bioLOGIC Data » bioLOGIC CategoryView » bioLOGIC VennView » Experimental Details »

bioLOGIC Data

bioLOGIC Data


Exact search


Query: ARRB2

RNAi screen result RNAPII IP (PI) CSB IP CSB IP (PI) Chrom. Chrom. (PI) Phosphorylation Ubiquitylation
W
[Click on the plots to view the data selection in the respective scatterplot]

Protein Results:

 Results for post-translational modifications: see below | Red/green: hit at lower/upper end of the respective screen
Gene name Point score Z-score sums RNAi high RNAi low RNAPII-IP (PI) CSB-IP CSB-IP (PI) Chrom. Chrom. (PI)
ARRB2 1 -3.730 2.000 -1.160 -0.340 0.096 0.051 -1.604

PTM Sites:

 Back to Protein Results | Red/green: hit at lower/upper end of the respective screen
Gene name PTM type PTM site UV UV (PI) Sequence
ARRB2 Ubiquitylation K199 -1.933 _VQFAPEK(gl)PGPQPSAETTR_

Background Information for ARRB2:


Pubmed-ARRB2 »
Uniprot-ARRB2 »
Biogrid-ARRB2 »
ProteomicsDB-ARRB2 »

Tumorportal-ARRB2 »
COSMIC-ARRB2 »
GenomeRNAi-ARRB2 »
Genecards-ARRB2


Protein-protein Interactions for ARRB2
Show screen data for Category Name and Description Link to cat description Data Source
Category members IP bait ARRB2 Cat. description Hein, Mann, Cell 2015
Category members IP bait AARSD1 Cat. description BioPlex, Huttlin, Gygi, Cell 2015
Category members IP bait C16orf71 Cat. description BioPlex, Huttlin, Gygi, Cell 2015
Category members IP bait CCDC102B Cat. description BioPlex, Huttlin, Gygi, Cell 2015
Category members IP bait EMILIN1 Cat. description BioPlex, Huttlin, Gygi, Cell 2015
Category members IP bait GPR156 Cat. description BioPlex, Huttlin, Gygi, Cell 2015
Category members IP bait GPR55 Cat. description BioPlex, Huttlin, Gygi, Cell 2015
Category members IP bait TFAP4 Cat. description BioPlex, Huttlin, Gygi, Cell 2015
Category members IP bait TNFSF8 Cat. description BioPlex, Huttlin, Gygi, Cell 2015
Category members IP bait TPCN2 Cat. description BioPlex, Huttlin, Gygi, Cell 2015


Protein Domains in ARRB2
Domain name Domain Description TC-NER relevance -log10(p-value)
Category members Arrestin IPR000698 0
Category members Arrestin-like_N IPR011021 0
Category members Arrestin_C-like IPR011022 0
Category members Ig_E-set IPR014756 0


Protein complexes (CORUM database) featuring ARRB2
Category Type Category ID Category Name Data Source TC-NER relevance -log10(p-value)
Category members Corum 1297 MKK4-ARRB2-ASK1 complex Database 0.11
Category members Corum 1298 MKK4-ARRB2-JNK3 complex Database 0


Categories featuring ARRB2
Category Type Category ID Category Name Data Source TC-NER relevance -log10(p-value)
Category members GO Category GO:0005515 protein binding Database INF
Category members GO Category GO:0005634 nucleus Database INF
Category members GO Category GO:0005829 cytosol Database INF
Category members GO Category GO:0005737 cytoplasm Database 12.81
Category members GO Category GO:0015031 protein transport Database 3.48
Category members GO Category GO:0031625 ubiquitin protein ligase binding Database 2.54
Category members GO Category GO:0019904 protein domain specific binding Database 1.85
Category members GO Category GO:0007186 G-protein coupled receptor signaling pathway Database 1.53
Category members Pathway Pathway_645 PID_CXCR4_PATHWAY 0 1.42
Category members Pathway Pathway_666 KEGG_ENDOCYTOSIS 0 1.25
Category members GO Category GO:0005886 plasma membrane Database 1.21
Category members GO Category GO:0006366 transcription from RNA polymerase II promoter Database 0.96
Category members GO Category GO:0043197 dendritic spine Database 0.86
Category members GO Category GO:0032947 protein complex scaffold Database 0.82
Category members Pathway Pathway_267 KEGG_OLFACTORY_TRANSDUCTION 0 0.75
Category members Pathway Pathway_995 PID_ALK1_PATHWAY 0 0.69
Category members GO Category GO:0070374 positive regulation of ERK1 and ERK2 cascade Database 0.65
Category members Pathway Pathway_662 PID_IL8_CXCR2_PATHWAY 0 0.62
Category members Pathway Pathway_933 PID_TGFBR_PATHWAY 0 0.52
Category members GO Category GO:0032403 protein complex binding Database 0.49
Category members Pathway Pathway_992 PID_ARF6_PATHWAY 0 0.46
Category members Pathway Pathway_53 REACTOME_HEMOSTASIS 0 0.4
Category members GO Category GO:0007596 blood coagulation Database 0.4
Category members GO Category GO:0032226 positive regulation of synaptic transmission, dopaminergic Database 0.34
Category members Pathway Pathway_117 REACTOME_SIGNALING_BY_NOTCH 0 0.33
Category members GO Category GO:0005622 intracellular Database 0.32
Category members GO Category GO:0006897 endocytosis Database 0.31
Category members GO Category GO:0006309 apoptotic DNA fragmentation Database 0.26
Category members GO Category GO:0043065 positive regulation of apoptotic process Database 0.26
Category members GO Category GO:0007179 transforming growth factor beta receptor signaling pathway Database 0.25
Category members GO Category GO:0043161 proteasome-mediated ubiquitin-dependent protein catabolic process Database 0.23
Category members GO Category GO:0001934 positive regulation of protein phosphorylation Database 0.22
Category members Pathway Pathway_789 REACTOME_SIGNALING_BY_NOTCH1 0 0.22
Category members GO Category GO:0005905 coated pit Database 0.17
Category members Pathway Pathway_555 PID_NEPHRIN_NEPH1_PATHWAY 0 0.17
Category members GO Category GO:0030168 platelet activation Database 0.13
Category members GO Category GO:0045953 negative regulation of natural killer cell mediated cytotoxicity Database 0.13
Category members GO Category GO:0051019 mitogen-activated protein kinase binding Database 0.13
Category members GO Category GO:0043422 protein kinase B binding Database 0.12
Category members Pathway Pathway_56 REACTOME_PLATELET_ACTIVATION_SIGNALING_AND_AGGREGATION 0 0.11
Category members Pathway Pathway_984 PID_HEDGEHOG_GLI_PATHWAY 0 0.1
Category members Pathway Pathway_417 PID_WNT_NONCANONICAL_PATHWAY 0 0.09
Category members GO Category GO:0001664 G-protein coupled receptor binding Database 0.09
Category members GO Category GO:0016567 protein ubiquitination Database 0.07
Category members GO Category GO:0045211 postsynaptic membrane Database 0.06
Category members GO Category GO:0034392 negative regulation of smooth muscle cell apoptotic process Database 0.05
Category members GO Category GO:0007219 Notch signaling pathway Database 0.05
Category members GO Category GO:0001932 regulation of protein phosphorylation Database 0.04
Category members GO Category GO:0032088 negative regulation of NF-kappaB transcription factor activity Database 0.04
Category members GO Category GO:0032695 negative regulation of interleukin-12 production Database 0.04
Category members GO Category GO:0050965 detection of temperature stimulus involved in sensory perception of pain Database 0.04
Category members GO Category GO:0016323 basolateral plasma membrane Database 0.04
Category members GO Category GO:0032715 negative regulation of interleukin-6 production Database 0.03
Category members GO Category GO:0031623 receptor internalization Database 0.02
Category members Pathway Pathway_663 PID_IL8_CXCR1_PATHWAY 0 0.01
Category members Pathway Pathway_252 KEGG_CHEMOKINE_SIGNALING_PATHWAY 0 0
Category members Pathway Pathway_430 PID_TXA2PATHWAY 0 0
Category members Pathway Pathway_594 PID_HEDGEHOG_2PATHWAY 0 0
Category members Pathway Pathway_610 PID_NFKAPPAB_ATYPICAL_PATHWAY 0 0
Category members Pathway Pathway_715 KEGG_MAPK_SIGNALING_PATHWAY 0 0
Category members Pathway Pathway_831 REACTOME_ACTIVATED_NOTCH1_TRANSMITS_SIGNAL_TO_THE_NUCLEUS 0 0
Category members Pathway Pathway_994 REACTOME_THROMBIN_SIGNALLING_THROUGH_PROTEINASE_ACTIVATED_RECEPTORS_PARS 0 0
Category members GO Category GO:0002031 G-protein coupled receptor internalization Database 0
Category members GO Category GO:0002032 desensitization of G-protein coupled receptor protein signaling pathway by arrestin Database 0
Category members GO Category GO:0002092 positive regulation of receptor internalization Database 0
Category members GO Category GO:0005102 receptor binding Database 0
Category members GO Category GO:0007165 signal transduction Database 0
Category members GO Category GO:0007420 brain development Database 0
Category members GO Category GO:0007628 adult walking behavior Database 0
Category members GO Category GO:0008277 regulation of G-protein coupled receptor protein signaling pathway Database 0
Category members GO Category GO:0014069 postsynaptic density Database 0
Category members GO Category GO:0030139 endocytic vesicle Database 0
Category members GO Category GO:0031397 negative regulation of protein ubiquitination Database 0
Category members GO Category GO:0031398 positive regulation of protein ubiquitination Database 0
Category members GO Category GO:0031410 cytoplasmic vesicle Database 0
Category members GO Category GO:0031691 alpha-1A adrenergic receptor binding Database 0
Category members GO Category GO:0031692 alpha-1B adrenergic receptor binding Database 0
Category members GO Category GO:0031701 angiotensin receptor binding Database 0
Category members GO Category GO:0031702 type 1 angiotensin receptor binding Database 0
Category members GO Category GO:0031748 D1 dopamine receptor binding Database 0
Category members GO Category GO:0031762 follicle-stimulating hormone receptor binding Database 0
Category members GO Category GO:0032691 negative regulation of interleukin-1 beta production Database 0
Category members GO Category GO:0032720 negative regulation of tumor necrosis factor production Database 0
Category members GO Category GO:0034122 negative regulation of toll-like receptor signaling pathway Database 0
Category members GO Category GO:0034260 negative regulation of GTPase activity Database 0
Category members GO Category GO:0042699 follicle-stimulating hormone signaling pathway Database 0
Category members GO Category GO:0050731 positive regulation of peptidyl-tyrosine phosphorylation Database 0
Category members GO Category GO:0051897 positive regulation of protein kinase B signaling Database 0
Category members GO Category GO:0051928 positive regulation of calcium ion transport Database 0
Category members GO Category GO:0060326 cell chemotaxis Database 0
Category members GO Category GO:0060765 regulation of androgen receptor signaling pathway Database 0


.

© Copyright Svejstrup Laboratory 2015