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Query: DLG1

RNAi screen result RNAPII IP (PI) CSB IP CSB IP (PI) Chrom. Chrom. (PI) Phosphorylation Ubiquitylation
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[Click on the plots to view the data selection in the respective scatterplot]

Protein Results:

 Results for post-translational modifications: see below | Red/green: hit at lower/upper end of the respective screen
Gene name Point score Z-score sums RNAi high RNAi low RNAPII-IP (PI) CSB-IP CSB-IP (PI) Chrom. Chrom. (PI)
DLG1 1 6.310 0.400 -0.220 1.552 0.102 0.488

PTM Sites:

 Back to Protein Results | Red/green: hit at lower/upper end of the respective screen
Gene name PTM type PTM site UV UV (PI) Sequence
DLG1 Ubiquitylation K321 1.264 1.435 _IMEIK(gl)LIK_
DLG1 Phosphorylation S158 0.773 _NLSEIENVHGFVSHSHIS(ph)PIK_
DLG1 Phosphorylation S575 0.255 0.729 _EQMMNSSISSGSGS(ph)LR_
DLG1 Phosphorylation S122 -1.073 _YQDEDTPPQEHIS(ph)PQITNEVIGPELVHVSEK_
DLG1 Phosphorylation T115 -0.707 -1.378 _YQDEDT(ph)PPQEHISPQITNEVIGPELVHVSEK_
DLG1 Phosphorylation S102 -1.455 _SKPSEPIQPVNTWEISSLPSSTVTSETLPSSLS(ph)PSVEK_
DLG1 Ubiquitylation K361 0.180 _IIEGGAAHK(gl)DGK_
DLG1 Ubiquitylation K452 -0.704 _YSPVSK(gl)AVLGDDEITREPR_
DLG1 Ubiquitylation K556 0.105 _FEAK(gl)IHDLR_
DLG1 Phosphorylation S573 0.697 _EQM(ox)M(ox)NSSISSGS(ph)GSLR_
DLG1 Ubiquitylation K843 1.259 _SMENIMEMNK(gl)R_

Background Information for DLG1:


Pubmed-DLG1 »
Uniprot-DLG1 »
Biogrid-DLG1 »
ProteomicsDB-DLG1 »

Tumorportal-DLG1 »
COSMIC-DLG1 »
GenomeRNAi-DLG1 »
Genecards-DLG1


Protein-protein Interactions for DLG1
Show screen data for Category Name and Description Link to cat description Data Source
Category members IP bait DLG3 Cat. description Hein, Mann, Cell 2015
Category members IP bait KIF26B Cat. description Hein, Mann, Cell 2015
Category members IP bait LIN7C Cat. description Hein, Mann, Cell 2015
Category members IP bait EFNB3 Cat. description BioPlex, Huttlin, Gygi, Cell 2015
Category members IP bait GJB7 Cat. description BioPlex, Huttlin, Gygi, Cell 2015
Category members IP bait GPRC5B Cat. description BioPlex, Huttlin, Gygi, Cell 2015
Category members IP bait LIN7C Cat. description BioPlex, Huttlin, Gygi, Cell 2015
Category members IP bait MPP2 Cat. description BioPlex, Huttlin, Gygi, Cell 2015
Category members IP bait PRDM1 Cat. description BioPlex, Huttlin, Gygi, Cell 2015


Protein Domains in DLG1
Domain name Domain Description TC-NER relevance -log10(p-value)
Category members P-loop_NTPase IPR027417 2.83
Category members L27 IPR004172 1.84
Category members GK/Ca_channel_bsu IPR008145 1.36
Category members Guanylate_kin-like IPR008144 1.32
Category members DLG1 IPR016313 0.2
Category members PDZ_assoc IPR019583 0.2
Category members MAGUK_PEST_N IPR019590 0.2
Category members PDZ IPR001478 0.15
Category members L27_1 IPR015143 0.12
Category members SH3_2 IPR011511 0.08
Category members SH3_domain IPR001452 0


Protein complexes (CORUM database) featuring DLG1
Category Type Category ID Category Name Data Source TC-NER relevance -log10(p-value)
Category members Corum 3207 LIN2-LIN7-SAP97-MINT1 complex Database 0
Category members Corum 4869 beta(1)-AR receptosome (ADRB1-SAP97-AKAP79-PRKAR2A) Database 0


Categories featuring DLG1
Category Type Category ID Category Name Data Source TC-NER relevance -log10(p-value)
Category members GO Category GO:0005515 protein binding Database INF
Category members GO Category GO:0005634 nucleus Database INF
Category members GO Category GO:0005829 cytosol Database INF
Category members GO Category GO:0005737 cytoplasm Database 12.81
Category members GO Category GO:0019048 modulation by virus of host morphology or physiology Database 7.81
Category members Pathway Pathway_292 PID_ECADHERIN_NASCENT_AJ_PATHWAY 0 2.74
Category members GO Category GO:0004385 guanylate kinase activity Database 1.77
Category members GO Category GO:0005789 endoplasmic reticulum membrane Database 1.57
Category members GO Category GO:0008022 protein C-terminus binding Database 1.43
Category members GO Category GO:0005911 cell-cell junction Database 1.4
Category members Pathway Pathway_1075 REACTOME_L1CAM_INTERACTIONS 0 1.32
Category members GO Category GO:0005874 microtubule Database 1.21
Category members GO Category GO:0005886 plasma membrane Database 1.21
Category members GO Category GO:0007163 establishment or maintenance of cell polarity Database 1.08
Category members Pathway Pathway_673 REACTOME_AXON_GUIDANCE 0 1.06
Category members GO Category GO:0030866 cortical actin cytoskeleton organization Database 0.89
Category members GO Category GO:0032947 protein complex scaffold Database 0.82
Category members GO Category GO:0005923 tight junction Database 0.69
Category members Pathway Pathway_568 PID_CDC42_PATHWAY 0 0.68
Category members GO Category GO:0014704 intercalated disc Database 0.64
Category members GO Category GO:0005783 endoplasmic reticulum Database 0.62
Category members GO Category GO:0031253 cell projection membrane Database 0.6
Category members GO Category GO:0008104 protein localization Database 0.5
Category members GO Category GO:0008092 cytoskeletal protein binding Database 0.5
Category members GO Category GO:0043268 positive regulation of potassium ion transport Database 0.44
Category members GO Category GO:0016328 lateral plasma membrane Database 0.41
Category members GO Category GO:0048471 perinuclear region of cytoplasm Database 0.39
Category members GO Category GO:0019901 protein kinase binding Database 0.37
Category members GO Category GO:0042383 sarcolemma Database 0.36
Category members GO Category GO:0070830 tight junction assembly Database 0.36
Category members Pathway Pathway_42 REACTOME_DEVELOPMENTAL_BIOLOGY 0 0.32
Category members GO Category GO:0005794 Golgi apparatus Database 0.27
Category members GO Category GO:0007093 mitotic cell cycle checkpoint Database 0.27
Category members Pathway Pathway_587 KEGG_T_CELL_RECEPTOR_SIGNALING_PATHWAY 0 0.25
Category members GO Category GO:0007268 synaptic transmission Database 0.23
Category members GO Category GO:0030838 positive regulation of actin filament polymerization Database 0.21
Category members GO Category GO:0050680 negative regulation of epithelial cell proliferation Database 0.19
Category members Pathway Pathway_1011 REACTOME_TRAFFICKING_OF_AMPA_RECEPTORS 0 0.18
Category members GO Category GO:0031579 membrane raft organization Database 0.17
Category members GO Category GO:0019902 phosphatase binding Database 0.16
Category members GO Category GO:0007411 axon guidance Database 0.13
Category members GO Category GO:0001771 immunological synapse formation Database 0.11
Category members GO Category GO:0045121 membrane raft Database 0.11
Category members GO Category GO:0004721 phosphoprotein phosphatase activity Database 0.11
Category members GO Category GO:0007015 actin filament organization Database 0.08
Category members GO Category GO:0035748 myelin sheath abaxonal region Database 0.06
Category members GO Category GO:0045211 postsynaptic membrane Database 0.06
Category members GO Category GO:0045202 synapse Database 0.06
Category members GO Category GO:0042982 amyloid precursor protein metabolic process Database 0.04
Category members GO Category GO:0016323 basolateral plasma membrane Database 0.04
Category members GO Category GO:0044325 ion channel binding Database 0.03
Category members GO Category GO:0042110 T cell activation Database 0.02
Category members GO Category GO:0045930 negative regulation of mitotic cell cycle Database 0.01
Category members GO Category GO:0042391 regulation of membrane potential Database 0
Category members GO Category GO:0048704 embryonic skeletal system morphogenesis Database 0
Category members Pathway Pathway_1190 REACTOME_IONOTROPIC_ACTIVITY_OF_KAINATE_RECEPTORS 0 0
Category members Pathway Pathway_139 REACTOME_NEURONAL_SYSTEM 0 0
Category members Pathway Pathway_140 REACTOME_TRANSMISSION_ACROSS_CHEMICAL_SYNAPSES 0 0
Category members Pathway Pathway_230 REACTOME_NEUROTRANSMITTER_RECEPTOR_BINDING_AND_DOWNSTREAM_TRANSMISSION_IN_THE_POSTSYNAPTIC_CELL 0 0
Category members Pathway Pathway_678 REACTOME_ACTIVATION_OF_KAINATE_RECEPTORS_UPON_GLUTAMATE_BINDING 0 0
Category members GO Category GO:0001657 ureteric bud development Database 0
Category members GO Category GO:0001658 branching involved in ureteric bud morphogenesis Database 0
Category members GO Category GO:0001772 immunological synapse Database 0
Category members GO Category GO:0001935 endothelial cell proliferation Database 0
Category members GO Category GO:0002088 lens development in camera-type eye Database 0
Category members GO Category GO:0002369 T cell cytokine production Database 0
Category members GO Category GO:0008284 positive regulation of cell proliferation Database 0
Category members GO Category GO:0009898 cytoplasmic side of plasma membrane Database 0
Category members GO Category GO:0014069 postsynaptic density Database 0
Category members GO Category GO:0015459 potassium channel regulator activity Database 0
Category members GO Category GO:0016337 cell-cell adhesion Database 0
Category members GO Category GO:0030054 cell junction Database 0
Category members GO Category GO:0030432 peristalsis Database 0
Category members GO Category GO:0031434 mitogen-activated protein kinase kinase binding Database 0
Category members GO Category GO:0031594 neuromuscular junction Database 0
Category members GO Category GO:0032147 activation of protein kinase activity Database 0
Category members GO Category GO:0033268 node of Ranvier Database 0
Category members GO Category GO:0042130 negative regulation of T cell proliferation Database 0
Category members GO Category GO:0043219 lateral loop Database 0
Category members GO Category GO:0048608 reproductive structure development Database 0
Category members GO Category GO:0048729 tissue morphogenesis Database 0
Category members GO Category GO:0048745 smooth muscle tissue development Database 0
Category members GO Category GO:0060022 hard palate development Database 0


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