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Query: TBX3

This is a cancer-associated gene according to the Broad cancer gene census.

RNAi screen result RNAPII IP (PI) CSB IP CSB IP (PI) Chrom. Chrom. (PI) Phosphorylation Ubiquitylation
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[Click on the plots to view the data selection in the respective scatterplot]

Protein Results:

 Results for post-translational modifications: see below | Red/green: hit at lower/upper end of the respective screen
Gene name Point score Z-score sums RNAi high RNAi low RNAPII-IP (PI) CSB-IP CSB-IP (PI) Chrom. Chrom. (PI)
TBX3 0 -2.359 -0.160 0.160

PTM Sites:

 Back to Protein Results | Red/green: hit at lower/upper end of the respective screen
Gene name PTM type PTM site UV UV (PI) Sequence
TBX3 Ubiquitylation K466 -2.519 _EGTAPAK(gl)VEEAR_

Background Information for TBX3:


Pubmed-TBX3 »
Uniprot-TBX3 »
Biogrid-TBX3 »
ProteomicsDB-TBX3 »

Tumorportal-TBX3 »
COSMIC-TBX3 »
GenomeRNAi-TBX3 »
Genecards-TBX3


Protein-protein Interactions for TBX3
Show screen data for Category Name and Description Link to cat description Data Source
Category members IP bait CDCA5 Cat. description Hein, Mann, Cell 2015
Category members IP bait CDK8 Cat. description Hein, Mann, Cell 2015
Category members IP bait DCP1A Cat. description Hein, Mann, Cell 2015
Category members IP bait DNAJC11 Cat. description Hein, Mann, Cell 2015
Category members IP bait KIF21A Cat. description Hein, Mann, Cell 2015
Category members IP bait KIF21B Cat. description Hein, Mann, Cell 2015
Category members IP bait MAPK3 Cat. description Hein, Mann, Cell 2015
Category members IP bait NAA15 Cat. description Hein, Mann, Cell 2015
Category members IP bait SMAD3 Cat. description Hein, Mann, Cell 2015
Category members IP bait HNRPLL Cat. description BioPlex, Huttlin, Gygi, Cell 2015


Protein Domains in TBX3
Domain name Domain Description TC-NER relevance -log10(p-value)
Category members TBX IPR022582 0.13
Category members TF_T-box IPR001699 0
Category members TF_Brachyury IPR002070 0
Category members p53-like_TF_DNA-bd IPR008967 0


Protein complexes (CORUM database) featuring TBX3
Category Type Category ID Category Name Data Source TC-NER relevance -log10(p-value)


Categories featuring TBX3
Category Type Category ID Category Name Data Source TC-NER relevance -log10(p-value)
Category members GO Category GO:0005515 protein binding Database INF
Category members GO Category GO:0005634 nucleus Database INF
Category members GO Category GO:0045892 negative regulation of transcription, DNA-dependent Database 1.15
Category members Human mutations Broad_cancer_genes Broad cancer genes (Lawrence et al., 2014) literature 1.14
Category members GO Category GO:0006351 transcription, DNA-templated Database 1.07
Category members GO Category GO:0003700 sequence-specific DNA binding transcription factor activity Database 0.63
Category members GO Category GO:0043066 negative regulation of apoptotic process Database 0.6
Category members GO Category GO:0019827 stem cell maintenance Database 0.48
Category members GO Category GO:0030540 female genitalia development Database 0.44
Category members GO Category GO:0001102 RNA polymerase II activating transcription factor binding Database 0.31
Category members GO Category GO:0045893 positive regulation of transcription, DNA-dependent Database 0.28
Category members GO Category GO:0060021 palate development Database 0.23
Category members GO Category GO:0001701 in utero embryonic development Database 0.2
Category members GO Category GO:0006357 regulation of transcription from RNA polymerase II promoter Database 0.19
Category members GO Category GO:0043565 sequence-specific DNA binding Database 0.18
Category members GO Category GO:0060596 mammary placode formation Database 0.1
Category members GO Category GO:0001947 heart looping Database 0.08
Category members GO Category GO:0021761 limbic system development Database 0.08
Category members GO Category GO:0046884 follicle-stimulating hormone secretion Database 0.08
Category members GO Category GO:0042127 regulation of cell proliferation Database 0.06
Category members GO Category GO:0045787 positive regulation of cell cycle Database 0.04
Category members GO Category GO:0007569 cell aging Database 0.03
Category members GO Category GO:0000122 negative regulation of transcription from RNA polymerase II promoter Database 0.02
Category members GO Category GO:0001085 RNA polymerase II transcription factor binding Database 0
Category members GO Category GO:0001501 skeletal system development Database 0
Category members GO Category GO:0001568 blood vessel development Database 0
Category members GO Category GO:0003007 heart morphogenesis Database 0
Category members GO Category GO:0003151 outflow tract morphogenesis Database 0
Category members GO Category GO:0006355 regulation of transcription, DNA-dependent Database 0
Category members GO Category GO:0008284 positive regulation of cell proliferation Database 0
Category members GO Category GO:0008595 anterior/posterior axis specification, embryo Database 0
Category members GO Category GO:0009887 organ morphogenesis Database 0
Category members GO Category GO:0010159 specification of organ position Database 0
Category members GO Category GO:0030539 male genitalia development Database 0
Category members GO Category GO:0030857 negative regulation of epithelial cell differentiation Database 0
Category members GO Category GO:0030879 mammary gland development Database 0
Category members GO Category GO:0032275 luteinizing hormone secretion Database 0
Category members GO Category GO:0035108 limb morphogenesis Database 0
Category members GO Category GO:0035115 embryonic forelimb morphogenesis Database 0
Category members GO Category GO:0035136 forelimb morphogenesis Database 0
Category members GO Category GO:0042733 embryonic digit morphogenesis Database 0
Category members GO Category GO:0045662 negative regulation of myoblast differentiation Database 0
Category members GO Category GO:0048332 mesoderm morphogenesis Database 0
Category members GO Category GO:0055007 cardiac muscle cell differentiation Database 0
Category members GO Category GO:0060412 ventricular septum morphogenesis Database 0
Category members GO Category GO:0060444 branching involved in mammary gland duct morphogenesis Database 0
Category members GO Category GO:0060923 cardiac muscle cell fate commitment Database 0


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