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Query: TCF7L2

This is a cancer-associated gene according to the Broad and Sanger cancer gene census.

RNAi screen result RNAPII IP (PI) CSB IP CSB IP (PI) Chrom. Chrom. (PI) Phosphorylation Ubiquitylation
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[Click on the plots to view the data selection in the respective scatterplot]

Protein Results:

 Results for post-translational modifications: see below | Red/green: hit at lower/upper end of the respective screen
Gene name Point score Z-score sums RNAi high RNAi low RNAPII-IP (PI) CSB-IP CSB-IP (PI) Chrom. Chrom. (PI)
TCF7L2 0 -1.040 -0.550 0.790 -0.741

PTM Sites:

 Back to Protein Results | Red/green: hit at lower/upper end of the respective screen
Gene name PTM type PTM site UV UV (PI) Sequence
TCF7L2 Ubiquitylation K88 -0.867 -0.222 _ESLEEAAK(gl)R_

Background Information for TCF7L2:


Pubmed-TCF7L2 »
Uniprot-TCF7L2 »
Biogrid-TCF7L2 »
ProteomicsDB-TCF7L2 »

Tumorportal-TCF7L2 »
COSMIC-TCF7L2 »
GenomeRNAi-TCF7L2 »
Genecards-TCF7L2


Protein-protein Interactions for TCF7L2
Show screen data for Category Name and Description Link to cat description Data Source
Category members IP bait IKZF5 Cat. description BioPlex, Huttlin, Gygi, Cell 2015
Category members IP bait TCF7L2 Cat. description BioPlex, Huttlin, Gygi, Cell 2015


Protein Domains in TCF7L2
Domain name Domain Description TC-NER relevance -log10(p-value)
Category members HMG_box_dom IPR009071 0.31
Category members CTNNB1-bd_N IPR013558 0


Protein complexes (CORUM database) featuring TCF7L2
Category Type Category ID Category Name Data Source TC-NER relevance -log10(p-value)
Category members Corum 3155 Bipartite complex (TFC4, CTNNB1) Database 0


Categories featuring TCF7L2
Category Type Category ID Category Name Data Source TC-NER relevance -log10(p-value)
Category members GO Category GO:0005515 protein binding Database INF
Category members GO Category GO:0005634 nucleus Database INF
Category members GO Category GO:0005654 nucleoplasm Database INF
Category members GO Category GO:0003682 chromatin binding Database 6.07
Category members Human mutations Sanger_cancer_genes Sanger cancer genes Database 4.88
Category members DDR Literature pubmedid:19647519 Paulsen et al., 2009 siRNA screen for g-H2A.x phosphorylation 3.6
Category members GO Category GO:0016605 PML body Database 1.41
Category members GO Category GO:0045892 negative regulation of transcription, DNA-dependent Database 1.15
Category members Human mutations Broad_cancer_genes Broad cancer genes (Lawrence et al., 2014) literature 1.14
Category members GO Category GO:0006351 transcription, DNA-templated Database 1.07
Category members Pathway Pathway_634 KEGG_COLORECTAL_CANCER 0 0.98
Category members GO Category GO:0003700 sequence-specific DNA binding transcription factor activity Database 0.63
Category members Pathway Pathway_199 PID_BETA_CATENIN_NUC_PATHWAY 0 0.53
Category members GO Category GO:0050679 positive regulation of epithelial cell proliferation Database 0.5
Category members GO Category GO:0000790 nuclear chromatin Database 0.46
Category members GO Category GO:0035257 nuclear hormone receptor binding Database 0.44
Category members Pathway Pathway_747 KEGG_ADHERENS_JUNCTION 0 0.43
Category members GO Category GO:0019901 protein kinase binding Database 0.37
Category members GO Category GO:0008134 transcription factor binding Database 0.37
Category members GO Category GO:0001103 RNA polymerase II repressing transcription factor binding Database 0.36
Category members GO Category GO:0008013 beta-catenin binding Database 0.35
Category members GO Category GO:0043065 positive regulation of apoptotic process Database 0.26
Category members GO Category GO:0045295 gamma-catenin binding Database 0.23
Category members GO Category GO:0048641 regulation of skeletal muscle tissue development Database 0.23
Category members GO Category GO:0014003 oligodendrocyte development Database 0.21
Category members Pathway Pathway_533 KEGG_ENDOMETRIAL_CANCER 0 0.21
Category members GO Category GO:0005667 transcription factor complex Database 0.19
Category members GO Category GO:0006357 regulation of transcription from RNA polymerase II promoter Database 0.19
Category members GO Category GO:0043433 negative regulation of sequence-specific DNA binding transcription factor activity Database 0.18
Category members GO Category GO:0042593 glucose homeostasis Database 0.18
Category members GO Category GO:0043565 sequence-specific DNA binding Database 0.18
Category members GO Category GO:0045599 negative regulation of fat cell differentiation Database 0.13
Category members Pathway Pathway_177 KEGG_PROSTATE_CANCER 0 0.13
Category members GO Category GO:0009749 response to glucose Database 0.13
Category members GO Category GO:0045944 positive regulation of transcription from RNA polymerase II promoter Database 0.13
Category members GO Category GO:0016055 Wnt signaling pathway Database 0.11
Category members Pathway Pathway_679 KEGG_WNT_SIGNALING_PATHWAY 0 0.09
Category members GO Category GO:0032024 positive regulation of insulin secretion Database 0.07
Category members GO Category GO:0008283 cell proliferation Database 0.06
Category members GO Category GO:0030282 bone mineralization Database 0.06
Category members GO Category GO:0032252 secretory granule localization Database 0.06
Category members Disease phenotype DIABETES_MELLITUS_NONINSULIN-DEPENDENT DIABETES MELLITUS NONINSULIN-DEPENDENT Database 0.05
Category members GO Category GO:0048699 generation of neurons Database 0.04
Category members GO Category GO:0035411 catenin import into nucleus Database 0.04
Category members GO Category GO:0040037 negative regulation of fibroblast growth factor receptor signaling pathway Database 0.04
Category members GO Category GO:0048557 embryonic digestive tract morphogenesis Database 0.04
Category members Pathway Pathway_1007 KEGG_ARRHYTHMOGENIC_RIGHT_VENTRICULAR_CARDIOMYOPATHY_ARVC 0 0.03
Category members GO Category GO:0046827 positive regulation of protein export from nucleus Database 0.03
Category members GO Category GO:0021915 neural tube development Database 0.03
Category members GO Category GO:0000122 negative regulation of transcription from RNA polymerase II promoter Database 0.02
Category members GO Category GO:0031016 pancreas development Database 0.01
Category members GO Category GO:0044212 transcription regulatory region DNA binding Database 0
Category members Pathway Pathway_1163 KEGG_BASAL_CELL_CARCINOMA 0 0
Category members Pathway Pathway_24 KEGG_PATHWAYS_IN_CANCER 0 0
Category members Pathway Pathway_244 KEGG_MELANOGENESIS 0 0
Category members Pathway Pathway_443 PID_AP1_PATHWAY 0 0
Category members Pathway Pathway_606 KEGG_ACUTE_MYELOID_LEUKEMIA 0 0
Category members Pathway Pathway_944 KEGG_THYROID_CANCER 0 0
Category members GO Category GO:0000978 RNA polymerase II core promoter proximal region sequence-specific DNA binding Database 0
Category members GO Category GO:0001568 blood vessel development Database 0
Category members GO Category GO:0006355 regulation of transcription, DNA-dependent Database 0
Category members GO Category GO:0007050 cell cycle arrest Database 0
Category members GO Category GO:0007420 brain development Database 0
Category members GO Category GO:0010909 positive regulation of heparan sulfate proteoglycan biosynthetic process Database 0
Category members GO Category GO:0021983 pituitary gland development Database 0
Category members GO Category GO:0030514 negative regulation of BMP signaling pathway Database 0
Category members GO Category GO:0030538 embryonic genitalia morphogenesis Database 0
Category members GO Category GO:0031641 regulation of myelination Database 0
Category members GO Category GO:0032092 positive regulation of protein binding Database 0
Category members GO Category GO:0032350 regulation of hormone metabolic process Database 0
Category members GO Category GO:0032993 protein-DNA complex Database 0
Category members GO Category GO:0035019 somatic stem cell maintenance Database 0
Category members GO Category GO:0042475 odontogenesis of dentin-containing tooth Database 0
Category members GO Category GO:0043570 maintenance of DNA repeat elements Database 0
Category members GO Category GO:0043588 skin development Database 0
Category members GO Category GO:0044334 canonical Wnt signaling pathway involved in positive regulation of epithelial to mesenchymal transition Database 0
Category members GO Category GO:0045444 fat cell differentiation Database 0
Category members GO Category GO:0046621 negative regulation of organ growth Database 0
Category members GO Category GO:0048619 embryonic hindgut morphogenesis Database 0
Category members GO Category GO:0048625 myoblast fate commitment Database 0
Category members GO Category GO:0048660 regulation of smooth muscle cell proliferation Database 0
Category members GO Category GO:0048713 regulation of oligodendrocyte differentiation Database 0
Category members GO Category GO:0051897 positive regulation of protein kinase B signaling Database 0
Category members GO Category GO:0060070 canonical Wnt signaling pathway Database 0
Category members GO Category GO:0060325 face morphogenesis Database 0
Category members GO Category GO:0061178 regulation of insulin secretion involved in cellular response to glucose stimulus Database 0
Category members GO Category GO:0070016 armadillo repeat domain binding Database 0
Category members GO Category GO:0070369 beta-catenin-TCF7L2 complex Database 0


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