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Query: ITGAV

RNAi screen result RNAPII IP (PI) CSB IP CSB IP (PI) Chrom. Chrom. (PI) Phosphorylation Ubiquitylation
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[Click on the plots to view the data selection in the respective scatterplot]

Protein Results:

 Results for post-translational modifications: see below | Red/green: hit at lower/upper end of the respective screen
Gene name Point score Z-score sums RNAi high RNAi low RNAPII-IP (PI) CSB-IP CSB-IP (PI) Chrom. Chrom. (PI)
ITGAV 0 0.511 -0.297 -0.090 0.262

PTM Sites:

 Back to Protein Results | Red/green: hit at lower/upper end of the respective screen
Gene name PTM type PTM site UV UV (PI) Sequence
ITGAV Ubiquitylation K923 0.636 _GK(gl)SAILYVK_
ITGAV Ubiquitylation K233 0.373 _YDPNVYSIK(gl)YNNQLATR_
ITGAV Ubiquitylation K360 0.294 _ASGDFQTTK(gl)LNGFEVFAR_

Background Information for ITGAV:


Pubmed-ITGAV »
Uniprot-ITGAV »
Biogrid-ITGAV »
ProteomicsDB-ITGAV »

Tumorportal-ITGAV »
COSMIC-ITGAV »
GenomeRNAi-ITGAV »
Genecards-ITGAV


Protein-protein Interactions for ITGAV
Show screen data for Category Name and Description Link to cat description Data Source
Category members IP bait EIF3I Cat. description Hein, Mann, Cell 2015
Category members IP bait ITGB1 Cat. description Hein, Mann, Cell 2015
Category members IP bait B3GNT2 Cat. description BioPlex, Huttlin, Gygi, Cell 2015
Category members IP bait DEFA1 Cat. description BioPlex, Huttlin, Gygi, Cell 2015
Category members IP bait DPEP2 Cat. description BioPlex, Huttlin, Gygi, Cell 2015
Category members IP bait EDIL3 Cat. description BioPlex, Huttlin, Gygi, Cell 2015
Category members IP bait FCGR3B Cat. description BioPlex, Huttlin, Gygi, Cell 2015
Category members IP bait FUT8 Cat. description BioPlex, Huttlin, Gygi, Cell 2015
Category members IP bait GGH Cat. description BioPlex, Huttlin, Gygi, Cell 2015
Category members IP bait INSL5 Cat. description BioPlex, Huttlin, Gygi, Cell 2015
Category members IP bait LYZL2 Cat. description BioPlex, Huttlin, Gygi, Cell 2015
Category members IP bait NAAA Cat. description BioPlex, Huttlin, Gygi, Cell 2015
Category members IP bait PTCH1 Cat. description BioPlex, Huttlin, Gygi, Cell 2015
Category members IP bait ST3GAL1 Cat. description BioPlex, Huttlin, Gygi, Cell 2015
Category members IP bait ST8SIA4 Cat. description BioPlex, Huttlin, Gygi, Cell 2015
Category members IP bait SUSD4 Cat. description BioPlex, Huttlin, Gygi, Cell 2015
Category members IP bait TAZ Cat. description BioPlex, Huttlin, Gygi, Cell 2015
Category members IP bait TCTN2 Cat. description BioPlex, Huttlin, Gygi, Cell 2015
Category members IP bait TMEM25 Cat. description BioPlex, Huttlin, Gygi, Cell 2015
Category members IP bait TNFSF13B Cat. description BioPlex, Huttlin, Gygi, Cell 2015


Protein Domains in ITGAV
Domain name Domain Description TC-NER relevance -log10(p-value)
Category members FG-GAP IPR013517 0.3
Category members Int_alpha_beta-p IPR013519 0.1
Category members Integrin_alpha IPR000413 0.03
Category members Integrin_alpha-2 IPR013649 0.03
Category members Integrin_alpha_C_CS IPR018184 0


Protein complexes (CORUM database) featuring ITGAV
Category Type Category ID Category Name Data Source TC-NER relevance -log10(p-value)
Category members Corum 2343 ITGAV-ITGB5-PLAUR complex Database 0.04
Category members Corum 2347 ITGAV-ITGB5-SPP1 complex Database 0.04
Category members Corum 2352 ITGAV-ITGB6-SPP1 complex Database 0.04
Category members Corum 2885 ITGAV-ITGB1-SPP1 complex Database 0.04
Category members Corum 2342 ITGAV-ITGB8-MMP14-TGFB1 complex Database 0
Category members Corum 2345 ITGAV-ITGB5-ICAM4 complex Database 0
Category members Corum 2346 ITGAV-ITGB5-ADAM9 complex Database 0
Category members Corum 2348 ITGAV-ITGB5-CYR61 complex Database 0
Category members Corum 2350 ITGAV-ITGB5 complex Database 0
Category members Corum 2353 ITGAV-ITGB6-TGFB3 complex Database 0
Category members Corum 2354 ITGAV-ITGB6 complex Database 0
Category members Corum 2355 ITGAV-ITGB3-CD47-FCER2 complex Database 0
Category members Corum 2356 ITGB3-ITGAV-CD47 complex Database 0
Category members Corum 2358 ITGAV-ITGB3-SPP1 complex Database 0
Category members Corum 2359 ITGAV-ITGB3-ADAM15 complex Database 0
Category members Corum 2362 ITAGV-ITGB3-F11R complex Database 0
Category members Corum 2363 ITGAV-ITGB3-PXN-PTK2b complex Database 0
Category members Corum 2364 ITGAV-ITGB3-ADAM23 complex Database 0
Category members Corum 2366 ITGAV-ITGB3-PPAP2b complex Database 0
Category members Corum 2369 ITGAV-ITGB3-EGFR complex Database 0
Category members Corum 2373 ITGAV-ITGB3-SPP1 complex Database 0
Category members Corum 2374 ITGAV-ITGB3-LAMA4 complex Database 0
Category members Corum 2436 ITGAV-ITGB1 complex Database 0
Category members Corum 2846 ITGAV-ITGB3-THBS1 complex Database 0
Category members Corum 3103 ITGAV-ITGB3-SLC3A2 complex Database 0
Category members Corum 3110 ITGAV-P2RY2-GNA12 complex Database 0
Category members Corum 3117 ITGB5-ITGAV-VTN complex Database 0


Categories featuring ITGAV
Category Type Category ID Category Name Data Source TC-NER relevance -log10(p-value)
Category members GO Category GO:0005515 protein binding Database INF
Category members GO Category GO:0019048 modulation by virus of host morphology or physiology Database 7.81
Category members Pathway Pathway_621 REACTOME_ADAPTIVE_IMMUNE_SYSTEM 0 4.72
Category members Pathway Pathway_458 REACTOME_IMMUNE_SYSTEM 0 3
Category members Pathway Pathway_764 REACTOME_CLASS_I_MHC_MEDIATED_ANTIGEN_PROCESSING_PRESENTATION 0 2.56
Category members GO Category GO:0002474 antigen processing and presentation of peptide antigen via MHC class I Database 2.5
Category members GO Category GO:0002479 antigen processing and presentation of exogenous peptide antigen via MHC class I, TAP-dependent Database 2.46
Category members Pathway Pathway_763 REACTOME_ANTIGEN_PROCESSING_CROSS_PRESENTATION 0 2.24
Category members GO Category GO:0042590 antigen processing and presentation of exogenous peptide antigen via MHC class I Database 2.21
Category members Pathway Pathway_541 PID_FAK_PATHWAY 0 1.88
Category members GO Category GO:0005887 integral to plasma membrane Database 1.69
Category members Pathway Pathway_645 PID_CXCR4_PATHWAY 0 1.42
Category members Pathway Pathway_1075 REACTOME_L1CAM_INTERACTIONS 0 1.32
Category members GO Category GO:0005886 plasma membrane Database 1.21
Category members Pathway Pathway_561 PID_PDGFRB_PATHWAY 0 1.18
Category members Pathway Pathway_595 KEGG_FOCAL_ADHESION 0 1.08
Category members Pathway Pathway_673 REACTOME_AXON_GUIDANCE 0 1.06
Category members Pathway Pathway_295 PID_ARF6_TRAFFICKING_PATHWAY 0 0.9
Category members GO Category GO:0001618 virus receptor activity Database 0.83
Category members GO Category GO:0043066 negative regulation of apoptotic process Database 0.6
Category members GO Category GO:0016020 membrane Database 0.52
Category members Pathway Pathway_1076 REACTOME_SIGNAL_TRANSDUCTION_BY_L1 0 0.44
Category members Pathway Pathway_53 REACTOME_HEMOSTASIS 0 0.4
Category members GO Category GO:0007596 blood coagulation Database 0.4
Category members Pathway Pathway_42 REACTOME_DEVELOPMENTAL_BIOLOGY 0 0.32
Category members Pathway Pathway_987 PID_S1P_S1P3_PATHWAY 0 0.28
Category members GO Category GO:0030198 extracellular matrix organization Database 0.26
Category members GO Category GO:0070588 calcium ion transmembrane transport Database 0.25
Category members Pathway Pathway_581 PID_NECTIN_PATHWAY 0 0.21
Category members Pathway Pathway_710 PID_UPA_UPAR_PATHWAY 0 0.2
Category members GO Category GO:0009986 cell surface Database 0.17
Category members GO Category GO:0045335 phagocytic vesicle Database 0.16
Category members Pathway Pathway_437 PID_VEGFR1_2_PATHWAY 0 0.13
Category members GO Category GO:0007411 axon guidance Database 0.13
Category members Pathway Pathway_580 KEGG_REGULATION_OF_ACTIN_CYTOSKELETON 0 0.08
Category members Pathway Pathway_600 REACTOME_CELL_SURFACE_INTERACTIONS_AT_THE_VASCULAR_WALL 0 0.05
Category members GO Category GO:0046718 viral entry into host cell Database 0.04
Category members GO Category GO:0010888 negative regulation of lipid storage Database 0.04
Category members GO Category GO:0045785 positive regulation of cell adhesion Database 0.04
Category members GO Category GO:0050900 leukocyte migration Database 0.04
Category members Pathway Pathway_695 REACTOME_PECAM1_INTERACTIONS 0 0.04
Category members GO Category GO:0005080 protein kinase C binding Database 0.04
Category members GO Category GO:0008305 integrin complex Database 0.03
Category members Pathway Pathway_1007 KEGG_ARRHYTHMOGENIC_RIGHT_VENTRICULAR_CARDIOMYOPATHY_ARVC 0 0.03
Category members Pathway Pathway_521 PID_AVB3_INTEGRIN_PATHWAY 0 0.03
Category members GO Category GO:0009897 external side of plasma membrane Database 0
Category members Pathway Pathway_1008 KEGG_HYPERTROPHIC_CARDIOMYOPATHY_HCM 0 0
Category members Pathway Pathway_1027 PID_INTEGRIN1_PATHWAY 0 0
Category members Pathway Pathway_1160 PID_INTEGRIN5_PATHWAY 0 0
Category members Pathway Pathway_1217 KEGG_CELL_ADHESION_MOLECULES_CAMS 0 0
Category members Pathway Pathway_1286 PID_INTEGRIN_CS_PATHWAY 0 0
Category members Pathway Pathway_216 BIOCARTA_EDG1_PATHWAY 0 0
Category members Pathway Pathway_24 KEGG_PATHWAYS_IN_CANCER 0 0
Category members Pathway Pathway_262 KEGG_DILATED_CARDIOMYOPATHY 0 0
Category members Pathway Pathway_283 KEGG_SMALL_CELL_LUNG_CANCER 0 0
Category members Pathway Pathway_531 PID_PDGFRA_PATHWAY 0 0
Category members Pathway Pathway_564 PID_AVB3_OPN_PATHWAY 0 0
Category members Pathway Pathway_683 PID_S1P_S1P1_PATHWAY 0 0
Category members Pathway Pathway_740 PID_INTEGRIN3_PATHWAY 0 0
Category members Pathway Pathway_922 KEGG_ECM_RECEPTOR_INTERACTION 0 0
Category members Pathway Pathway_930 REACTOME_INTEGRIN_CELL_SURFACE_INTERACTIONS 0 0
Category members GO Category GO:0001525 angiogenesis Database 0
Category members GO Category GO:0001568 blood vessel development Database 0
Category members GO Category GO:0001846 opsonin binding Database 0
Category members GO Category GO:0005245 voltage-gated calcium channel activity Database 0
Category members GO Category GO:0007155 cell adhesion Database 0
Category members GO Category GO:0007160 cell-matrix adhesion Database 0
Category members GO Category GO:0007229 integrin-mediated signaling pathway Database 0
Category members GO Category GO:0008284 positive regulation of cell proliferation Database 0
Category members GO Category GO:0010745 negative regulation of macrophage derived foam cell differentiation Database 0
Category members GO Category GO:0030335 positive regulation of cell migration Database 0
Category members GO Category GO:0031994 insulin-like growth factor I binding Database 0
Category members GO Category GO:0032369 negative regulation of lipid transport Database 0
Category members GO Category GO:0033690 positive regulation of osteoblast proliferation Database 0
Category members GO Category GO:0043277 apoptotic cell clearance Database 0
Category members GO Category GO:0045715 negative regulation of low-density lipoprotein particle receptor biosynthetic process Database 0
Category members GO Category GO:0046872 metal ion binding Database 0
Category members GO Category GO:0050431 transforming growth factor beta binding Database 0
Category members GO Category GO:0050764 regulation of phagocytosis Database 0
Category members GO Category GO:0070371 ERK1 and ERK2 cascade Database 0


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