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Query: PTPRC

This is a cancer-associated gene according to the Sanger cancer gene census.

RNAi screen result RNAPII IP (PI) CSB IP CSB IP (PI) Chrom. Chrom. (PI) Phosphorylation Ubiquitylation
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[Click on the plots to view the data selection in the respective scatterplot]

Protein Results:

 Results for post-translational modifications: see below | Red/green: hit at lower/upper end of the respective screen
Gene name Point score Z-score sums RNAi high RNAi low RNAPII-IP (PI) CSB-IP CSB-IP (PI) Chrom. Chrom. (PI)
PTPRC 0 -0.157 0.900 -0.770

PTM Sites:

 Back to Protein Results | Red/green: hit at lower/upper end of the respective screen
Gene name PTM type PTM site UV UV (PI) Sequence
PTPRC Phosphorylation T91 -0.157 _(ac)LTTAKM(ox)PSVPLSSDPLPT(ph)HT(ph)TAFSPAST(ph)FER_
PTPRC Phosphorylation T93 -0.157 _(ac)LTTAKM(ox)PSVPLSSDPLPT(ph)HT(ph)TAFSPAST(ph)FER_
PTPRC Phosphorylation T94 -0.157 _(ac)LTTAKM(ox)PSVPLSSDPLPT(ph)HT(ph)TAFSPAST(ph)FER_
PTPRC Phosphorylation T101 -0.157 _(ac)LTTAKM(ox)PSVPLSSDPLPT(ph)HT(ph)TAFSPAST(ph)FER_

Background Information for PTPRC:


Pubmed-PTPRC »
Uniprot-PTPRC »
Biogrid-PTPRC »
ProteomicsDB-PTPRC »

Tumorportal-PTPRC »
COSMIC-PTPRC »
GenomeRNAi-PTPRC »
Genecards-PTPRC


Protein-protein Interactions for PTPRC
Show screen data for Category Name and Description Link to cat description Data Source


Protein Domains in PTPRC
Domain name Domain Description TC-NER relevance -log10(p-value)
Category members Fibronectin_type3 IPR003961 0.19
Category members Tyr_Pase_rcpt/non-rcpt IPR000242 0
Category members Tyr/Dual-sp_Pase IPR000387 0
Category members Tyr_Pase_cat IPR003595 0
Category members Prot-tyrosine_phosphatase-like IPR029021 0


Protein complexes (CORUM database) featuring PTPRC
Category Type Category ID Category Name Data Source TC-NER relevance -log10(p-value)


Categories featuring PTPRC
Category Type Category ID Category Name Data Source TC-NER relevance -log10(p-value)
Category members GO Category GO:0005515 protein binding Database INF
Category members GO Category GO:0016021 integral to membrane Database 7.67
Category members Human mutations Sanger_cancer_genes Sanger cancer genes Database 4.88
Category members Pathway Pathway_621 REACTOME_ADAPTIVE_IMMUNE_SYSTEM 0 4.72
Category members Pathway Pathway_458 REACTOME_IMMUNE_SYSTEM 0 3
Category members GO Category GO:0005887 integral to plasma membrane Database 1.69
Category members Pathway Pathway_645 PID_CXCR4_PATHWAY 0 1.42
Category members GO Category GO:0005886 plasma membrane Database 1.21
Category members Pathway Pathway_673 REACTOME_AXON_GUIDANCE 0 1.06
Category members Pathway Pathway_674 REACTOME_SEMAPHORIN_INTERACTIONS 0 0.96
Category members GO Category GO:0005925 focal adhesion Database 0.68
Category members GO Category GO:0010332 response to gamma radiation Database 0.52
Category members GO Category GO:0019901 protein kinase binding Database 0.37
Category members Pathway Pathway_42 REACTOME_DEVELOPMENTAL_BIOLOGY 0 0.32
Category members GO Category GO:0008201 heparin binding Database 0.27
Category members Pathway Pathway_625 SIG_PIP3_SIGNALING_IN_B_LYMPHOCYTES 0 0.26
Category members GO Category GO:0043065 positive regulation of apoptotic process Database 0.26
Category members Pathway Pathway_587 KEGG_T_CELL_RECEPTOR_SIGNALING_PATHWAY 0 0.25
Category members Pathway Pathway_535 SIG_BCR_SIGNALING_PATHWAY 0 0.24
Category members GO Category GO:0045588 positive regulation of gamma-delta T cell differentiation Database 0.22
Category members GO Category GO:0042098 T cell proliferation Database 0.21
Category members GO Category GO:0046641 positive regulation of alpha-beta T cell proliferation Database 0.21
Category members Pathway Pathway_573 REACTOME_TCR_SIGNALING 0 0.2
Category members GO Category GO:0009986 cell surface Database 0.17
Category members Pathway Pathway_705 PID_CD8_TCR_PATHWAY 0 0.17
Category members GO Category GO:0007411 axon guidance Database 0.13
Category members GO Category GO:0045059 positive thymic T cell selection Database 0.11
Category members GO Category GO:0045121 membrane raft Database 0.11
Category members GO Category GO:0050855 regulation of B cell receptor signaling pathway Database 0.11
Category members GO Category GO:0051726 regulation of cell cycle Database 0.11
Category members Pathway Pathway_499 KEGG_FC_GAMMA_R_MEDIATED_PHAGOCYTOSIS 0 0.1
Category members GO Category GO:0007166 cell surface receptor signaling pathway Database 0.1
Category members Pathway Pathway_687 PID_TCR_PATHWAY 0 0.08
Category members GO Category GO:0042100 B cell proliferation Database 0.08
Category members GO Category GO:0051607 defense response to virus Database 0.07
Category members GO Category GO:0043410 positive regulation of MAPK cascade Database 0.06
Category members GO Category GO:0050852 T cell receptor signaling pathway Database 0.06
Category members GO Category GO:0045860 positive regulation of protein kinase activity Database 0.06
Category members GO Category GO:0042102 positive regulation of T cell proliferation Database 0.04
Category members GO Category GO:0048864 stem cell development Database 0.03
Category members GO Category GO:0051209 release of sequestered calcium ion into cytosol Database 0.01
Category members GO Category GO:0009897 external side of plasma membrane Database 0
Category members GO Category GO:0050732 negative regulation of peptidyl-tyrosine phosphorylation Database 0
Category members Pathway Pathway_1032 REACTOME_SEMA4D_IN_SEMAPHORIN_SIGNALING 0 0
Category members Pathway Pathway_1216 BIOCARTA_BLYMPHOCYTE_PATHWAY 0 0
Category members Pathway Pathway_1217 KEGG_CELL_ADHESION_MOLECULES_CAMS 0 0
Category members Pathway Pathway_1234 REACTOME_PHOSPHORYLATION_OF_CD3_AND_TCR_ZETA_CHAINS 0 0
Category members Pathway Pathway_1283 BIOCARTA_TCRA_PATHWAY 0 0
Category members Pathway Pathway_1291 BIOCARTA_TCYTOTOXIC_PATHWAY 0 0
Category members Pathway Pathway_1292 BIOCARTA_THELPER_PATHWAY 0 0
Category members Pathway Pathway_207 KEGG_PRIMARY_IMMUNODEFICIENCY 0 0
Category members Pathway Pathway_241 BIOCARTA_CSK_PATHWAY 0 0
Category members Pathway Pathway_387 ST_T_CELL_SIGNAL_TRANSDUCTION 0 0
Category members Pathway Pathway_540 PID_BCR_5PATHWAY 0 0
Category members Disease phenotype SEVERE_COMBINED_IMMUNODEFICIENCY_AUTOSOMAL_RECESSIVE_T_CELL-NEGATIVE SEVERE COMBINED IMMUNODEFICIENCY AUTOSOMAL RECESSIVE T CELL-NEGATIVE Database 0
Category members GO Category GO:0000187 activation of MAPK activity Database 0
Category members GO Category GO:0001915 negative regulation of T cell mediated cytotoxicity Database 0
Category members GO Category GO:0001916 positive regulation of T cell mediated cytotoxicity Database 0
Category members GO Category GO:0001960 negative regulation of cytokine-mediated signaling pathway Database 0
Category members GO Category GO:0002244 hematopoietic progenitor cell differentiation Database 0
Category members GO Category GO:0002378 immunoglobulin biosynthetic process Database 0
Category members GO Category GO:0002711 positive regulation of T cell mediated immunity Database 0
Category members GO Category GO:0002925 positive regulation of humoral immune response mediated by circulating immunoglobulin Database 0
Category members GO Category GO:0004725 protein tyrosine phosphatase activity Database 0
Category members GO Category GO:0005001 transmembrane receptor protein tyrosine phosphatase activity Database 0
Category members GO Category GO:0006469 negative regulation of protein kinase activity Database 0
Category members GO Category GO:0006470 protein dephosphorylation Database 0
Category members GO Category GO:0006933 negative regulation of cell adhesion involved in substrate-bound cell migration Database 0
Category members GO Category GO:0007159 leukocyte cell-cell adhesion Database 0
Category members GO Category GO:0016311 dephosphorylation Database 0
Category members GO Category GO:0016791 phosphatase activity Database 0
Category members GO Category GO:0030183 B cell differentiation Database 0
Category members GO Category GO:0030217 T cell differentiation Database 0
Category members GO Category GO:0030890 positive regulation of B cell proliferation Database 0
Category members GO Category GO:0031953 negative regulation of protein autophosphorylation Database 0
Category members GO Category GO:0034113 heterotypic cell-cell adhesion Database 0
Category members GO Category GO:0035335 peptidyl-tyrosine dephosphorylation Database 0
Category members GO Category GO:0043395 heparan sulfate proteoglycan binding Database 0
Category members GO Category GO:0044770 cell cycle phase transition Database 0
Category members GO Category GO:0045060 negative thymic T cell selection Database 0
Category members GO Category GO:0045577 regulation of B cell differentiation Database 0
Category members GO Category GO:0045582 positive regulation of T cell differentiation Database 0
Category members GO Category GO:0048304 positive regulation of isotype switching to IgG isotypes Database 0
Category members GO Category GO:0048539 bone marrow development Database 0
Category members GO Category GO:0050853 B cell receptor signaling pathway Database 0


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