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Query: APC

This is a cancer-associated gene according to the Broad and Sanger cancer gene census.

RNAi screen result RNAPII IP (PI) CSB IP CSB IP (PI) Chrom. Chrom. (PI) Phosphorylation Ubiquitylation
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[Click on the plots to view the data selection in the respective scatterplot]

Protein Results:

 Results for post-translational modifications: see below | Red/green: hit at lower/upper end of the respective screen
Gene name Point score Z-score sums RNAi high RNAi low RNAPII-IP (PI) CSB-IP CSB-IP (PI) Chrom. Chrom. (PI)
APC 0 1.850 0.810 -0.720 0.008 0.065

PTM Sites:

 Back to Protein Results | Red/green: hit at lower/upper end of the respective screen
Gene name PTM type PTM site UV UV (PI) Sequence
APC Phosphorylation S1046 0.412 1.084 _YSDEQLNSGRQSPS(ph)QNER_
APC Phosphorylation S2571 0.693 0.817 _TGS(ph)SSSILSASSESSEK_
APC Phosphorylation S2673 0.326 0.501 _S(ph)GRSPTGNTPPVIDSVSEK_
APC Phosphorylation S1044 0.097 0.452 _YSDEQLNSGRQS(ph)PSQNER_
APC Phosphorylation S2095 0.363 _DIQRPDSEHGLS(ph)PDSENFDWK_
APC Phosphorylation S1362 -0.007 0.328 _AVEFSSGAKS(ph)PSK_
APC Phosphorylation S749 0.276 _YKDANIM(ox)SPGS(ph)SLPSLHVR_
APC Phosphorylation S2262 -0.026 0.240 _TPASKS(ph)PSEGQTATTSPR_
APC Phosphorylation S746 0.284 0.140 _DANIMS(ph)PGSSLPSLHVR_
APC Phosphorylation T2678 -0.028 0.136 _SPT(ph)GNTPPVIDSVSEK_
APC Phosphorylation T1775 0.099 _KPT(ph)SPVKPIPQNTEYR_
APC Phosphorylation S1776 0.019 0.099 _KPTS(ph)PVKPIPQNTEYR_
APC Phosphorylation S2676 -0.478 0.096 _SGRS(ph)PTGNTPPVIDSVSEK_
APC Phosphorylation S2127 -0.031 _AIQEGANSIVSSLHQAAAAACLS(ph)R_
APC Phosphorylation S2451 -0.249 -0.285 _EAPS(ph)PTLR_
APC Phosphorylation S782 -0.471 -0.446 _ALEAELDAQHLSETFDNIDNLS(ph)PK_
APC Phosphorylation S2537 -0.505 _SHSES(ph)PSRLPINR_
APC Phosphorylation T1440 -1.261 -0.875 _SKT(ph)PPPPPQTAQTK_
APC Phosphorylation S2260 -0.624 _TPAS(ph)KSPSEGQTATTSPR_

Background Information for APC:


Pubmed-APC »
Uniprot-APC »
Biogrid-APC »
ProteomicsDB-APC »

Tumorportal-APC »
COSMIC-APC »
GenomeRNAi-APC »
Genecards-APC


Protein-protein Interactions for APC
Show screen data for Category Name and Description Link to cat description Data Source
Category members IP bait APC Cat. description Hein, Mann, Cell 2015
Category members IP bait AXIN1 Cat. description Hein, Mann, Cell 2015
Category members IP bait CTNNB1 Cat. description Hein, Mann, Cell 2015
Category members IP bait FBXW11 Cat. description Hein, Mann, Cell 2015
Category members IP bait FLOT2 Cat. description Hein, Mann, Cell 2015
Category members IP bait GSK3B Cat. description Hein, Mann, Cell 2015
Category members IP bait JUP Cat. description Hein, Mann, Cell 2015
Category members IP bait KIF7 Cat. description Hein, Mann, Cell 2015
Category members IP bait MAPRE1 Cat. description Hein, Mann, Cell 2015
Category members IP bait NHSL1 Cat. description Hein, Mann, Cell 2015
Category members IP bait SYNPO Cat. description Hein, Mann, Cell 2015
Category members IP bait TNKS2 Cat. description Hein, Mann, Cell 2015
Category members IP bait ACADVL Cat. description BioPlex, Huttlin, Gygi, Cell 2015
Category members IP bait AP2M1 Cat. description BioPlex, Huttlin, Gygi, Cell 2015
Category members IP bait BTRC Cat. description BioPlex, Huttlin, Gygi, Cell 2015
Category members IP bait CCDC6 Cat. description BioPlex, Huttlin, Gygi, Cell 2015
Category members IP bait CTBP1 Cat. description BioPlex, Huttlin, Gygi, Cell 2015
Category members IP bait CTNNA3 Cat. description BioPlex, Huttlin, Gygi, Cell 2015
Category members IP bait CTNNBIP1 Cat. description BioPlex, Huttlin, Gygi, Cell 2015
Category members IP bait FBXW11 Cat. description BioPlex, Huttlin, Gygi, Cell 2015
Category members IP bait KIAA1683 Cat. description BioPlex, Huttlin, Gygi, Cell 2015
Category members IP bait LIN7C Cat. description BioPlex, Huttlin, Gygi, Cell 2015
Category members IP bait LZTS2 Cat. description BioPlex, Huttlin, Gygi, Cell 2015
Category members IP bait SYNC Cat. description BioPlex, Huttlin, Gygi, Cell 2015
Category members IP bait ZNF408 Cat. description BioPlex, Huttlin, Gygi, Cell 2015
Category members IP bait ZNF785 Cat. description BioPlex, Huttlin, Gygi, Cell 2015


Protein Domains in APC
Domain name Domain Description TC-NER relevance -log10(p-value)
Category members ARM-type_fold IPR016024 9.26
Category members Armadillo IPR000225 1.58
Category members APC_dom IPR026831 0


Protein complexes (CORUM database) featuring APC
Category Type Category ID Category Name Data Source TC-NER relevance -log10(p-value)
Category members Corum 3166 AXIN-APC-betaCatenin-GSK3B complex Database 0.52
Category members Corum 3004 APC-Axin-1-beta-catenin complex Database 0.21
Category members Corum 3008 60S APC containing complex Database 0.21
Category members Corum 933 SCRIB-APC complex Database 0.11
Category members Corum 1909 APC-DLG4 complex Database 0


Categories featuring APC
Category Type Category ID Category Name Data Source TC-NER relevance -log10(p-value)
Category members GO Category GO:0005515 protein binding Database INF
Category members GO Category GO:0005634 nucleus Database INF
Category members GO Category GO:0005829 cytosol Database INF
Category members GO Category GO:0005737 cytoplasm Database 12.81
Category members GO Category GO:0005488 binding Database 9.32
Category members Human mutations Sanger_cancer_genes Sanger cancer genes Database 4.88
Category members GO Category GO:0006974 cellular response to DNA damage stimulus Database 3.57
Category members GO Category GO:0006921 cellular component disassembly involved in execution phase of apoptosis Database 2.98
Category members Pathway Pathway_807 REACTOME_SIGNALING_BY_WNT 0 2.74
Category members Pathway Pathway_876 REACTOME_APOPTOTIC_EXECUTION_PHASE 0 2.5
Category members Pathway Pathway_837 REACTOME_APOPTOSIS 0 2.39
Category members GO Category GO:0000776 kinetochore Database 2.24
Category members GO Category GO:0006915 apoptotic process Database 2.12
Category members GO Category GO:0030027 lamellipodium Database 1.77
Category members GO Category GO:0030426 growth cone Database 1.61
Category members GO Category GO:0007091 metaphase/anaphase transition of mitotic cell cycle Database 1.58
Category members Pathway Pathway_877 REACTOME_APOPTOTIC_CLEAVAGE_OF_CELLULAR_PROTEINS 0 1.25
Category members Pathway Pathway_1257 REACTOME_CTNNB1_PHOSPHORYLATION_CASCADE 0 1.21
Category members GO Category GO:0005886 plasma membrane Database 1.21
Category members Human mutations Broad_cancer_genes Broad cancer genes (Lawrence et al., 2014) literature 1.14
Category members GO Category GO:0005913 cell-cell adherens junction Database 1.05
Category members Pathway Pathway_634 KEGG_COLORECTAL_CANCER 0 0.98
Category members GO Category GO:0043409 negative regulation of MAPK cascade Database 0.87
Category members Pathway Pathway_507 PID_MET_PATHWAY 0 0.82
Category members GO Category GO:0008017 microtubule binding Database 0.79
Category members GO Category GO:0000281 mitotic cytokinesis Database 0.77
Category members GO Category GO:0005813 centrosome Database 0.75
Category members GO Category GO:0005923 tight junction Database 0.69
Category members Pathway Pathway_568 PID_CDC42_PATHWAY 0 0.68
Category members GO Category GO:0007094 mitotic spindle assembly checkpoint Database 0.68
Category members GO Category GO:0032587 ruffle membrane Database 0.65
Category members Pathway Pathway_671 PID_WNT_CANONICAL_PATHWAY 0 0.64
Category members GO Category GO:0030334 regulation of cell migration Database 0.61
Category members GO Category GO:0031253 cell projection membrane Database 0.6
Category members Pathway Pathway_840 ST_WNT_BETA_CATENIN_PATHWAY 0 0.6
Category members Pathway Pathway_628 BIOCARTA_GSK3_PATHWAY 0 0.6
Category members GO Category GO:0043066 negative regulation of apoptotic process Database 0.6
Category members GO Category GO:0006461 protein complex assembly Database 0.57
Category members Pathway Pathway_199 PID_BETA_CATENIN_NUC_PATHWAY 0 0.53
Category members GO Category GO:0019827 stem cell maintenance Database 0.48
Category members GO Category GO:0051010 microtubule plus-end binding Database 0.47
Category members GO Category GO:0045597 positive regulation of cell differentiation Database 0.45
Category members GO Category GO:0016328 lateral plasma membrane Database 0.41
Category members GO Category GO:0019901 protein kinase binding Database 0.37
Category members GO Category GO:0070830 tight junction assembly Database 0.36
Category members GO Category GO:0008013 beta-catenin binding Database 0.35
Category members GO Category GO:0030877 beta-catenin destruction complex Database 0.31
Category members GO Category GO:0032886 regulation of microtubule-based process Database 0.29
Category members Pathway Pathway_1176 BIOCARTA_PITX2_PATHWAY 0 0.29
Category members GO Category GO:0008285 negative regulation of cell proliferation Database 0.28
Category members Pathway Pathway_1173 BIOCARTA_PS1_PATHWAY 0 0.28
Category members GO Category GO:0043065 positive regulation of apoptotic process Database 0.26
Category members Pathway Pathway_383 PID_P53_DOWNSTREAM_PATHWAY 0 0.23
Category members GO Category GO:0030424 axon Database 0.23
Category members GO Category GO:0045295 gamma-catenin binding Database 0.23
Category members GO Category GO:0030856 regulation of epithelial cell differentiation Database 0.23
Category members Disease phenotype Desmoid_tumor_somatic Desmoid tumor somatic Database 0.21
Category members GO Category GO:0044337 canonical Wnt signaling pathway involved in positive regulation of apoptotic process Database 0.21
Category members Pathway Pathway_533 KEGG_ENDOMETRIAL_CANCER 0 0.21
Category members GO Category GO:0050680 negative regulation of epithelial cell proliferation Database 0.19
Category members Disease phenotype MISMATCH_REPAIR_CANCER_SYNDROME MISMATCH REPAIR CANCER SYNDROME Database 0.18
Category members GO Category GO:0007389 pattern specification process Database 0.18
Category members GO Category GO:0031274 positive regulation of pseudopodium assembly Database 0.18
Category members GO Category GO:0007409 axonogenesis Database 0.13
Category members GO Category GO:0051726 regulation of cell cycle Database 0.11
Category members GO Category GO:0016055 Wnt signaling pathway Database 0.11
Category members GO Category GO:0051276 chromosome organization Database 0.1
Category members Pathway Pathway_679 KEGG_WNT_SIGNALING_PATHWAY 0 0.09
Category members Disease phenotype HEPATOCELLULAR_CARCINOMA HEPATOCELLULAR CARCINOMA Database 0.09
Category members Pathway Pathway_735 ST_MYOCYTE_AD_PATHWAY 0 0.09
Category members Pathway Pathway_580 KEGG_REGULATION_OF_ACTIN_CYTOSKELETON 0 0.08
Category members Pathway Pathway_941 BIOCARTA_WNT_PATHWAY 0 0.08
Category members Disease phenotype Medulloblastoma Medulloblastoma Database 0.08
Category members Pathway Pathway_513 ST_ADRENERGIC 0 0.08
Category members GO Category GO:0009952 anterior/posterior pattern specification Database 0.06
Category members Pathway Pathway_293 PID_CDC42_REG_PATHWAY 0 0.05
Category members GO Category GO:0005881 cytoplasmic microtubule Database 0.04
Category members GO Category GO:0009954 proximal/distal pattern formation Database 0.04
Category members GO Category GO:0045785 positive regulation of cell adhesion Database 0.04
Category members Pathway Pathway_1128 BIOCARTA_TGFB_PATHWAY 0 0.04
Category members GO Category GO:0033077 T cell differentiation in thymus Database 0.03
Category members Pathway Pathway_942 PID_PS1_PATHWAY 0 0.03
Category members Pathway Pathway_517 ST_GRANULE_CELL_SURVIVAL_PATHWAY 0 0.02
Category members Pathway Pathway_1175 PID_BETA_CATENIN_DEG_PATHWAY 0 0.01
Category members Pathway Pathway_1163 KEGG_BASAL_CELL_CARCINOMA 0 0
Category members Pathway Pathway_24 KEGG_PATHWAYS_IN_CANCER 0 0
Category members Pathway Pathway_290 WNT_SIGNALING 0 0
Category members Pathway Pathway_872 BIOCARTA_ALK_PATHWAY 0 0
Category members Disease phenotype Gastric_cancer Gastric cancer Database 0
Category members GO Category GO:0001822 kidney development Database 0
Category members GO Category GO:0001942 hair follicle development Database 0
Category members GO Category GO:0007026 negative regulation of microtubule depolymerization Database 0
Category members GO Category GO:0007050 cell cycle arrest Database 0
Category members GO Category GO:0007155 cell adhesion Database 0
Category members GO Category GO:0009798 axis specification Database 0
Category members GO Category GO:0009953 dorsal/ventral pattern formation Database 0
Category members GO Category GO:0016477 cell migration Database 0
Category members GO Category GO:0019887 protein kinase regulator activity Database 0
Category members GO Category GO:0030178 negative regulation of Wnt signaling pathway Database 0
Category members GO Category GO:0030335 positive regulation of cell migration Database 0
Category members GO Category GO:0030858 positive regulation of epithelial cell differentiation Database 0
Category members GO Category GO:0031116 positive regulation of microtubule polymerization Database 0
Category members GO Category GO:0031122 cytoplasmic microtubule organization Database 0
Category members GO Category GO:0035019 somatic stem cell maintenance Database 0
Category members GO Category GO:0035371 microtubule plus-end Database 0
Category members GO Category GO:0042995 cell projection Database 0
Category members GO Category GO:0043588 skin development Database 0
Category members GO Category GO:0044295 axonal growth cone Database 0
Category members GO Category GO:0044336 canonical Wnt signaling pathway involved in negative regulation of apoptotic process Database 0
Category members GO Category GO:0045595 regulation of cell differentiation Database 0
Category members GO Category GO:0045667 regulation of osteoblast differentiation Database 0
Category members GO Category GO:0045670 regulation of osteoclast differentiation Database 0
Category members GO Category GO:0045732 positive regulation of protein catabolic process Database 0
Category members GO Category GO:0045736 negative regulation of cyclin-dependent protein serine/threonine kinase activity Database 0
Category members GO Category GO:0046716 muscle cell cellular homeostasis Database 0
Category members GO Category GO:0048538 thymus development Database 0
Category members GO Category GO:0051781 positive regulation of cell division Database 0
Category members GO Category GO:0051988 regulation of attachment of spindle microtubules to kinetochore Database 0
Category members GO Category GO:0060041 retina development in camera-type eye Database 0
Category members GO Category GO:0060070 canonical Wnt signaling pathway Database 0
Category members GO Category GO:0060770 negative regulation of epithelial cell proliferation involved in prostate gland development Database 0


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