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Query: NKX2-5

RNAi screen result RNAPII IP (PI) CSB IP CSB IP (PI) Chrom. Chrom. (PI) Phosphorylation Ubiquitylation
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[Click on the plots to view the data selection in the respective scatterplot]

Protein Results:

 Results for post-translational modifications: see below | Red/green: hit at lower/upper end of the respective screen
Gene name Point score Z-score sums RNAi high RNAi low RNAPII-IP (PI) CSB-IP CSB-IP (PI) Chrom. Chrom. (PI)
NKX2-5 0 1.517 -0.150 1.230 0.174 0.236
NKX2-5 0 1.517 -0.150 1.230 -0.123

PTM Sites:

 Back to Protein Results | Red/green: hit at lower/upper end of the respective screen
Gene name PTM type PTM site UV UV (PI) Sequence

Background Information for NKX2-5:


Pubmed-NKX2-5 »
Uniprot-NKX2-5 »
Biogrid-NKX2-5 »
ProteomicsDB-NKX2-5 »

Tumorportal-NKX2-5 »
COSMIC-NKX2-5 »
GenomeRNAi-NKX2-5 »
Genecards-NKX2-5


Protein-protein Interactions for NKX2-5
Show screen data for Category Name and Description Link to cat description Data Source
Category members IP bait GRB2 Cat. description BioPlex, Huttlin, Gygi, Cell 2015


Protein Domains in NKX2-5
Domain name Domain Description TC-NER relevance -log10(p-value)
Category members Homeobox_dom IPR001356 0.63
Category members Homeobox_metazoa IPR020479 0.28
Category members Homeodomain-like IPR009057 0


Protein complexes (CORUM database) featuring NKX2-5
Category Type Category ID Category Name Data Source TC-NER relevance -log10(p-value)


Categories featuring NKX2-5
Category Type Category ID Category Name Data Source TC-NER relevance -log10(p-value)
Category members GO Category GO:0005515 protein binding Database INF
Category members GO Category GO:0005634 nucleus Database INF
Category members GO Category GO:0005737 cytoplasm Database 12.81
Category members GO Category GO:0003682 chromatin binding Database 6.07
Category members GO Category GO:0003677 DNA binding Database 1.53
Category members GO Category GO:0045892 negative regulation of transcription, DNA-dependent Database 1.15
Category members GO Category GO:0003700 sequence-specific DNA binding transcription factor activity Database 0.63
Category members GO Category GO:0043066 negative regulation of apoptotic process Database 0.6
Category members Pathway Pathway_845 PID_SMAD2_3NUCLEAR_PATHWAY 0 0.46
Category members GO Category GO:0008134 transcription factor binding Database 0.37
Category members GO Category GO:0045823 positive regulation of heart contraction Database 0.32
Category members GO Category GO:0055005 ventricular cardiac myofibril assembly Database 0.32
Category members GO Category GO:0045893 positive regulation of transcription, DNA-dependent Database 0.28
Category members GO Category GO:0046982 protein heterodimerization activity Database 0.28
Category members GO Category GO:0030509 BMP signaling pathway Database 0.2
Category members GO Category GO:0005667 transcription factor complex Database 0.19
Category members GO Category GO:0006357 regulation of transcription from RNA polymerase II promoter Database 0.19
Category members GO Category GO:0043565 sequence-specific DNA binding Database 0.18
Category members GO Category GO:0003148 outflow tract septum morphogenesis Database 0.13
Category members GO Category GO:0045944 positive regulation of transcription from RNA polymerase II promoter Database 0.13
Category members Disease phenotype HYPOPLASTIC_LEFT_HEART_SYNDROME HYPOPLASTIC LEFT HEART SYNDROME Database 0.11
Category members Disease phenotype TETRALOGY_OF_FALLOT TETRALOGY OF FALLOT Database 0.11
Category members GO Category GO:0060928 atrioventricular node cell development Database 0.11
Category members GO Category GO:0051891 positive regulation of cardioblast differentiation Database 0.1
Category members GO Category GO:0001947 heart looping Database 0.08
Category members GO Category GO:0001104 RNA polymerase II transcription cofactor activity Database 0.08
Category members GO Category GO:0003208 cardiac ventricle morphogenesis Database 0.08
Category members GO Category GO:0010667 negative regulation of cardiac muscle cell apoptotic process Database 0.08
Category members GO Category GO:0030154 cell differentiation Database 0.06
Category members GO Category GO:0000122 negative regulation of transcription from RNA polymerase II promoter Database 0.02
Category members GO Category GO:0060413 atrial septum morphogenesis Database 0.02
Category members GO Category GO:0044212 transcription regulatory region DNA binding Database 0
Category members Pathway Pathway_641 BIOCARTA_NFAT_PATHWAY 0 0
Category members Pathway Pathway_872 BIOCARTA_ALK_PATHWAY 0 0
Category members Disease phenotype Athyreosis Athyreosis Database 0
Category members Disease phenotype Atrial_septal_defect_ostium_secundum_type Atrial septal defect ostium secundum type Database 0
Category members Disease phenotype Conotruncal_heart_malformations Conotruncal heart malformations Database 0
Category members Disease phenotype Familial_atrial_fibrillation Familial atrial fibrillation Database 0
Category members Disease phenotype Familial_isolated_congenital_asplenia Familial isolated congenital asplenia Database 0
Category members Disease phenotype Familial_progressive_cardiac_conduction_defect Familial progressive cardiac conduction defect Database 0
Category members Disease phenotype Single_ventricular_septal_defect Single ventricular septal defect Database 0
Category members Disease phenotype Thyroid_hypoplasia Thyroid hypoplasia Database 0
Category members GO Category GO:0001190 RNA polymerase II transcription factor binding transcription factor activity involved in positive regulation of transcription Database 0
Category members GO Category GO:0001570 vasculogenesis Database 0
Category members GO Category GO:0003007 heart morphogenesis Database 0
Category members GO Category GO:0003151 outflow tract morphogenesis Database 0
Category members GO Category GO:0003161 cardiac conduction system development Database 0
Category members GO Category GO:0003162 atrioventricular node development Database 0
Category members GO Category GO:0003166 bundle of His development Database 0
Category members GO Category GO:0003211 cardiac ventricle formation Database 0
Category members GO Category GO:0003221 right ventricular cardiac muscle tissue morphogenesis Database 0
Category members GO Category GO:0003222 ventricular trabecula myocardium morphogenesis Database 0
Category members GO Category GO:0003278 apoptotic process involved in heart morphogenesis Database 0
Category members GO Category GO:0003350 pulmonary myocardium development Database 0
Category members GO Category GO:0003705 RNA polymerase II distal enhancer sequence-specific DNA binding transcription factor activity Database 0
Category members GO Category GO:0006355 regulation of transcription, DNA-dependent Database 0
Category members GO Category GO:0007507 heart development Database 0
Category members GO Category GO:0007512 adult heart development Database 0
Category members GO Category GO:0008284 positive regulation of cell proliferation Database 0
Category members GO Category GO:0010628 positive regulation of gene expression Database 0
Category members GO Category GO:0010735 positive regulation of transcription via serum response element binding Database 0
Category members GO Category GO:0010736 serum response element binding Database 0
Category members GO Category GO:0010765 positive regulation of sodium ion transport Database 0
Category members GO Category GO:0010832 negative regulation of myotube differentiation Database 0
Category members GO Category GO:0030097 hemopoiesis Database 0
Category members GO Category GO:0030878 thyroid gland development Database 0
Category members GO Category GO:0035050 embryonic heart tube development Database 0
Category members GO Category GO:0042803 protein homodimerization activity Database 0
Category members GO Category GO:0045214 sarcomere organization Database 0
Category members GO Category GO:0045666 positive regulation of neuron differentiation Database 0
Category members GO Category GO:0048536 spleen development Database 0
Category members GO Category GO:0048738 cardiac muscle tissue development Database 0
Category members GO Category GO:0055007 cardiac muscle cell differentiation Database 0
Category members GO Category GO:0055008 cardiac muscle tissue morphogenesis Database 0
Category members GO Category GO:0055014 atrial cardiac muscle cell development Database 0
Category members GO Category GO:0055015 ventricular cardiac muscle cell development Database 0
Category members GO Category GO:0055117 regulation of cardiac muscle contraction Database 0
Category members GO Category GO:0060037 pharyngeal system development Database 0
Category members GO Category GO:0060038 cardiac muscle cell proliferation Database 0
Category members GO Category GO:0060043 regulation of cardiac muscle cell proliferation Database 0
Category members GO Category GO:0060047 heart contraction Database 0
Category members GO Category GO:0060048 cardiac muscle contraction Database 0
Category members GO Category GO:0060070 canonical Wnt signaling pathway Database 0
Category members GO Category GO:0060261 positive regulation of transcription initiation from RNA polymerase II promoter Database 0
Category members GO Category GO:0060347 heart trabecula formation Database 0
Category members GO Category GO:0060412 ventricular septum morphogenesis Database 0
Category members GO Category GO:0060971 embryonic heart tube left/right pattern formation Database 0


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