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Query: PRKCI

RNAi screen result RNAPII IP (PI) CSB IP CSB IP (PI) Chrom. Chrom. (PI) Phosphorylation Ubiquitylation
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[Click on the plots to view the data selection in the respective scatterplot]

Protein Results:

 Results for post-translational modifications: see below | Red/green: hit at lower/upper end of the respective screen
Gene name Point score Z-score sums RNAi high RNAi low RNAPII-IP (PI) CSB-IP CSB-IP (PI) Chrom. Chrom. (PI)
PRKCI 0 3.161 0.730 -0.460 1.483 0.192 0.350

PTM Sites:

 Back to Protein Results | Red/green: hit at lower/upper end of the respective screen
Gene name PTM type PTM site UV UV (PI) Sequence
PRKCI Ubiquitylation K488 -0.090 0.847 _SLSVK(gl)AASVLK_
PRKCI Ubiquitylation K244 0.289 _ESGK(gl)ASSSLGLQDFDLLR_

Background Information for PRKCI:


Pubmed-PRKCI »
Uniprot-PRKCI »
Biogrid-PRKCI »
ProteomicsDB-PRKCI »

Tumorportal-PRKCI »
COSMIC-PRKCI »
GenomeRNAi-PRKCI »
Genecards-PRKCI


Protein-protein Interactions for PRKCI
Show screen data for Category Name and Description Link to cat description Data Source
Category members IP bait LLGL1 Cat. description Hein, Mann, Cell 2015
Category members IP bait LLGL2 Cat. description Hein, Mann, Cell 2015
Category members IP bait PARD6A Cat. description Hein, Mann, Cell 2015
Category members IP bait PARD6B Cat. description Hein, Mann, Cell 2015
Category members IP bait PRKCI Cat. description Hein, Mann, Cell 2015
Category members IP bait ARHGEF16 Cat. description BioPlex, Huttlin, Gygi, Cell 2015
Category members IP bait CD44 Cat. description BioPlex, Huttlin, Gygi, Cell 2015
Category members IP bait FARP2 Cat. description BioPlex, Huttlin, Gygi, Cell 2015
Category members IP bait FGB Cat. description BioPlex, Huttlin, Gygi, Cell 2015
Category members IP bait FYN Cat. description BioPlex, Huttlin, Gygi, Cell 2015
Category members IP bait GPR156 Cat. description BioPlex, Huttlin, Gygi, Cell 2015
Category members IP bait KBTBD7 Cat. description BioPlex, Huttlin, Gygi, Cell 2015
Category members IP bait KERA Cat. description BioPlex, Huttlin, Gygi, Cell 2015
Category members IP bait LLGL2 Cat. description BioPlex, Huttlin, Gygi, Cell 2015
Category members IP bait NGEF Cat. description BioPlex, Huttlin, Gygi, Cell 2015
Category members IP bait PARD6B Cat. description BioPlex, Huttlin, Gygi, Cell 2015
Category members IP bait PDGFD Cat. description BioPlex, Huttlin, Gygi, Cell 2015
Category members IP bait PRKCZ Cat. description BioPlex, Huttlin, Gygi, Cell 2015
Category members IP bait RASSF8 Cat. description BioPlex, Huttlin, Gygi, Cell 2015
Category members IP bait RHOJ Cat. description BioPlex, Huttlin, Gygi, Cell 2015


Protein Domains in PRKCI
Domain name Domain Description TC-NER relevance -log10(p-value)
Category members PE/DAG-bd IPR002219 0.63
Category members DAG/PE-bd IPR020454 0.18
Category members Kinase-like_dom IPR011009 0.03
Category members OPR_PB1 IPR000270 0
Category members Prot_kinase_dom IPR000719 0
Category members AGC-kinase_C IPR000961 0
Category members Ser-Thr/Tyr_kinase_cat_dom IPR001245 0
Category members Ser/Thr_dual-sp_kinase IPR002290 0
Category members PKC_zeta IPR012233 0
Category members Pkinase_C IPR017892 0
Category members Tyr_kinase_cat_dom IPR020635 0


Protein complexes (CORUM database) featuring PRKCI
Category Type Category ID Category Name Data Source TC-NER relevance -log10(p-value)
Category members Corum 956 PAR-3-PAR-6B-PRKCI complex Database 0.52
Category members Corum 955 LLGL2-PAR-6B-PRKCI complex Database 0.32
Category members Corum 847 RICH1-PAR3-aPKC polarity complex Database 0.08
Category members Corum 959 LLGL1-PAR-6B-PRKCI complex Database 0.01
Category members Corum 2143 MAP2K5-PRKCI-SQSTM1 complex Database 0


Categories featuring PRKCI
Category Type Category ID Category Name Data Source TC-NER relevance -log10(p-value)
Category members GO Category GO:0005515 protein binding Database INF
Category members GO Category GO:0005634 nucleus Database INF
Category members GO Category GO:0005829 cytosol Database INF
Category members GO Category GO:0005737 cytoplasm Database 12.81
Category members GO Category GO:0005524 ATP binding Database 5.54
Category members GO Category GO:0043234 protein complex Database 2.73
Category members GO Category GO:0031252 cell leading edge Database 2.52
Category members Pathway Pathway_221 REACTOME_SIGNALLING_BY_NGF 0 2.14
Category members Pathway Pathway_413 KEGG_TIGHT_JUNCTION 0 2.08
Category members GO Category GO:0019904 protein domain specific binding Database 1.85
Category members Pathway Pathway_455 PID_INSULIN_GLUCOSE_PATHWAY 0 1.7
Category members Pathway Pathway_666 KEGG_ENDOCYTOSIS 0 1.25
Category members GO Category GO:0005886 plasma membrane Database 1.21
Category members GO Category GO:0016192 vesicle-mediated transport Database 1.1
Category members Pathway Pathway_507 PID_MET_PATHWAY 0 0.82
Category members GO Category GO:0004674 protein serine/threonine kinase activity Database 0.66
Category members GO Category GO:0043524 negative regulation of neuron apoptotic process Database 0.66
Category members GO Category GO:0048011 neurotrophin TRK receptor signaling pathway Database 0.63
Category members GO Category GO:0032869 cellular response to insulin stimulus Database 0.63
Category members GO Category GO:0043066 negative regulation of apoptotic process Database 0.6
Category members GO Category GO:0070830 tight junction assembly Database 0.36
Category members GO Category GO:0006612 protein targeting to membrane Database 0.29
Category members GO Category GO:0005768 endosome Database 0.29
Category members GO Category GO:0008270 zinc ion binding Database 0.29
Category members GO Category GO:0034329 cell junction assembly Database 0.29
Category members Pathway Pathway_560 REACTOME_CELL_CELL_COMMUNICATION 0 0.25
Category members Pathway Pathway_739 REACTOME_P75_NTR_RECEPTOR_MEDIATED_SIGNALLING 0 0.23
Category members GO Category GO:0043220 Schmidt-Lanterman incisure Database 0.21
Category members Pathway Pathway_44 KEGG_INSULIN_SIGNALING_PATHWAY 0 0.21
Category members GO Category GO:0004672 protein kinase activity Database 0.19
Category members Pathway Pathway_555 PID_NEPHRIN_NEPH1_PATHWAY 0 0.17
Category members GO Category GO:0061024 membrane organization Database 0.13
Category members GO Category GO:0035089 establishment of apical/basal cell polarity Database 0.11
Category members GO Category GO:0045216 cell-cell junction organization Database 0.1
Category members GO Category GO:0004697 protein kinase C activity Database 0.09
Category members GO Category GO:0007015 actin filament organization Database 0.08
Category members GO Category GO:0010976 positive regulation of neuron projection development Database 0.05
Category members GO Category GO:0034613 cellular protein localization Database 0.04
Category members GO Category GO:0006468 protein phosphorylation Database 0.04
Category members Pathway Pathway_557 PID_P75_NTR_PATHWAY 0 0.04
Category members GO Category GO:0048194 Golgi vesicle budding Database 0.04
Category members Pathway Pathway_644 PID_TRKR_PATHWAY 0 0.04
Category members GO Category GO:0070555 response to interleukin-1 Database 0.02
Category members GO Category GO:0034351 negative regulation of glial cell apoptotic process Database 0.01
Category members GO Category GO:0004713 protein tyrosine kinase activity Database 0.01
Category members Pathway Pathway_1236 REACTOME_TIGHT_JUNCTION_INTERACTIONS 0 0
Category members Pathway Pathway_1237 REACTOME_CELL_CELL_JUNCTION_ORGANIZATION 0 0
Category members Pathway Pathway_571 PID_INSULIN_PATHWAY 0 0
Category members Pathway Pathway_631 PID_IL1_PATHWAY 0 0
Category members Pathway Pathway_738 PID_TNF_PATHWAY 0 0
Category members Pathway Pathway_786 REACTOME_P75NTR_RECRUITS_SIGNALLING_COMPLEXES 0 0
Category members Pathway Pathway_806 REACTOME_P75NTR_SIGNALS_VIA_NFKB 0 0
Category members Pathway Pathway_925 REACTOME_CELL_JUNCTION_ORGANIZATION 0 0
Category members GO Category GO:0005543 phospholipid binding Database 0
Category members GO Category GO:0007010 cytoskeleton organization Database 0
Category members GO Category GO:0016324 apical plasma membrane Database 0
Category members GO Category GO:0016477 cell migration Database 0
Category members GO Category GO:0016772 transferase activity, transferring phosphorus-containing groups Database 0
Category members GO Category GO:0035556 intracellular signal transduction Database 0
Category members GO Category GO:0042462 eye photoreceptor cell development Database 0
Category members GO Category GO:0043434 response to peptide hormone Database 0
Category members GO Category GO:0045177 apical part of cell Database 0
Category members GO Category GO:0045197 establishment or maintenance of epithelial cell apical/basal polarity Database 0
Category members GO Category GO:0046326 positive regulation of glucose import Database 0
Category members GO Category GO:0046903 secretion Database 0
Category members GO Category GO:0051092 positive regulation of NF-kappaB transcription factor activity Database 0
Category members GO Category GO:0060252 positive regulation of glial cell proliferation Database 0


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