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Query: SIN3A

RNAi screen result RNAPII IP (PI) CSB IP CSB IP (PI) Chrom. Chrom. (PI) Phosphorylation Ubiquitylation
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[Click on the plots to view the data selection in the respective scatterplot]

Protein Results:

 Results for post-translational modifications: see below | Red/green: hit at lower/upper end of the respective screen
Gene name Point score Z-score sums RNAi high RNAi low RNAPII-IP (PI) CSB-IP CSB-IP (PI) Chrom. Chrom. (PI)
SIN3A 0 3.999 -0.610 0.780 0.378 -0.208 0.304 -0.168 0.410

PTM Sites:

 Back to Protein Results | Red/green: hit at lower/upper end of the respective screen
Gene name PTM type PTM site UV UV (PI) Sequence
SIN3A Phosphorylation S1112 0.623 0.725 _YM(ox)NSDTTS(ph)PELR_
SIN3A Phosphorylation T1111 0.691 0.517 _YM(ox)NSDTT(ph)SPELR_
SIN3A Phosphorylation S832 0.764 0.363 _GDLS(ph)DVEEEEEEEM(ox)DVDEATGAVKK_
SIN3A Ubiquitylation K875 0.131 0.003 _LLFSNTAAQK(gl)LR_
SIN3A Ubiquitylation K937 -0.224 -0.025 _DK(gl)SDSPAIQLR_
SIN3A Phosphorylation S940 -0.107 _DKSDS(ph)PAIQLR_
SIN3A Ubiquitylation K638 -0.223 _VLEAIQK(gl)K_
SIN3A Ubiquitylation K639 -0.223 _VLEAIQK(gl)K_
SIN3A Phosphorylation T266 -0.572 _VSKPSQLQAHTPASQQT(ph)PPLPPYASPR_
SIN3A Phosphorylation S277 -1.598 _S(ph)PPVQPHTPVTISLGTAPSLQNNQPVEFNHAINYVNK_
SIN3A Phosphorylation S295 -1.959 _SPPVQPHTPVTISLGTAPS(ph)LQNNQPVEFNHAINYVNK_
SIN3A Ubiquitylation K155 0.182 _EFK(gl)SQSIDTPGVISR_
SIN3A Ubiquitylation K715 1.012 _GFNK(gl)VWR_

Background Information for SIN3A:


Pubmed-SIN3A »
Uniprot-SIN3A »
Biogrid-SIN3A »
ProteomicsDB-SIN3A »

Tumorportal-SIN3A »
COSMIC-SIN3A »
GenomeRNAi-SIN3A »
Genecards-SIN3A


Protein-protein Interactions for SIN3A
Show screen data for Category Name and Description Link to cat description Data Source
Category members IP bait FAM60A Cat. description Hein, Mann, Cell 2015
Category members IP bait HDAC1 Cat. description Hein, Mann, Cell 2015
Category members IP bait MAX Cat. description Hein, Mann, Cell 2015
Category members IP bait SAP30 Cat. description Hein, Mann, Cell 2015
Category members IP bait SIN3A Cat. description Hein, Mann, Cell 2015
Category members IP bait SIN3B Cat. description Hein, Mann, Cell 2015
Category members IP bait TCF20 Cat. description Hein, Mann, Cell 2015
Category members IP bait C13orf31 Cat. description BioPlex, Huttlin, Gygi, Cell 2015
Category members IP bait DDX41 Cat. description BioPlex, Huttlin, Gygi, Cell 2015
Category members IP bait FAM60A Cat. description BioPlex, Huttlin, Gygi, Cell 2015
Category members IP bait HDAC1 Cat. description BioPlex, Huttlin, Gygi, Cell 2015
Category members IP bait ING2 Cat. description BioPlex, Huttlin, Gygi, Cell 2015
Category members IP bait MDK Cat. description BioPlex, Huttlin, Gygi, Cell 2015
Category members IP bait MIER2 Cat. description BioPlex, Huttlin, Gygi, Cell 2015
Category members IP bait MXD1 Cat. description BioPlex, Huttlin, Gygi, Cell 2015
Category members IP bait MXD3 Cat. description BioPlex, Huttlin, Gygi, Cell 2015
Category members IP bait PHF23 Cat. description BioPlex, Huttlin, Gygi, Cell 2015
Category members IP bait RBBP7 Cat. description BioPlex, Huttlin, Gygi, Cell 2015
Category members IP bait SUDS3 Cat. description BioPlex, Huttlin, Gygi, Cell 2015
Category members IP bait TFAP4 Cat. description BioPlex, Huttlin, Gygi, Cell 2015
Category members IP bait ZNF704 Cat. description BioPlex, Huttlin, Gygi, Cell 2015


Protein Domains in SIN3A
Domain name Domain Description TC-NER relevance -log10(p-value)
Category members HDAC_interact IPR013194 0.08
Category members PAH IPR003822 0


Protein complexes (CORUM database) featuring SIN3A
Category Type Category ID Category Name Data Source TC-NER relevance -log10(p-value)
Category members Corum 1257 ALL-1 supercomplex Database 4.3
Category members Corum 739 SIN3-ING1b complex II Database 4.24
Category members Corum 714 BRM-SIN3A complex Database 4.02
Category members Corum 713 BRG1-SIN3A complex Database 3.51
Category members Corum 806 BRM-SIN3A-HDAC complex Database 2.48
Category members Corum 2721 HCF-1 complex Database 2.08
Category members Corum 803 BRG1-SIN3A-HDAC containing SWI/SNF remodeling complex I Database 2.01
Category members Corum 3048 mSin3A complex Database 1.84
Category members Corum 691 SIN3-SAP25 complex Database 1.77
Category members Corum 743 SIN3-SAP25 complex Database 1.77
Category members Corum 591 SAP complex (Sin3-associated protein complex) Database 1.75
Category members Corum 283 Sin3 complex Database 1.47
Category members Corum 54 SIN3 complex Database 1.47
Category members Corum 732 SIN3 complex Database 1.47
Category members Corum 738 SIN3-ING1b complex I Database 1.47
Category members Corum 596 SIN3-HDAC-SAP30-ARID4 complex Database 1.42
Category members Corum 695 SIN3-HDAC-SAP30-ARID4 complex Database 1.42
Category members Corum 698 SIN3-HDAC-SAP30-ARID4 complex Database 1.42
Category members Corum 592 SAP complex (Sin3-associated protein complex) Database 1.33
Category members Corum 749 MeCP2-SIN3A-HDAC complex Database 1.25
Category members Corum 5184 SWI/SNF chromatin-remodeling complex Database 1.23
Category members Corum 49 DNMT3B complex Database 1.05
Category members Corum 3167 NCOR-SIN3-HDAC-HESX1 complex Database 0.94
Category members Corum 2851 ING2 complex Database 0.74
Category members Corum 3053 mSin3A-HDAC1-HDAC2 complex Database 0.72
Category members Corum 3263 HERP1/HEY2-NCOR-SIN3A complex Database 0.68
Category members Corum 696 BRMS1-SIN3-HDAC complex Database 0.66
Category members Corum 747 NCOR-SIN3-HDAC1 complex Database 0.52
Category members Corum 745 NCOR-SIN3-RPD3 complex Database 0.47
Category members Corum 1505 NCOR2 complex Database 0.15
Category members Corum 3961 SMAD3-cSKI-SIN3A-HDAC1 complex Database 0.08
Category members Corum 1232 REST-CoREST-mSIN3A complex Database 0.08
Category members Corum 3054 MAD1-mSin3A-HDAC2 complex Database 0.08
Category members Corum 3149 NK-3-Groucho-HIPK2-SIN3A-RbpA48-HDAC1 complex Database 0.04
Category members Corum 3044 SKI-NCOR1-SIN3A-HDAC1 complex Database 0


Categories featuring SIN3A
Category Type Category ID Category Name Data Source TC-NER relevance -log10(p-value)
Category members GO Category GO:0005515 protein binding Database INF
Category members GO Category GO:0005634 nucleus Database INF
Category members GO Category GO:0005654 nucleoplasm Database INF
Category members GO Category GO:0005730 nucleolus Database 13.38
Category members GO Category GO:0003682 chromatin binding Database 6.07
Category members GO Category GO:0006260 DNA replication Database 3.34
Category members GO Category GO:0043234 protein complex Database 2.73
Category members Pathway Pathway_881 PID_TELOMERASE_PATHWAY 0 2.64
Category members GO Category GO:0000785 chromatin Database 2.59
Category members GO Category GO:0000776 kinetochore Database 2.24
Category members GO Category GO:0003677 DNA binding Database 1.53
Category members GO Category GO:0045892 negative regulation of transcription, DNA-dependent Database 1.15
Category members Pathway Pathway_943 PID_HDAC_CLASSI_PATHWAY 0 1.08
Category members GO Category GO:0003700 sequence-specific DNA binding transcription factor activity Database 0.63
Category members GO Category GO:0043066 negative regulation of apoptotic process Database 0.6
Category members GO Category GO:0032403 protein complex binding Database 0.49
Category members Pathway Pathway_32 KEGG_HUNTINGTONS_DISEASE 0 0.46
Category members Pathway Pathway_845 PID_SMAD2_3NUCLEAR_PATHWAY 0 0.46
Category members Pathway Pathway_53 REACTOME_HEMOSTASIS 0 0.4
Category members GO Category GO:0007596 blood coagulation Database 0.4
Category members GO Category GO:0008134 transcription factor binding Database 0.37
Category members GO Category GO:0001103 RNA polymerase II repressing transcription factor binding Database 0.36
Category members GO Category GO:0016580 Sin3 complex Database 0.35
Category members GO Category GO:0044281 small molecule metabolic process Database 0.35
Category members GO Category GO:0001102 RNA polymerase II activating transcription factor binding Database 0.31
Category members GO Category GO:0017053 transcriptional repressor complex Database 0.28
Category members Pathway Pathway_1 REACTOME_FATTY_ACID_TRIACYLGLYCEROL_AND_KETONE_BODY_METABOLISM 0 0.23
Category members Pathway Pathway_210 PID_CMYB_PATHWAY 0 0.2
Category members GO Category GO:0001701 in utero embryonic development Database 0.2
Category members GO Category GO:0005667 transcription factor complex Database 0.19
Category members GO Category GO:0045944 positive regulation of transcription from RNA polymerase II promoter Database 0.13
Category members Pathway Pathway_984 PID_HEDGEHOG_GLI_PATHWAY 0 0.1
Category members Pathway Pathway_385 REACTOME_FACTORS_INVOLVED_IN_MEGAKARYOCYTE_DEVELOPMENT_AND_PLATELET_PRODUCTION 0 0.07
Category members GO Category GO:0010971 positive regulation of G2/M transition of mitotic cell cycle Database 0.07
Category members GO Category GO:0001106 RNA polymerase II transcription corepressor activity Database 0.06
Category members GO Category GO:0034613 cellular protein localization Database 0.04
Category members GO Category GO:0043619 regulation of transcription from RNA polymerase II promoter in response to oxidative stress Database 0.03
Category members GO Category GO:0000122 negative regulation of transcription from RNA polymerase II promoter Database 0.02
Category members GO Category GO:0010243 response to organonitrogen compound Database 0.02
Category members Pathway Pathway_1097 BIOCARTA_ETS_PATHWAY 0 0
Category members Pathway Pathway_4 REACTOME_METABOLISM_OF_LIPIDS_AND_LIPOPROTEINS 0 0
Category members GO Category GO:0002218 activation of innate immune response Database 0
Category members GO Category GO:0002230 positive regulation of defense response to virus by host Database 0
Category members GO Category GO:0003714 transcription corepressor activity Database 0
Category members GO Category GO:0006355 regulation of transcription, DNA-dependent Database 0
Category members GO Category GO:0006476 protein deacetylation Database 0
Category members GO Category GO:0007568 aging Database 0
Category members GO Category GO:0031937 positive regulation of chromatin silencing Database 0
Category members GO Category GO:0033558 protein deacetylase activity Database 0
Category members GO Category GO:0044255 cellular lipid metabolic process Database 0
Category members GO Category GO:0071333 cellular response to glucose stimulus Database 0


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