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Query: PKD1

RNAi screen result RNAPII IP (PI) CSB IP CSB IP (PI) Chrom. Chrom. (PI) Phosphorylation Ubiquitylation
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[Click on the plots to view the data selection in the respective scatterplot]

Protein Results:

 Results for post-translational modifications: see below | Red/green: hit at lower/upper end of the respective screen
Gene name Point score Z-score sums RNAi high RNAi low RNAPII-IP (PI) CSB-IP CSB-IP (PI) Chrom. Chrom. (PI)
PKD1 0 1.821 -0.900 0.980

PTM Sites:

 Back to Protein Results | Red/green: hit at lower/upper end of the respective screen
Gene name PTM type PTM site UV UV (PI) Sequence
PKD1 Phosphorylation T867 0.841 _GT(ph)YHVRLEVNNTVSGAAAQADVR_

Background Information for PKD1:


Pubmed-PKD1 »
Uniprot-PKD1 »
Biogrid-PKD1 »
ProteomicsDB-PKD1 »

Tumorportal-PKD1 »
COSMIC-PKD1 »
GenomeRNAi-PKD1 »
Genecards-PKD1


Protein-protein Interactions for PKD1
Show screen data for Category Name and Description Link to cat description Data Source


Protein Domains in PKD1
Domain name Domain Description TC-NER relevance -log10(p-value)
Category members Leu-rich_rpt_typical-subtyp IPR003591 0.57
Category members PKD_1 IPR000434 0.32
Category members Cys-rich_flank_reg_C IPR000483 0.21
Category members C-type_lectin IPR001304 0.21
Category members LRR-contain_N IPR000372 0.13
Category members Lipase_LipOase IPR008976 0.02
Category members C-type_lectin_fold IPR016187 0.01
Category members GPS IPR000203 0
Category members PKD_dom IPR000601 0
Category members PLAT/LH2_dom IPR001024 0
Category members PKD/REJ-like IPR002859 0
Category members WSC_carb-bd IPR002889 0
Category members Fe_hydrogenase IPR009016 0
Category members PKD1_2_channel IPR013122 0
Category members WSC_carb-bd_subgr IPR013994 0
Category members REJ-like IPR014010 0
Category members PKD/Chitinase_dom IPR022409 0


Protein complexes (CORUM database) featuring PKD1
Category Type Category ID Category Name Data Source TC-NER relevance -log10(p-value)
Category members Corum 5177 Polycystin-1 multiprotein complex (ACTN1, CDH1, SRC, JUP, VCL, CTNNB1, PXN, BCAR1, PKD1, PTK2, TLN1) Database 0.31
Category members Corum 2416 ITGB1-RAP1A-PKD1 complex Database 0.17
Category members Corum 521 Polycystin-1-E-cadherin-beta-catenin complex Database 0
Category members Corum 522 Polycystin-1-E-cadherin-beta-catenin-Flotillin-2 complex Database 0


Categories featuring PKD1
Category Type Category ID Category Name Data Source TC-NER relevance -log10(p-value)
Category members GO Category GO:0005515 protein binding Database INF
Category members GO Category GO:0005634 nucleus Database INF
Category members GO Category GO:0005737 cytoplasm Database 12.81
Category members GO Category GO:0016021 integral to membrane Database 7.67
Category members GO Category GO:0019904 protein domain specific binding Database 1.85
Category members GO Category GO:0005887 integral to plasma membrane Database 1.69
Category members GO Category GO:0005886 plasma membrane Database 1.21
Category members GO Category GO:0016020 membrane Database 0.52
Category members GO Category GO:0001889 liver development Database 0.51
Category members GO Category GO:0007218 neuropeptide signaling pathway Database 0.45
Category members GO Category GO:0016328 lateral plasma membrane Database 0.41
Category members GO Category GO:0019901 protein kinase binding Database 0.37
Category members GO Category GO:0007156 homophilic cell adhesion Database 0.28
Category members GO Category GO:0005794 Golgi apparatus Database 0.27
Category members GO Category GO:0070588 calcium ion transmembrane transport Database 0.25
Category members GO Category GO:0001701 in utero embryonic development Database 0.2
Category members GO Category GO:0018105 peptidyl-serine phosphorylation Database 0.18
Category members GO Category GO:0042994 cytoplasmic sequestering of transcription factor Database 0.14
Category members GO Category GO:0045944 positive regulation of transcription from RNA polymerase II promoter Database 0.13
Category members GO Category GO:0005262 calcium channel activity Database 0.08
Category members Disease phenotype Autosomal_dominant_polycystic_kidney_disease_type_1_with_tuberous_sclerosis Autosomal dominant polycystic kidney disease type 1 with tuberous sclerosis Database 0.04
Category members GO Category GO:0002133 polycystin complex Database 0.04
Category members GO Category GO:0016323 basolateral plasma membrane Database 0.04
Category members GO Category GO:0044325 ion channel binding Database 0.03
Category members GO Category GO:0021915 neural tube development Database 0.03
Category members GO Category GO:0001502 cartilage condensation Database 0
Category members GO Category GO:0001568 blood vessel development Database 0
Category members GO Category GO:0001822 kidney development Database 0
Category members GO Category GO:0001892 embryonic placenta development Database 0
Category members GO Category GO:0005261 cation channel activity Database 0
Category members GO Category GO:0005929 cilium Database 0
Category members GO Category GO:0006611 protein export from nucleus Database 0
Category members GO Category GO:0006807 nitrogen compound metabolic process Database 0
Category members GO Category GO:0006816 calcium ion transport Database 0
Category members GO Category GO:0007050 cell cycle arrest Database 0
Category members GO Category GO:0007160 cell-matrix adhesion Database 0
Category members GO Category GO:0007161 calcium-independent cell-matrix adhesion Database 0
Category members GO Category GO:0007204 positive regulation of cytosolic calcium ion concentration Database 0
Category members GO Category GO:0007259 JAK-STAT cascade Database 0
Category members GO Category GO:0007507 heart development Database 0
Category members GO Category GO:0009653 anatomical structure morphogenesis Database 0
Category members GO Category GO:0016337 cell-cell adhesion Database 0
Category members GO Category GO:0021510 spinal cord development Database 0
Category members GO Category GO:0030246 carbohydrate binding Database 0
Category members GO Category GO:0031512 motile primary cilium Database 0
Category members GO Category GO:0031659 positive regulation of cyclin-dependent protein serine/threonine kinase activity involved in G1/S transition of mitotic cell cycle Database 0
Category members GO Category GO:0032092 positive regulation of protein binding Database 0
Category members GO Category GO:0043588 skin development Database 0
Category members GO Category GO:0048565 digestive tract development Database 0
Category members GO Category GO:0048754 branching morphogenesis of an epithelial tube Database 0
Category members GO Category GO:0048806 genitalia development Database 0
Category members GO Category GO:0050982 detection of mechanical stimulus Database 0
Category members GO Category GO:0051216 cartilage development Database 0
Category members GO Category GO:0060236 regulation of mitotic spindle organization Database 0
Category members GO Category GO:0060428 lung epithelium development Database 0
Category members GO Category GO:0060674 placenta blood vessel development Database 0
Category members GO Category GO:0061136 regulation of proteasomal protein catabolic process Database 0


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