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Query: CRKL

RNAi screen result RNAPII IP (PI) CSB IP CSB IP (PI) Chrom. Chrom. (PI) Phosphorylation Ubiquitylation
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[Click on the plots to view the data selection in the respective scatterplot]

Protein Results:

 Results for post-translational modifications: see below | Red/green: hit at lower/upper end of the respective screen
Gene name Point score Z-score sums RNAi high RNAi low RNAPII-IP (PI) CSB-IP CSB-IP (PI) Chrom. Chrom. (PI)
CRKL 0 0.050 0.290 -0.620

PTM Sites:

 Back to Protein Results | Red/green: hit at lower/upper end of the respective screen
Gene name PTM type PTM site UV UV (PI) Sequence
CRKL Phosphorylation S41 0.868 _DS(ph)STCPGDYVLSVSENSR_
CRKL Phosphorylation S107 -0.818 -1.177 _YPS(ph)PPMGSVSAPNLPTAEDNLEYVR_

Background Information for CRKL:


Pubmed-CRKL »
Uniprot-CRKL »
Biogrid-CRKL »
ProteomicsDB-CRKL »

Tumorportal-CRKL »
COSMIC-CRKL »
GenomeRNAi-CRKL »
Genecards-CRKL


Protein-protein Interactions for CRKL
Show screen data for Category Name and Description Link to cat description Data Source
Category members IP bait CRKL Cat. description Hein, Mann, Cell 2015
Category members IP bait IFIT5 Cat. description BioPlex, Huttlin, Gygi, Cell 2015


Protein Domains in CRKL
Domain name Domain Description TC-NER relevance -log10(p-value)
Category members SH3_2 IPR011511 0.08
Category members SH2 IPR000980 0.05
Category members SH3_domain IPR001452 0


Protein complexes (CORUM database) featuring CRKL
Category Type Category ID Category Name Data Source TC-NER relevance -log10(p-value)
Category members Corum 2511 CRKL-WIPF1-WAS complex Database 0.04
Category members Corum 2476 CRKL-PDGFRA-CRK-RAPGEF1 complex Database 0
Category members Corum 2510 ZAP70-CRKL-WIPF1-WAS complex Database 0


Categories featuring CRKL
Category Type Category ID Category Name Data Source TC-NER relevance -log10(p-value)
Category members GO Category GO:0005515 protein binding Database INF
Category members GO Category GO:0005829 cytosol Database INF
Category members Pathway Pathway_458 REACTOME_IMMUNE_SYSTEM 0 3
Category members Pathway Pathway_595 KEGG_FOCAL_ADHESION 0 1.08
Category members Pathway Pathway_507 PID_MET_PATHWAY 0 0.82
Category members Pathway Pathway_529 KEGG_NEUROTROPHIN_SIGNALING_PATHWAY 0 0.75
Category members Pathway Pathway_1061 BIOCARTA_INTEGRIN_PATHWAY 0 0.66
Category members GO Category GO:0048011 neurotrophin TRK receptor signaling pathway Database 0.63
Category members Pathway Pathway_255 REACTOME_DOWNSTREAM_SIGNAL_TRANSDUCTION 0 0.42
Category members Pathway Pathway_247 REACTOME_SIGNALING_BY_PDGF 0 0.4
Category members Pathway Pathway_603 PID_IGF1_PATHWAY 0 0.39
Category members Pathway Pathway_505 REACTOME_CYTOKINE_SIGNALING_IN_IMMUNE_SYSTEM 0 0.33
Category members GO Category GO:0005768 endosome Database 0.29
Category members Pathway Pathway_565 KEGG_CHRONIC_MYELOID_LEUKEMIA 0 0.22
Category members Pathway Pathway_44 KEGG_INSULIN_SIGNALING_PATHWAY 0 0.21
Category members Pathway Pathway_534 BIOCARTA_GLEEVEC_PATHWAY 0 0.18
Category members GO Category GO:0007389 pattern specification process Database 0.18
Category members GO Category GO:0000186 activation of MAPKK activity Database 0.16
Category members Pathway Pathway_537 PID_IFNG_PATHWAY 0 0.11
Category members Pathway Pathway_499 KEGG_FC_GAMMA_R_MEDIATED_PHAGOCYTOSIS 0 0.1
Category members Pathway Pathway_580 KEGG_REGULATION_OF_ACTIN_CYTOSKELETON 0 0.08
Category members GO Category GO:0009952 anterior/posterior pattern specification Database 0.06
Category members Pathway Pathway_653 BIOCARTA_MET_PATHWAY 0 0.04
Category members Pathway Pathway_1059 PID_TCR_JNK_PATHWAY 0 0.04
Category members Pathway Pathway_644 PID_TRKR_PATHWAY 0 0.04
Category members Pathway Pathway_23 KEGG_RENAL_CELL_CARCINOMA 0 0.03
Category members Pathway Pathway_558 PID_REELIN_PATHWAY 0 0.01
Category members Pathway Pathway_665 PID_EPHA_FWDPATHWAY 0 0.01
Category members Pathway Pathway_24 KEGG_PATHWAYS_IN_CANCER 0 0
Category members Pathway Pathway_252 KEGG_CHEMOKINE_SIGNALING_PATHWAY 0 0
Category members Pathway Pathway_445 ST_DIFFERENTIATION_PATHWAY_IN_PC12_CELLS 0 0
Category members Pathway Pathway_504 REACTOME_SIGNALING_BY_ILS 0 0
Category members Pathway Pathway_506 REACTOME_IL_3_5_AND_GM_CSF_SIGNALING 0 0
Category members Pathway Pathway_522 PID_KIT_PATHWAY 0 0
Category members Pathway Pathway_531 PID_PDGFRA_PATHWAY 0 0
Category members Pathway Pathway_575 KEGG_ERBB_SIGNALING_PATHWAY 0 0
Category members Pathway Pathway_576 REACTOME_REGULATION_OF_SIGNALING_BY_CBL 0 0
Category members Pathway Pathway_591 BIOCARTA_IL2RB_PATHWAY 0 0
Category members Pathway Pathway_693 BIOCARTA_PYK2_PATHWAY 0 0
Category members Pathway Pathway_703 PID_EPO_PATHWAY 0 0
Category members Pathway Pathway_715 KEGG_MAPK_SIGNALING_PATHWAY 0 0
Category members Disease phenotype Distal_22q11.2_microdeletion_syndrome Distal 22q11.2 microdeletion syndrome Database 0
Category members GO Category GO:0001568 blood vessel development Database 0
Category members GO Category GO:0004871 signal transducer activity Database 0
Category members GO Category GO:0005070 SH3/SH2 adaptor activity Database 0
Category members GO Category GO:0007254 JNK cascade Database 0
Category members GO Category GO:0007265 Ras protein signal transduction Database 0
Category members GO Category GO:0007507 heart development Database 0
Category members GO Category GO:0009887 organ morphogenesis Database 0
Category members GO Category GO:0035556 intracellular signal transduction Database 0
Category members GO Category GO:0048538 thymus development Database 0
Category members GO Category GO:0060017 parathyroid gland development Database 0


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