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Query: HTT

RNAi screen result RNAPII IP (PI) CSB IP CSB IP (PI) Chrom. Chrom. (PI) Phosphorylation Ubiquitylation
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[Click on the plots to view the data selection in the respective scatterplot]

Protein Results:

 Results for post-translational modifications: see below | Red/green: hit at lower/upper end of the respective screen
Gene name Point score Z-score sums RNAi high RNAi low RNAPII-IP (PI) CSB-IP CSB-IP (PI) Chrom. Chrom. (PI)
HTT 1 5.092 -0.200 -0.360 0.632 0.847 0.550

PTM Sites:

 Back to Protein Results | Red/green: hit at lower/upper end of the respective screen
Gene name PTM type PTM site UV UV (PI) Sequence
HTT Phosphorylation S1874 1.994 1.028 _LLSPQMS(ph)GEEEDSDLAAK_
HTT Phosphorylation S432 0.317 0.640 _SGSIVELIAGGGSSCS(ph)PVLSR_
HTT Phosphorylation S419 0.595 0.531 _SGS(ph)IVELIAGGGSSCS(ph)PVLSR_
HTT Phosphorylation S430 0.402 0.494 _SGSIVELIAGGGSS(ph)CSPVLSR_
HTT Phosphorylation S1195 -0.222 0.264 _EKEPGEQAS(ph)VPLSPK_
HTT Ubiquitylation K260 -0.128 _AFIANLK(gl)_
HTT Ubiquitylation K1402 0.169 -0.538 _VSTQLK(gl)TNLTSVTK_
HTT Phosphorylation S1199 -0.456 -0.970 _GKEKEPGEQASVPLS(ph)PK_

Background Information for HTT:


Pubmed-HTT »
Uniprot-HTT »
Biogrid-HTT »
ProteomicsDB-HTT »

Tumorportal-HTT »
COSMIC-HTT »
GenomeRNAi-HTT »
Genecards-HTT


Protein-protein Interactions for HTT
Show screen data for Category Name and Description Link to cat description Data Source
Category members IP bait BAG3 Cat. description Hein, Mann, Cell 2015
Category members IP bait BSDC1 Cat. description Hein, Mann, Cell 2015
Category members IP bait CDC26 Cat. description Hein, Mann, Cell 2015
Category members IP bait CENPE Cat. description Hein, Mann, Cell 2015
Category members IP bait HUWE1 Cat. description Hein, Mann, Cell 2015
Category members IP bait KIF18A Cat. description Hein, Mann, Cell 2015
Category members IP bait KIF23 Cat. description Hein, Mann, Cell 2015
Category members IP bait LLGL1 Cat. description Hein, Mann, Cell 2015
Category members IP bait M6PR Cat. description Hein, Mann, Cell 2015
Category members IP bait MAPK3 Cat. description Hein, Mann, Cell 2015
Category members IP bait MORC3 Cat. description Hein, Mann, Cell 2015
Category members IP bait MSN Cat. description Hein, Mann, Cell 2015
Category members IP bait RAPGEF2 Cat. description Hein, Mann, Cell 2015
Category members IP bait RASSF1 Cat. description Hein, Mann, Cell 2015
Category members IP bait SMAD3 Cat. description Hein, Mann, Cell 2015
Category members IP bait CRYL1 Cat. description BioPlex, Huttlin, Gygi, Cell 2015
Category members IP bait FEZ1 Cat. description BioPlex, Huttlin, Gygi, Cell 2015
Category members IP bait GPR77 Cat. description BioPlex, Huttlin, Gygi, Cell 2015
Category members IP bait HLA-B Cat. description BioPlex, Huttlin, Gygi, Cell 2015
Category members IP bait IL17RA Cat. description BioPlex, Huttlin, Gygi, Cell 2015
Category members IP bait MPP1 Cat. description BioPlex, Huttlin, Gygi, Cell 2015
Category members IP bait NPY2R Cat. description BioPlex, Huttlin, Gygi, Cell 2015
Category members IP bait OPRM1 Cat. description BioPlex, Huttlin, Gygi, Cell 2015
Category members IP bait PRMT2 Cat. description BioPlex, Huttlin, Gygi, Cell 2015
Category members IP bait RAB30 Cat. description BioPlex, Huttlin, Gygi, Cell 2015
Category members IP bait SNX21 Cat. description BioPlex, Huttlin, Gygi, Cell 2015
Category members IP bait SYT12 Cat. description BioPlex, Huttlin, Gygi, Cell 2015
Category members IP bait TKT Cat. description BioPlex, Huttlin, Gygi, Cell 2015


Protein Domains in HTT
Domain name Domain Description TC-NER relevance -log10(p-value)
Category members ARM-type_fold IPR016024 9.26
Category members HEAT IPR000357 3.83


Protein complexes (CORUM database) featuring HTT
Category Type Category ID Category Name Data Source TC-NER relevance -log10(p-value)
Category members Corum 2241 HD-RAB8A-OPTN complex Database 0.05
Category members Corum 2242 TGM2-HD-CALM1 complex Database 0
Category members Corum 2243 TGM2-HD complex Database 0


Categories featuring HTT
Category Type Category ID Category Name Data Source TC-NER relevance -log10(p-value)
Category members GO Category GO:0005515 protein binding Database INF
Category members GO Category GO:0005634 nucleus Database INF
Category members GO Category GO:0005829 cytosol Database INF
Category members GO Category GO:0005737 cytoplasm Database 12.81
Category members GO Category GO:0005488 binding Database 9.32
Category members GO Category GO:0043234 protein complex Database 2.73
Category members GO Category GO:0006915 apoptotic process Database 2.12
Category members GO Category GO:0002039 p53 binding Database 2.06
Category members GO Category GO:0006606 protein import into nucleus Database 1.81
Category members GO Category GO:0051881 regulation of mitochondrial membrane potential Database 1.57
Category members GO Category GO:0043524 negative regulation of neuron apoptotic process Database 0.66
Category members GO Category GO:0005783 endoplasmic reticulum Database 0.62
Category members GO Category GO:0030659 cytoplasmic vesicle membrane Database 0.62
Category members GO Category GO:0043066 negative regulation of apoptotic process Database 0.6
Category members Pathway Pathway_32 KEGG_HUNTINGTONS_DISEASE 0 0.46
Category members GO Category GO:0016197 endosomal transport Database 0.43
Category members GO Category GO:0008134 transcription factor binding Database 0.37
Category members GO Category GO:0046902 regulation of mitochondrial membrane permeability Database 0.33
Category members GO Category GO:0000132 establishment of mitotic spindle orientation Database 0.29
Category members GO Category GO:0006888 ER to Golgi vesicle-mediated transport Database 0.28
Category members GO Category GO:0005794 Golgi apparatus Database 0.27
Category members GO Category GO:0030425 dendrite Database 0.26
Category members GO Category GO:0042802 identical protein binding Database 0.26
Category members GO Category GO:0051402 neuron apoptotic process Database 0.25
Category members GO Category GO:0045505 dynein intermediate chain binding Database 0.24
Category members Pathway Pathway_383 PID_P53_DOWNSTREAM_PATHWAY 0 0.23
Category members GO Category GO:0030424 axon Database 0.23
Category members GO Category GO:0047496 vesicle transport along microtubule Database 0.19
Category members GO Category GO:0016023 cytoplasmic membrane-bounded vesicle Database 0.17
Category members GO Category GO:0022008 neurogenesis Database 0.16
Category members GO Category GO:0000052 citrulline metabolic process Database 0.15
Category members GO Category GO:0016234 inclusion body Database 0.14
Category members GO Category GO:0048167 regulation of synaptic plasticity Database 0.14
Category members GO Category GO:0007030 Golgi organization Database 0.13
Category members GO Category GO:0046825 regulation of protein export from nucleus Database 0.11
Category members GO Category GO:0048487 beta-tubulin binding Database 0.1
Category members GO Category GO:0000050 urea cycle Database 0.09
Category members GO Category GO:0019244 lactate biosynthetic process from pyruvate Database 0.09
Category members GO Category GO:0005770 late endosome Database 0.09
Category members GO Category GO:0019805 quinolinate biosynthetic process Database 0.07
Category members GO Category GO:0009952 anterior/posterior pattern specification Database 0.06
Category members GO Category GO:0007029 endoplasmic reticulum organization Database 0.05
Category members GO Category GO:0008340 determination of adult lifespan Database 0.05
Category members GO Category GO:0006890 retrograde vesicle-mediated transport, Golgi to ER Database 0.05
Category members GO Category GO:0007569 cell aging Database 0.03
Category members GO Category GO:0005776 autophagic vacuole Database 0
Category members GO Category GO:0006839 mitochondrial transport Database 0
Category members GO Category GO:0007005 mitochondrion organization Database 0
Category members GO Category GO:0007212 dopamine receptor signaling pathway Database 0
Category members GO Category GO:0007283 spermatogenesis Database 0
Category members GO Category GO:0007369 gastrulation Database 0
Category members GO Category GO:0007417 central nervous system development Database 0
Category members GO Category GO:0007420 brain development Database 0
Category members GO Category GO:0007611 learning or memory Database 0
Category members GO Category GO:0007612 learning Database 0
Category members GO Category GO:0007625 grooming behavior Database 0
Category members GO Category GO:0007626 locomotory behavior Database 0
Category members GO Category GO:0008088 axon cargo transport Database 0
Category members GO Category GO:0008306 associative learning Database 0
Category members GO Category GO:0008542 visual learning Database 0
Category members GO Category GO:0009653 anatomical structure morphogenesis Database 0
Category members GO Category GO:0009790 embryo development Database 0
Category members GO Category GO:0021756 striatum development Database 0
Category members GO Category GO:0030072 peptide hormone secretion Database 0
Category members GO Category GO:0030073 insulin secretion Database 0
Category members GO Category GO:0034047 regulation of protein phosphatase type 2A activity Database 0
Category members GO Category GO:0034452 dynactin binding Database 0
Category members GO Category GO:0035176 social behavior Database 0
Category members GO Category GO:0042445 hormone metabolic process Database 0
Category members GO Category GO:0048341 paraxial mesoderm formation Database 0
Category members GO Category GO:0048513 organ development Database 0
Category members GO Category GO:0048666 neuron development Database 0
Category members GO Category GO:0051592 response to calcium ion Database 0
Category members GO Category GO:0051938 L-glutamate import Database 0
Category members GO Category GO:0055072 iron ion homeostasis Database 0


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