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Query: PAK2

RNAi screen result RNAPII IP (PI) CSB IP CSB IP (PI) Chrom. Chrom. (PI) Phosphorylation Ubiquitylation
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[Click on the plots to view the data selection in the respective scatterplot]

Protein Results:

 Results for post-translational modifications: see below | Red/green: hit at lower/upper end of the respective screen
Gene name Point score Z-score sums RNAi high RNAi low RNAPII-IP (PI) CSB-IP CSB-IP (PI) Chrom. Chrom. (PI)
PAK2 0 1.638 -0.760 1.040

PTM Sites:

 Back to Protein Results | Red/green: hit at lower/upper end of the respective screen
Gene name PTM type PTM site UV UV (PI) Sequence
PAK2 Phosphorylation S141 -0.294 -0.321 _YLS(ph)FTPPEK_
PAK2 Phosphorylation S2 -1.228 -0.902 _(ac)S(ph)DNGELEDKPPAPPVR_
PAK2 Ubiquitylation K136 1.213 _FYDSNTVK(gl)QK_
PAK2 Ubiquitylation K370 -0.565 _DIK(gl)SDNVLLGMEGSVK_

Background Information for PAK2:


Pubmed-PAK2 »
Uniprot-PAK2 »
Biogrid-PAK2 »
ProteomicsDB-PAK2 »

Tumorportal-PAK2 »
COSMIC-PAK2 »
GenomeRNAi-PAK2 »
Genecards-PAK2


Protein-protein Interactions for PAK2
Show screen data for Category Name and Description Link to cat description Data Source
Category members IP bait CDKN2AIP Cat. description Hein, Mann, Cell 2015
Category members IP bait MYL12A;MYL12B Cat. description Hein, Mann, Cell 2015
Category members IP bait PAK2 Cat. description Hein, Mann, Cell 2015
Category members IP bait RACGAP1 Cat. description Hein, Mann, Cell 2015
Category members IP bait ARHGEF6 Cat. description BioPlex, Huttlin, Gygi, Cell 2015
Category members IP bait FBXO28 Cat. description BioPlex, Huttlin, Gygi, Cell 2015
Category members IP bait FGB Cat. description BioPlex, Huttlin, Gygi, Cell 2015
Category members IP bait FSD1 Cat. description BioPlex, Huttlin, Gygi, Cell 2015
Category members IP bait ICAM1 Cat. description BioPlex, Huttlin, Gygi, Cell 2015
Category members IP bait KIFAP3 Cat. description BioPlex, Huttlin, Gygi, Cell 2015
Category members IP bait LPXN Cat. description BioPlex, Huttlin, Gygi, Cell 2015
Category members IP bait NCK2 Cat. description BioPlex, Huttlin, Gygi, Cell 2015
Category members IP bait OCRL Cat. description BioPlex, Huttlin, Gygi, Cell 2015
Category members IP bait OR10H3 Cat. description BioPlex, Huttlin, Gygi, Cell 2015
Category members IP bait PLK2 Cat. description BioPlex, Huttlin, Gygi, Cell 2015
Category members IP bait RHOJ Cat. description BioPlex, Huttlin, Gygi, Cell 2015
Category members IP bait SNRNP27 Cat. description BioPlex, Huttlin, Gygi, Cell 2015
Category members IP bait SOX2 Cat. description BioPlex, Huttlin, Gygi, Cell 2015
Category members IP bait USP47 Cat. description BioPlex, Huttlin, Gygi, Cell 2015


Protein Domains in PAK2
Domain name Domain Description TC-NER relevance -log10(p-value)
Category members CRIB_dom IPR000095 0.13
Category members WASP_C IPR011026 0.08
Category members Kinase-like_dom IPR011009 0.03
Category members Prot_kinase_dom IPR000719 0
Category members Ser-Thr/Tyr_kinase_cat_dom IPR001245 0
Category members Ser/Thr_dual-sp_kinase IPR002290 0
Category members Tyr_kinase_cat_dom IPR020635 0


Protein complexes (CORUM database) featuring PAK2
Category Type Category ID Category Name Data Source TC-NER relevance -log10(p-value)


Categories featuring PAK2
Category Type Category ID Category Name Data Source TC-NER relevance -log10(p-value)
Category members GO Category GO:0005515 protein binding Database INF
Category members GO Category GO:0005634 nucleus Database INF
Category members GO Category GO:0005829 cytosol Database INF
Category members GO Category GO:0016032 viral process Database INF
Category members GO Category GO:0005737 cytoplasm Database 12.81
Category members Pathway Pathway_197 REACTOME_HIV_INFECTION 0 12.07
Category members Pathway Pathway_196 REACTOME_HOST_INTERACTIONS_OF_HIV_FACTORS 0 9.67
Category members GO Category GO:0019048 modulation by virus of host morphology or physiology Database 7.81
Category members GO Category GO:0005524 ATP binding Database 5.54
Category members Pathway Pathway_621 REACTOME_ADAPTIVE_IMMUNE_SYSTEM 0 4.72
Category members Pathway Pathway_458 REACTOME_IMMUNE_SYSTEM 0 3
Category members GO Category GO:0006921 cellular component disassembly involved in execution phase of apoptosis Database 2.98
Category members Pathway Pathway_876 REACTOME_APOPTOTIC_EXECUTION_PHASE 0 2.5
Category members Pathway Pathway_837 REACTOME_APOPTOSIS 0 2.39
Category members GO Category GO:0006915 apoptotic process Database 2.12
Category members Pathway Pathway_1147 REACTOME_SEMA3A_PAK_DEPENDENT_AXON_REPULSION 0 1.89
Category members Pathway Pathway_962 BIOCARTA_FAS_PATHWAY 0 1.75
Category members Pathway Pathway_309 ST_INTEGRIN_SIGNALING_PATHWAY 0 1.35
Category members GO Category GO:0005886 plasma membrane Database 1.21
Category members Pathway Pathway_595 KEGG_FOCAL_ADHESION 0 1.08
Category members GO Category GO:0030036 actin cytoskeleton organization Database 1.08
Category members Pathway Pathway_673 REACTOME_AXON_GUIDANCE 0 1.06
Category members Pathway Pathway_674 REACTOME_SEMAPHORIN_INTERACTIONS 0 0.96
Category members Pathway Pathway_194 REACTOME_THE_ROLE_OF_NEF_IN_HIV1_REPLICATION_AND_DISEASE_PATHOGENESIS 0 0.83
Category members Pathway Pathway_507 PID_MET_PATHWAY 0 0.82
Category members GO Category GO:0042981 regulation of apoptotic process Database 0.79
Category members Pathway Pathway_669 PID_RAC1_PATHWAY 0 0.68
Category members Pathway Pathway_568 PID_CDC42_PATHWAY 0 0.68
Category members GO Category GO:0004674 protein serine/threonine kinase activity Database 0.66
Category members GO Category GO:0043066 negative regulation of apoptotic process Database 0.6
Category members GO Category GO:0050690 regulation of defense response to virus by virus Database 0.49
Category members Pathway Pathway_963 BIOCARTA_TNFR1_PATHWAY 0 0.44
Category members GO Category GO:0048471 perinuclear region of cytoplasm Database 0.39
Category members GO Category GO:0019901 protein kinase binding Database 0.37
Category members GO Category GO:0038095 Fc-epsilon receptor signaling pathway Database 0.36
Category members Pathway Pathway_838 SIG_REGULATION_OF_THE_ACTIN_CYTOSKELETON_BY_RHO_GTPASES 0 0.35
Category members Pathway Pathway_42 REACTOME_DEVELOPMENTAL_BIOLOGY 0 0.32
Category members Pathway Pathway_795 REACTOME_REGULATION_OF_APOPTOSIS 0 0.31
Category members Pathway Pathway_510 SIG_CHEMOTAXIS 0 0.28
Category members GO Category GO:0042802 identical protein binding Database 0.26
Category members Pathway Pathway_587 KEGG_T_CELL_RECEPTOR_SIGNALING_PATHWAY 0 0.25
Category members GO Category GO:0046777 protein autophosphorylation Database 0.23
Category members Pathway Pathway_701 REACTOME_GENERATION_OF_SECOND_MESSENGER_MOLECULES 0 0.22
Category members GO Category GO:0016310 phosphorylation Database 0.21
Category members Pathway Pathway_573 REACTOME_TCR_SIGNALING 0 0.2
Category members GO Category GO:0004672 protein kinase activity Database 0.19
Category members Pathway Pathway_1036 REACTOME_CD28_DEPENDENT_VAV1_PATHWAY 0 0.18
Category members Pathway Pathway_165 SIG_PIP3_SIGNALING_IN_CARDIAC_MYOCTES 0 0.18
Category members GO Category GO:0018105 peptidyl-serine phosphorylation Database 0.18
Category members Pathway Pathway_960 BIOCARTA_HIVNEF_PATHWAY 0 0.17
Category members Pathway Pathway_858 PID_MYC_PATHWAY 0 0.17
Category members Pathway Pathway_437 PID_VEGFR1_2_PATHWAY 0 0.13
Category members GO Category GO:0007411 axon guidance Database 0.13
Category members Pathway Pathway_1041 BIOCARTA_AGR_PATHWAY 0 0.13
Category members Pathway Pathway_622 REACTOME_CD28_CO_STIMULATION 0 0.13
Category members GO Category GO:0007409 axonogenesis Database 0.13
Category members GO Category GO:0004702 receptor signaling protein serine/threonine kinase activity Database 0.1
Category members Pathway Pathway_580 KEGG_REGULATION_OF_ACTIN_CYTOSKELETON 0 0.08
Category members GO Category GO:0007015 actin filament organization Database 0.08
Category members Pathway Pathway_620 REACTOME_COSTIMULATION_BY_THE_CD28_FAMILY 0 0.06
Category members GO Category GO:0050852 T cell receptor signaling pathway Database 0.06
Category members GO Category GO:0045087 innate immune response Database 0.05
Category members GO Category GO:0006468 protein phosphorylation Database 0.04
Category members GO Category GO:0061098 positive regulation of protein tyrosine kinase activity Database 0.04
Category members Pathway Pathway_1034 KEGG_AXON_GUIDANCE 0 0.04
Category members Pathway Pathway_23 KEGG_RENAL_CELL_CARCINOMA 0 0.03
Category members GO Category GO:0004713 protein tyrosine kinase activity Database 0.01
Category members Pathway Pathway_1000 BIOCARTA_MAPK_PATHWAY 0 0
Category members Pathway Pathway_1031 REACTOME_SIGNALING_BY_ROBO_RECEPTOR 0 0
Category members Pathway Pathway_1039 PID_P38_ALPHA_BETA_PATHWAY 0 0
Category members Pathway Pathway_1148 REACTOME_ACTIVATION_OF_RAC 0 0
Category members Pathway Pathway_387 ST_T_CELL_SIGNAL_TRANSDUCTION 0 0
Category members Pathway Pathway_500 PID_FCER1_PATHWAY 0 0
Category members Pathway Pathway_575 KEGG_ERBB_SIGNALING_PATHWAY 0 0
Category members Pathway Pathway_597 BIOCARTA_FCER1_PATHWAY 0 0
Category members Pathway Pathway_715 KEGG_MAPK_SIGNALING_PATHWAY 0 0
Category members GO Category GO:0006469 negative regulation of protein kinase activity Database 0
Category members GO Category GO:0007165 signal transduction Database 0
Category members GO Category GO:0016772 transferase activity, transferring phosphorus-containing groups Database 0
Category members GO Category GO:0030296 protein tyrosine kinase activator activity Database 0
Category members GO Category GO:0031295 T cell costimulation Database 0
Category members GO Category GO:0040008 regulation of growth Database 0
Category members GO Category GO:0050731 positive regulation of peptidyl-tyrosine phosphorylation Database 0


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