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bioLOGIC Data

Query: MSX2

RNAi screen result	RNAPII IP (PI)	CSB IP	CSB IP (PI)	Chrom.	Chrom. (PI)	Phosphorylation	Ubiquitylation
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[Click on the plots to view the data selection in the respective scatterplot]

Protein Results:
Results for post-translational modifications: see below | Red/green: hit at lower/upper end of the respective screen

Gene name	Point score	Z-score sums	RNAi high	RNAi low	RNAPII-IP (PI)	CSB-IP	CSB-IP (PI)	Chrom.	Chrom. (PI)
MSX2	1	2.808	-0.260	0.240

PTM Sites:
Back to Protein Results | Red/green: hit at lower/upper end of the respective screen

Gene name	PTM type	PTM site	UV	UV (PI)	Sequence
MSX2	Phosphorylation	S63		3.351	_EAS(ph)PLPAESASAGATLRPLLLSGHGAR_
MSX2	Phosphorylation	S123		-0.062	_SENSEDGAAWMQEPGRYS(ph)PPPR_
MSX2	Phosphorylation	S91	-0.783	-0.727	_EAHS(ph)PGPLVKPFETASVK_
MSX2	Phosphorylation	S3	-1.986	-1.774	_(ac)AS(ph)PSKGNDLFSPDEEGPAVVAGPGPGPGGAEGAAEER_
MSX2	Phosphorylation	S5	-1.986		_AS(ph)PS(ph)KGNDLFSPDEEGPAVVAGPGPGPGGAEGAAEER_

Background Information for MSX2:

Pubmed-MSX2 »

Uniprot-MSX2 »

Biogrid-MSX2 »

ProteomicsDB-MSX2 »

Tumorportal-MSX2 »

COSMIC-MSX2 »

GenomeRNAi-MSX2 »

Genecards-MSX2

Protein-protein Interactions for MSX2

Show screen data for	Category Name and Description	Link to cat description	Data Source
Category members	IP bait MSX2	Cat. description	BioPlex, Huttlin, Gygi, Cell 2015

Protein Domains in MSX2

	Domain name	Domain Description	TC-NER relevance -log10(p-value)
Category members	Homeobox_dom	IPR001356	0.63
Category members	Homeobox_metazoa	IPR020479	0.28
Category members	Homeodomain-like	IPR009057	0

Protein complexes (CORUM database) featuring MSX2

	Category Type	Category ID	Category Name	Data Source	TC-NER relevance -log10(p-value)

Categories featuring MSX2

	Category Type	Category ID	Category Name	Data Source	TC-NER relevance -log10(p-value)
Category members	GO Category	GO:0005515	protein binding	Database	INF
Category members	GO Category	GO:0005634	nucleus	Database	INF
Category members	GO Category	GO:0005737	cytoplasm	Database	12.81
Category members	GO Category	GO:0003677	DNA binding	Database	1.53
Category members	GO Category	GO:0045892	negative regulation of transcription, DNA-dependent	Database	1.15
Category members	GO Category	GO:0006366	transcription from RNA polymerase II promoter	Database	0.96
Category members	GO Category	GO:0042981	regulation of apoptotic process	Database	0.79
Category members	GO Category	GO:0003700	sequence-specific DNA binding transcription factor activity	Database	0.63
Category members	GO Category	GO:0043066	negative regulation of apoptotic process	Database	0.6
Category members	GO Category	GO:0008134	transcription factor binding	Database	0.37
Category members	GO Category	GO:0008285	negative regulation of cell proliferation	Database	0.28
Category members	GO Category	GO:0043065	positive regulation of apoptotic process	Database	0.26
Category members	GO Category	GO:0003712	transcription cofactor activity	Database	0.21
Category members	GO Category	GO:0030509	BMP signaling pathway	Database	0.2
Category members	GO Category	GO:0005667	transcription factor complex	Database	0.19
Category members	GO Category	GO:0043565	sequence-specific DNA binding	Database	0.18
Category members	GO Category	GO:0060349	bone morphogenesis	Database	0.17
Category members	GO Category	GO:0045599	negative regulation of fat cell differentiation	Database	0.13
Category members	Disease phenotype	PARIETAL_FORAMINA	PARIETAL FORAMINA	Database	0.13
Category members	GO Category	GO:0003148	outflow tract septum morphogenesis	Database	0.13
Category members	GO Category	GO:0002076	osteoblast development	Database	0.13
Category members	GO Category	GO:0042476	odontogenesis	Database	0.09
Category members	GO Category	GO:0023019	signal transduction involved in regulation of gene expression	Database	0.08
Category members	GO Category	GO:0009952	anterior/posterior pattern specification	Database	0.06
Category members	GO Category	GO:0030513	positive regulation of BMP signaling pathway	Database	0.05
Category members	GO Category	GO:0002063	chondrocyte development	Database	0.04
Category members	GO Category	GO:0000122	negative regulation of transcription from RNA polymerase II promoter	Database	0.02
Category members	GO Category	GO:0000989	transcription factor binding transcription factor activity	Database	0.01
Category members	GO Category	GO:0044212	transcription regulatory region DNA binding	Database	0
Category members	GO Category	GO:0000978	RNA polymerase II core promoter proximal region sequence-specific DNA binding	Database	0
Category members	GO Category	GO:0000982	RNA polymerase II core promoter proximal region sequence-specific DNA binding transcription factor activity	Database	0
Category members	GO Category	GO:0001503	ossification	Database	0
Category members	GO Category	GO:0001649	osteoblast differentiation	Database	0
Category members	GO Category	GO:0003151	outflow tract morphogenesis	Database	0
Category members	GO Category	GO:0003198	epithelial to mesenchymal transition involved in endocardial cushion formation	Database	0
Category members	GO Category	GO:0003416	endochondral bone growth	Database	0
Category members	GO Category	GO:0006355	regulation of transcription, DNA-dependent	Database	0
Category members	GO Category	GO:0030326	embryonic limb morphogenesis	Database	0
Category members	GO Category	GO:0032792	negative regulation of CREB transcription factor activity	Database	0
Category members	GO Category	GO:0035115	embryonic forelimb morphogenesis	Database	0
Category members	GO Category	GO:0035116	embryonic hindlimb morphogenesis	Database	0
Category members	GO Category	GO:0035313	wound healing, spreading of epidermal cells	Database	0
Category members	GO Category	GO:0035880	embryonic nail plate morphogenesis	Database	0
Category members	GO Category	GO:0042060	wound healing	Database	0
Category members	GO Category	GO:0042640	anagen	Database	0
Category members	GO Category	GO:0042733	embryonic digit morphogenesis	Database	0
Category members	GO Category	GO:0045617	negative regulation of keratinocyte differentiation	Database	0
Category members	GO Category	GO:0045669	positive regulation of osteoblast differentiation	Database	0
Category members	GO Category	GO:0048863	stem cell differentiation	Database	0
Category members	GO Category	GO:0051216	cartilage development	Database	0
Category members	GO Category	GO:0060346	bone trabecula formation	Database	0
Category members	GO Category	GO:0060363	cranial suture morphogenesis	Database	0
Category members	GO Category	GO:0060364	frontal suture morphogenesis	Database	0
Category members	GO Category	GO:0060444	branching involved in mammary gland duct morphogenesis	Database	0
Category members	GO Category	GO:0061180	mammary gland epithelium development	Database	0
Category members	GO Category	GO:0061312	BMP signaling pathway involved in heart development	Database	0
Category members	GO Category	GO:0070166	enamel mineralization	Database	0
Category members	GO Category	GO:0071363	cellular response to growth factor stimulus	Database	0
Category members	GO Category	GO:0071392	cellular response to estradiol stimulus	Database	0