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Query: SMO

This is a cancer-associated gene according to the Sanger cancer gene census.

RNAi screen result RNAPII IP (PI) CSB IP CSB IP (PI) Chrom. Chrom. (PI) Phosphorylation Ubiquitylation
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[Click on the plots to view the data selection in the respective scatterplot]

Protein Results:

 Results for post-translational modifications: see below | Red/green: hit at lower/upper end of the respective screen
Gene name Point score Z-score sums RNAi high RNAi low RNAPII-IP (PI) CSB-IP CSB-IP (PI) Chrom. Chrom. (PI)
SMO 1 2.642 -0.690 1.110 1.532

PTM Sites:

 Back to Protein Results | Red/green: hit at lower/upper end of the respective screen
Gene name PTM type PTM site UV UV (PI) Sequence

Background Information for SMO:


Pubmed-SMO »
Uniprot-SMO »
Biogrid-SMO »
ProteomicsDB-SMO »

Tumorportal-SMO »
COSMIC-SMO »
GenomeRNAi-SMO »
Genecards-SMO


Protein-protein Interactions for SMO
Show screen data for Category Name and Description Link to cat description Data Source
Category members IP bait SMO Cat. description Hein, Mann, Cell 2015
Category members IP bait FAM189B Cat. description BioPlex, Huttlin, Gygi, Cell 2015


Protein Domains in SMO
Domain name Domain Description TC-NER relevance -log10(p-value)
Category members GPCR_2_secretin-like IPR000832 0.27
Category members GPCR_2-like IPR017981 0.05
Category members Frizzled IPR000539 0.03
Category members Frizzled_dom IPR020067 0


Protein complexes (CORUM database) featuring SMO
Category Type Category ID Category Name Data Source TC-NER relevance -log10(p-value)


Categories featuring SMO
Category Type Category ID Category Name Data Source TC-NER relevance -log10(p-value)
Category members GO Category GO:0005515 protein binding Database INF
Category members GO Category GO:0005737 cytoplasm Database 12.81
Category members GO Category GO:0016021 integral to membrane Database 7.67
Category members Human mutations Sanger_cancer_genes Sanger cancer genes Database 4.88
Category members Pathway Pathway_1105 REACTOME_GPCR_LIGAND_BINDING 0 2.35
Category members GO Category GO:0007224 smoothened signaling pathway Database 2.11
Category members GO Category GO:0004930 G-protein coupled receptor activity Database 2.1
Category members GO Category GO:0007186 G-protein coupled receptor signaling pathway Database 1.53
Category members GO Category GO:0005886 plasma membrane Database 1.21
Category members Pathway Pathway_1104 REACTOME_CLASS_B_2_SECRETIN_FAMILY_RECEPTORS 0 0.93
Category members Pathway Pathway_256 REACTOME_SIGNALING_BY_GPCR 0 0.83
Category members GO Category GO:0043066 negative regulation of apoptotic process Database 0.6
Category members GO Category GO:0016020 membrane Database 0.52
Category members GO Category GO:0050679 positive regulation of epithelial cell proliferation Database 0.5
Category members GO Category GO:0048589 developmental growth Database 0.45
Category members GO Category GO:0043231 intracellular membrane-bounded organelle Database 0.43
Category members GO Category GO:0007275 multicellular organismal development Database 0.31
Category members GO Category GO:0030165 PDZ domain binding Database 0.29
Category members GO Category GO:0005794 Golgi apparatus Database 0.27
Category members GO Category GO:0001701 in utero embryonic development Database 0.2
Category members GO Category GO:0007389 pattern specification process Database 0.18
Category members GO Category GO:0034504 protein localization to nucleus Database 0.15
Category members GO Category GO:0004888 transmembrane signaling receptor activity Database 0.15
Category members GO Category GO:0045944 positive regulation of transcription from RNA polymerase II promoter Database 0.13
Category members GO Category GO:0003323 type B pancreatic cell development Database 0.1
Category members Pathway Pathway_984 PID_HEDGEHOG_GLI_PATHWAY 0 0.1
Category members GO Category GO:0007166 cell surface receptor signaling pathway Database 0.1
Category members GO Category GO:0001947 heart looping Database 0.08
Category members GO Category GO:0021953 central nervous system neuron differentiation Database 0.06
Category members GO Category GO:0021984 adenohypophysis development Database 0.06
Category members GO Category GO:0008406 gonad development Database 0.06
Category members GO Category GO:0031069 hair follicle morphogenesis Database 0.06
Category members GO Category GO:0048846 axon extension involved in axon guidance Database 0.05
Category members GO Category GO:0050821 protein stabilization Database 0.04
Category members GO Category GO:0031102 neuron projection regeneration Database 0.04
Category members GO Category GO:0048853 forebrain morphogenesis Database 0.04
Category members Pathway Pathway_1151 KEGG_HEDGEHOG_SIGNALING_PATHWAY 0 0.04
Category members GO Category GO:0035264 multicellular organism growth Database 0.04
Category members GO Category GO:0048557 embryonic digestive tract morphogenesis Database 0.04
Category members GO Category GO:0048703 embryonic viscerocranium morphogenesis Database 0.02
Category members GO Category GO:0017147 Wnt-protein binding Database 0.02
Category members GO Category GO:0000122 negative regulation of transcription from RNA polymerase II promoter Database 0.02
Category members GO Category GO:0048663 neuron fate commitment Database 0.02
Category members GO Category GO:0060413 atrial septum morphogenesis Database 0.02
Category members GO Category GO:0043392 negative regulation of DNA binding Database 0.01
Category members GO Category GO:0045880 positive regulation of smoothened signaling pathway Database 0.01
Category members GO Category GO:0007494 midgut development Database 0.01
Category members Pathway Pathway_1154 BIOCARTA_SHH_PATHWAY 0 0
Category members Pathway Pathway_1163 KEGG_BASAL_CELL_CARCINOMA 0 0
Category members Pathway Pathway_24 KEGG_PATHWAYS_IN_CANCER 0 0
Category members Pathway Pathway_594 PID_HEDGEHOG_2PATHWAY 0 0
Category members GO Category GO:0001503 ossification Database 0
Category members GO Category GO:0001570 vasculogenesis Database 0
Category members GO Category GO:0001649 osteoblast differentiation Database 0
Category members GO Category GO:0001708 cell fate specification Database 0
Category members GO Category GO:0001755 neural crest cell migration Database 0
Category members GO Category GO:0002052 positive regulation of neuroblast proliferation Database 0
Category members GO Category GO:0002053 positive regulation of mesenchymal cell proliferation Database 0
Category members GO Category GO:0003007 heart morphogenesis Database 0
Category members GO Category GO:0003140 determination of left/right asymmetry in lateral mesoderm Database 0
Category members GO Category GO:0005113 patched binding Database 0
Category members GO Category GO:0005901 caveola Database 0
Category members GO Category GO:0005929 cilium Database 0
Category members GO Category GO:0007228 positive regulation of hh target transcription factor activity Database 0
Category members GO Category GO:0007283 spermatogenesis Database 0
Category members GO Category GO:0007368 determination of left/right symmetry Database 0
Category members GO Category GO:0007417 central nervous system development Database 0
Category members GO Category GO:0008144 drug binding Database 0
Category members GO Category GO:0008284 positive regulation of cell proliferation Database 0
Category members GO Category GO:0009953 dorsal/ventral pattern formation Database 0
Category members GO Category GO:0010002 cardioblast differentiation Database 0
Category members GO Category GO:0010468 regulation of gene expression Database 0
Category members GO Category GO:0010628 positive regulation of gene expression Database 0
Category members GO Category GO:0010629 negative regulation of gene expression Database 0
Category members GO Category GO:0021508 floor plate formation Database 0
Category members GO Category GO:0021696 cerebellar cortex morphogenesis Database 0
Category members GO Category GO:0021794 thalamus development Database 0
Category members GO Category GO:0021904 dorsal/ventral neural tube patterning Database 0
Category members GO Category GO:0021938 smoothened signaling pathway involved in regulation of cerebellar granule cell precursor cell proliferation Database 0
Category members GO Category GO:0030857 negative regulation of epithelial cell differentiation Database 0
Category members GO Category GO:0031017 exocrine pancreas development Database 0
Category members GO Category GO:0031076 embryonic camera-type eye development Database 0
Category members GO Category GO:0032474 otolith morphogenesis Database 0
Category members GO Category GO:0042307 positive regulation of protein import into nucleus Database 0
Category members GO Category GO:0042475 odontogenesis of dentin-containing tooth Database 0
Category members GO Category GO:0042693 muscle cell fate commitment Database 0
Category members GO Category GO:0042813 Wnt-activated receptor activity Database 0
Category members GO Category GO:0043025 neuronal cell body Database 0
Category members GO Category GO:0048468 cell development Database 0
Category members GO Category GO:0048565 digestive tract development Database 0
Category members GO Category GO:0048702 embryonic neurocranium morphogenesis Database 0
Category members GO Category GO:0048752 semicircular canal morphogenesis Database 0
Category members GO Category GO:0051799 negative regulation of hair follicle development Database 0
Category members GO Category GO:0060070 canonical Wnt signaling pathway Database 0
Category members GO Category GO:0060170 ciliary membrane Database 0
Category members GO Category GO:0060644 mammary gland epithelial cell differentiation Database 0
Category members GO Category GO:0060684 epithelial-mesenchymal cell signaling Database 0
Category members GO Category GO:0060830 ciliary receptor clustering involved in smoothened signaling pathway Database 0
Category members GO Category GO:0061053 somite development Database 0
Category members GO Category GO:0061113 pancreas morphogenesis Database 0
Category members GO Category GO:0071397 cellular response to cholesterol Database 0


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