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Query: CALR

RNAi screen result RNAPII IP (PI) CSB IP CSB IP (PI) Chrom. Chrom. (PI) Phosphorylation Ubiquitylation
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[Click on the plots to view the data selection in the respective scatterplot]

Protein Results:

 Results for post-translational modifications: see below | Red/green: hit at lower/upper end of the respective screen
Gene name Point score Z-score sums RNAi high RNAi low RNAPII-IP (PI) CSB-IP CSB-IP (PI) Chrom. Chrom. (PI)
CALR 0 2.533 -1.300 2.220 0.480 0.054

PTM Sites:

 Back to Protein Results | Red/green: hit at lower/upper end of the respective screen
Gene name PTM type PTM site UV UV (PI) Sequence
CALR Ubiquitylation K48 0.703 _SDFGK(gl)FVLSSGK_
CALR Ubiquitylation K153 -0.924 0.619 _GK(gl)NVLINK_
CALR Ubiquitylation K159 -1.004 0.381 _NVLINK(gl)DIR_

Background Information for CALR:


Pubmed-CALR »
Uniprot-CALR »
Biogrid-CALR »
ProteomicsDB-CALR »

Tumorportal-CALR »
COSMIC-CALR »
GenomeRNAi-CALR »
Genecards-CALR


Protein-protein Interactions for CALR
Show screen data for Category Name and Description Link to cat description Data Source
Category members IP bait BMP4 Cat. description BioPlex, Huttlin, Gygi, Cell 2015
Category members IP bait CHI3L1 Cat. description BioPlex, Huttlin, Gygi, Cell 2015
Category members IP bait INHA Cat. description BioPlex, Huttlin, Gygi, Cell 2015
Category members IP bait NTM Cat. description BioPlex, Huttlin, Gygi, Cell 2015
Category members IP bait SFRP4 Cat. description BioPlex, Huttlin, Gygi, Cell 2015
Category members IP bait WNT7A Cat. description BioPlex, Huttlin, Gygi, Cell 2015


Protein Domains in CALR
Domain name Domain Description TC-NER relevance -log10(p-value)
Category members Calret/calnex IPR001580 0
Category members ConA-like_lec_gl_sf IPR008985 0
Category members Calreticulin/calnexin_P_dom IPR009033 0


Protein complexes (CORUM database) featuring CALR
Category Type Category ID Category Name Data Source TC-NER relevance -log10(p-value)
Category members Corum 1223 H2AX complex, isolated from cells without IR exposure Database 8.51
Category members Corum 1227 H2AX complex II Database 7.93
Category members Corum 1226 H2AX complex I Database 1.58


Categories featuring CALR
Category Type Category ID Category Name Data Source TC-NER relevance -log10(p-value)
Category members Pathway Pathway_371 REACTOME_INFLUENZA_LIFE_CYCLE 0 INF
Category members GO Category GO:0005515 protein binding Database INF
Category members GO Category GO:0005634 nucleus Database INF
Category members GO Category GO:0005829 cytosol Database INF
Category members GO Category GO:0005737 cytoplasm Database 12.81
Category members Pathway Pathway_11 REACTOME_METABOLISM_OF_PROTEINS 0 12.01
Category members GO Category GO:0005576 extracellular region Database 10.9
Category members GO Category GO:0044267 cellular protein metabolic process Database 10.42
Category members GO Category GO:0006457 protein folding Database 4.93
Category members GO Category GO:0005615 extracellular space Database 4.72
Category members Pathway Pathway_621 REACTOME_ADAPTIVE_IMMUNE_SYSTEM 0 4.72
Category members GO Category GO:0051082 unfolded protein binding Database 3.74
Category members DDR Literature pubmedid:19647519 Paulsen et al., 2009 siRNA screen for g-H2A.x phosphorylation 3.6
Category members Pathway Pathway_458 REACTOME_IMMUNE_SYSTEM 0 3
Category members Pathway Pathway_765 REACTOME_ER_PHAGOSOME_PATHWAY 0 2.74
Category members GO Category GO:0043234 protein complex Database 2.73
Category members Pathway Pathway_764 REACTOME_CLASS_I_MHC_MEDIATED_ANTIGEN_PROCESSING_PRESENTATION 0 2.56
Category members GO Category GO:0031625 ubiquitin protein ligase binding Database 2.54
Category members GO Category GO:0002474 antigen processing and presentation of peptide antigen via MHC class I Database 2.5
Category members GO Category GO:0002479 antigen processing and presentation of exogenous peptide antigen via MHC class I, TAP-dependent Database 2.46
Category members Pathway Pathway_763 REACTOME_ANTIGEN_PROCESSING_CROSS_PRESENTATION 0 2.24
Category members GO Category GO:0042590 antigen processing and presentation of exogenous peptide antigen via MHC class I Database 2.21
Category members GO Category GO:0051087 chaperone binding Database 1.69
Category members GO Category GO:0003677 DNA binding Database 1.53
Category members GO Category GO:0003729 mRNA binding Database 1.38
Category members GO Category GO:0030968 endoplasmic reticulum unfolded protein response Database 1.35
Category members GO Category GO:0006987 activation of signaling protein activity involved in unfolded protein response Database 1.26
Category members GO Category GO:0045892 negative regulation of transcription, DNA-dependent Database 1.15
Category members Pathway Pathway_147 REACTOME_UNFOLDED_PROTEIN_RESPONSE 0 1.08
Category members GO Category GO:0030866 cortical actin cytoskeleton organization Database 0.89
Category members GO Category GO:0042981 regulation of apoptotic process Database 0.79
Category members GO Category GO:0042493 response to drug Database 0.66
Category members GO Category GO:0005783 endoplasmic reticulum Database 0.62
Category members GO Category GO:0005578 proteinaceous extracellular matrix Database 0.53
Category members Pathway Pathway_766 REACTOME_ANTIGEN_PRESENTATION_FOLDING_ASSEMBLY_AND_PEPTIDE_LOADING_OF_CLASS_I_MHC 0 0.47
Category members GO Category GO:0031012 extracellular matrix Database 0.45
Category members GO Category GO:0043231 intracellular membrane-bounded organelle Database 0.43
Category members Pathway Pathway_146 REACTOME_DIABETES_PATHWAYS 0 0.39
Category members GO Category GO:0048471 perinuclear region of cytoplasm Database 0.39
Category members GO Category GO:0017148 negative regulation of translation Database 0.34
Category members Pathway Pathway_916 REACTOME_ACTIVATION_OF_CHAPERONE_GENES_BY_ATF6_ALPHA 0 0.33
Category members GO Category GO:0005622 intracellular Database 0.32
Category members Pathway Pathway_915 REACTOME_ACTIVATION_OF_CHAPERONES_BY_ATF6_ALPHA 0 0.31
Category members GO Category GO:0008270 zinc ion binding Database 0.29
Category members GO Category GO:0005794 Golgi apparatus Database 0.27
Category members GO Category GO:0009986 cell surface Database 0.17
Category members GO Category GO:0034504 protein localization to nucleus Database 0.15
Category members GO Category GO:0050681 androgen receptor binding Database 0.12
Category members GO Category GO:0005509 calcium ion binding Database 0.11
Category members GO Category GO:0005178 integrin binding Database 0.09
Category members Pathway Pathway_767 KEGG_ANTIGEN_PROCESSING_AND_PRESENTATION 0 0.09
Category members GO Category GO:0005844 polysome Database 0.09
Category members GO Category GO:0022417 protein maturation by protein folding Database 0.08
Category members GO Category GO:0050821 protein stabilization Database 0.04
Category members GO Category GO:0045787 positive regulation of cell cycle Database 0.04
Category members GO Category GO:0042921 glucocorticoid receptor signaling pathway Database 0.04
Category members GO Category GO:0045665 negative regulation of neuron differentiation Database 0.04
Category members GO Category GO:0005506 iron ion binding Database 0.04
Category members GO Category GO:0000122 negative regulation of transcription from RNA polymerase II promoter Database 0.02
Category members GO Category GO:0048387 negative regulation of retinoic acid receptor signaling pathway Database 0.01
Category members GO Category GO:0009897 external side of plasma membrane Database 0
Category members Pathway Pathway_464 REACTOME_N_GLYCAN_TRIMMING_IN_THE_ER_AND_CALNEXIN_CALRETICULIN_CYCLE 0 0
Category members Pathway Pathway_465 REACTOME_CALNEXIN_CALRETICULIN_CYCLE 0 0
Category members Pathway Pathway_641 BIOCARTA_NFAT_PATHWAY 0 0
Category members Pathway Pathway_94 REACTOME_POST_TRANSLATIONAL_PROTEIN_MODIFICATION 0 0
Category members Pathway Pathway_95 REACTOME_ASPARAGINE_N_LINKED_GLYCOSYLATION 0 0
Category members Disease phenotype Essential_thrombocythemia Essential thrombocythemia Database 0
Category members Disease phenotype Myelofibrosis_with_myeloid_metaplasia Myelofibrosis with myeloid metaplasia Database 0
Category members GO Category GO:0001669 acrosomal vesicle Database 0
Category members GO Category GO:0001849 complement component C1q binding Database 0
Category members GO Category GO:0001948 glycoprotein binding Database 0
Category members GO Category GO:0005788 endoplasmic reticulum lumen Database 0
Category members GO Category GO:0006355 regulation of transcription, DNA-dependent Database 0
Category members GO Category GO:0006611 protein export from nucleus Database 0
Category members GO Category GO:0006874 cellular calcium ion homeostasis Database 0
Category members GO Category GO:0007050 cell cycle arrest Database 0
Category members GO Category GO:0007283 spermatogenesis Database 0
Category members GO Category GO:0008284 positive regulation of cell proliferation Database 0
Category members GO Category GO:0010033 response to organic substance Database 0
Category members GO Category GO:0010628 positive regulation of gene expression Database 0
Category members GO Category GO:0016529 sarcoplasmic reticulum Database 0
Category members GO Category GO:0018279 protein N-linked glycosylation via asparagine Database 0
Category members GO Category GO:0030246 carbohydrate binding Database 0
Category members GO Category GO:0032355 response to estradiol Database 0
Category members GO Category GO:0033018 sarcoplasmic reticulum lumen Database 0
Category members GO Category GO:0033144 negative regulation of intracellular steroid hormone receptor signaling pathway Database 0
Category members GO Category GO:0033574 response to testosterone Database 0
Category members GO Category GO:0040020 regulation of meiosis Database 0
Category members GO Category GO:0042277 peptide binding Database 0
Category members GO Category GO:0042562 hormone binding Database 0
Category members GO Category GO:0043687 post-translational protein modification Database 0
Category members GO Category GO:0044183 protein binding involved in protein folding Database 0
Category members GO Category GO:0045740 positive regulation of DNA replication Database 0
Category members GO Category GO:0050766 positive regulation of phagocytosis Database 0
Category members GO Category GO:0051208 sequestering of calcium ion Database 0
Category members GO Category GO:0055007 cardiac muscle cell differentiation Database 0
Category members GO Category GO:0061077 chaperone-mediated protein folding Database 0
Category members GO Category GO:0071285 cellular response to lithium ion Database 0
Category members GO Category GO:0071310 cellular response to organic substance Database 0


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