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Query: ILK

RNAi screen result RNAPII IP (PI) CSB IP CSB IP (PI) Chrom. Chrom. (PI) Phosphorylation Ubiquitylation
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[Click on the plots to view the data selection in the respective scatterplot]

Protein Results:

 Results for post-translational modifications: see below | Red/green: hit at lower/upper end of the respective screen
Gene name Point score Z-score sums RNAi high RNAi low RNAPII-IP (PI) CSB-IP CSB-IP (PI) Chrom. Chrom. (PI)
ILK 1 2.390 -1.560 3.680 -0.463 -0.527

PTM Sites:

 Back to Protein Results | Red/green: hit at lower/upper end of the respective screen
Gene name PTM type PTM site UV UV (PI) Sequence
ILK Ubiquitylation K426 -0.300 _LMK(gl)ICMNEDPAK_
ILK Ubiquitylation K85 -0.777 _DIVQK(gl)LLQYK_
ILK Ubiquitylation K435 -2.732 _ICMNEDPAK(gl)RPK_

Background Information for ILK:


Pubmed-ILK »
Uniprot-ILK »
Biogrid-ILK »
ProteomicsDB-ILK »

Tumorportal-ILK »
COSMIC-ILK »
GenomeRNAi-ILK »
Genecards-ILK


Protein-protein Interactions for ILK
Show screen data for Category Name and Description Link to cat description Data Source
Category members IP bait ILK Cat. description Hein, Mann, Cell 2015
Category members IP bait LIMS1 Cat. description BioPlex, Huttlin, Gygi, Cell 2015
Category members IP bait PARVA Cat. description BioPlex, Huttlin, Gygi, Cell 2015
Category members IP bait PARVG Cat. description BioPlex, Huttlin, Gygi, Cell 2015
Category members IP bait RSU1 Cat. description BioPlex, Huttlin, Gygi, Cell 2015


Protein Domains in ILK
Domain name Domain Description TC-NER relevance -log10(p-value)
Category members Kinase-like_dom IPR011009 0.03
Category members Prot_kinase_dom IPR000719 0
Category members Ser-Thr/Tyr_kinase_cat_dom IPR001245 0
Category members Ankyrin_rpt IPR002110 0
Category members Ser/Thr_dual-sp_kinase IPR002290 0
Category members Tyr_kinase_cat_dom IPR020635 0
Category members Ankyrin_rpt-contain_dom IPR020683 0


Protein complexes (CORUM database) featuring ILK
Category Type Category ID Category Name Data Source TC-NER relevance -log10(p-value)
Category members Corum 5498 ILK-PARVB-ARHGEF6 complex Database 0.17


Categories featuring ILK
Category Type Category ID Category Name Data Source TC-NER relevance -log10(p-value)
Category members GO Category GO:0005515 protein binding Database INF
Category members GO Category GO:0005829 cytosol Database INF
Category members GO Category GO:0005737 cytoplasm Database 12.81
Category members GO Category GO:0005524 ATP binding Database 5.54
Category members GO Category GO:0043234 protein complex Database 2.73
Category members GO Category GO:0030027 lamellipodium Database 1.77
Category members Pathway Pathway_924 PID_ILK_PATHWAY 0 1.75
Category members GO Category GO:0043034 costamere Database 1.42
Category members GO Category GO:0005911 cell-cell junction Database 1.4
Category members Pathway Pathway_309 ST_INTEGRIN_SIGNALING_PATHWAY 0 1.35
Category members GO Category GO:0005886 plasma membrane Database 1.21
Category members Pathway Pathway_595 KEGG_FOCAL_ADHESION 0 1.08
Category members GO Category GO:0043198 dendritic shaft Database 0.93
Category members GO Category GO:0005925 focal adhesion Database 0.68
Category members GO Category GO:0004674 protein serine/threonine kinase activity Database 0.66
Category members GO Category GO:0043524 negative regulation of neuron apoptotic process Database 0.66
Category members GO Category GO:0014044 Schwann cell development Database 0.62
Category members GO Category GO:0043066 negative regulation of apoptotic process Database 0.6
Category members GO Category GO:0042327 positive regulation of phosphorylation Database 0.52
Category members GO Category GO:0019901 protein kinase binding Database 0.37
Category members GO Category GO:0032956 regulation of actin cytoskeleton organization Database 0.33
Category members GO Category GO:0022011 myelination in peripheral nervous system Database 0.33
Category members GO Category GO:0034329 cell junction assembly Database 0.29
Category members GO Category GO:0045893 positive regulation of transcription, DNA-dependent Database 0.28
Category members GO Category GO:0034446 substrate adhesion-dependent cell spreading Database 0.26
Category members Pathway Pathway_560 REACTOME_CELL_CELL_COMMUNICATION 0 0.25
Category members GO Category GO:0030424 axon Database 0.23
Category members Pathway Pathway_533 KEGG_ENDOMETRIAL_CANCER 0 0.21
Category members GO Category GO:0004672 protein kinase activity Database 0.19
Category members Pathway Pathway_923 REACTOME_CELL_EXTRACELLULAR_MATRIX_INTERACTIONS 0 0.18
Category members GO Category GO:0018105 peptidyl-serine phosphorylation Database 0.18
Category members GO Category GO:0050775 positive regulation of dendrite morphogenesis Database 0.15
Category members GO Category GO:0005178 integrin binding Database 0.09
Category members GO Category GO:0010667 negative regulation of cardiac muscle cell apoptotic process Database 0.08
Category members GO Category GO:0008283 cell proliferation Database 0.06
Category members GO Category GO:0043410 positive regulation of MAPK cascade Database 0.06
Category members GO Category GO:0030017 sarcomere Database 0.06
Category members GO Category GO:0030513 positive regulation of BMP signaling pathway Database 0.05
Category members GO Category GO:0006468 protein phosphorylation Database 0.04
Category members Pathway Pathway_521 PID_AVB3_INTEGRIN_PATHWAY 0 0.03
Category members GO Category GO:0007569 cell aging Database 0.03
Category members GO Category GO:0032288 myelin assembly Database 0.02
Category members GO Category GO:0004713 protein tyrosine kinase activity Database 0.01
Category members Pathway Pathway_43 KEGG_PPAR_SIGNALING_PATHWAY 0 0
Category members Pathway Pathway_553 BIOCARTA_PTEN_PATHWAY 0 0
Category members Pathway Pathway_564 PID_AVB3_OPN_PATHWAY 0 0
Category members Pathway Pathway_619 SA_PTEN_PATHWAY 0 0
Category members Pathway Pathway_925 REACTOME_CELL_JUNCTION_ORGANIZATION 0 0
Category members GO Category GO:0001558 regulation of cell growth Database 0
Category members GO Category GO:0001658 branching involved in ureteric bud morphogenesis Database 0
Category members GO Category GO:0001954 positive regulation of cell-matrix adhesion Database 0
Category members GO Category GO:0004871 signal transducer activity Database 0
Category members GO Category GO:0006469 negative regulation of protein kinase activity Database 0
Category members GO Category GO:0007050 cell cycle arrest Database 0
Category members GO Category GO:0007160 cell-matrix adhesion Database 0
Category members GO Category GO:0007229 integrin-mediated signaling pathway Database 0
Category members GO Category GO:0008284 positive regulation of cell proliferation Database 0
Category members GO Category GO:0009966 regulation of signal transduction Database 0
Category members GO Category GO:0014912 negative regulation of smooth muscle cell migration Database 0
Category members GO Category GO:0016772 transferase activity, transferring phosphorus-containing groups Database 0
Category members GO Category GO:0017124 SH3 domain binding Database 0
Category members GO Category GO:0021675 nerve development Database 0
Category members GO Category GO:0030030 cell projection organization Database 0
Category members GO Category GO:0030335 positive regulation of cell migration Database 0
Category members GO Category GO:0043025 neuronal cell body Database 0
Category members GO Category GO:0043195 terminal bouton Database 0
Category members GO Category GO:0043206 extracellular fibril organization Database 0
Category members GO Category GO:0043406 positive regulation of MAP kinase activity Database 0
Category members GO Category GO:0043491 protein kinase B signaling Database 0
Category members GO Category GO:0045197 establishment or maintenance of epithelial cell apical/basal polarity Database 0
Category members GO Category GO:0045663 positive regulation of myoblast differentiation Database 0
Category members GO Category GO:0045669 positive regulation of osteoblast differentiation Database 0
Category members GO Category GO:0045773 positive regulation of axon extension Database 0
Category members GO Category GO:0048662 negative regulation of smooth muscle cell proliferation Database 0
Category members GO Category GO:0048812 neuron projection morphogenesis Database 0
Category members GO Category GO:0050772 positive regulation of axonogenesis Database 0
Category members GO Category GO:0051291 protein heterooligomerization Database 0
Category members GO Category GO:0051897 positive regulation of protein kinase B signaling Database 0


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