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Query: PRKD2

RNAi screen result RNAPII IP (PI) CSB IP CSB IP (PI) Chrom. Chrom. (PI) Phosphorylation Ubiquitylation
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[Click on the plots to view the data selection in the respective scatterplot]

Protein Results:

 Results for post-translational modifications: see below | Red/green: hit at lower/upper end of the respective screen
Gene name Point score Z-score sums RNAi high RNAi low RNAPII-IP (PI) CSB-IP CSB-IP (PI) Chrom. Chrom. (PI)
PRKD2 0 3.395 0.050 0.170
PRKD2 0 3.395 0.050 0.170 0.914

PTM Sites:

 Back to Protein Results | Red/green: hit at lower/upper end of the respective screen
Gene name PTM type PTM site UV UV (PI) Sequence
PRKD2 Ubiquitylation K730 1.177 _IIGEK(gl)SFR_
PRKD2 Phosphorylation S197 0.239 0.895 _RLS(ph)STSLASGHSVR_
PRKD2 Phosphorylation S214 0.216 0.302 _LGTSES(ph)LPCTAEELSR_
PRKD2 Phosphorylation S212 0.113 _LGTS(ph)ESLPCTAEELSR_
PRKD2 Phosphorylation T211 -0.119 _LGT(ph)SESLPCTAEELSR_
PRKD2 Phosphorylation S886 -0.718 -0.305 _DLGGACPPQDHDMQGLAERIS(ph)VL_
PRKD2 Phosphorylation S710 -0.413 -0.511 _S(ph)VVGTPAYLAPEVLLNQGYNR_
PRKD2 Phosphorylation T714 -0.279 _S(ph)VVGTPAYLAPEVLLNQGYNR_

Background Information for PRKD2:


Pubmed-PRKD2 »
Uniprot-PRKD2 »
Biogrid-PRKD2 »
ProteomicsDB-PRKD2 »

Tumorportal-PRKD2 »
COSMIC-PRKD2 »
GenomeRNAi-PRKD2 »
Genecards-PRKD2


Protein-protein Interactions for PRKD2
Show screen data for Category Name and Description Link to cat description Data Source
Category members IP bait PRKD2 Cat. description Hein, Mann, Cell 2015
Category members IP bait ARPC5 Cat. description BioPlex, Huttlin, Gygi, Cell 2015
Category members IP bait DOCK5 Cat. description BioPlex, Huttlin, Gygi, Cell 2015
Category members IP bait GML Cat. description BioPlex, Huttlin, Gygi, Cell 2015
Category members IP bait IL13RA2 Cat. description BioPlex, Huttlin, Gygi, Cell 2015
Category members IP bait PHYHIP Cat. description BioPlex, Huttlin, Gygi, Cell 2015
Category members IP bait PLA2G10 Cat. description BioPlex, Huttlin, Gygi, Cell 2015
Category members IP bait RFFL Cat. description BioPlex, Huttlin, Gygi, Cell 2015
Category members IP bait SKP2 Cat. description BioPlex, Huttlin, Gygi, Cell 2015
Category members IP bait ST8SIA4 Cat. description BioPlex, Huttlin, Gygi, Cell 2015
Category members IP bait TPSB2 Cat. description BioPlex, Huttlin, Gygi, Cell 2015
Category members IP bait TSC22D4 Cat. description BioPlex, Huttlin, Gygi, Cell 2015


Protein Domains in PRKD2
Domain name Domain Description TC-NER relevance -log10(p-value)
Category members PE/DAG-bd IPR002219 0.63
Category members DAG/PE-bd IPR020454 0.18
Category members PH_domain IPR001849 0.14
Category members Kinase-like_dom IPR011009 0.03
Category members Prot_kinase_dom IPR000719 0
Category members Ser-Thr/Tyr_kinase_cat_dom IPR001245 0
Category members Ser/Thr_dual-sp_kinase IPR002290 0
Category members LipoPS_kinase IPR010440 0
Category members Tyr_kinase_cat_dom IPR020635 0


Protein complexes (CORUM database) featuring PRKD2
Category Type Category ID Category Name Data Source TC-NER relevance -log10(p-value)


Categories featuring PRKD2
Category Type Category ID Category Name Data Source TC-NER relevance -log10(p-value)
Category members GO Category GO:0005515 protein binding Database INF
Category members GO Category GO:0005634 nucleus Database INF
Category members GO Category GO:0005737 cytoplasm Database 12.81
Category members GO Category GO:0005524 ATP binding Database 5.54
Category members GO Category GO:0005886 plasma membrane Database 1.21
Category members GO Category GO:0004674 protein serine/threonine kinase activity Database 0.66
Category members GO Category GO:0070374 positive regulation of ERK1 and ERK2 cascade Database 0.65
Category members GO Category GO:0016020 membrane Database 0.52
Category members GO Category GO:0005622 intracellular Database 0.32
Category members GO Category GO:0005794 Golgi apparatus Database 0.27
Category members GO Category GO:0046777 protein autophosphorylation Database 0.23
Category members GO Category GO:0045766 positive regulation of angiogenesis Database 0.19
Category members GO Category GO:0004672 protein kinase activity Database 0.19
Category members GO Category GO:0018105 peptidyl-serine phosphorylation Database 0.18
Category members GO Category GO:0045944 positive regulation of transcription from RNA polymerase II promoter Database 0.13
Category members GO Category GO:0043536 positive regulation of blood vessel endothelial cell migration Database 0.09
Category members GO Category GO:0004697 protein kinase C activity Database 0.09
Category members GO Category GO:0061154 endothelial tube morphogenesis Database 0.08
Category members GO Category GO:0008219 cell death Database 0.08
Category members GO Category GO:0035924 cellular response to vascular endothelial growth factor stimulus Database 0.06
Category members GO Category GO:0050852 T cell receptor signaling pathway Database 0.06
Category members GO Category GO:0032743 positive regulation of interleukin-2 production Database 0.05
Category members GO Category GO:0006468 protein phosphorylation Database 0.04
Category members GO Category GO:0045785 positive regulation of cell adhesion Database 0.04
Category members GO Category GO:0033138 positive regulation of peptidyl-serine phosphorylation Database 0.03
Category members GO Category GO:0004713 protein tyrosine kinase activity Database 0.01
Category members GO Category GO:0001525 angiogenesis Database 0
Category members GO Category GO:0001938 positive regulation of endothelial cell proliferation Database 0
Category members GO Category GO:0007155 cell adhesion Database 0
Category members GO Category GO:0009103 lipopolysaccharide biosynthetic process Database 0
Category members GO Category GO:0010595 positive regulation of endothelial cell migration Database 0
Category members GO Category GO:0016772 transferase activity, transferring phosphorus-containing groups Database 0
Category members GO Category GO:0016773 phosphotransferase activity, alcohol group as acceptor Database 0
Category members GO Category GO:0030949 positive regulation of vascular endothelial growth factor receptor signaling pathway Database 0
Category members GO Category GO:0032757 positive regulation of interleukin-8 production Database 0
Category members GO Category GO:0032793 positive regulation of CREB transcription factor activity Database 0
Category members GO Category GO:0035556 intracellular signal transduction Database 0
Category members GO Category GO:0038033 positive regulation of endothelial cell chemotaxis by VEGF-activated vascular endothelial growth factor receptor signaling pathway Database 0
Category members GO Category GO:0045743 positive regulation of fibroblast growth factor receptor signaling pathway Database 0
Category members GO Category GO:0046872 metal ion binding Database 0
Category members GO Category GO:0048010 vascular endothelial growth factor receptor signaling pathway Database 0
Category members GO Category GO:0050862 positive regulation of T cell receptor signaling pathway Database 0
Category members GO Category GO:0051091 positive regulation of sequence-specific DNA binding transcription factor activity Database 0
Category members GO Category GO:0051092 positive regulation of NF-kappaB transcription factor activity Database 0


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