bioLOGIC Data » bioLOGIC CategoryView » bioLOGIC VennView » Experimental Details »

bioLOGIC Data

bioLOGIC Data


Exact search


Query: FOXO3

RNAi screen result RNAPII IP (PI) CSB IP CSB IP (PI) Chrom. Chrom. (PI) Phosphorylation Ubiquitylation
W
[Click on the plots to view the data selection in the respective scatterplot]

Protein Results:

 Results for post-translational modifications: see below | Red/green: hit at lower/upper end of the respective screen
Gene name Point score Z-score sums RNAi high RNAi low RNAPII-IP (PI) CSB-IP CSB-IP (PI) Chrom. Chrom. (PI)
FOXO3 2 10.029 -0.410 -0.120

PTM Sites:

 Back to Protein Results | Red/green: hit at lower/upper end of the respective screen
Gene name PTM type PTM site UV UV (PI) Sequence
FOXO3 Phosphorylation S284 4.138 6.011 _AALQTAPESADDS(ph)PSQLSK_
FOXO3 Phosphorylation S253 2.510 _AVS(ph)MDNSNKYTK_
FOXO3 Phosphorylation S425 1.471 _GSGLGS(ph)PTSSFNSTVFGPSSLNSLR_
FOXO3 Phosphorylation S421 1.295 _GS(ph)GLGSPTSSFNSTVFGPSSLNSLR_
FOXO3 Phosphorylation S12 -1.324 _(ac)AEAPASPAPLS(ph)PLEVELDPEFEPQSRPR_

Background Information for FOXO3:


Pubmed-FOXO3 »
Uniprot-FOXO3 »
Biogrid-FOXO3 »
ProteomicsDB-FOXO3 »

Tumorportal-FOXO3 »
COSMIC-FOXO3 »
GenomeRNAi-FOXO3 »
Genecards-FOXO3


Protein-protein Interactions for FOXO3
Show screen data for Category Name and Description Link to cat description Data Source


Protein Domains in FOXO3
Domain name Domain Description TC-NER relevance -log10(p-value)
Category members TF_fork_head IPR001766 0


Protein complexes (CORUM database) featuring FOXO3
Category Type Category ID Category Name Data Source TC-NER relevance -log10(p-value)
Category members Corum 2707 SMAD3-SMAD4-FOXO3-FOXG1 complex Database 0.32
Category members Corum 1338 FOXO3-PCAF complex, oxidative stress stimulated Database 0.29
Category members Corum 2760 SMAD3-SMAD4-FOXO3 complex Database 0.11
Category members Corum 2593 FOXO3-SIRT1 complex, oxidative stress stimulated Database 0
Category members Corum 2678 FOXO3-TP53 complex, oxidative stress stimulated Database 0


Categories featuring FOXO3
Category Type Category ID Category Name Data Source TC-NER relevance -log10(p-value)
Category members GO Category GO:0005515 protein binding Database INF
Category members GO Category GO:0005634 nucleus Database INF
Category members GO Category GO:0005654 nucleoplasm Database INF
Category members GO Category GO:0005829 cytosol Database INF
Category members GO Category GO:0005737 cytoplasm Database 12.81
Category members Pathway Pathway_621 REACTOME_ADAPTIVE_IMMUNE_SYSTEM 0 4.72
Category members GO Category GO:0006974 cellular response to DNA damage stimulus Database 3.57
Category members Pathway Pathway_458 REACTOME_IMMUNE_SYSTEM 0 3
Category members Pathway Pathway_934 PID_PI3KCI_AKT_PATHWAY 0 2.5
Category members Pathway Pathway_259 REACTOME_NGF_SIGNALLING_VIA_TRKA_FROM_THE_PLASMA_MEMBRANE 0 2.34
Category members Pathway Pathway_221 REACTOME_SIGNALLING_BY_NGF 0 2.14
Category members Pathway Pathway_660 REACTOME_SIGNALING_BY_THE_B_CELL_RECEPTOR_BCR 0 2.12
Category members GO Category GO:0006915 apoptotic process Database 2.12
Category members Pathway Pathway_706 REACTOME_DOWNSTREAM_SIGNALING_EVENTS_OF_B_CELL_RECEPTOR_BCR 0 1.96
Category members Pathway Pathway_636 PID_PI3K_PLC_TRK_PATHWAY 0 1.85
Category members Pathway Pathway_258 REACTOME_SIGNALING_BY_EGFR_IN_CANCER 0 1.81
Category members GO Category GO:0003677 DNA binding Database 1.53
Category members Pathway Pathway_265 REACTOME_SIGNALING_BY_FGFR_IN_DISEASE 0 1.42
Category members Pathway Pathway_549 REACTOME_GAB1_SIGNALOSOME 0 1.25
Category members GO Category GO:0006351 transcription, DNA-templated Database 1.07
Category members GO Category GO:0048015 phosphatidylinositol-mediated signaling Database 0.98
Category members Pathway Pathway_118 PID_FOXO_PATHWAY 0 0.97
Category members Pathway Pathway_529 KEGG_NEUROTROPHIN_SIGNALING_PATHWAY 0 0.75
Category members Pathway Pathway_229 REACTOME_SIGNALING_BY_ERBB2 0 0.68
Category members GO Category GO:0048011 neurotrophin TRK receptor signaling pathway Database 0.63
Category members GO Category GO:0003700 sequence-specific DNA binding transcription factor activity Database 0.63
Category members Pathway Pathway_708 REACTOME_PIP3_ACTIVATES_AKT_SIGNALING 0 0.61
Category members Pathway Pathway_254 REACTOME_SIGNALING_BY_FGFR 0 0.61
Category members GO Category GO:0016020 membrane Database 0.52
Category members Pathway Pathway_599 REACTOME_SIGNALING_BY_SCF_KIT 0 0.48
Category members Pathway Pathway_845 PID_SMAD2_3NUCLEAR_PATHWAY 0 0.46
Category members Pathway Pathway_542 BIOCARTA_AKT_PATHWAY 0 0.45
Category members Pathway Pathway_255 REACTOME_DOWNSTREAM_SIGNAL_TRANSDUCTION 0 0.42
Category members Pathway Pathway_247 REACTOME_SIGNALING_BY_PDGF 0 0.4
Category members Pathway Pathway_590 REACTOME_PI_3K_CASCADE 0 0.37
Category members Pathway Pathway_607 REACTOME_PI3K_EVENTS_IN_ERBB2_SIGNALING 0 0.37
Category members GO Category GO:0019901 protein kinase binding Database 0.37
Category members GO Category GO:0038095 Fc-epsilon receptor signaling pathway Database 0.36
Category members Pathway Pathway_744 PID_HDAC_CLASSIII_PATHWAY 0 0.34
Category members Pathway Pathway_282 KEGG_NON_SMALL_CELL_LUNG_CANCER 0 0.33
Category members Pathway Pathway_214 REACTOME_DOWNSTREAM_SIGNALING_OF_ACTIVATED_FGFR 0 0.33
Category members Pathway Pathway_42 REACTOME_DEVELOPMENTAL_BIOLOGY 0 0.32
Category members Pathway Pathway_604 REACTOME_PI3K_AKT_ACTIVATION 0 0.32
Category members Pathway Pathway_614 REACTOME_PI3K_EVENTS_IN_ERBB4_SIGNALING 0 0.32
Category members GO Category GO:0008543 fibroblast growth factor receptor signaling pathway Database 0.29
Category members GO Category GO:0045893 positive regulation of transcription, DNA-dependent Database 0.28
Category members GO Category GO:0007173 epidermal growth factor receptor signaling pathway Database 0.26
Category members Pathway Pathway_625 SIG_PIP3_SIGNALING_IN_B_LYMPHOCYTES 0 0.26
Category members GO Category GO:0045648 positive regulation of erythrocyte differentiation Database 0.23
Category members Pathway Pathway_142 PID_MYC_REPRESS_PATHWAY 0 0.21
Category members Pathway Pathway_533 KEGG_ENDOMETRIAL_CANCER 0 0.21
Category members GO Category GO:0008286 insulin receptor signaling pathway Database 0.2
Category members GO Category GO:0007389 pattern specification process Database 0.18
Category members GO Category GO:0042593 glucose homeostasis Database 0.18
Category members GO Category GO:0043565 sequence-specific DNA binding Database 0.18
Category members Pathway Pathway_165 SIG_PIP3_SIGNALING_IN_CARDIAC_MYOCTES 0 0.18
Category members GO Category GO:0045944 positive regulation of transcription from RNA polymerase II promoter Database 0.13
Category members Pathway Pathway_450 BIOCARTA_LONGEVITY_PATHWAY 0 0.13
Category members Pathway Pathway_200 PID_P73PATHWAY 0 0.11
Category members GO Category GO:0001547 antral ovarian follicle growth Database 0.07
Category members GO Category GO:0042127 regulation of cell proliferation Database 0.06
Category members Pathway Pathway_545 REACTOME_SIGNALING_BY_ERBB4 0 0.05
Category members GO Category GO:0045087 innate immune response Database 0.05
Category members GO Category GO:0030330 DNA damage response, signal transduction by p53 class mediator Database 0.04
Category members GO Category GO:0000122 negative regulation of transcription from RNA polymerase II promoter Database 0.02
Category members Pathway Pathway_1210 REACTOME_SIGNALING_BY_NODAL 0 0
Category members Pathway Pathway_252 KEGG_CHEMOKINE_SIGNALING_PATHWAY 0 0
Category members Pathway Pathway_502 PID_PI3KCI_PATHWAY 0 0
Category members Pathway Pathway_522 PID_KIT_PATHWAY 0 0
Category members Pathway Pathway_553 BIOCARTA_PTEN_PATHWAY 0 0
Category members Pathway Pathway_571 PID_INSULIN_PATHWAY 0 0
Category members Pathway Pathway_585 PID_IL2_PI3K_PATHWAY 0 0
Category members Pathway Pathway_613 BIOCARTA_ACH_PATHWAY 0 0
Category members GO Category GO:0001542 ovulation from ovarian follicle Database 0
Category members GO Category GO:0001556 oocyte maturation Database 0
Category members GO Category GO:0006355 regulation of transcription, DNA-dependent Database 0
Category members GO Category GO:0006417 regulation of translation Database 0
Category members GO Category GO:0008301 DNA binding, bending Database 0
Category members GO Category GO:0009790 embryo development Database 0
Category members GO Category GO:0009888 tissue development Database 0
Category members GO Category GO:0043525 positive regulation of neuron apoptotic process Database 0


.

© Copyright Svejstrup Laboratory 2015