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Query: APOB

RNAi screen result RNAPII IP (PI) CSB IP CSB IP (PI) Chrom. Chrom. (PI) Phosphorylation Ubiquitylation
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[Click on the plots to view the data selection in the respective scatterplot]

Protein Results:

 Results for post-translational modifications: see below | Red/green: hit at lower/upper end of the respective screen
Gene name Point score Z-score sums RNAi high RNAi low RNAPII-IP (PI) CSB-IP CSB-IP (PI) Chrom. Chrom. (PI)
APOB 0 -3.657 0.130 0.050 -4.359 0.702

PTM Sites:

 Back to Protein Results | Red/green: hit at lower/upper end of the respective screen
Gene name PTM type PTM site UV UV (PI) Sequence

Background Information for APOB:


Pubmed-APOB »
Uniprot-APOB »
Biogrid-APOB »
ProteomicsDB-APOB »

Tumorportal-APOB »
COSMIC-APOB »
GenomeRNAi-APOB »
Genecards-APOB


Protein-protein Interactions for APOB
Show screen data for Category Name and Description Link to cat description Data Source
Category members IP bait ANLN Cat. description Hein, Mann, Cell 2015
Category members IP bait ARX Cat. description Hein, Mann, Cell 2015
Category members IP bait CHMP6 Cat. description Hein, Mann, Cell 2015
Category members IP bait CRKL Cat. description Hein, Mann, Cell 2015
Category members IP bait MYH9 Cat. description Hein, Mann, Cell 2015
Category members IP bait MZT1 Cat. description Hein, Mann, Cell 2015
Category members IP bait PAX6 Cat. description Hein, Mann, Cell 2015
Category members IP bait PCNA Cat. description Hein, Mann, Cell 2015
Category members IP bait RAD21 Cat. description Hein, Mann, Cell 2015
Category members IP bait STMN1 Cat. description Hein, Mann, Cell 2015
Category members IP bait AUP1 Cat. description BioPlex, Huttlin, Gygi, Cell 2015
Category members IP bait CKLF Cat. description BioPlex, Huttlin, Gygi, Cell 2015
Category members IP bait LITAF Cat. description BioPlex, Huttlin, Gygi, Cell 2015
Category members IP bait MFSD4 Cat. description BioPlex, Huttlin, Gygi, Cell 2015
Category members IP bait P2RY12 Cat. description BioPlex, Huttlin, Gygi, Cell 2015
Category members IP bait RPN2 Cat. description BioPlex, Huttlin, Gygi, Cell 2015
Category members IP bait SLC10A7 Cat. description BioPlex, Huttlin, Gygi, Cell 2015
Category members IP bait SLC22A9 Cat. description BioPlex, Huttlin, Gygi, Cell 2015
Category members IP bait SLC2A2 Cat. description BioPlex, Huttlin, Gygi, Cell 2015
Category members IP bait SLC37A3 Cat. description BioPlex, Huttlin, Gygi, Cell 2015
Category members IP bait SMPD3 Cat. description BioPlex, Huttlin, Gygi, Cell 2015
Category members IP bait TMEM128 Cat. description BioPlex, Huttlin, Gygi, Cell 2015
Category members IP bait TMEM41B Cat. description BioPlex, Huttlin, Gygi, Cell 2015
Category members IP bait YIPF3 Cat. description BioPlex, Huttlin, Gygi, Cell 2015
Category members IP bait ZDHHC11 Cat. description BioPlex, Huttlin, Gygi, Cell 2015
Category members IP bait ZFYVE27 Cat. description BioPlex, Huttlin, Gygi, Cell 2015


Protein Domains in APOB
Domain name Domain Description TC-NER relevance -log10(p-value)
Category members ARM-type_fold IPR016024 9.26
Category members Lipid_transpt_N IPR001747 0.04
Category members Vitellinogen_superhlx IPR011030 0.04
Category members Lipid_transp_b-sht_shell IPR015819 0.04


Protein complexes (CORUM database) featuring APOB
Category Type Category ID Category Name Data Source TC-NER relevance -log10(p-value)


Categories featuring APOB
Category Type Category ID Category Name Data Source TC-NER relevance -log10(p-value)
Category members GO Category GO:0005515 protein binding Database INF
Category members GO Category GO:0005829 cytosol Database INF
Category members DDR Literature pubmedid:TBD2_UV_increased Elia et al, 2015 UV increased acetylation events Elia et al. INF
Category members GO Category GO:0005737 cytoplasm Database 12.81
Category members GO Category GO:0005576 extracellular region Database 10.9
Category members GO Category GO:0005488 binding Database 9.32
Category members GO Category GO:0005615 extracellular space Database 4.72
Category members GO Category GO:0019899 enzyme binding Database 1.57
Category members GO Category GO:0005789 endoplasmic reticulum membrane Database 1.57
Category members GO Category GO:0005769 early endosome Database 1.26
Category members GO Category GO:0005886 plasma membrane Database 1.21
Category members GO Category GO:0006642 triglyceride mobilization Database 0.66
Category members GO Category GO:0010269 response to selenium ion Database 0.65
Category members GO Category GO:0005783 endoplasmic reticulum Database 0.62
Category members GO Category GO:0043231 intracellular membrane-bounded organelle Database 0.43
Category members Pathway Pathway_53 REACTOME_HEMOSTASIS 0 0.4
Category members GO Category GO:0007596 blood coagulation Database 0.4
Category members GO Category GO:0032496 response to lipopolysaccharide Database 0.35
Category members GO Category GO:0044281 small molecule metabolic process Database 0.35
Category members Pathway Pathway_720 REACTOME_PLATELET_SENSITIZATION_BY_LDL 0 0.29
Category members GO Category GO:0046982 protein heterodimerization activity Database 0.28
Category members GO Category GO:0008201 heparin binding Database 0.27
Category members GO Category GO:0007603 phototransduction, visible light Database 0.25
Category members Pathway Pathway_957 PID_AMB2_NEUTROPHILS_PATHWAY 0 0.2
Category members GO Category GO:0001701 in utero embryonic development Database 0.2
Category members GO Category GO:0001523 retinoid metabolic process Database 0.1
Category members Pathway Pathway_285 REACTOME_PLATELET_HOMEOSTASIS 0 0.08
Category members GO Category GO:0008203 cholesterol metabolic process Database 0.08
Category members GO Category GO:0034383 low-density lipoprotein particle clearance Database 0.07
Category members Pathway Pathway_600 REACTOME_CELL_SURFACE_INTERACTIONS_AT_THE_VASCULAR_WALL 0 0.05
Category members GO Category GO:0010886 positive regulation of cholesterol storage Database 0.05
Category members GO Category GO:0050750 low-density lipoprotein particle receptor binding Database 0.04
Category members GO Category GO:0050900 leukocyte migration Database 0.04
Category members GO Category GO:0071356 cellular response to tumor necrosis factor Database 0.03
Category members GO Category GO:0012506 vesicle membrane Database 0.01
Category members GO Category GO:0010744 positive regulation of macrophage derived foam cell differentiation Database 0
Category members Pathway Pathway_186 PID_HNF3A_PATHWAY 0 0
Category members Pathway Pathway_4 REACTOME_METABOLISM_OF_LIPIDS_AND_LIPOPROTEINS 0 0
Category members Pathway Pathway_490 REACTOME_LIPID_DIGESTION_MOBILIZATION_AND_TRANSPORT 0 0
Category members Pathway Pathway_491 REACTOME_CHYLOMICRON_MEDIATED_LIPID_TRANSPORT 0 0
Category members Pathway Pathway_492 REACTOME_LIPOPROTEIN_METABOLISM 0 0
Category members Disease phenotype Familial_hypobetalipoproteinemia Familial hypobetalipoproteinemia Database 0
Category members Disease phenotype Homozygous_familial_hypercholesterolemia Homozygous familial hypercholesterolemia Database 0
Category members GO Category GO:0005319 lipid transporter activity Database 0
Category members GO Category GO:0005543 phospholipid binding Database 0
Category members GO Category GO:0005788 endoplasmic reticulum lumen Database 0
Category members GO Category GO:0006629 lipid metabolic process Database 0
Category members GO Category GO:0006869 lipid transport Database 0
Category members GO Category GO:0006898 receptor-mediated endocytosis Database 0
Category members GO Category GO:0007283 spermatogenesis Database 0
Category members GO Category GO:0007399 nervous system development Database 0
Category members GO Category GO:0008289 lipid binding Database 0
Category members GO Category GO:0009566 fertilization Database 0
Category members GO Category GO:0009615 response to virus Database 0
Category members GO Category GO:0009743 response to carbohydrate Database 0
Category members GO Category GO:0009791 post-embryonic development Database 0
Category members GO Category GO:0010008 endosome membrane Database 0
Category members GO Category GO:0010033 response to organic substance Database 0
Category members GO Category GO:0010884 positive regulation of lipid storage Database 0
Category members GO Category GO:0016042 lipid catabolic process Database 0
Category members GO Category GO:0017127 cholesterol transporter activity Database 0
Category members GO Category GO:0019433 triglyceride catabolic process Database 0
Category members GO Category GO:0030301 cholesterol transport Database 0
Category members GO Category GO:0030317 sperm motility Database 0
Category members GO Category GO:0030669 clathrin-coated endocytic vesicle membrane Database 0
Category members GO Category GO:0031904 endosome lumen Database 0
Category members GO Category GO:0033344 cholesterol efflux Database 0
Category members GO Category GO:0034361 very-low-density lipoprotein particle Database 0
Category members GO Category GO:0034362 low-density lipoprotein particle Database 0
Category members GO Category GO:0034363 intermediate-density lipoprotein particle Database 0
Category members GO Category GO:0034374 low-density lipoprotein particle remodeling Database 0
Category members GO Category GO:0034379 very-low-density lipoprotein particle assembly Database 0
Category members GO Category GO:0042157 lipoprotein metabolic process Database 0
Category members GO Category GO:0042158 lipoprotein biosynthetic process Database 0
Category members GO Category GO:0042159 lipoprotein catabolic process Database 0
Category members GO Category GO:0042627 chylomicron Database 0
Category members GO Category GO:0042632 cholesterol homeostasis Database 0
Category members GO Category GO:0042953 lipoprotein transport Database 0
Category members GO Category GO:0045540 regulation of cholesterol biosynthetic process Database 0
Category members GO Category GO:0048844 artery morphogenesis Database 0
Category members GO Category GO:0071379 cellular response to prostaglandin stimulus Database 0


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