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Query: NKX2-1

This is a cancer-associated gene according to the Sanger cancer gene census.

RNAi screen result RNAPII IP (PI) CSB IP CSB IP (PI) Chrom. Chrom. (PI) Phosphorylation Ubiquitylation
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[Click on the plots to view the data selection in the respective scatterplot]

Protein Results:

 Results for post-translational modifications: see below | Red/green: hit at lower/upper end of the respective screen
Gene name Point score Z-score sums RNAi high RNAi low RNAPII-IP (PI) CSB-IP CSB-IP (PI) Chrom. Chrom. (PI)
NKX2-1 0 0.767 -0.730 0.480 0.174 0.236
NKX2-1 0 0.767 -0.730 0.480 -0.123

PTM Sites:

 Back to Protein Results | Red/green: hit at lower/upper end of the respective screen
Gene name PTM type PTM site UV UV (PI) Sequence

Background Information for NKX2-1:


Pubmed-NKX2-1 »
Uniprot-NKX2-1 »
Biogrid-NKX2-1 »
ProteomicsDB-NKX2-1 »

Tumorportal-NKX2-1 »
COSMIC-NKX2-1 »
GenomeRNAi-NKX2-1 »
Genecards-NKX2-1


Protein-protein Interactions for NKX2-1
Show screen data for Category Name and Description Link to cat description Data Source


Protein Domains in NKX2-1
Domain name Domain Description TC-NER relevance -log10(p-value)
Category members Homeobox_dom IPR001356 0.63
Category members Homeobox_metazoa IPR020479 0.28
Category members Homeodomain-like IPR009057 0


Protein complexes (CORUM database) featuring NKX2-1
Category Type Category ID Category Name Data Source TC-NER relevance -log10(p-value)


Categories featuring NKX2-1
Category Type Category ID Category Name Data Source TC-NER relevance -log10(p-value)
Category members GO Category GO:0005515 protein binding Database INF
Category members GO Category GO:0005634 nucleus Database INF
Category members GO Category GO:0005654 nucleoplasm Database INF
Category members Human mutations Sanger_cancer_genes Sanger cancer genes Database 4.88
Category members GO Category GO:0003677 DNA binding Database 1.53
Category members GO Category GO:0030336 negative regulation of cell migration Database 0.85
Category members GO Category GO:0003700 sequence-specific DNA binding transcription factor activity Database 0.63
Category members GO Category GO:0030324 lung development Database 0.39
Category members GO Category GO:0045893 positive regulation of transcription, DNA-dependent Database 0.28
Category members GO Category GO:0005667 transcription factor complex Database 0.19
Category members GO Category GO:0006357 regulation of transcription from RNA polymerase II promoter Database 0.19
Category members GO Category GO:0021879 forebrain neuron differentiation Database 0.19
Category members GO Category GO:0007389 pattern specification process Database 0.18
Category members GO Category GO:0043565 sequence-specific DNA binding Database 0.18
Category members GO Category GO:0007411 axon guidance Database 0.13
Category members GO Category GO:0045944 positive regulation of transcription from RNA polymerase II promoter Database 0.13
Category members GO Category GO:0022029 telencephalon cell migration Database 0.11
Category members Disease phenotype Papillary_or_follicular_thyroid_carcinoma Papillary or follicular thyroid carcinoma Database 0.09
Category members Pathway Pathway_39 PID_HNF3B_PATHWAY 0 0.08
Category members GO Category GO:0007492 endoderm development Database 0.06
Category members GO Category GO:0060430 lung saccule development Database 0.04
Category members GO Category GO:0048646 anatomical structure formation involved in morphogenesis Database 0.04
Category members GO Category GO:0000122 negative regulation of transcription from RNA polymerase II promoter Database 0.02
Category members GO Category GO:0048663 neuron fate commitment Database 0.02
Category members GO Category GO:0030512 negative regulation of transforming growth factor beta receptor signaling pathway Database 0.02
Category members GO Category GO:0009725 response to hormone Database 0.01
Category members GO Category GO:0044212 transcription regulatory region DNA binding Database 0
Category members Disease phenotype Athyreosis Athyreosis Database 0
Category members Disease phenotype Thyroid_hypoplasia Thyroid hypoplasia Database 0
Category members GO Category GO:0001764 neuron migration Database 0
Category members GO Category GO:0003705 RNA polymerase II distal enhancer sequence-specific DNA binding transcription factor activity Database 0
Category members GO Category GO:0006355 regulation of transcription, DNA-dependent Database 0
Category members GO Category GO:0006644 phospholipid metabolic process Database 0
Category members GO Category GO:0007420 brain development Database 0
Category members GO Category GO:0007626 locomotory behavior Database 0
Category members GO Category GO:0009887 organ morphogenesis Database 0
Category members GO Category GO:0010628 positive regulation of gene expression Database 0
Category members GO Category GO:0010719 negative regulation of epithelial to mesenchymal transition Database 0
Category members GO Category GO:0021537 telencephalon development Database 0
Category members GO Category GO:0021766 hippocampus development Database 0
Category members GO Category GO:0021795 cerebral cortex cell migration Database 0
Category members GO Category GO:0021798 forebrain dorsal/ventral pattern formation Database 0
Category members GO Category GO:0021877 forebrain neuron fate commitment Database 0
Category members GO Category GO:0021892 cerebral cortex GABAergic interneuron differentiation Database 0
Category members GO Category GO:0021895 cerebral cortex neuron differentiation Database 0
Category members GO Category GO:0021983 pituitary gland development Database 0
Category members GO Category GO:0030878 thyroid gland development Database 0
Category members GO Category GO:0030900 forebrain development Database 0
Category members GO Category GO:0033327 Leydig cell differentiation Database 0
Category members GO Category GO:0048709 oligodendrocyte differentiation Database 0
Category members GO Category GO:0060441 epithelial tube branching involved in lung morphogenesis Database 0
Category members GO Category GO:0060486 Clara cell differentiation Database 0
Category members GO Category GO:0060510 Type II pneumocyte differentiation Database 0


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