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Query: BBS4

RNAi screen result RNAPII IP (PI) CSB IP CSB IP (PI) Chrom. Chrom. (PI) Phosphorylation Ubiquitylation
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[Click on the plots to view the data selection in the respective scatterplot]

Protein Results:

 Results for post-translational modifications: see below | Red/green: hit at lower/upper end of the respective screen
Gene name Point score Z-score sums RNAi high RNAi low RNAPII-IP (PI) CSB-IP CSB-IP (PI) Chrom. Chrom. (PI)
BBS4 0 -0.615 0.310 0.160

PTM Sites:

 Back to Protein Results | Red/green: hit at lower/upper end of the respective screen
Gene name PTM type PTM site UV UV (PI) Sequence
BBS4 Ubiquitylation K28 -0.615 _TQFPVSTESQK(gl)PR_
BBS4 Ubiquitylation K408 -2.242 _NALAQYQEMEK(gl)K_
BBS4 Ubiquitylation K409 -2.242 _NALAQYQEMEK(gl)K_
BBS4 Ubiquitylation K302 -2.331 _YVAAISCLK(gl)R_

Background Information for BBS4:


Pubmed-BBS4 »
Uniprot-BBS4 »
Biogrid-BBS4 »
ProteomicsDB-BBS4 »

Tumorportal-BBS4 »
COSMIC-BBS4 »
GenomeRNAi-BBS4 »
Genecards-BBS4


Protein-protein Interactions for BBS4
Show screen data for Category Name and Description Link to cat description Data Source
Category members IP bait AZI1 Cat. description Hein, Mann, Cell 2015
Category members IP bait CEP72 Cat. description Hein, Mann, Cell 2015
Category members IP bait FGFR1OP Cat. description Hein, Mann, Cell 2015
Category members IP bait KIF7 Cat. description Hein, Mann, Cell 2015
Category members IP bait LRRCC1 Cat. description Hein, Mann, Cell 2015
Category members IP bait MIB1 Cat. description Hein, Mann, Cell 2015
Category members IP bait OFD1 Cat. description Hein, Mann, Cell 2015
Category members IP bait PCM1 Cat. description Hein, Mann, Cell 2015
Category members IP bait BBS1 Cat. description BioPlex, Huttlin, Gygi, Cell 2015
Category members IP bait BBS5 Cat. description BioPlex, Huttlin, Gygi, Cell 2015
Category members IP bait BBS7 Cat. description BioPlex, Huttlin, Gygi, Cell 2015
Category members IP bait C10orf96 Cat. description BioPlex, Huttlin, Gygi, Cell 2015
Category members IP bait LZTFL1 Cat. description BioPlex, Huttlin, Gygi, Cell 2015
Category members IP bait NME3 Cat. description BioPlex, Huttlin, Gygi, Cell 2015


Protein Domains in BBS4
Domain name Domain Description TC-NER relevance -log10(p-value)
Category members TPR_1 IPR001440 1.39
Category members TPR-contain_dom IPR013026 0.97
Category members TPR_repeat IPR019734 0.93
Category members TPR_2 IPR013105 0.45


Protein complexes (CORUM database) featuring BBS4
Category Type Category ID Category Name Data Source TC-NER relevance -log10(p-value)


Categories featuring BBS4
Category Type Category ID Category Name Data Source TC-NER relevance -log10(p-value)
Category members GO Category GO:0005515 protein binding Database INF
Category members GO Category GO:0005737 cytoplasm Database 12.81
Category members GO Category GO:0015031 protein transport Database 3.48
Category members GO Category GO:0046907 intracellular transport Database 3.25
Category members GO Category GO:0000281 mitotic cytokinesis Database 0.77
Category members GO Category GO:0005813 centrosome Database 0.75
Category members GO Category GO:0008104 protein localization Database 0.5
Category members GO Category GO:0000226 microtubule cytoskeleton organization Database 0.5
Category members GO Category GO:0003777 microtubule motor activity Database 0.49
Category members GO Category GO:0021987 cerebral cortex development Database 0.37
Category members GO Category GO:0001103 RNA polymerase II repressing transcription factor binding Database 0.36
Category members GO Category GO:0048487 beta-tubulin binding Database 0.1
Category members GO Category GO:0034464 BBSome Database 0.1
Category members GO Category GO:0001947 heart looping Database 0.08
Category members GO Category GO:0060296 regulation of cilium beat frequency involved in ciliary motility Database 0.08
Category members GO Category GO:0051457 maintenance of protein location in nucleus Database 0.05
Category members GO Category GO:0032465 regulation of cytokinesis Database 0.05
Category members GO Category GO:0051297 centrosome organization Database 0.04
Category members Disease phenotype BARDET-BIEDL_SYNDROME BARDET-BIEDL SYNDROME Database 0
Category members GO Category GO:0000242 pericentriolar material Database 0
Category members GO Category GO:0001843 neural tube closure Database 0
Category members GO Category GO:0001895 retina homeostasis Database 0
Category members GO Category GO:0003085 negative regulation of systemic arterial blood pressure Database 0
Category members GO Category GO:0005814 centriole Database 0
Category members GO Category GO:0005932 microtubule basal body Database 0
Category members GO Category GO:0007286 spermatid development Database 0
Category members GO Category GO:0007601 visual perception Database 0
Category members GO Category GO:0007608 sensory perception of smell Database 0
Category members GO Category GO:0010629 negative regulation of gene expression Database 0
Category members GO Category GO:0016358 dendrite development Database 0
Category members GO Category GO:0019216 regulation of lipid metabolic process Database 0
Category members GO Category GO:0021756 striatum development Database 0
Category members GO Category GO:0021766 hippocampus development Database 0
Category members GO Category GO:0030534 adult behavior Database 0
Category members GO Category GO:0031513 nonmotile primary cilium Database 0
Category members GO Category GO:0031514 motile cilium Database 0
Category members GO Category GO:0032402 melanosome transport Database 0
Category members GO Category GO:0033210 leptin-mediated signaling pathway Database 0
Category members GO Category GO:0033365 protein localization to organelle Database 0
Category members GO Category GO:0034451 centriolar satellite Database 0
Category members GO Category GO:0034452 dynactin binding Database 0
Category members GO Category GO:0034454 microtubule anchoring at centrosome Database 0
Category members GO Category GO:0035058 nonmotile primary cilium assembly Database 0
Category members GO Category GO:0038108 negative regulation of appetite by leptin-mediated signaling pathway Database 0
Category members GO Category GO:0040018 positive regulation of multicellular organism growth Database 0
Category members GO Category GO:0042384 cilium assembly Database 0
Category members GO Category GO:0043014 alpha-tubulin binding Database 0
Category members GO Category GO:0044321 response to leptin Database 0
Category members GO Category GO:0045444 fat cell differentiation Database 0
Category members GO Category GO:0045494 photoreceptor cell maintenance Database 0
Category members GO Category GO:0046548 retinal rod cell development Database 0
Category members GO Category GO:0048854 brain morphogenesis Database 0
Category members GO Category GO:0051877 pigment granule aggregation in cell center Database 0
Category members GO Category GO:0060027 convergent extension involved in gastrulation Database 0
Category members GO Category GO:0060170 ciliary membrane Database 0
Category members GO Category GO:0060271 cilium morphogenesis Database 0


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