin IPR013151 0.23
Category members Ig_sub2 IPR003598 0.21
Category members Fibronectin_type3 IPR003961 0.19
Category members Ig_I-set IPR013098 0.13
Category members Ig_V-set IPR013106 0.09
Category members Kinase-like_dom IPR011009 0.03
Category members Prot_kinase_dom IPR000719 0
Category members Ser-Thr/Tyr_kinase_cat_dom IPR001245 0
Category members VWF_A IPR002035 0
Category members Ser/Thr_dual-sp_kinase IPR002290 0
Category members Ig_V-set_subgr IPR003596 0
Category members RNaseH-like_dom IPR012337 0
Category members Tyr_kinase_cat_dom IPR020635 0
Category members Calpain_domain_III IPR022682 0
Category members AB_hydrolase IPR029058 0


Protein complexes (CORUM database) featuring TTN
Category Type Category ID Category Name Data Source TC-NER relevance -log10(p-value)


Categories featuring TTN
Category Type Category ID Category Name Data Source TC-NER relevance -log10(p-value)
Category members GO Category GO:0005515 protein binding Database INF
Category members GO Category GO:0005634 nucleus Database INF
Category members GO Category GO:0005829 cytosol Database INF
Category members GO Category GO:0005737 cytoplasm Database 12.81
Category members GO Category GO:0005576 extracellular region Database 10.9
Category members GO Category GO:0005488 binding Database 9.32
Category members GO Category GO:0005524 ATP binding Database 5.54
Category members GO Category GO:0000794 condensed nuclear chromosome Database 1.58
Category members GO Category GO:0019899 enzyme binding Database 1.57
Category members GO Category GO:0051015 actin filament binding Database 0.99
Category members GO Category GO:0003676 nucleic acid binding Database 0.83
Category members GO Category GO:0005516 calmodulin binding Database 0.74
Category members GO Category GO:0004674 protein serine/threonine kinase activity Database 0.66
Category members GO Category GO:0007596 blood coagulation Database 0.4
Category members GO Category GO:0019901 protein kinase binding Database 0.37
Category members GO Category GO:0030018 Z disc Database 0.32
Category members GO Category GO:0005794 Golgi apparatus Database 0.27
Category members GO Category GO:0042802 identical protein binding Database 0.26
Category members GO Category GO:0001701 in utero embryonic development Database 0.2
Category members GO Category GO:0004672 protein kinase activity Database 0.19
Category members GO Category GO:0006941 striated muscle contraction Database 0.14
Category members GO Category GO:0030168 platelet activation Database 0.13
Category members GO Category GO:0005509 calcium ion binding Database 0.11
Category members Disease phenotype Familial_isolated_dilated_cardiomyopathy Familial isolated dilated cardiomyopathy Database 0.08
Category members GO Category GO:0043621 protein self-association Database 0.07
Category members GO Category GO:0030017 sarcomere Database 0.06
Category members Disease phenotype Familial_isolated_arrhythmogenic_ventricular_dysplasia_biventricular_form Familial isolated arrhythmogenic ventricular dysplasia biventricular form Database 0.05
Category members Disease phenotype Familial_isolated_arrhythmogenic_ventricular_dysplasia_left_dominant_form Familial isolated arrhythmogenic ventricular dysplasia left dominant form Database 0.05
Category members Disease phenotype Familial_isolated_arrhythmogenic_ventricular_dysplasia_right_dominant_form Familial isolated arrhythmogenic ventricular dysplasia right dominant form Database 0.05
Category members GO Category GO:0006468 protein phosphorylation Database 0.04
Category members GO Category GO:0031433 telethonin binding Database 0.04
Category members GO Category GO:0051371 muscle alpha-actinin binding Database 0.03
Category members GO Category GO:0045859 regulation of protein kinase activity Database 0.01
Category members GO Category GO:0007076 mitotic chromosome condensation Database 0.01
Category members GO Category GO:0004713 protein tyrosine kinase activity Database 0.01
Category members Pathway Pathway_1008 KEGG_HYPERTROPHIC_CARDIOMYOPATHY_HCM 0 0
Category members Pathway Pathway_262 KEGG_DILATED_CARDIOMYOPATHY 0 0
Category members Disease phenotype Autosomal_recessive_centronuclear_myopathy Autosomal recessive centronuclear myopathy Database 0
Category members Disease phenotype Classic_multiminicore_myopathy Classic multiminicore myopathy Database 0
Category members GO Category GO:0002020 protease binding Database 0
Category members GO Category GO:0002576 platelet degranulation Database 0
Category members GO Category GO:0003007 heart morphogenesis Database 0
Category members GO Category GO:0003300 cardiac muscle hypertrophy Database 0
Category members GO Category GO:0005865 striated muscle thin filament Database 0
Category members GO Category GO:0006936 muscle contraction Database 0
Category members GO Category GO:0007512 adult heart development Database 0
Category members GO Category GO:0008307 structural constituent of muscle Database 0
Category members GO Category GO:0016772 transferase activity, transferring phosphorus-containing groups Database 0
Category members GO Category GO:0030049 muscle filament sliding Database 0
Category members GO Category GO:0030240 skeletal muscle thin filament assembly Database 0
Category members GO Category GO:0030241 skeletal muscle myosin thick filament assembly Database 0
Category members GO Category GO:0031430 M band Database 0
Category members GO Category GO:0031672 A band Database 0
Category members GO Category GO:0031674 I band Database 0
Category members GO Category GO:0035995 detection of muscle stretch Database 0
Category members GO Category GO:0042805 actinin binding Database 0
Category members GO Category GO:0045214 sarcomere organization Database 0
Category members GO Category GO:0048739 cardiac muscle fiber development Database 0
Category members GO Category GO:0048769 sarcomerogenesis Database 0
Category members GO Category GO:0050790 regulation of catalytic activity Database 0
Category members GO Category GO:0051592 response to calcium ion Database 0
Category members GO Category GO:0055002 striated muscle cell development Database 0
Category members GO Category GO:0055003 cardiac myofibril assembly Database 0
Category members GO Category GO:0055008 cardiac muscle tissue morphogenesis Database 0
Category members GO Category GO:0060048 cardiac muscle contraction Database 0


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