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Query: HMGA2

This is a cancer-associated gene according to the Sanger cancer gene census.

RNAi screen result RNAPII IP (PI) CSB IP CSB IP (PI) Chrom. Chrom. (PI) Phosphorylation Ubiquitylation
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[Click on the plots to view the data selection in the respective scatterplot]

Protein Results:

 Results for post-translational modifications: see below | Red/green: hit at lower/upper end of the respective screen
Gene name Point score Z-score sums RNAi high RNAi low RNAPII-IP (PI) CSB-IP CSB-IP (PI) Chrom. Chrom. (PI)
HMGA2 0 -0.101 0.340 -0.490

PTM Sites:

 Back to Protein Results | Red/green: hit at lower/upper end of the respective screen
Gene name PTM type PTM site UV UV (PI) Sequence
HMGA2 Phosphorylation S105 -0.055 -0.046 _KPAQEETEETSSQES(ph)AEED_
HMGA2 Phosphorylation S44 -0.564 -0.762 _KQQQEPTGEPS(ph)PK_

Background Information for HMGA2:


Pubmed-HMGA2 »
Uniprot-HMGA2 »
Biogrid-HMGA2 »
ProteomicsDB-HMGA2 »

Tumorportal-HMGA2 »
COSMIC-HMGA2 »
GenomeRNAi-HMGA2 »
Genecards-HMGA2


Protein-protein Interactions for HMGA2
Show screen data for Category Name and Description Link to cat description Data Source


Protein Domains in HMGA2
Domain name Domain Description TC-NER relevance -log10(p-value)
Category members HMGI/HMGY IPR000116 0.08
Category members AT_hook_DNA-bd_motif IPR017956 0
Category members AT_hook-like IPR020478 0


Protein complexes (CORUM database) featuring HMGA2
Category Type Category ID Category Name Data Source TC-NER relevance -log10(p-value)


Categories featuring HMGA2
Category Type Category ID Category Name Data Source TC-NER relevance -log10(p-value)
Category members GO Category GO:0005515 protein binding Database INF
Category members GO Category GO:0005634 nucleus Database INF
Category members GO Category GO:0006325 chromatin organization Database 5.02
Category members Human mutations Sanger_cancer_genes Sanger cancer genes Database 4.88
Category members GO Category GO:0000785 chromatin Database 2.59
Category members GO Category GO:0007067 mitosis Database 2.23
Category members GO Category GO:0019899 enzyme binding Database 1.57
Category members GO Category GO:0003677 DNA binding Database 1.53
Category members GO Category GO:0045892 negative regulation of transcription, DNA-dependent Database 1.15
Category members GO Category GO:0000228 nuclear chromosome Database 0.89
Category members GO Category GO:0043066 negative regulation of apoptotic process Database 0.6
Category members GO Category GO:0030325 adrenal gland development Database 0.52
Category members GO Category GO:0008134 transcription factor binding Database 0.37
Category members GO Category GO:0007275 multicellular organismal development Database 0.31
Category members GO Category GO:0045893 positive regulation of transcription, DNA-dependent Database 0.28
Category members GO Category GO:0035985 senescence-associated heterochromatin focus Database 0.26
Category members GO Category GO:0035986 senescence-associated heterochromatin focus assembly Database 0.26
Category members GO Category GO:0043065 positive regulation of apoptotic process Database 0.26
Category members GO Category GO:0003906 DNA-(apurinic or apyrimidinic site) lyase activity Database 0.16
Category members GO Category GO:0002062 chondrocyte differentiation Database 0.13
Category members GO Category GO:0010564 regulation of cell cycle process Database 0.13
Category members GO Category GO:0045944 positive regulation of transcription from RNA polymerase II promoter Database 0.13
Category members GO Category GO:0043922 negative regulation by host of viral transcription Database 0.12
Category members GO Category GO:0000975 regulatory region DNA binding Database 0.11
Category members GO Category GO:0001047 core promoter binding Database 0.11
Category members GO Category GO:0071158 positive regulation of cell cycle arrest Database 0.11
Category members GO Category GO:0031507 heterochromatin assembly Database 0.08
Category members GO Category GO:0035987 endodermal cell differentiation Database 0.08
Category members GO Category GO:0060123 regulation of growth hormone secretion Database 0.08
Category members GO Category GO:0035497 cAMP response element binding Database 0.08
Category members GO Category GO:0008283 cell proliferation Database 0.06
Category members GO Category GO:0035988 chondrocyte proliferation Database 0.05
Category members GO Category GO:0006284 base-excision repair Database 0.04
Category members GO Category GO:0001078 RNA polymerase II core promoter proximal region sequence-specific DNA binding transcription factor activity involved in negative regulation of transcription Database 0.04
Category members GO Category GO:0048333 mesodermal cell differentiation Database 0.03
Category members GO Category GO:0000122 negative regulation of transcription from RNA polymerase II promoter Database 0.02
Category members GO Category GO:0043392 negative regulation of DNA binding Database 0.01
Category members GO Category GO:0031492 nucleosomal DNA binding Database 0.01
Category members Disease phenotype 12q14_microdeletion_syndrome 12q14 microdeletion syndrome Database 0
Category members Disease phenotype Dedifferentiated_liposarcoma Dedifferentiated liposarcoma Database 0
Category members Disease phenotype LEIOMYOMA_UTERINE LEIOMYOMA UTERINE Database 0
Category members Disease phenotype Well-differentiated_liposarcoma Well-differentiated liposarcoma Database 0
Category members GO Category GO:0000988 protein binding transcription factor activity Database 0
Category members GO Category GO:0001077 RNA polymerase II core promoter proximal region sequence-specific DNA binding transcription factor activity involved in positive regulation of transcription Database 0
Category members GO Category GO:0001837 epithelial to mesenchymal transition Database 0
Category members GO Category GO:0003680 AT DNA binding Database 0
Category members GO Category GO:0004677 DNA-dependent protein kinase activity Database 0
Category members GO Category GO:0006355 regulation of transcription, DNA-dependent Database 0
Category members GO Category GO:0007095 mitotic G2 DNA damage checkpoint Database 0
Category members GO Category GO:0007165 signal transduction Database 0
Category members GO Category GO:0007283 spermatogenesis Database 0
Category members GO Category GO:0008284 positive regulation of cell proliferation Database 0
Category members GO Category GO:0008301 DNA binding, bending Database 0
Category members GO Category GO:0008584 male gonad development Database 0
Category members GO Category GO:0009615 response to virus Database 0
Category members GO Category GO:0010628 positive regulation of gene expression Database 0
Category members GO Category GO:0021846 cell proliferation in forebrain Database 0
Category members GO Category GO:0021983 pituitary gland development Database 0
Category members GO Category GO:0030261 chromosome condensation Database 0
Category members GO Category GO:0032993 protein-DNA complex Database 0
Category members GO Category GO:0033144 negative regulation of intracellular steroid hormone receptor signaling pathway Database 0
Category members GO Category GO:0035019 somatic stem cell maintenance Database 0
Category members GO Category GO:0040018 positive regulation of multicellular organism growth Database 0
Category members GO Category GO:0042769 DNA damage response, detection of DNA damage Database 0
Category members GO Category GO:0045444 fat cell differentiation Database 0
Category members GO Category GO:0045869 negative regulation of single stranded viral RNA replication via double stranded DNA intermediate Database 0
Category members GO Category GO:0046332 SMAD binding Database 0
Category members GO Category GO:0046426 negative regulation of JAK-STAT cascade Database 0
Category members GO Category GO:0048712 negative regulation of astrocyte differentiation Database 0
Category members GO Category GO:0048762 mesenchymal cell differentiation Database 0
Category members GO Category GO:0048863 stem cell differentiation Database 0
Category members GO Category GO:0051091 positive regulation of sequence-specific DNA binding transcription factor activity Database 0
Category members GO Category GO:0051575 5'-deoxyribose-5-phosphate lyase activity Database 0
Category members GO Category GO:0060612 adipose tissue development Database 0
Category members GO Category GO:0060613 fat pad development Database 0
Category members GO Category GO:0070742 C2H2 zinc finger domain binding Database 0
Category members GO Category GO:0071141 SMAD protein complex Database 0


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