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Query: GATA3

This is a cancer-associated gene according to the Broad and Sanger cancer gene census.

RNAi screen result RNAPII IP (PI) CSB IP CSB IP (PI) Chrom. Chrom. (PI) Phosphorylation Ubiquitylation
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[Click on the plots to view the data selection in the respective scatterplot]

Protein Results:

 Results for post-translational modifications: see below | Red/green: hit at lower/upper end of the respective screen
Gene name Point score Z-score sums RNAi high RNAi low RNAPII-IP (PI) CSB-IP CSB-IP (PI) Chrom. Chrom. (PI)
GATA3 0 -1.758 0.000 -0.660

PTM Sites:

 Back to Protein Results | Red/green: hit at lower/upper end of the respective screen
Gene name PTM type PTM site UV UV (PI) Sequence
GATA3 Phosphorylation S162 -1.195 -0.563 _DVS(ph)PDPSLSTPGSAGSAR_

Background Information for GATA3:


Pubmed-GATA3 »
Uniprot-GATA3 »
Biogrid-GATA3 »
ProteomicsDB-GATA3 »

Tumorportal-GATA3 »
COSMIC-GATA3 »
GenomeRNAi-GATA3 »
Genecards-GATA3


Protein-protein Interactions for GATA3
Show screen data for Category Name and Description Link to cat description Data Source


Protein Domains in GATA3
Domain name Domain Description TC-NER relevance -log10(p-value)
Category members Znf_GATA IPR000679 0.29
Category members TF_GATA-1/2/3 IPR016374 0


Protein complexes (CORUM database) featuring GATA3
Category Type Category ID Category Name Data Source TC-NER relevance -log10(p-value)


Categories featuring GATA3
Category Type Category ID Category Name Data Source TC-NER relevance -log10(p-value)
Category members GO Category GO:0005515 protein binding Database INF
Category members GO Category GO:0005634 nucleus Database INF
Category members GO Category GO:0005654 nucleoplasm Database INF
Category members GO Category GO:0005730 nucleolus Database 13.38
Category members Human mutations Sanger_cancer_genes Sanger cancer genes Database 4.88
Category members GO Category GO:0003713 transcription coactivator activity Database 3.68
Category members GO Category GO:0003677 DNA binding Database 1.53
Category members GO Category GO:0045892 negative regulation of transcription, DNA-dependent Database 1.15
Category members Human mutations Broad_cancer_genes Broad cancer genes (Lawrence et al., 2014) literature 1.14
Category members GO Category GO:0006366 transcription from RNA polymerase II promoter Database 0.96
Category members GO Category GO:0045786 negative regulation of cell cycle Database 0.93
Category members GO Category GO:0042493 response to drug Database 0.66
Category members GO Category GO:0003700 sequence-specific DNA binding transcription factor activity Database 0.63
Category members GO Category GO:0010332 response to gamma radiation Database 0.52
Category members Pathway Pathway_845 PID_SMAD2_3NUCLEAR_PATHWAY 0 0.46
Category members GO Category GO:0000790 nuclear chromatin Database 0.46
Category members GO Category GO:0045597 positive regulation of cell differentiation Database 0.45
Category members GO Category GO:0048589 developmental growth Database 0.45
Category members GO Category GO:0043627 response to estrogen Database 0.4
Category members Pathway Pathway_53 REACTOME_HEMOSTASIS 0 0.4
Category members GO Category GO:0007596 blood coagulation Database 0.4
Category members GO Category GO:0008134 transcription factor binding Database 0.37
Category members GO Category GO:0035799 ureter maturation Database 0.33
Category members GO Category GO:0006952 defense response Database 0.32
Category members Pathway Pathway_45 PID_REG_GR_PATHWAY 0 0.31
Category members Pathway Pathway_849 PID_NOTCH_PATHWAY 0 0.29
Category members GO Category GO:0008270 zinc ion binding Database 0.29
Category members GO Category GO:0008285 negative regulation of cell proliferation Database 0.28
Category members GO Category GO:0045893 positive regulation of transcription, DNA-dependent Database 0.28
Category members Disease phenotype Precursor_B-cell_acute_lymphoblastic_leukemia Precursor B-cell acute lymphoblastic leukemia Database 0.25
Category members GO Category GO:0032689 negative regulation of interferon-gamma production Database 0.25
Category members GO Category GO:0051569 regulation of histone H3-K4 methylation Database 0.21
Category members GO Category GO:0000977 RNA polymerase II regulatory region sequence-specific DNA binding Database 0.21
Category members Pathway Pathway_210 PID_CMYB_PATHWAY 0 0.2
Category members GO Category GO:0001701 in utero embryonic development Database 0.2
Category members GO Category GO:0071353 cellular response to interleukin-4 Database 0.19
Category members GO Category GO:0006357 regulation of transcription from RNA polymerase II promoter Database 0.19
Category members GO Category GO:0043565 sequence-specific DNA binding Database 0.18
Category members GO Category GO:0035162 embryonic hemopoiesis Database 0.17
Category members GO Category GO:0030218 erythrocyte differentiation Database 0.13
Category members GO Category GO:0000976 transcription regulatory region sequence-specific DNA binding Database 0.13
Category members GO Category GO:0045599 negative regulation of fat cell differentiation Database 0.13
Category members GO Category GO:0007411 axon guidance Database 0.13
Category members GO Category GO:0002572 pro-T cell differentiation Database 0.13
Category members GO Category GO:0035898 parathyroid hormone secretion Database 0.13
Category members GO Category GO:0045944 positive regulation of transcription from RNA polymerase II promoter Database 0.13
Category members GO Category GO:0045471 response to ethanol Database 0.1
Category members Pathway Pathway_385 REACTOME_FACTORS_INVOLVED_IN_MEGAKARYOCYTE_DEVELOPMENT_AND_PLATELET_PRODUCTION 0 0.07
Category members GO Category GO:0050852 T cell receptor signaling pathway Database 0.06
Category members GO Category GO:0003180 aortic valve morphogenesis Database 0.05
Category members GO Category GO:0005134 interleukin-2 receptor binding Database 0.05
Category members GO Category GO:0033600 negative regulation of mammary gland epithelial cell proliferation Database 0.05
Category members GO Category GO:0001819 positive regulation of cytokine production Database 0.05
Category members GO Category GO:0048872 homeostasis of number of cells Database 0.05
Category members GO Category GO:0000979 RNA polymerase II core promoter sequence-specific DNA binding Database 0.05
Category members GO Category GO:0001078 RNA polymerase II core promoter proximal region sequence-specific DNA binding transcription factor activity involved in negative regulation of transcription Database 0.04
Category members GO Category GO:0048646 anatomical structure formation involved in morphogenesis Database 0.04
Category members GO Category GO:0071356 cellular response to tumor necrosis factor Database 0.03
Category members GO Category GO:0033077 T cell differentiation in thymus Database 0.03
Category members GO Category GO:0000122 negative regulation of transcription from RNA polymerase II promoter Database 0.02
Category members GO Category GO:0044212 transcription regulatory region DNA binding Database 0
Category members Pathway Pathway_1130 BIOCARTA_GATA3_PATHWAY 0 0
Category members Pathway Pathway_489 PID_NFAT_TFPATHWAY 0 0
Category members Pathway Pathway_909 PID_IL27_PATHWAY 0 0
Category members GO Category GO:0000902 cell morphogenesis Database 0
Category members GO Category GO:0000987 core promoter proximal region sequence-specific DNA binding Database 0
Category members GO Category GO:0001046 core promoter sequence-specific DNA binding Database 0
Category members GO Category GO:0001071 nucleic acid binding transcription factor activity Database 0
Category members GO Category GO:0001077 RNA polymerase II core promoter proximal region sequence-specific DNA binding transcription factor activity involved in positive regulation of transcription Database 0
Category members GO Category GO:0001158 enhancer sequence-specific DNA binding Database 0
Category members GO Category GO:0001709 cell fate determination Database 0
Category members GO Category GO:0001764 neuron migration Database 0
Category members GO Category GO:0001775 cell activation Database 0
Category members GO Category GO:0001822 kidney development Database 0
Category members GO Category GO:0001823 mesonephros development Database 0
Category members GO Category GO:0002088 lens development in camera-type eye Database 0
Category members GO Category GO:0003215 cardiac right ventricle morphogenesis Database 0
Category members GO Category GO:0003281 ventricular septum development Database 0
Category members GO Category GO:0006355 regulation of transcription, DNA-dependent Database 0
Category members GO Category GO:0006959 humoral immune response Database 0
Category members GO Category GO:0007165 signal transduction Database 0
Category members GO Category GO:0007399 nervous system development Database 0
Category members GO Category GO:0008584 male gonad development Database 0
Category members GO Category GO:0009615 response to virus Database 0
Category members GO Category GO:0009653 anatomical structure morphogenesis Database 0
Category members GO Category GO:0009791 post-embryonic development Database 0
Category members GO Category GO:0009967 positive regulation of signal transduction Database 0
Category members GO Category GO:0010595 positive regulation of endothelial cell migration Database 0
Category members GO Category GO:0010629 negative regulation of gene expression Database 0
Category members GO Category GO:0014065 phosphatidylinositol 3-kinase signaling Database 0
Category members GO Category GO:0030182 neuron differentiation Database 0
Category members GO Category GO:0030217 T cell differentiation Database 0
Category members GO Category GO:0031929 TOR signaling Database 0
Category members GO Category GO:0032703 negative regulation of interleukin-2 production Database 0
Category members GO Category GO:0032736 positive regulation of interleukin-13 production Database 0
Category members GO Category GO:0032753 positive regulation of interleukin-4 production Database 0
Category members GO Category GO:0032754 positive regulation of interleukin-5 production Database 0
Category members GO Category GO:0035457 cellular response to interferon-alpha Database 0
Category members GO Category GO:0042035 regulation of cytokine biosynthetic process Database 0
Category members GO Category GO:0042421 norepinephrine biosynthetic process Database 0
Category members GO Category GO:0042472 inner ear morphogenesis Database 0
Category members GO Category GO:0043370 regulation of CD4-positive, alpha-beta T cell differentiation Database 0
Category members GO Category GO:0043523 regulation of neuron apoptotic process Database 0
Category members GO Category GO:0043583 ear development Database 0
Category members GO Category GO:0045061 thymic T cell selection Database 0
Category members GO Category GO:0045064 T-helper 2 cell differentiation Database 0
Category members GO Category GO:0045582 positive regulation of T cell differentiation Database 0
Category members GO Category GO:0046983 protein dimerization activity Database 0
Category members GO Category GO:0048469 cell maturation Database 0
Category members GO Category GO:0048485 sympathetic nervous system development Database 0
Category members GO Category GO:0048538 thymus development Database 0
Category members GO Category GO:0048568 embryonic organ development Database 0
Category members GO Category GO:0050728 negative regulation of inflammatory response Database 0
Category members GO Category GO:0051897 positive regulation of protein kinase B signaling Database 0
Category members GO Category GO:0060017 parathyroid gland development Database 0
Category members GO Category GO:0060037 pharyngeal system development Database 0
Category members GO Category GO:0060065 uterus development Database 0
Category members GO Category GO:0060231 mesenchymal to epithelial transition Database 0
Category members GO Category GO:0060374 mast cell differentiation Database 0
Category members GO Category GO:0060676 ureteric bud formation Database 0
Category members GO Category GO:0061290 canonical Wnt signaling pathway involved in metanephric kidney development Database 0
Category members GO Category GO:0070888 E-box binding Database 0
Category members GO Category GO:0071345 cellular response to cytokine stimulus Database 0


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