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Query: ZEB1

RNAi screen result RNAPII IP (PI) CSB IP CSB IP (PI) Chrom. Chrom. (PI) Phosphorylation Ubiquitylation
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[Click on the plots to view the data selection in the respective scatterplot]

Protein Results:

 Results for post-translational modifications: see below | Red/green: hit at lower/upper end of the respective screen
Gene name Point score Z-score sums RNAi high RNAi low RNAPII-IP (PI) CSB-IP CSB-IP (PI) Chrom. Chrom. (PI)
ZEB1 0 -0.040 0.640 -0.450

PTM Sites:

 Back to Protein Results | Red/green: hit at lower/upper end of the respective screen
Gene name PTM type PTM site UV UV (PI) Sequence
ZEB1 Phosphorylation S1025 0.260 _REAEERDS(ph)TEQEEAGPEILSNEHVGAR_
ZEB1 Phosphorylation T1026 0.260 _REAEERDS(ph)TEQEEAGPEILSNEHVGAR_
ZEB1 Ubiquitylation K398 -0.697 0.131 _SEK(gl)LPEDLTVK_
ZEB1 Phosphorylation S713 -0.669 -0.753 _NNDQPQSANANEPQDSTVNLQS(ph)PLK_
ZEB1 Ubiquitylation K77 0.237 _FTSLK(gl)EHIK_

Background Information for ZEB1:


Pubmed-ZEB1 »
Uniprot-ZEB1 »
Biogrid-ZEB1 »
ProteomicsDB-ZEB1 »

Tumorportal-ZEB1 »
COSMIC-ZEB1 »
GenomeRNAi-ZEB1 »
Genecards-ZEB1


Protein-protein Interactions for ZEB1
Show screen data for Category Name and Description Link to cat description Data Source
Category members IP bait SYNCRIP Cat. description Hein, Mann, Cell 2015
Category members IP bait CTBP1 Cat. description BioPlex, Huttlin, Gygi, Cell 2015
Category members IP bait DCAF15 Cat. description BioPlex, Huttlin, Gygi, Cell 2015


Protein Domains in ZEB1
Domain name Domain Description TC-NER relevance -log10(p-value)
Category members Znf_C2H2-like IPR015880 1.29
Category members Znf_C2H2 IPR007087 0.92
Category members Homeobox_dom IPR001356 0.63
Category members Homeodomain-like IPR009057 0


Protein complexes (CORUM database) featuring ZEB1
Category Type Category ID Category Name Data Source TC-NER relevance -log10(p-value)
Category members Corum 642 CtBP complex Database 3.6
Category members Corum 643 CtBP core complex Database 1.41


Categories featuring ZEB1
Category Type Category ID Category Name Data Source TC-NER relevance -log10(p-value)
Category members GO Category GO:0005515 protein binding Database INF
Category members GO Category GO:0005634 nucleus Database INF
Category members GO Category GO:0005737 cytoplasm Database 12.81
Category members GO Category GO:0003682 chromatin binding Database 6.07
Category members GO Category GO:0003713 transcription coactivator activity Database 3.68
Category members Pathway Pathway_924 PID_ILK_PATHWAY 0 1.75
Category members GO Category GO:0003677 DNA binding Database 1.53
Category members GO Category GO:0006955 immune response Database 1.22
Category members GO Category GO:0045892 negative regulation of transcription, DNA-dependent Database 1.15
Category members GO Category GO:0006351 transcription, DNA-templated Database 1.07
Category members GO Category GO:0003676 nucleic acid binding Database 0.83
Category members GO Category GO:0003690 double-stranded DNA binding Database 0.66
Category members GO Category GO:0003700 sequence-specific DNA binding transcription factor activity Database 0.63
Category members GO Category GO:0008134 transcription factor binding Database 0.37
Category members Disease phenotype Fuchs_endothelial_corneal_dystrophy Fuchs endothelial corneal dystrophy Database 0.36
Category members GO Category GO:0008270 zinc ion binding Database 0.29
Category members GO Category GO:0008285 negative regulation of cell proliferation Database 0.28
Category members GO Category GO:0005667 transcription factor complex Database 0.19
Category members GO Category GO:0006357 regulation of transcription from RNA polymerase II promoter Database 0.19
Category members GO Category GO:0007389 pattern specification process Database 0.18
Category members GO Category GO:0043565 sequence-specific DNA binding Database 0.18
Category members GO Category GO:0045944 positive regulation of transcription from RNA polymerase II promoter Database 0.13
Category members GO Category GO:0051150 regulation of smooth muscle cell differentiation Database 0.13
Category members GO Category GO:0008283 cell proliferation Database 0.06
Category members Disease phenotype Posterior_polymorphous_corneal_dystrophy Posterior polymorphous corneal dystrophy Database 0.04
Category members GO Category GO:0000122 negative regulation of transcription from RNA polymerase II promoter Database 0.02
Category members GO Category GO:0048596 embryonic camera-type eye morphogenesis Database 0.01
Category members GO Category GO:0048704 embryonic skeletal system morphogenesis Database 0
Category members GO Category GO:0003714 transcription corepressor activity Database 0
Category members GO Category GO:0006355 regulation of transcription, DNA-dependent Database 0
Category members GO Category GO:0007417 central nervous system development Database 0
Category members GO Category GO:0014823 response to activity Database 0
Category members GO Category GO:0017015 regulation of transforming growth factor beta receptor signaling pathway Database 0
Category members GO Category GO:0030857 negative regulation of epithelial cell differentiation Database 0
Category members GO Category GO:0030900 forebrain development Database 0
Category members GO Category GO:0031667 response to nutrient levels Database 0
Category members GO Category GO:0033081 regulation of T cell differentiation in thymus Database 0
Category members GO Category GO:0045666 positive regulation of neuron differentiation Database 0
Category members GO Category GO:0046872 metal ion binding Database 0
Category members GO Category GO:0048513 organ development Database 0
Category members GO Category GO:0048598 embryonic morphogenesis Database 0
Category members GO Category GO:0048752 semicircular canal morphogenesis Database 0
Category members GO Category GO:0051216 cartilage development Database 0
Category members GO Category GO:0070888 E-box binding Database 0
Category members GO Category GO:0071230 cellular response to amino acid stimulus Database 0


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