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Query: ROCK1

RNAi screen result RNAPII IP (PI) CSB IP CSB IP (PI) Chrom. Chrom. (PI) Phosphorylation Ubiquitylation
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[Click on the plots to view the data selection in the respective scatterplot]

Protein Results:

 Results for post-translational modifications: see below | Red/green: hit at lower/upper end of the respective screen
Gene name Point score Z-score sums RNAi high RNAi low RNAPII-IP (PI) CSB-IP CSB-IP (PI) Chrom. Chrom. (PI)
ROCK1 0 0.446 -1.420 2.380 -0.112 -0.732

PTM Sites:

 Back to Protein Results | Red/green: hit at lower/upper end of the respective screen
Gene name PTM type PTM site UV UV (PI) Sequence
ROCK1 Phosphorylation S1105 -0.245 -0.845 _LLDLSDSTSVAS(ph)FPSADETDGNLPESR_

Background Information for ROCK1:


Pubmed-ROCK1 »
Uniprot-ROCK1 »
Biogrid-ROCK1 »
ProteomicsDB-ROCK1 »

Tumorportal-ROCK1 »
COSMIC-ROCK1 »
GenomeRNAi-ROCK1 »
Genecards-ROCK1


Protein-protein Interactions for ROCK1
Show screen data for Category Name and Description Link to cat description Data Source
Category members IP bait DYNC1LI1 Cat. description Hein, Mann, Cell 2015
Category members IP bait NEIL3 Cat. description Hein, Mann, Cell 2015
Category members IP bait ROCK1 Cat. description Hein, Mann, Cell 2015
Category members IP bait SMAD3 Cat. description Hein, Mann, Cell 2015
Category members IP bait SNAP29 Cat. description Hein, Mann, Cell 2015
Category members IP bait XRCC5 Cat. description Hein, Mann, Cell 2015
Category members IP bait ADD2 Cat. description BioPlex, Huttlin, Gygi, Cell 2015
Category members IP bait IL20RA Cat. description BioPlex, Huttlin, Gygi, Cell 2015
Category members IP bait MAGEB4 Cat. description BioPlex, Huttlin, Gygi, Cell 2015
Category members IP bait ROCK2 Cat. description BioPlex, Huttlin, Gygi, Cell 2015


Protein Domains in ROCK1
Domain name Domain Description TC-NER relevance -log10(p-value)
Category members PE/DAG-bd IPR002219 0.63
Category members PH_domain IPR001849 0.14
Category members HR1_rho-bd IPR011072 0.07
Category members Kinase-like_dom IPR011009 0.03
Category members Prot_kinase_dom IPR000719 0
Category members AGC-kinase_C IPR000961 0
Category members Ser-Thr/Tyr_kinase_cat_dom IPR001245 0
Category members Ser/Thr_dual-sp_kinase IPR002290 0
Category members Pkinase_C IPR017892 0
Category members Tyr_kinase_cat_dom IPR020635 0


Protein complexes (CORUM database) featuring ROCK1
Category Type Category ID Category Name Data Source TC-NER relevance -log10(p-value)


Categories featuring ROCK1
Category Type Category ID Category Name Data Source TC-NER relevance -log10(p-value)
Category members GO Category GO:0005515 protein binding Database INF
Category members GO Category GO:0005829 cytosol Database INF
Category members GO Category GO:0005524 ATP binding Database 5.54
Category members GO Category GO:0006921 cellular component disassembly involved in execution phase of apoptosis Database 2.98
Category members Pathway Pathway_876 REACTOME_APOPTOTIC_EXECUTION_PHASE 0 2.5
Category members Pathway Pathway_837 REACTOME_APOPTOSIS 0 2.39
Category members GO Category GO:0006915 apoptotic process Database 2.12
Category members GO Category GO:0030027 lamellipodium Database 1.77
Category members Pathway Pathway_466 PID_ECADHERIN_STABILIZATION_PATHWAY 0 1.4
Category members Pathway Pathway_309 ST_INTEGRIN_SIGNALING_PATHWAY 0 1.35
Category members Pathway Pathway_243 REACTOME_GPCR_DOWNSTREAM_SIGNALING 0 1.27
Category members Pathway Pathway_877 REACTOME_APOPTOTIC_CLEAVAGE_OF_CELLULAR_PROTEINS 0 1.25
Category members GO Category GO:0005886 plasma membrane Database 1.21
Category members Pathway Pathway_240 BIOCARTA_PAR1_PATHWAY 0 1.11
Category members Pathway Pathway_595 KEGG_FOCAL_ADHESION 0 1.08
Category members GO Category GO:0030036 actin cytoskeleton organization Database 1.08
Category members Pathway Pathway_673 REACTOME_AXON_GUIDANCE 0 1.06
Category members Pathway Pathway_674 REACTOME_SEMAPHORIN_INTERACTIONS 0 0.96
Category members Pathway Pathway_256 REACTOME_SIGNALING_BY_GPCR 0 0.83
Category members GO Category GO:0017048 Rho GTPase binding Database 0.69
Category members Pathway Pathway_1061 BIOCARTA_INTEGRIN_PATHWAY 0 0.66
Category members GO Category GO:0004674 protein serine/threonine kinase activity Database 0.66
Category members GO Category GO:0043524 negative regulation of neuron apoptotic process Database 0.66
Category members GO Category GO:0005856 cytoskeleton Database 0.63
Category members Pathway Pathway_677 BIOCARTA_MYOSIN_PATHWAY 0 0.53
Category members Pathway Pathway_1026 KEGG_PATHOGENIC_ESCHERICHIA_COLI_INFECTION 0 0.45
Category members Pathway Pathway_838 SIG_REGULATION_OF_THE_ACTIN_CYTOSKELETON_BY_RHO_GTPASES 0 0.35
Category members GO Category GO:0032956 regulation of actin cytoskeleton organization Database 0.33
Category members GO Category GO:0001726 ruffle Database 0.33
Category members Pathway Pathway_42 REACTOME_DEVELOPMENTAL_BIOLOGY 0 0.32
Category members Pathway Pathway_667 BIOCARTA_RHO_PATHWAY 0 0.3
Category members Pathway Pathway_562 PID_NCADHERIN_PATHWAY 0 0.29
Category members Pathway Pathway_510 SIG_CHEMOTAXIS 0 0.28
Category members Pathway Pathway_1135 PID_PRL_SIGNALING_EVENTS_PATHWAY 0 0.27
Category members Pathway Pathway_536 BIOCARTA_ECM_PATHWAY 0 0.25
Category members Pathway Pathway_957 PID_AMB2_NEUTROPHILS_PATHWAY 0 0.2
Category members Pathway Pathway_605 KEGG_LEUKOCYTE_TRANSENDOTHELIAL_MIGRATION 0 0.2
Category members GO Category GO:0004672 protein kinase activity Database 0.19
Category members Pathway Pathway_428 PID_THROMBIN_PAR1_PATHWAY 0 0.18
Category members GO Category GO:0050901 leukocyte tethering or rolling Database 0.17
Category members Pathway Pathway_893 KEGG_TGF_BETA_SIGNALING_PATHWAY 0 0.14
Category members Pathway Pathway_629 PID_EPHB_FWD_PATHWAY 0 0.14
Category members Pathway Pathway_437 PID_VEGFR1_2_PATHWAY 0 0.13
Category members GO Category GO:0007411 axon guidance Database 0.13
Category members Pathway Pathway_679 KEGG_WNT_SIGNALING_PATHWAY 0 0.09
Category members Pathway Pathway_417 PID_WNT_NONCANONICAL_PATHWAY 0 0.09
Category members Pathway Pathway_580 KEGG_REGULATION_OF_ACTIN_CYTOSKELETON 0 0.08
Category members GO Category GO:0032059 bleb Database 0.08
Category members GO Category GO:0006468 protein phosphorylation Database 0.04
Category members GO Category GO:0032060 bleb assembly Database 0.04
Category members GO Category GO:0050900 leukocyte migration Database 0.04
Category members Pathway Pathway_1034 KEGG_AXON_GUIDANCE 0 0.04
Category members Pathway Pathway_521 PID_AVB3_INTEGRIN_PATHWAY 0 0.03
Category members Pathway Pathway_386 ST_FAS_SIGNALING_PATHWAY 0 0.02
Category members Pathway Pathway_160 KEGG_VASCULAR_SMOOTH_MUSCLE_CONTRACTION 0 0.01
Category members GO Category GO:0004713 protein tyrosine kinase activity Database 0.01
Category members Pathway Pathway_665 PID_EPHA_FWDPATHWAY 0 0.01
Category members Pathway Pathway_1032 REACTOME_SEMA4D_IN_SEMAPHORIN_SIGNALING 0 0
Category members Pathway Pathway_1035 REACTOME_SEMA4D_INDUCED_CELL_MIGRATION_AND_GROWTH_CONE_COLLAPSE 0 0
Category members Pathway Pathway_1040 BIOCARTA_MAL_PATHWAY 0 0
Category members Pathway Pathway_252 KEGG_CHEMOKINE_SIGNALING_PATHWAY 0 0
Category members Pathway Pathway_430 PID_TXA2PATHWAY 0 0
Category members Pathway Pathway_623 REACTOME_G_ALPHA1213_SIGNALLING_EVENTS 0 0
Category members Pathway Pathway_658 ST_GA13_PATHWAY 0 0
Category members Pathway Pathway_668 PID_RHOA_PATHWAY 0 0
Category members Pathway Pathway_684 PID_THROMBIN_PAR4_PATHWAY 0 0
Category members GO Category GO:0000139 Golgi membrane Database 0
Category members GO Category GO:0003383 apical constriction Database 0
Category members GO Category GO:0005814 centriole Database 0
Category members GO Category GO:0006939 smooth muscle contraction Database 0
Category members GO Category GO:0007159 leukocyte cell-cell adhesion Database 0
Category members GO Category GO:0007165 signal transduction Database 0
Category members GO Category GO:0007266 Rho protein signal transduction Database 0
Category members GO Category GO:0016525 negative regulation of angiogenesis Database 0
Category members GO Category GO:0016772 transferase activity, transferring phosphorus-containing groups Database 0
Category members GO Category GO:0022614 membrane to membrane docking Database 0
Category members GO Category GO:0030155 regulation of cell adhesion Database 0
Category members GO Category GO:0032970 regulation of actin filament-based process Database 0
Category members GO Category GO:0035556 intracellular signal transduction Database 0
Category members GO Category GO:0045616 regulation of keratinocyte differentiation Database 0
Category members GO Category GO:0046872 metal ion binding Database 0
Category members GO Category GO:0051451 myoblast migration Database 0
Category members GO Category GO:0051492 regulation of stress fiber assembly Database 0
Category members GO Category GO:0051893 regulation of focal adhesion assembly Database 0
Category members GO Category GO:0051894 positive regulation of focal adhesion assembly Database 0


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