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Query: ERCC2

This is a cancer-associated gene according to the Broad and Sanger cancer gene census.

RNAi screen result RNAPII IP (PI) CSB IP CSB IP (PI) Chrom. Chrom. (PI) Phosphorylation Ubiquitylation
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[Click on the plots to view the data selection in the respective scatterplot]

Protein Results:

 Results for post-translational modifications: see below | Red/green: hit at lower/upper end of the respective screen
Gene name Point score Z-score sums RNAi high RNAi low RNAPII-IP (PI) CSB-IP CSB-IP (PI) Chrom. Chrom. (PI)
ERCC2 2 9.565 -0.590 1.060 -0.491 1.066

PTM Sites:

 Back to Protein Results | Red/green: hit at lower/upper end of the respective screen
Gene name PTM type PTM site UV UV (PI) Sequence
ERCC2 Ubiquitylation K268 5.973 1.957 _CQGNLETLQK(gl)TVLR_
ERCC2 Ubiquitylation K507 -2.034 _GNDQVAISSK(gl)FETR_

Background Information for ERCC2:


Pubmed-ERCC2 »
Uniprot-ERCC2 »
Biogrid-ERCC2 »
ProteomicsDB-ERCC2 »

Tumorportal-ERCC2 »
COSMIC-ERCC2 »
GenomeRNAi-ERCC2 »
Genecards-ERCC2


Protein-protein Interactions for ERCC2
Show screen data for Category Name and Description Link to cat description Data Source
Category members IP bait GTF2H5 Cat. description Hein, Mann, Cell 2015
Category members IP bait CCNH Cat. description BioPlex, Huttlin, Gygi, Cell 2015
Category members IP bait CDK7 Cat. description BioPlex, Huttlin, Gygi, Cell 2015
Category members IP bait MNAT1 Cat. description BioPlex, Huttlin, Gygi, Cell 2015


Protein Domains in ERCC2
Domain name Domain Description TC-NER relevance -log10(p-value)
Category members SNF2_N IPR000330 3.38
Category members P-loop_NTPase IPR027417 2.83
Category members Helicase-like_DEXD_c2 IPR006554 0.06
Category members ATP-dep_Helicase_C IPR006555 0.06
Category members DEAD_2 IPR010614 0.06
Category members DNA_helicase_DNA-repair_Rad3 IPR013020 0.06
Category members Helic_SF1/SF2_ATP-bd_DinG/Rad3 IPR014013 0.06


Protein complexes (CORUM database) featuring ERCC2
Category Type Category ID Category Name Data Source TC-NER relevance -log10(p-value)
Category members Corum 2825 BRCA1-RNA polymerase II complex Database 1.38
Category members Corum 103 RNA polymerase II holoenzyme complex Database 1.07
Category members Corum 1009 TFIIH transcription factor complex Database 0.82
Category members Corum 1029 TFIIH transcription factor complex Database 0.82
Category members Corum 1036 TFIIH transcription factor complex Database 0.82
Category members Corum 107 TFIIH transcription factor complex Database 0.82
Category members Corum 5495 TFIIH transcription factor complex (ERCC2, ERCC3, GTF2H1, CDK7, CCNH, GTF2H2) Database 0.67
Category members Corum 1030 CAK-ERCC2 complex Database 0
Category members Corum 2660 ERCC2/CAK complex Database 0


Categories featuring ERCC2
Category Type Category ID Category Name Data Source TC-NER relevance -log10(p-value)
Category members GO Category GO:0005515 protein binding Database INF
Category members GO Category GO:0005634 nucleus Database INF
Category members GO Category GO:0005654 nucleoplasm Database INF
Category members GO Category GO:0006281 DNA repair Database INF
Category members GO Category GO:0010467 gene expression Database INF
Category members GO Category GO:0016032 viral process Database INF
Category members Pathway Pathway_373 REACTOME_MRNA_PROCESSING 0 12.92
Category members GO Category GO:0005737 cytoplasm Database 12.81
Category members Pathway Pathway_197 REACTOME_HIV_INFECTION 0 12.07
Category members Pathway Pathway_376 REACTOME_HIV_LIFE_CYCLE 0 9.45
Category members Pathway Pathway_348 REACTOME_TRANSCRIPTION 0 9
Category members Pathway Pathway_351 REACTOME_RNA_POL_I_TRANSCRIPTION 0 8.31
Category members Pathway Pathway_338 REACTOME_DNA_REPAIR 0 8.18
Category members Pathway Pathway_350 REACTOME_RNA_POL_I_RNA_POL_III_AND_MITOCHONDRIAL_TRANSCRIPTION 0 7.97
Category members GO Category GO:0019048 modulation by virus of host morphology or physiology Database 7.81
Category members Pathway Pathway_374 REACTOME_LATE_PHASE_OF_HIV_LIFE_CYCLE 0 7.57
Category members GO Category GO:0006289 nucleotide-excision repair Database 6.65
Category members GO Category GO:0006283 transcription-coupled nucleotide-excision repair Database 6.58
Category members Pathway Pathway_342 REACTOME_NUCLEOTIDE_EXCISION_REPAIR 0 5.83
Category members GO Category GO:0005524 ATP binding Database 5.54
Category members Pathway Pathway_339 KEGG_NUCLEOTIDE_EXCISION_REPAIR 0 4.91
Category members Human mutations Sanger_cancer_genes Sanger cancer genes Database 4.88
Category members GO Category GO:0050434 positive regulation of viral transcription Database 4.8
Category members GO Category GO:0004003 ATP-dependent DNA helicase activity Database 4.66
Category members Pathway Pathway_336 REACTOME_TRANSCRIPTION_COUPLED_NER_TC_NER 0 4.6
Category members Pathway Pathway_857 REACTOME_FORMATION_OF_INCISION_COMPLEX_IN_GG_NER 0 4.24
Category members Pathway Pathway_378 REACTOME_FORMATION_OF_TRANSCRIPTION_COUPLED_NER_TC_NER_REPAIR_COMPLEX 0 3.95
Category members GO Category GO:0000718 nucleotide-excision repair, DNA damage removal Database 3.83
Category members Pathway Pathway_346 REACTOME_RNA_POL_I_TRANSCRIPTION_INITIATION 0 3.42
Category members Pathway Pathway_360 REACTOME_FORMATION_OF_RNA_POL_II_ELONGATION_COMPLEX_ 0 3.35
Category members Pathway Pathway_344 REACTOME_GLOBAL_GENOMIC_NER_GG_NER 0 3.29
Category members GO Category GO:0006360 transcription from RNA polymerase I promoter Database 2.66
Category members Pathway Pathway_375 REACTOME_RNA_POL_II_TRANSCRIPTION 0 2.46
Category members GO Category GO:0006361 transcription initiation from RNA polymerase I promoter Database 2.41
Category members GO Category GO:0008094 DNA-dependent ATPase activity Database 2.31
Category members GO Category GO:0006915 apoptotic process Database 2.12
Category members GO Category GO:0006368 transcription elongation from RNA polymerase II promoter Database 2.03
Category members Pathway Pathway_345 REACTOME_RNA_POL_I_TRANSCRIPTION_TERMINATION 0 1.9
Category members Pathway Pathway_363 REACTOME_RNA_POL_II_PRE_TRANSCRIPTION_EVENTS 0 1.84
Category members GO Category GO:0047485 protein N-terminus binding Database 1.84
Category members GO Category GO:0006363 termination of RNA polymerase I transcription Database 1.71
Category members GO Category GO:0016818 hydrolase activity, acting on acid anhydrides, in phosphorus-containing anhydrides Database 1.64
Category members Pathway Pathway_361 REACTOME_FORMATION_OF_THE_HIV1_EARLY_ELONGATION_COMPLEX 0 1.57
Category members Pathway Pathway_362 REACTOME_MRNA_CAPPING 0 1.57
Category members GO Category GO:0003677 DNA binding Database 1.53
Category members GO Category GO:0006362 transcription elongation from RNA polymerase I promoter Database 1.47
Category members GO Category GO:0008022 protein C-terminus binding Database 1.43
Category members GO Category GO:0040016 embryonic cleavage Database 1.36
Category members GO Category GO:0006370 7-methylguanosine mRNA capping Database 1.26
Category members Human mutations Broad_cancer_genes Broad cancer genes (Lawrence et al., 2014) literature 1.14
Category members Disease phenotype COFS_syndrome COFS syndrome Database 0.98
Category members GO Category GO:0006366 transcription from RNA polymerase II promoter Database 0.96
Category members Human mutations pubmedid:24460190 The molecular pathology of melanoma: an integrated taxonomy of melanocytic neoplasia (Bastian, 2014). Research article 0.88
Category members GO Category GO:0005675 holo TFIIH complex Database 0.83
Category members GO Category GO:0003676 nucleic acid binding Database 0.83
Category members GO Category GO:0008026 ATP-dependent helicase activity Database 0.79
Category members GO Category GO:0009411 response to UV Database 0.79
Category members GO Category GO:0060218 hematopoietic stem cell differentiation Database 0.74
Category members GO Category GO:0009650 UV protection Database 0.68
Category members GO Category GO:0043066 negative regulation of apoptotic process Database 0.6
Category members GO Category GO:0008353 RNA polymerase II carboxy-terminal domain kinase activity Database 0.42
Category members GO Category GO:0005819 spindle Database 0.41
Category members Disease phenotype TRICHOTHIODYSTROPHY_PHOTOSENSITIVE TRICHOTHIODYSTROPHY PHOTOSENSITIVE Database 0.35
Category members GO Category GO:0000441 SSL2-core TFIIH complex Database 0.35
Category members GO Category GO:0044281 small molecule metabolic process Database 0.35
Category members Pathway Pathway_370 REACTOME_RNA_POL_II_TRANSCRIPTION_PRE_INITIATION_AND_PROMOTER_OPENING 0 0.34
Category members GO Category GO:0019907 cyclin-dependent protein kinase activating kinase holoenzyme complex Database 0.3
Category members GO Category GO:0045893 positive regulation of transcription, DNA-dependent Database 0.28
Category members GO Category GO:0030198 extracellular matrix organization Database 0.26
Category members Disease phenotype TRICHOTHIODYSTROPHY_NONPHOTOSENSITIVE_1 TRICHOTHIODYSTROPHY NONPHOTOSENSITIVE 1 Database 0.25
Category members GO Category GO:0006367 transcription initiation from RNA polymerase II promoter Database 0.25
Category members GO Category GO:0048820 hair follicle maturation Database 0.24
Category members GO Category GO:0001701 in utero embryonic development Database 0.2
Category members GO Category GO:0004672 protein kinase activity Database 0.19
Category members GO Category GO:0032289 central nervous system myelin formation Database 0.17
Category members GO Category GO:0035315 hair cell differentiation Database 0.17
Category members GO Category GO:0043139 5'-3' DNA helicase activity Database 0.17
Category members GO Category GO:0007059 chromosome segregation Database 0.13
Category members GO Category GO:0045944 positive regulation of transcription from RNA polymerase II promoter Database 0.13
Category members GO Category GO:0006139 nucleobase-containing compound metabolic process Database 0.08
Category members GO Category GO:0016817 hydrolase activity, acting on acid anhydrides Database 0.06
Category members GO Category GO:0008283 cell proliferation Database 0.06
Category members GO Category GO:0022405 hair cycle process Database 0.06
Category members GO Category GO:0030282 bone mineralization Database 0.06
Category members GO Category GO:0033683 nucleotide-excision repair, DNA incision Database 0.06
Category members GO Category GO:0006468 protein phosphorylation Database 0.04
Category members GO Category GO:0035264 multicellular organism growth Database 0.04
Category members GO Category GO:0001666 response to hypoxia Database 0
Category members GO Category GO:0006979 response to oxidative stress Database 0
Category members GO Category GO:0007568 aging Database 0
Category members GO Category GO:0009791 post-embryonic development Database 0
Category members GO Category GO:0021510 spinal cord development Database 0
Category members GO Category GO:0043249 erythrocyte maturation Database 0
Category members GO Category GO:0043388 positive regulation of DNA binding Database 0
Category members GO Category GO:0043588 skin development Database 0
Category members GO Category GO:0046872 metal ion binding Database 0
Category members GO Category GO:0051539 4 iron, 4 sulfur cluster binding Database 0


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