bioLOGIC Data » bioLOGIC CategoryView » bioLOGIC VennView » Experimental Details »

bioLOGIC Data

bioLOGIC Data


Exact search


Query: SKI

RNAi screen result RNAPII IP (PI) CSB IP CSB IP (PI) Chrom. Chrom. (PI) Phosphorylation Ubiquitylation
W
[Click on the plots to view the data selection in the respective scatterplot]

Protein Results:

 Results for post-translational modifications: see below | Red/green: hit at lower/upper end of the respective screen
Gene name Point score Z-score sums RNAi high RNAi low RNAPII-IP (PI) CSB-IP CSB-IP (PI) Chrom. Chrom. (PI)
SKI 1 -0.287 -1.870 2.800 -1.139 -0.588

PTM Sites:

 Back to Protein Results | Red/green: hit at lower/upper end of the respective screen
Gene name PTM type PTM site UV UV (PI) Sequence
SKI Ubiquitylation K294 -0.126 -0.054 _AYILLSQDYTGK(gl)EEQAR_
SKI Ubiquitylation K365 -0.244 -0.390 _TLAGSSNK(gl)SLGCVHPR_
SKI Phosphorylation S432 -0.742 -0.438 _VVSS(ph)PPCAAAVSR_
SKI Phosphorylation S431 -0.475 _VVS(ph)SPPCAAAVSR_
SKI Phosphorylation S480 -1.160 -1.491 _LTVDTPGAPETLAPVAAPEEDKDS(ph)EAEVEVESR_

Background Information for SKI:


Pubmed-SKI »
Uniprot-SKI »
Biogrid-SKI »
ProteomicsDB-SKI »

Tumorportal-SKI »
COSMIC-SKI »
GenomeRNAi-SKI »
Genecards-SKI


Protein-protein Interactions for SKI
Show screen data for Category Name and Description Link to cat description Data Source
Category members IP bait LTBR Cat. description BioPlex, Huttlin, Gygi, Cell 2015
Category members IP bait RALBP1 Cat. description BioPlex, Huttlin, Gygi, Cell 2015


Protein Domains in SKI
Domain name Domain Description TC-NER relevance -log10(p-value)
Category members Transform_Ski IPR003380 0.26
Category members c-SKI_SMAD4-bd_dom IPR014890 0.24
Category members SAND_dom-like IPR010919 0.08
Category members DNA-bd_dom_put IPR009061 0


Protein complexes (CORUM database) featuring SKI
Category Type Category ID Category Name Data Source TC-NER relevance -log10(p-value)
Category members Corum 3204 SMAD2-SKI-NCOR complex Database 0.76
Category members Corum 3198 SMAD2-SKI complex Database 0.33
Category members Corum 3729 SKI-SMAD2 hexameric complex Database 0.33
Category members Corum 3739 SKI-SMAD2-SMAD4 pentameric complex Database 0.33
Category members Corum 3206 SMAD4-SKI-NCOR complex Database 0.31
Category members Corum 3205 SMAD3-SKI-NCOR complex Database 0.09
Category members Corum 3961 SMAD3-cSKI-SIN3A-HDAC1 complex Database 0.08
Category members Corum 3044 SKI-NCOR1-SIN3A-HDAC1 complex Database 0
Category members Corum 3199 SMAD3-SKI complex Database 0
Category members Corum 3733 SKI-SMAD3 hexameric complex Database 0
Category members Corum 3740 SKI-SMAD3-SMAD4 pentameric complex Database 0
Category members Corum 3959 SMAD3-SMAD4-cSKI, TGF(beta)-dependent Database 0


Categories featuring SKI
Category Type Category ID Category Name Data Source TC-NER relevance -log10(p-value)
Category members GO Category GO:0005515 protein binding Database INF
Category members GO Category GO:0005634 nucleus Database INF
Category members GO Category GO:0005654 nucleoplasm Database INF
Category members GO Category GO:0010467 gene expression Database INF
Category members GO Category GO:0005737 cytoplasm Database 12.81
Category members GO Category GO:0003682 chromatin binding Database 6.07
Category members GO Category GO:0000166 nucleotide binding Database 5.91
Category members GO Category GO:0031625 ubiquitin protein ligase binding Database 2.54
Category members GO Category GO:0019904 protein domain specific binding Database 1.85
Category members GO Category GO:0016605 PML body Database 1.41
Category members GO Category GO:0006351 transcription, DNA-templated Database 1.07
Category members Pathway Pathway_777 REACTOME_SIGNALING_BY_TGF_BETA_RECEPTOR_COMPLEX 0 0.89
Category members GO Category GO:0042981 regulation of apoptotic process Database 0.79
Category members GO Category GO:0005813 centrosome Database 0.75
Category members Pathway Pathway_845 PID_SMAD2_3NUCLEAR_PATHWAY 0 0.46
Category members GO Category GO:0019901 protein kinase binding Database 0.37
Category members GO Category GO:0022011 myelination in peripheral nervous system Database 0.33
Category members GO Category GO:0045668 negative regulation of osteoblast differentiation Database 0.29
Category members GO Category GO:0008270 zinc ion binding Database 0.29
Category members GO Category GO:0008285 negative regulation of cell proliferation Database 0.28
Category members GO Category GO:0017053 transcriptional repressor complex Database 0.28
Category members GO Category GO:0006367 transcription initiation from RNA polymerase II promoter Database 0.25
Category members GO Category GO:0007179 transforming growth factor beta receptor signaling pathway Database 0.25
Category members GO Category GO:0060021 palate development Database 0.23
Category members Pathway Pathway_210 PID_CMYB_PATHWAY 0 0.2
Category members GO Category GO:0030509 BMP signaling pathway Database 0.2
Category members GO Category GO:0005667 transcription factor complex Database 0.19
Category members GO Category GO:0043585 nose morphogenesis Database 0.18
Category members Pathway Pathway_802 REACTOME_TRANSCRIPTIONAL_ACTIVITY_OF_SMAD2_SMAD3_SMAD4_HETEROTRIMER 0 0.17
Category members GO Category GO:0060349 bone morphogenesis Database 0.17
Category members GO Category GO:0070207 protein homotrimerization Database 0.16
Category members GO Category GO:0045944 positive regulation of transcription from RNA polymerase II promoter Database 0.13
Category members Pathway Pathway_822 REACTOME_GENERIC_TRANSCRIPTION_PATHWAY 0 0.09
Category members Pathway Pathway_823 REACTOME_DOWNREGULATION_OF_SMAD2_3_SMAD4_TRANSCRIPTIONAL_ACTIVITY 0 0.07
Category members GO Category GO:0008283 cell proliferation Database 0.06
Category members GO Category GO:0021772 olfactory bulb development Database 0.06
Category members GO Category GO:0043010 camera-type eye development Database 0.05
Category members GO Category GO:0016604 nuclear body Database 0.04
Category members Pathway Pathway_1211 REACTOME_SIGNALING_BY_BMP 0 0.04
Category members GO Category GO:0000122 negative regulation of transcription from RNA polymerase II promoter Database 0.02
Category members GO Category GO:0030512 negative regulation of transforming growth factor beta receptor signaling pathway Database 0.02
Category members GO Category GO:0002089 lens morphogenesis in camera-type eye Database 0.01
Category members Pathway Pathway_1133 PID_BMP_PATHWAY 0 0
Category members Disease phenotype 1p36_deletion_syndrome 1p36 deletion syndrome Database 0
Category members Disease phenotype Shprintzen-Goldberg_craniosynostosis_syndrome Shprintzen-Goldberg craniosynostosis syndrome Database 0
Category members Disease phenotype SHPRINTZEN-GOLDBERG_SYNDROME SHPRINTZEN-GOLDBERG SYNDROME Database 0
Category members GO Category GO:0001843 neural tube closure Database 0
Category members GO Category GO:0003714 transcription corepressor activity Database 0
Category members GO Category GO:0009948 anterior/posterior axis specification Database 0
Category members GO Category GO:0010626 negative regulation of Schwann cell proliferation Database 0
Category members GO Category GO:0014902 myotube differentiation Database 0
Category members GO Category GO:0030177 positive regulation of Wnt signaling pathway Database 0
Category members GO Category GO:0030326 embryonic limb morphogenesis Database 0
Category members GO Category GO:0030514 negative regulation of BMP signaling pathway Database 0
Category members GO Category GO:0031064 negative regulation of histone deacetylation Database 0
Category members GO Category GO:0032926 negative regulation of activin receptor signaling pathway Database 0
Category members GO Category GO:0035019 somatic stem cell maintenance Database 0
Category members GO Category GO:0043388 positive regulation of DNA binding Database 0
Category members GO Category GO:0046332 SMAD binding Database 0
Category members GO Category GO:0046811 histone deacetylase inhibitor activity Database 0
Category members GO Category GO:0048147 negative regulation of fibroblast proliferation Database 0
Category members GO Category GO:0048593 camera-type eye morphogenesis Database 0
Category members GO Category GO:0048741 skeletal muscle fiber development Database 0
Category members GO Category GO:0048870 cell motility Database 0
Category members GO Category GO:0060041 retina development in camera-type eye Database 0
Category members GO Category GO:0060325 face morphogenesis Database 0
Category members GO Category GO:0060395 SMAD protein signal transduction Database 0
Category members GO Category GO:0070491 repressing transcription factor binding Database 0


.

© Copyright Svejstrup Laboratory 2015