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Query: LEF1

RNAi screen result RNAPII IP (PI) CSB IP CSB IP (PI) Chrom. Chrom. (PI) Phosphorylation Ubiquitylation
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[Click on the plots to view the data selection in the respective scatterplot]

Protein Results:

 Results for post-translational modifications: see below | Red/green: hit at lower/upper end of the respective screen
Gene name Point score Z-score sums RNAi high RNAi low RNAPII-IP (PI) CSB-IP CSB-IP (PI) Chrom. Chrom. (PI)
LEF1 0 -1.040 -0.710 0.790 -0.741

PTM Sites:

 Back to Protein Results | Red/green: hit at lower/upper end of the respective screen
Gene name PTM type PTM site UV UV (PI) Sequence
LEF1 Ubiquitylation K88 -0.867 -0.222 _ESLEEAAK(gl)R_

Background Information for LEF1:


Pubmed-LEF1 »
Uniprot-LEF1 »
Biogrid-LEF1 »
ProteomicsDB-LEF1 »

Tumorportal-LEF1 »
COSMIC-LEF1 »
GenomeRNAi-LEF1 »
Genecards-LEF1


Protein-protein Interactions for LEF1
Show screen data for Category Name and Description Link to cat description Data Source
Category members IP bait LEF1 Cat. description BioPlex, Huttlin, Gygi, Cell 2015


Protein Domains in LEF1
Domain name Domain Description TC-NER relevance -log10(p-value)
Category members HMG_box_dom IPR009071 0.31
Category members CTNNB1-bd_N IPR013558 0


Protein complexes (CORUM database) featuring LEF1
Category Type Category ID Category Name Data Source TC-NER relevance -log10(p-value)


Categories featuring LEF1
Category Type Category ID Category Name Data Source TC-NER relevance -log10(p-value)
Category members GO Category GO:0005515 protein binding Database INF
Category members GO Category GO:0005634 nucleus Database INF
Category members GO Category GO:0005737 cytoplasm Database 12.81
Category members GO Category GO:0003682 chromatin binding Database 6.07
Category members GO Category GO:0003677 DNA binding Database 1.53
Category members GO Category GO:0045892 negative regulation of transcription, DNA-dependent Database 1.15
Category members Pathway Pathway_634 KEGG_COLORECTAL_CANCER 0 0.98
Category members GO Category GO:0006366 transcription from RNA polymerase II promoter Database 0.96
Category members GO Category GO:0042393 histone binding Database 0.94
Category members GO Category GO:0003700 sequence-specific DNA binding transcription factor activity Database 0.63
Category members Pathway Pathway_628 BIOCARTA_GSK3_PATHWAY 0 0.6
Category members GO Category GO:0043066 negative regulation of apoptotic process Database 0.6
Category members Pathway Pathway_199 PID_BETA_CATENIN_NUC_PATHWAY 0 0.53
Category members Pathway Pathway_747 KEGG_ADHERENS_JUNCTION 0 0.43
Category members GO Category GO:0008134 transcription factor binding Database 0.37
Category members GO Category GO:0008013 beta-catenin binding Database 0.35
Category members Pathway Pathway_1176 BIOCARTA_PITX2_PATHWAY 0 0.29
Category members GO Category GO:0045893 positive regulation of transcription, DNA-dependent Database 0.28
Category members GO Category GO:0001228 RNA polymerase II transcription regulatory region sequence-specific DNA binding transcription factor activity involved in positive regulation of transcription Database 0.27
Category members GO Category GO:0043923 positive regulation by host of viral transcription Database 0.27
Category members GO Category GO:0001944 vasculature development Database 0.24
Category members GO Category GO:0032713 negative regulation of interleukin-4 production Database 0.23
Category members GO Category GO:0032714 negative regulation of interleukin-5 production Database 0.23
Category members GO Category GO:0045063 T-helper 1 cell differentiation Database 0.23
Category members GO Category GO:0045295 gamma-catenin binding Database 0.23
Category members GO Category GO:0060021 palate development Database 0.23
Category members GO Category GO:0000977 RNA polymerase II regulatory region sequence-specific DNA binding Database 0.21
Category members Pathway Pathway_533 KEGG_ENDOMETRIAL_CANCER 0 0.21
Category members Pathway Pathway_210 PID_CMYB_PATHWAY 0 0.2
Category members GO Category GO:0030509 BMP signaling pathway Database 0.2
Category members GO Category GO:0005667 transcription factor complex Database 0.19
Category members GO Category GO:0071353 cellular response to interleukin-4 Database 0.19
Category members GO Category GO:0006357 regulation of transcription from RNA polymerase II promoter Database 0.19
Category members GO Category GO:0021879 forebrain neuron differentiation Database 0.19
Category members GO Category GO:0043565 sequence-specific DNA binding Database 0.18
Category members Pathway Pathway_177 KEGG_PROSTATE_CANCER 0 0.13
Category members GO Category GO:0010718 positive regulation of epithelial to mesenchymal transition Database 0.13
Category members GO Category GO:0045944 positive regulation of transcription from RNA polymerase II promoter Database 0.13
Category members GO Category GO:0002040 sprouting angiogenesis Database 0.12
Category members GO Category GO:0016055 Wnt signaling pathway Database 0.11
Category members GO Category GO:0021861 forebrain radial glial cell differentiation Database 0.1
Category members Pathway Pathway_679 KEGG_WNT_SIGNALING_PATHWAY 0 0.09
Category members Pathway Pathway_941 BIOCARTA_WNT_PATHWAY 0 0.08
Category members GO Category GO:0030111 regulation of Wnt signaling pathway Database 0.08
Category members GO Category GO:0042100 B cell proliferation Database 0.08
Category members GO Category GO:0021542 dentate gyrus development Database 0.06
Category members GO Category GO:0043027 cysteine-type endopeptidase inhibitor activity involved in apoptotic process Database 0.05
Category members GO Category GO:0032696 negative regulation of interleukin-13 production Database 0.04
Category members GO Category GO:0030854 positive regulation of granulocyte differentiation Database 0.04
Category members Pathway Pathway_1007 KEGG_ARRHYTHMOGENIC_RIGHT_VENTRICULAR_CARDIOMYOPATHY_ARVC 0 0.03
Category members GO Category GO:0000122 negative regulation of transcription from RNA polymerase II promoter Database 0.02
Category members GO Category GO:0043392 negative regulation of DNA binding Database 0.01
Category members GO Category GO:0044212 transcription regulatory region DNA binding Database 0
Category members Pathway Pathway_1163 KEGG_BASAL_CELL_CARCINOMA 0 0
Category members Pathway Pathway_24 KEGG_PATHWAYS_IN_CANCER 0 0
Category members Pathway Pathway_244 KEGG_MELANOGENESIS 0 0
Category members Pathway Pathway_290 WNT_SIGNALING 0 0
Category members Pathway Pathway_606 KEGG_ACUTE_MYELOID_LEUKEMIA 0 0
Category members Pathway Pathway_944 KEGG_THYROID_CANCER 0 0
Category members GO Category GO:0001569 patterning of blood vessels Database 0
Category members GO Category GO:0001649 osteoblast differentiation Database 0
Category members GO Category GO:0001755 neural crest cell migration Database 0
Category members GO Category GO:0001756 somitogenesis Database 0
Category members GO Category GO:0001837 epithelial to mesenchymal transition Database 0
Category members GO Category GO:0003705 RNA polymerase II distal enhancer sequence-specific DNA binding transcription factor activity Database 0
Category members GO Category GO:0008284 positive regulation of cell proliferation Database 0
Category members GO Category GO:0008301 DNA binding, bending Database 0
Category members GO Category GO:0010628 positive regulation of gene expression Database 0
Category members GO Category GO:0016202 regulation of striated muscle tissue development Database 0
Category members GO Category GO:0021766 hippocampus development Database 0
Category members GO Category GO:0021854 hypothalamus development Database 0
Category members GO Category GO:0021873 forebrain neuroblast division Database 0
Category members GO Category GO:0021943 formation of radial glial scaffolds Database 0
Category members GO Category GO:0022407 regulation of cell-cell adhesion Database 0
Category members GO Category GO:0022408 negative regulation of cell-cell adhesion Database 0
Category members GO Category GO:0022409 positive regulation of cell-cell adhesion Database 0
Category members GO Category GO:0030223 neutrophil differentiation Database 0
Category members GO Category GO:0030284 estrogen receptor activity Database 0
Category members GO Category GO:0030307 positive regulation of cell growth Database 0
Category members GO Category GO:0030326 embryonic limb morphogenesis Database 0
Category members GO Category GO:0030331 estrogen receptor binding Database 0
Category members GO Category GO:0030335 positive regulation of cell migration Database 0
Category members GO Category GO:0030879 mammary gland development Database 0
Category members GO Category GO:0032993 protein-DNA complex Database 0
Category members GO Category GO:0033153 T cell receptor V(D)J recombination Database 0
Category members GO Category GO:0035326 enhancer binding Database 0
Category members GO Category GO:0042475 odontogenesis of dentin-containing tooth Database 0
Category members GO Category GO:0043154 negative regulation of cysteine-type endopeptidase activity involved in apoptotic process Database 0
Category members GO Category GO:0043586 tongue development Database 0
Category members GO Category GO:0043966 histone H3 acetylation Database 0
Category members GO Category GO:0043967 histone H4 acetylation Database 0
Category members GO Category GO:0045843 negative regulation of striated muscle tissue development Database 0
Category members GO Category GO:0046632 alpha-beta T cell differentiation Database 0
Category members GO Category GO:0048069 eye pigmentation Database 0
Category members GO Category GO:0048341 paraxial mesoderm formation Database 0
Category members GO Category GO:0048468 cell development Database 0
Category members GO Category GO:0048747 muscle fiber development Database 0
Category members GO Category GO:0050909 sensory perception of taste Database 0
Category members GO Category GO:0060033 anatomical structure regression Database 0
Category members GO Category GO:0060070 canonical Wnt signaling pathway Database 0
Category members GO Category GO:0060325 face morphogenesis Database 0
Category members GO Category GO:0060326 cell chemotaxis Database 0
Category members GO Category GO:0060561 apoptotic process involved in morphogenesis Database 0
Category members GO Category GO:0060710 chorio-allantoic fusion Database 0
Category members GO Category GO:0061153 trachea gland development Database 0
Category members GO Category GO:0070016 armadillo repeat domain binding Database 0
Category members GO Category GO:0070742 C2H2 zinc finger domain binding Database 0
Category members GO Category GO:0071345 cellular response to cytokine stimulus Database 0


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