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Query: HLA-A

This is a cancer-associated gene according to the Broad cancer gene census.

RNAi screen result RNAPII IP (PI) CSB IP CSB IP (PI) Chrom. Chrom. (PI) Phosphorylation Ubiquitylation
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[Click on the plots to view the data selection in the respective scatterplot]

Protein Results:

 Results for post-translational modifications: see below | Red/green: hit at lower/upper end of the respective screen
Gene name Point score Z-score sums RNAi high RNAi low RNAPII-IP (PI) CSB-IP CSB-IP (PI) Chrom. Chrom. (PI)
HLA-A 0 2.043 0.790 -0.840
HLA-A 0 2.043 0.790 -0.840 -0.626
HLA-A 0 2.043 0.790 -0.840 1.149

PTM Sites:

 Back to Protein Results | Red/green: hit at lower/upper end of the respective screen
Gene name PTM type PTM site UV UV (PI) Sequence
HLA-A Ubiquitylation K168 0.549 _SWTAADMAAQITK(gl)R_
HLA-A Ubiquitylation K370 0.345 0.434 _K(gl)GGSYTQAASSDSAQGSDVSLTACK(gl)V_
HLA-A Ubiquitylation K346 -0.072 -0.211 _K(gl)GGSYTQAASSDSAQGSDVSLTACK(gl)V_
HLA-A Ubiquitylation K92 -0.349 _NVK(gl)AQSQTDRVDLGTLR_

Background Information for HLA-A:


Pubmed-HLA-A »
Uniprot-HLA-A »
Biogrid-HLA-A »
ProteomicsDB-HLA-A »

Tumorportal-HLA-A »
COSMIC-HLA-A »
GenomeRNAi-HLA-A »
Genecards-HLA-A


Protein-protein Interactions for HLA-A
Show screen data for Category Name and Description Link to cat description Data Source
Category members IP bait ADAM33 Cat. description BioPlex, Huttlin, Gygi, Cell 2015
Category members IP bait CARKD Cat. description BioPlex, Huttlin, Gygi, Cell 2015
Category members IP bait CD1B Cat. description BioPlex, Huttlin, Gygi, Cell 2015
Category members IP bait HLA-B Cat. description BioPlex, Huttlin, Gygi, Cell 2015
Category members IP bait HLA-C Cat. description BioPlex, Huttlin, Gygi, Cell 2015
Category members IP bait HLA-DPA1 Cat. description BioPlex, Huttlin, Gygi, Cell 2015
Category members IP bait HLA-G Cat. description BioPlex, Huttlin, Gygi, Cell 2015
Category members IP bait PTCH1 Cat. description BioPlex, Huttlin, Gygi, Cell 2015
Category members IP bait SLC39A5 Cat. description BioPlex, Huttlin, Gygi, Cell 2015
Category members IP bait TCTN2 Cat. description BioPlex, Huttlin, Gygi, Cell 2015
Category members IP bait TMPRSS11B Cat. description BioPlex, Huttlin, Gygi, Cell 2015
Category members IP bait TMPRSS3 Cat. description BioPlex, Huttlin, Gygi, Cell 2015


Protein Domains in HLA-A
Domain name Domain Description TC-NER relevance -log10(p-value)
Category members Ig-like_dom IPR007110 0.6
Category members MHC_I/II-like_Ag-recog IPR011162 0.02
Category members MHC_I_a_a1/a2 IPR001039 0
Category members Ig_C1-set IPR003597 0
Category members MHC_I_a_C IPR010579 0
Category members MHC_I_a IPR027648 0


Protein complexes (CORUM database) featuring HLA-A
Category Type Category ID Category Name Data Source TC-NER relevance -log10(p-value)


Categories featuring HLA-A
Category Type Category ID Category Name Data Source TC-NER relevance -log10(p-value)
Category members GO Category GO:0005515 protein binding Database INF
Category members Pathway Pathway_197 REACTOME_HIV_INFECTION 0 12.07
Category members Pathway Pathway_196 REACTOME_HOST_INTERACTIONS_OF_HIV_FACTORS 0 9.67
Category members GO Category GO:0019048 modulation by virus of host morphology or physiology Database 7.81
Category members GO Category GO:0016021 integral to membrane Database 7.67
Category members Pathway Pathway_621 REACTOME_ADAPTIVE_IMMUNE_SYSTEM 0 4.72
Category members Pathway Pathway_458 REACTOME_IMMUNE_SYSTEM 0 3
Category members Pathway Pathway_765 REACTOME_ER_PHAGOSOME_PATHWAY 0 2.74
Category members Pathway Pathway_764 REACTOME_CLASS_I_MHC_MEDIATED_ANTIGEN_PROCESSING_PRESENTATION 0 2.56
Category members GO Category GO:0002474 antigen processing and presentation of peptide antigen via MHC class I Database 2.5
Category members GO Category GO:0002479 antigen processing and presentation of exogenous peptide antigen via MHC class I, TAP-dependent Database 2.46
Category members Pathway Pathway_763 REACTOME_ANTIGEN_PROCESSING_CROSS_PRESENTATION 0 2.24
Category members GO Category GO:0042590 antigen processing and presentation of exogenous peptide antigen via MHC class I Database 2.21
Category members Pathway Pathway_666 KEGG_ENDOCYTOSIS 0 1.25
Category members GO Category GO:0006955 immune response Database 1.22
Category members GO Category GO:0005886 plasma membrane Database 1.21
Category members Human mutations Broad_cancer_genes Broad cancer genes (Lawrence et al., 2014) literature 1.14
Category members Pathway Pathway_195 REACTOME_NEF_MEDIATES_DOWN_MODULATION_OF_CELL_SURFACE_RECEPTORS_BY_RECRUITING_THEM_TO_CLATHRIN_ADAPTERS 0 1.08
Category members Pathway Pathway_699 REACTOME_INTERFERON_SIGNALING 0 0.86
Category members Pathway Pathway_194 REACTOME_THE_ROLE_OF_NEF_IN_HIV1_REPLICATION_AND_DISEASE_PATHOGENESIS 0 0.83
Category members GO Category GO:0031901 early endosome membrane Database 0.58
Category members GO Category GO:0016020 membrane Database 0.52
Category members Pathway Pathway_766 REACTOME_ANTIGEN_PRESENTATION_FOLDING_ASSEMBLY_AND_PEPTIDE_LOADING_OF_CLASS_I_MHC 0 0.47
Category members GO Category GO:0019221 cytokine-mediated signaling pathway Database 0.44
Category members GO Category GO:0030670 phagocytic vesicle membrane Database 0.37
Category members Pathway Pathway_1266 REACTOME_NEF_MEDIATED_DOWNREGULATION_OF_MHC_CLASS_I_COMPLEX_CELL_SURFACE_EXPRESSION 0 0.36
Category members Pathway Pathway_505 REACTOME_CYTOKINE_SIGNALING_IN_IMMUNE_SYSTEM 0 0.33
Category members Disease phenotype SEVERE_CUTANEOUS_ADVERSE_REACTION_SUSCEPTIBILITY_TO SEVERE CUTANEOUS ADVERSE REACTION SUSCEPTIBILITY TO Database 0.17
Category members Pathway Pathway_705 PID_CD8_TCR_PATHWAY 0 0.17
Category members Pathway Pathway_894 KEGG_GRAFT_VERSUS_HOST_DISEASE 0 0.12
Category members Pathway Pathway_767 KEGG_ANTIGEN_PROCESSING_AND_PRESENTATION 0 0.09
Category members Pathway Pathway_647 BIOCARTA_NKCELLS_PATHWAY 0 0.06
Category members GO Category GO:0019882 antigen processing and presentation Database 0.03
Category members Pathway Pathway_1270 REACTOME_ENDOSOMAL_VACUOLAR_PATHWAY 0 0.03
Category members GO Category GO:0002480 antigen processing and presentation of exogenous peptide antigen via MHC class I, TAP-independent Database 0.03
Category members Pathway Pathway_446 KEGG_AUTOIMMUNE_THYROID_DISEASE 0 0
Category members Pathway Pathway_1014 KEGG_VIRAL_MYOCARDITIS 0 0
Category members Pathway Pathway_1080 BIOCARTA_CTL_PATHWAY 0 0
Category members Pathway Pathway_1217 KEGG_CELL_ADHESION_MOLECULES_CAMS 0 0
Category members Pathway Pathway_1218 REACTOME_IMMUNOREGULATORY_INTERACTIONS_BETWEEN_A_LYMPHOID_AND_A_NON_LYMPHOID_CELL 0 0
Category members Pathway Pathway_395 KEGG_TYPE_I_DIABETES_MELLITUS 0 0
Category members Pathway Pathway_423 PID_IL12_2PATHWAY 0 0
Category members Pathway Pathway_443 PID_AP1_PATHWAY 0 0
Category members Pathway Pathway_646 KEGG_NATURAL_KILLER_CELL_MEDIATED_CYTOTOXICITY 0 0
Category members Pathway Pathway_897 PID_CD8_TCR_DOWNSTREAM_PATHWAY 0 0
Category members Pathway Pathway_898 REACTOME_INTERFERON_GAMMA_SIGNALING 0 0
Category members Pathway Pathway_905 KEGG_ALLOGRAFT_REJECTION 0 0
Category members Pathway Pathway_913 REACTOME_INTERFERON_ALPHA_BETA_SIGNALING 0 0
Category members GO Category GO:0000139 Golgi membrane Database 0
Category members GO Category GO:0001916 positive regulation of T cell mediated cytotoxicity Database 0
Category members GO Category GO:0005102 receptor binding Database 0
Category members GO Category GO:0012507 ER to Golgi transport vesicle membrane Database 0
Category members GO Category GO:0042605 peptide antigen binding Database 0
Category members GO Category GO:0042612 MHC class I protein complex Database 0
Category members GO Category GO:0050776 regulation of immune response Database 0
Category members GO Category GO:0060333 interferon-gamma-mediated signaling pathway Database 0
Category members GO Category GO:0060337 type I interferon signaling pathway Database 0


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