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Query: BMPR1A

This is a cancer-associated gene according to the Sanger cancer gene census.

RNAi screen result RNAPII IP (PI) CSB IP CSB IP (PI) Chrom. Chrom. (PI) Phosphorylation Ubiquitylation
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[Click on the plots to view the data selection in the respective scatterplot]

Protein Results:

 Results for post-translational modifications: see below | Red/green: hit at lower/upper end of the respective screen
Gene name Point score Z-score sums RNAi high RNAi low RNAPII-IP (PI) CSB-IP CSB-IP (PI) Chrom. Chrom. (PI)
BMPR1A 0 0.437 0.020 -0.130

PTM Sites:

 Back to Protein Results | Red/green: hit at lower/upper end of the respective screen
Gene name PTM type PTM site UV UV (PI) Sequence
BMPR1A Ubiquitylation K232 -0.391 0.172 _TIAK(gl)QIQMVR_
BMPR1A Ubiquitylation K477 0.265 -0.134 _EVVCVK(gl)R_

Background Information for BMPR1A:


Pubmed-BMPR1A »
Uniprot-BMPR1A »
Biogrid-BMPR1A »
ProteomicsDB-BMPR1A »

Tumorportal-BMPR1A »
COSMIC-BMPR1A »
GenomeRNAi-BMPR1A »
Genecards-BMPR1A


Protein-protein Interactions for BMPR1A
Show screen data for Category Name and Description Link to cat description Data Source
Category members IP bait BMPR1A Cat. description Hein, Mann, Cell 2015
Category members IP bait ACVR1 Cat. description BioPlex, Huttlin, Gygi, Cell 2015
Category members IP bait ARRDC3 Cat. description BioPlex, Huttlin, Gygi, Cell 2015
Category members IP bait C12orf59 Cat. description BioPlex, Huttlin, Gygi, Cell 2015
Category members IP bait C14orf37 Cat. description BioPlex, Huttlin, Gygi, Cell 2015
Category members IP bait C16orf58 Cat. description BioPlex, Huttlin, Gygi, Cell 2015
Category members IP bait CD83 Cat. description BioPlex, Huttlin, Gygi, Cell 2015
Category members IP bait CLDND1 Cat. description BioPlex, Huttlin, Gygi, Cell 2015
Category members IP bait FAM171B Cat. description BioPlex, Huttlin, Gygi, Cell 2015
Category members IP bait FSHR Cat. description BioPlex, Huttlin, Gygi, Cell 2015
Category members IP bait GPR114 Cat. description BioPlex, Huttlin, Gygi, Cell 2015
Category members IP bait HAVCR2 Cat. description BioPlex, Huttlin, Gygi, Cell 2015
Category members IP bait HEPACAM2 Cat. description BioPlex, Huttlin, Gygi, Cell 2015
Category members IP bait IFNGR1 Cat. description BioPlex, Huttlin, Gygi, Cell 2015
Category members IP bait IL17RB Cat. description BioPlex, Huttlin, Gygi, Cell 2015
Category members IP bait IL1R1 Cat. description BioPlex, Huttlin, Gygi, Cell 2015
Category members IP bait IL4R Cat. description BioPlex, Huttlin, Gygi, Cell 2015
Category members IP bait LITAF Cat. description BioPlex, Huttlin, Gygi, Cell 2015
Category members IP bait LRRIQ1 Cat. description BioPlex, Huttlin, Gygi, Cell 2015
Category members IP bait MANSC1 Cat. description BioPlex, Huttlin, Gygi, Cell 2015
Category members IP bait MAS1 Cat. description BioPlex, Huttlin, Gygi, Cell 2015
Category members IP bait MRAP2 Cat. description BioPlex, Huttlin, Gygi, Cell 2015
Category members IP bait PDCD1 Cat. description BioPlex, Huttlin, Gygi, Cell 2015
Category members IP bait PDGFRB Cat. description BioPlex, Huttlin, Gygi, Cell 2015
Category members IP bait PTGER3 Cat. description BioPlex, Huttlin, Gygi, Cell 2015
Category members IP bait SLC20A1 Cat. description BioPlex, Huttlin, Gygi, Cell 2015
Category members IP bait SNX11 Cat. description BioPlex, Huttlin, Gygi, Cell 2015
Category members IP bait TGFBR2 Cat. description BioPlex, Huttlin, Gygi, Cell 2015
Category members IP bait TLR2 Cat. description BioPlex, Huttlin, Gygi, Cell 2015
Category members IP bait TNFRSF10A Cat. description BioPlex, Huttlin, Gygi, Cell 2015
Category members IP bait TPCN2 Cat. description BioPlex, Huttlin, Gygi, Cell 2015


Protein Domains in BMPR1A
Domain name Domain Description TC-NER relevance -log10(p-value)
Category members Kinase-like_dom IPR011009 0.03
Category members Activin_rcpt IPR000472 0
Category members Prot_kinase_dom IPR000719 0
Category members Ser-Thr/Tyr_kinase_cat_dom IPR001245 0
Category members Ser/Thr_dual-sp_kinase IPR002290 0
Category members TGF_beta_rcpt_GS IPR003605 0
Category members Tyr_kinase_cat_dom IPR020635 0


Protein complexes (CORUM database) featuring BMPR1A
Category Type Category ID Category Name Data Source TC-NER relevance -log10(p-value)
Category members Corum 3043 BMP2-BRIA complex Database 0


Categories featuring BMPR1A
Category Type Category ID Category Name Data Source TC-NER relevance -log10(p-value)
Category members GO Category GO:0005515 protein binding Database INF
Category members GO Category GO:0016021 integral to membrane Database 7.67
Category members GO Category GO:0005524 ATP binding Database 5.54
Category members Human mutations Sanger_cancer_genes Sanger cancer genes Database 4.88
Category members Pathway Pathway_448 KEGG_CYTOKINE_CYTOKINE_RECEPTOR_INTERACTION 0 2.05
Category members GO Category GO:0006955 immune response Database 1.22
Category members GO Category GO:0005886 plasma membrane Database 1.21
Category members GO Category GO:0006366 transcription from RNA polymerase II promoter Database 0.96
Category members GO Category GO:0004674 protein serine/threonine kinase activity Database 0.66
Category members GO Category GO:0016020 membrane Database 0.52
Category members GO Category GO:0050679 positive regulation of epithelial cell proliferation Database 0.5
Category members GO Category GO:0019827 stem cell maintenance Database 0.48
Category members GO Category GO:0048589 developmental growth Database 0.45
Category members GO Category GO:0030324 lung development Database 0.39
Category members GO Category GO:0045893 positive regulation of transcription, DNA-dependent Database 0.28
Category members GO Category GO:0030425 dendrite Database 0.26
Category members GO Category GO:0007179 transforming growth factor beta receptor signaling pathway Database 0.25
Category members GO Category GO:0060021 palate development Database 0.23
Category members GO Category GO:0010862 positive regulation of pathway-restricted SMAD protein phosphorylation Database 0.23
Category members GO Category GO:0030509 BMP signaling pathway Database 0.2
Category members GO Category GO:0001701 in utero embryonic development Database 0.2
Category members GO Category GO:0004672 protein kinase activity Database 0.19
Category members GO Category GO:0007389 pattern specification process Database 0.18
Category members Pathway Pathway_893 KEGG_TGF_BETA_SIGNALING_PATHWAY 0 0.14
Category members Disease phenotype Hereditary_nonpolyposis_colon_cancer Hereditary nonpolyposis colon cancer Database 0.14
Category members GO Category GO:0001707 mesoderm formation Database 0.11
Category members GO Category GO:0048339 paraxial mesoderm development Database 0.09
Category members GO Category GO:0030154 cell differentiation Database 0.06
Category members GO Category GO:0009952 anterior/posterior pattern specification Database 0.06
Category members GO Category GO:0007492 endoderm development Database 0.06
Category members GO Category GO:0007398 ectoderm development Database 0.04
Category members GO Category GO:0006468 protein phosphorylation Database 0.04
Category members Pathway Pathway_1211 REACTOME_SIGNALING_BY_BMP 0 0.04
Category members GO Category GO:0004713 protein tyrosine kinase activity Database 0.01
Category members Pathway Pathway_1133 PID_BMP_PATHWAY 0 0
Category members Pathway Pathway_872 BIOCARTA_ALK_PATHWAY 0 0
Category members Disease phenotype CHROMOSOME_10q23_DELETION_SYNDROME CHROMOSOME 10q23 DELETION SYNDROME Database 0
Category members Disease phenotype Generalized_juvenile_polyposis/juvenile_polyposis_coli Generalized juvenile polyposis/juvenile polyposis coli Database 0
Category members Disease phenotype Juvenile_polyposis_of_infancy Juvenile polyposis of infancy Database 0
Category members GO Category GO:0000981 sequence-specific DNA binding RNA polymerase II transcription factor activity Database 0
Category members GO Category GO:0001756 somitogenesis Database 0
Category members GO Category GO:0001880 Mullerian duct regression Database 0
Category members GO Category GO:0002053 positive regulation of mesenchymal cell proliferation Database 0
Category members GO Category GO:0003007 heart morphogenesis Database 0
Category members GO Category GO:0003272 endocardial cushion formation Database 0
Category members GO Category GO:0004675 transmembrane receptor protein serine/threonine kinase activity Database 0
Category members GO Category GO:0005024 transforming growth factor beta-activated receptor activity Database 0
Category members GO Category GO:0005901 caveola Database 0
Category members GO Category GO:0007399 nervous system development Database 0
Category members GO Category GO:0007507 heart development Database 0
Category members GO Category GO:0009950 dorsal/ventral axis specification Database 0
Category members GO Category GO:0009953 dorsal/ventral pattern formation Database 0
Category members GO Category GO:0014032 neural crest cell development Database 0
Category members GO Category GO:0016772 transferase activity, transferring phosphorus-containing groups Database 0
Category members GO Category GO:0021983 pituitary gland development Database 0
Category members GO Category GO:0030501 positive regulation of bone mineralization Database 0
Category members GO Category GO:0035137 hindlimb morphogenesis Database 0
Category members GO Category GO:0042475 odontogenesis of dentin-containing tooth Database 0
Category members GO Category GO:0042733 embryonic digit morphogenesis Database 0
Category members GO Category GO:0042803 protein homodimerization activity Database 0
Category members GO Category GO:0043025 neuronal cell body Database 0
Category members GO Category GO:0045669 positive regulation of osteoblast differentiation Database 0
Category members GO Category GO:0046332 SMAD binding Database 0
Category members GO Category GO:0046872 metal ion binding Database 0
Category members GO Category GO:0048368 lateral mesoderm development Database 0
Category members GO Category GO:0048378 regulation of lateral mesodermal cell fate specification Database 0
Category members GO Category GO:0048568 embryonic organ development Database 0
Category members GO Category GO:0048598 embryonic morphogenesis Database 0
Category members GO Category GO:0050768 negative regulation of neurogenesis Database 0
Category members GO Category GO:0051216 cartilage development Database 0
Category members GO Category GO:0060391 positive regulation of SMAD protein import into nucleus Database 0
Category members GO Category GO:0060914 heart formation Database 0


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