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Query: PRKD1

RNAi screen result RNAPII IP (PI) CSB IP CSB IP (PI) Chrom. Chrom. (PI) Phosphorylation Ubiquitylation
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[Click on the plots to view the data selection in the respective scatterplot]

Protein Results:

 Results for post-translational modifications: see below | Red/green: hit at lower/upper end of the respective screen
Gene name Point score Z-score sums RNAi high RNAi low RNAPII-IP (PI) CSB-IP CSB-IP (PI) Chrom. Chrom. (PI)
PRKD1 0 3.166 1.050 0.130

PTM Sites:

 Back to Protein Results | Red/green: hit at lower/upper end of the respective screen
Gene name PTM type PTM site UV UV (PI) Sequence
PRKD1 Ubiquitylation K730 1.177 _IIGEK(gl)SFR_
PRKD1 Phosphorylation S207 0.941 1.048 _RLS(ph)NVSLTGVSTIR_
PRKD1 Phosphorylation S251 0.474 0.751 _SNS(ph)QSYIGRPIHLDK_
PRKD1 Phosphorylation S399 0.023 0.162 _TIS(ph)PSTSNNIPLMR_
PRKD1 Phosphorylation S236 -0.132 _TSSAELSTSAPDEPLLSPVS(ph)PGFEQK_
PRKD1 Phosphorylation T219 -0.068 -0.162 _T(ph)SSAELSTSAPDEPLLQK_
PRKD1 Phosphorylation S744 -0.226 -0.287 _S(ph)VVGTPAYLAPEVLR_
PRKD1 Phosphorylation S221 -0.662 -0.500 _TSS(ph)AELSTSAPDEPLLQK_
PRKD1 Phosphorylation S225 -0.970 -0.919 _TSSAELSTS(ph)APDEPLLSPVSPGFEQK_

Background Information for PRKD1:


Pubmed-PRKD1 »
Uniprot-PRKD1 »
Biogrid-PRKD1 »
ProteomicsDB-PRKD1 »

Tumorportal-PRKD1 »
COSMIC-PRKD1 »
GenomeRNAi-PRKD1 »
Genecards-PRKD1


Protein-protein Interactions for PRKD1
Show screen data for Category Name and Description Link to cat description Data Source
Category members IP bait FUCA1 Cat. description BioPlex, Huttlin, Gygi, Cell 2015
Category members IP bait SIX2 Cat. description BioPlex, Huttlin, Gygi, Cell 2015


Protein Domains in PRKD1
Domain name Domain Description TC-NER relevance -log10(p-value)
Category members PE/DAG-bd IPR002219 0.63
Category members DAG/PE-bd IPR020454 0.18
Category members PH_domain IPR001849 0.14
Category members Kinase-like_dom IPR011009 0.03
Category members Prot_kinase_dom IPR000719 0
Category members Ser-Thr/Tyr_kinase_cat_dom IPR001245 0
Category members Ser/Thr_dual-sp_kinase IPR002290 0
Category members Tyr_kinase_cat_dom IPR020635 0


Protein complexes (CORUM database) featuring PRKD1
Category Type Category ID Category Name Data Source TC-NER relevance -log10(p-value)


Categories featuring PRKD1
Category Type Category ID Category Name Data Source TC-NER relevance -log10(p-value)
Category members GO Category GO:0005515 protein binding Database INF
Category members GO Category GO:0005634 nucleus Database INF
Category members GO Category GO:0005829 cytosol Database INF
Category members GO Category GO:0005737 cytoplasm Database 12.81
Category members GO Category GO:0005524 ATP binding Database 5.54
Category members GO Category GO:0005938 cell cortex Database 2.26
Category members GO Category GO:0006915 apoptotic process Database 2.12
Category members GO Category GO:0005887 integral to plasma membrane Database 1.69
Category members GO Category GO:0005911 cell-cell junction Database 1.4
Category members GO Category GO:0005886 plasma membrane Database 1.21
Category members Pathway Pathway_237 PID_LYSOPHOSPHOLIPID_PATHWAY 0 1.09
Category members GO Category GO:0004674 protein serine/threonine kinase activity Database 0.66
Category members GO Category GO:0006954 inflammatory response Database 0.49
Category members Pathway Pathway_603 PID_IGF1_PATHWAY 0 0.39
Category members GO Category GO:0044281 small molecule metabolic process Database 0.35
Category members GO Category GO:0005794 Golgi apparatus Database 0.27
Category members GO Category GO:0042802 identical protein binding Database 0.26
Category members GO Category GO:0046777 protein autophosphorylation Database 0.23
Category members GO Category GO:0045766 positive regulation of angiogenesis Database 0.19
Category members GO Category GO:0004672 protein kinase activity Database 0.19
Category members GO Category GO:0048193 Golgi vesicle transport Database 0.19
Category members GO Category GO:0018105 peptidyl-serine phosphorylation Database 0.18
Category members GO Category GO:0005802 trans-Golgi network Database 0.13
Category members GO Category GO:0007030 Golgi organization Database 0.13
Category members GO Category GO:0045944 positive regulation of transcription from RNA polymerase II promoter Database 0.13
Category members GO Category GO:0043536 positive regulation of blood vessel endothelial cell migration Database 0.09
Category members GO Category GO:0004697 protein kinase C activity Database 0.09
Category members GO Category GO:0008283 cell proliferation Database 0.06
Category members GO Category GO:0035924 cellular response to vascular endothelial growth factor stimulus Database 0.06
Category members GO Category GO:0010976 positive regulation of neuron projection development Database 0.05
Category members GO Category GO:0045087 innate immune response Database 0.05
Category members GO Category GO:0006468 protein phosphorylation Database 0.04
Category members GO Category GO:0033138 positive regulation of peptidyl-serine phosphorylation Database 0.03
Category members GO Category GO:0004713 protein tyrosine kinase activity Database 0.01
Category members Pathway Pathway_100 REACTOME_PHOSPHOLIPID_METABOLISM 0 0
Category members Pathway Pathway_128 REACTOME_SPHINGOLIPID_METABOLISM 0 0
Category members Pathway Pathway_4 REACTOME_METABOLISM_OF_LIPIDS_AND_LIPOPROTEINS 0 0
Category members Pathway Pathway_498 REACTOME_SPHINGOLIPID_DE_NOVO_BIOSYNTHESIS 0 0
Category members Pathway Pathway_658 ST_GA13_PATHWAY 0 0
Category members GO Category GO:0001525 angiogenesis Database 0
Category members GO Category GO:0001938 positive regulation of endothelial cell proliferation Database 0
Category members GO Category GO:0006665 sphingolipid metabolic process Database 0
Category members GO Category GO:0007165 signal transduction Database 0
Category members GO Category GO:0007229 integrin-mediated signaling pathway Database 0
Category members GO Category GO:0010595 positive regulation of endothelial cell migration Database 0
Category members GO Category GO:0010837 regulation of keratinocyte proliferation Database 0
Category members GO Category GO:0016772 transferase activity, transferring phosphorus-containing groups Database 0
Category members GO Category GO:0030148 sphingolipid biosynthetic process Database 0
Category members GO Category GO:0032793 positive regulation of CREB transcription factor activity Database 0
Category members GO Category GO:0034599 cellular response to oxidative stress Database 0
Category members GO Category GO:0035556 intracellular signal transduction Database 0
Category members GO Category GO:0038033 positive regulation of endothelial cell chemotaxis by VEGF-activated vascular endothelial growth factor receptor signaling pathway Database 0
Category members GO Category GO:0043123 positive regulation of I-kappaB kinase/NF-kappaB signaling Database 0
Category members GO Category GO:0045669 positive regulation of osteoblast differentiation Database 0
Category members GO Category GO:0045806 negative regulation of endocytosis Database 0
Category members GO Category GO:0046872 metal ion binding Database 0
Category members GO Category GO:0048010 vascular endothelial growth factor receptor signaling pathway Database 0
Category members GO Category GO:0051092 positive regulation of NF-kappaB transcription factor activity Database 0
Category members GO Category GO:0060548 negative regulation of cell death Database 0


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