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Query: DNMT1

RNAi screen result RNAPII IP (PI) CSB IP CSB IP (PI) Chrom. Chrom. (PI) Phosphorylation Ubiquitylation
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[Click on the plots to view the data selection in the respective scatterplot]

Protein Results:

 Results for post-translational modifications: see below | Red/green: hit at lower/upper end of the respective screen
Gene name Point score Z-score sums RNAi high RNAi low RNAPII-IP (PI) CSB-IP CSB-IP (PI) Chrom. Chrom. (PI)
DNMT1 2 6.775 0.150 -0.150 0.077 -0.109 -1.422 0.572
DNMT1 2 6.775 0.150 -0.150 0.134 -0.347 -0.054

PTM Sites:

 Back to Protein Results | Red/green: hit at lower/upper end of the respective screen
Gene name PTM type PTM site UV UV (PI) Sequence
DNMT1 Ubiquitylation K586 1.686 3.368 _DLIK(gl)LAGVTLGQR_
DNMT1 Ubiquitylation K675 1.267 0.915 _DMVK(gl)FGGSGR_
DNMT1 Phosphorylation S143 0.877 0.220 _SKS(ph)DGEAKPEPSPSPR_
DNMT1 Ubiquitylation K997 0.042 0.154 _IK(gl)EIFCPK_
DNMT1 Phosphorylation S954 -0.318 0.057 _LSS(ph)PVKRPR_
DNMT1 Ubiquitylation K1483 1.983 -0.103 _GVCSCVEAGK(gl)ACDPAAR_
DNMT1 Phosphorylation S714 -0.773 -0.554 _EADDDEEVDDNIPEMPS(ph)PKK_
DNMT1 Phosphorylation S127 -0.755 -0.836 _VGM(ox)ADANS(ph)PPKPLSKPR_
DNMT1 Phosphorylation S154 -1.926 -0.876 _SDGEAKPEPSPS(ph)PR_
DNMT1 Phosphorylation S152 -0.685 -1.347 _SDGEAKPEPS(ph)PSPR_
DNMT1 Ubiquitylation K981 -0.298 -1.482 _YSDYIK(gl)GSNLDAPEPYR_
DNMT1 Ubiquitylation K961 -3.166 _K(gl)EPVDEDLYPEHYR_

Background Information for DNMT1:


Pubmed-DNMT1 »
Uniprot-DNMT1 »
Biogrid-DNMT1 »
ProteomicsDB-DNMT1 »

Tumorportal-DNMT1 »
COSMIC-DNMT1 »
GenomeRNAi-DNMT1 »
Genecards-DNMT1


Protein-protein Interactions for DNMT1
Show screen data for Category Name and Description Link to cat description Data Source
Category members IP bait CDK2 Cat. description Hein, Mann, Cell 2015
Category members IP bait DCTN3 Cat. description Hein, Mann, Cell 2015
Category members IP bait MYH14 Cat. description Hein, Mann, Cell 2015
Category members IP bait MYL12A;MYL12B Cat. description Hein, Mann, Cell 2015
Category members IP bait PCNA Cat. description Hein, Mann, Cell 2015
Category members IP bait USP7 Cat. description Hein, Mann, Cell 2015


Protein Domains in DNMT1
Domain name Domain Description TC-NER relevance -log10(p-value)
Category members BAH_dom IPR001025 0.62
Category members C5_MeTfrase IPR001525 0.23
Category members SAM-dependent_MTases-like IPR029063 0.04
Category members Znf_CXXC IPR002857 0
Category members DMAP1-bd IPR010506 0


Protein complexes (CORUM database) featuring DNMT1
Category Type Category ID Category Name Data Source TC-NER relevance -log10(p-value)
Category members Corum 5695 TIP5-DNMT-HDAC1 complex Database 0.98
Category members Corum 860 DNMT1-G9a-PCNA complex Database 0.82
Category members Corum 862 DNMT1-G9a complex Database 0.33
Category members Corum 1470 pRb2/p130-multimolecular complex (DNMT1, E2F5, SuV39H1, HDAC1, RBL2) Database 0.23
Category members Corum 5117 pRb2/p130-multimolecular complex (DNMT1, E2F4, SuV39H1, HDAC1, RBL2) Database 0.23
Category members Corum 1488 DNMT1-RB1-HDAC1-E2F1 complex Database 0.2
Category members Corum 1491 RGS6-DNMT1-DMAP1 complex Database 0.06
Category members Corum 1490 DAXX-DNMT1-DMAP1 complex Database 0.04


Categories featuring DNMT1
Category Type Category ID Category Name Data Source TC-NER relevance -log10(p-value)
Category members GO Category GO:0003723 RNA binding Database INF
Category members GO Category GO:0005515 protein binding Database INF
Category members GO Category GO:0005634 nucleus Database INF
Category members DDR Literature pubmedid:TBD2_UV_increased Elia et al, 2015 UV increased acetylation events Elia et al. INF
Category members GO Category GO:0003682 chromatin binding Database 6.07
Category members GO Category GO:0000792 heterochromatin Database 5.45
Category members GO Category GO:0003677 DNA binding Database 1.53
Category members GO Category GO:0045892 negative regulation of transcription, DNA-dependent Database 1.15
Category members GO Category GO:0006351 transcription, DNA-templated Database 1.07
Category members GO Category GO:0051571 positive regulation of histone H3-K4 methylation Database 0.99
Category members GO Category GO:0005657 replication fork Database 0.95
Category members GO Category GO:0051573 negative regulation of histone H3-K9 methylation Database 0.84
Category members GO Category GO:0008327 methyl-CpG binding Database 0.52
Category members GO Category GO:0008134 transcription factor binding Database 0.37
Category members GO Category GO:0009008 DNA-methyltransferase activity Database 0.32
Category members GO Category GO:0005721 centromeric heterochromatin Database 0.3
Category members GO Category GO:0008270 zinc ion binding Database 0.29
Category members GO Category GO:0003886 DNA (cytosine-5-)-methyltransferase activity Database 0.23
Category members GO Category GO:0006306 DNA methylation Database 0.22
Category members Pathway Pathway_406 PID_RB_1PATHWAY 0 0.21
Category members GO Category GO:0016568 chromatin modification Database 0.18
Category members GO Category GO:0042127 regulation of cell proliferation Database 0.06
Category members Pathway Pathway_400 KEGG_CYSTEINE_AND_METHIONINE_METABOLISM 0 0.04
Category members GO Category GO:0016458 gene silencing Database 0.03
Category members GO Category GO:0000122 negative regulation of transcription from RNA polymerase II promoter Database 0.02
Category members GO Category GO:0008168 methyltransferase activity Database 0
Category members GO Category GO:0010216 maintenance of DNA methylation Database 0
Category members GO Category GO:0010468 regulation of gene expression Database 0
Category members GO Category GO:0010628 positive regulation of gene expression Database 0
Category members GO Category GO:0071230 cellular response to amino acid stimulus Database 0


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